Annals of Medical Research最新文献_第8页

Serum hypoxia-inducible factor 1 alpha levels in stroke 脑卒中患者血清缺氧诱导因子1 α水平

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.08.186

Esen ekli, Asl du, Dilcan Kotan, Asuman zkan

{"title":"Serum hypoxia-inducible factor 1 alpha levels in stroke","authors":"Esen ekli, Asl du, Dilcan Kotan, Asuman zkan","doi":"10.5455/annalsmedres.2023.08.186","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.186","url":null,"abstract":"Aim: In order to survive, human cells must adapt to changes in the oxygen level of their environment. Many endogenous mechanisms operate in hypoxia. Hypoxia-inducible factor 1 (HIF-1) is a transcriptional protein involved in the head of the cascade that regulates the response of brain and other tissues to hypoxia. HIF-1 alpha (HIF-1α) is the main molecule that responds to hypoxia and is an important marker of cerebral hypoperfusion. Materials and Methods: 39 acute stroke patients aged between 18-80 years and 38 control patients included in our study. We aimed to examine the serum HIF-1α levels in early period of acute ischemic stroke. We also aimed to evaluate its usefulness in determining tissue damage due to hypoxia and the prognosis of the disease. Results: Serum HIF-1α levels were higher in acute ischemic stroke patients compared to the control group (p= 0.000). There was no significant correlation between infarct volumes, NHISS scores, blood pressure and HIF-1α values of the stroke patients. Conclusion: HIF-1α could be an important biomarker in detecting cerebral hypoxia. It is possible to study this in human peripheral blood. Its usability in stroke may become widespread with studies on its therapeutic target.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134981039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Cystitis Model: The Response of Sprague-Dawley Rats’ Bladder To Surfactant Instillation 人工膀胱炎模型:Sprague-Dawley大鼠膀胱对表面活性剂的反应

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.08.267

C. Yeşildal, O. Yilmaz, S. Yenigurbuz, A. Sade, Y. Kızılkan, A. Albayrak, M. Ilgi

{"title":"Artificial Cystitis Model: The Response of Sprague-Dawley Rats’ Bladder To Surfactant Instillation","authors":"C. Yeşildal, O. Yilmaz, S. Yenigurbuz, A. Sade, Y. Kızılkan, A. Albayrak, M. Ilgi","doi":"10.5455/annalsmedres.2022.08.267","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.267","url":null,"abstract":"Abstract Objectives: Chemical cystitis is a disease that causes mortality and morbidity. It’s treatment is really difficult. We aimed to present a low-cost, successful, easy-to-access, and easily applicable treatment option for the treatment of this disease. Materials and Methods: 16 Sprague-Dawley rats were divided into 4 groups. 1 group is a sham group, 2’nd is saline, 3’rd surfactant before chemical cystitis, and 4’th group is surfactant after chemical cystitis. On the 4th day, all groups are sacrificed and their bladders are sent for histochemical examination. The pathological data of the subjects were evaluated according to the levels of hemorrhage, edema, inflammation, and congestion. Data were evaluated by scoring between 0-2. 0 none, 1 Moderate, and 2 highly present. Results: There was no statistically significant difference found between the groups in terms of all parameters (p=0.111). The difference was not found statistically significant in the pairwise comparison of the groups (p>0.05). Conclusion: Surfactant had no preventive or therapeutic effect on the chemical cystitis developed in mice. The simple saline application seems to be more effective.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85809820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Title: The effects of demographic transformation due to refugee migration in Turkey on maternal and neonatal outcomesRunning Title: Syrian pregnancies and their adverse outcomes 标题:土耳其难民移民导致的人口结构转变对孕产妇和新生儿结局的影响

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.06.185

Sad krer

{"title":"Title: The effects of demographic transformation due to refugee migration in Turkey on maternal and neonatal outcomes\u0000\u0000Running Title: Syrian pregnancies and their adverse outcomes","authors":"Sad krer","doi":"10.5455/annalsmedres.2022.06.185","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.06.185","url":null,"abstract":"Objective: This research analyzes the obstetric and neonatal outcomes of Syrian and Turkish pregnant women. Methods: This retrospective cross-sectional study included 1,823 pregnant Turkish and Syrian women aged 13 to 47 who gave birth at a tertiary care facility in the Mediterranean region of Turkey. Between September 2020 and August 2021, 940 Turkish and 883 Syrian refugees (SYR) pregnant women participated in the study. The groups were compared for demographic data, obstetric outcomes, and neonatal features. Results: The maternal age distribution for SYR includes younger ages (p<0,001). The literacy status among Syrians is lower than that of Turks (p<0,001). Syrian pregnant women have a lower prevalence of cesarean section (CS); they have a greater rate of first spontaneous vaginal delivery (fSVD) and spontaneous vaginal delivery (SVD) than Turkish pregnant women (p<0,001). Amniotic membrane rupture is more prevalent among pregnant Syrian women (p=0,007). APGAR scores differ by nationality (p=0.004). There is a significant difference in maternal hemoglobin median values (g/dL) according to nationality (p<0.001). There is a substantial difference between the birth weights of newborns with low birth weight (LBW) (1500 ≤ - <2500 grams) and those with 2500 grams or more in both groups (p<0.001). Conclusion: There is a strong correlation between education and prenatal care utilization. As women's education levels increase, the rates of prenatal care also increase. Antenatal care is the most valuable and effective method for preventing adverse pregnancy and neonatal outcomes.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88625635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alamandine alleviates methotrexate-induced nephrotoxicity in rats by targeting oxidative stress and inflammation Alamandine通过靶向氧化应激和炎症减轻甲氨蝶呤诱导的大鼠肾毒性

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.06.128

A. Yıldız, M. Aras, M. Gunata, M. Durhan, S. Polat, H. Parlakpınar, Y. Cigremis, N. Vardı

{"title":"Alamandine alleviates methotrexate-induced nephrotoxicity in rats by targeting oxidative stress and inflammation","authors":"A. Yıldız, M. Aras, M. Gunata, M. Durhan, S. Polat, H. Parlakpınar, Y. Cigremis, N. Vardı","doi":"10.5455/annalsmedres.2023.06.128","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.06.128","url":null,"abstract":"Aim: Nephrotoxicity due to the use of methotrexate (Mtx) is one of the most important problems associated with chemotherapy. Oxidative stress and inflammation are the major pathomechanisms of Mtx-induced nephrotoxicity. Alamandine (Ala), a new member of the renin-angiotensin system (RAS), is an important peptide with antioxidant and anti-inflammatory capacities. In this study, it was investigated whether Ala ameliorates Mtx-induced kidney damage by reducing oxidative stress and inflammation. Materials and Methods: Male Wistar albino rats were assigned into three groups: control group, Mtx group, and Mtx+Ala group. At the end of the experiment, kidney tissues were quickly removed. Glutathione (GSH) and malondialdehyde (MDA) levels were measured to determine the oxidative state in kidney tissues. In addition, tissue samples were assessed as histopathological and immunohistochemical for heat shock protein 60 (HSP60), caspase-3, tumor necrosis factor-α (TNF-α), and receptor-interacting protein kinase-3 (RIPK3). Results: Mtx treatment resulted in reduced GSH content, elevated MDA level, increased heat shock protein 60 (HSP60), and caspase-3 expression. These changes in kidney tissues of rats treated with Mtx triggered oxidative stress characterized by apoptosis and kidney damage. Mtx also markedly increased the expression of TNF-α, an inflammation marker, and RIPK3, a marker of necroptosis. However, Ala administration significantly alleviated Mtx-induced kidney damage by reducing apoptosis and necroptosis by suppressing oxidative stress and inflammation. Conclusion: Taken together, our results support that Ala treatment can serve as a new and promising therapeutic strategy against Mtx-induced nephrotoxicity. Keywords: Alamandine; methotrexate; oxidative stress; inflammation; apoptosis; necroptosis; nephrotoxicity","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84851859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective Analysis of Poisoning Cases in the Pediatric Intensive Care Unit 儿科重症监护病房中毒病例回顾性分析

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.05.114

S. Yavuz, Ali Avc, Feyat Tunç, Sabahattin Ekin

{"title":"Retrospective Analysis of Poisoning Cases in the Pediatric Intensive Care Unit","authors":"S. Yavuz, Ali Avc, Feyat Tunç, Sabahattin Ekin","doi":"10.5455/annalsmedres.2023.05.114","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.05.114","url":null,"abstract":"Aim: According to the World Health Organization (WHO) data, poisonings are still a significant reason for mortality and morbidity in the childhood group. The rapid technological developments and the change in socio-cultural structures have caused an increase in chemical substances in homes, and the easy access of children to these chemicals has increased the possibility of poisoning. We aimed to make a retrospective analysis of patients with a diagnosis of poisoning hospitalized in the pediatric intensive care unit (PICU). Materials and methods: The current clinical study is a retrospective, observational, single-center study and contains children adopted to the tertiary PICU of the 16-bed Batman Training and Research Hospital between March 2021 and March 2022 with a diagnosis of acute poisoning. Results: Forty patients were female (56.3%), and 31 patients were male (43.7%). All patients were admitted to the intensive care unit for advanced and supportive treatment. Supportive treatment was sufficient for 42 patients (59.2%). As advanced treatment; N-acetylcysteine infusion was given to 14 patients (19.7), oxygen to 3 patients (4.2%), inotropic support to 2 patients (2.8%), mechanical ventilatory support to 1 patient (1.4%), and antidote to 1 patient (1.4%). No mortality was observed, but some patients progressed morbidly and needed a mechanical ventilator and inotropic agent support. Conclusion: No mortality was observed, but some patients progressed morbidly and needed mechanical ventilatory support and inotropic agents. For this reason, the physician who first encounters the patient in the emergency department should evaluate each patient and the poison separately.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86932800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVALUATION OF MANDIBULAR FRACTURE PATTERNS AND TREATMENT METHODS: A SINGLE CENTER RETROSPECTIVE STUDY 评估下颌骨骨折类型和治疗方法:一项单中心回顾性研究

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.05.120

C. Asan, Emil Mursalov, A. Demirba, E. Soylu, S. Bilge, C. Topan, Y. Kaba, A. Alkan

{"title":"EVALUATION OF MANDIBULAR FRACTURE PATTERNS AND TREATMENT METHODS: A SINGLE CENTER RETROSPECTIVE STUDY","authors":"C. Asan, Emil Mursalov, A. Demirba, E. Soylu, S. Bilge, C. Topan, Y. Kaba, A. Alkan","doi":"10.5455/annalsmedres.2023.05.120","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.05.120","url":null,"abstract":"Objectives: Mandible fractures are among the most common bone fractures in the maxillofacial region. Correct and early treatment is important in mandible fractures. The aim of this study is to retrospectively examine and analyze the patterns and treatment methods of mandibular fractures seen in patients admitted with trauma. Methods: Patients treated for mandible fractures between 2006- 2021 years were included in this retrospective study. The files and archive records of the patients were scanned retrospectively. Demographic, clinical and radiological data were recorded. The treatment methods of the patients included in the study were evaluated. Results: 176 patients with a total of 246 fractures were included to the study. Simple fractures were found in 130 patients, green tree fractures in 12 patients, and comminuted fractures in 34 patients. There were 147 un-favorable and 29 favorable fractures in total. Fall was found to be the most common etiologic cause in all gender and age groups (n=55, 31.2%). Angle fracture was observed most frequently in single fracture cases, while condyle fracture was the most common accompanying fracture type in multiple fractures. 88 patients were treated with the open and, 56 with the closed approach, and 32 with both the open and closed approach. Conclusion: Fracture type and etiologic cause are closely related with the type of the fracture. Mandible fractures should be carefully examined and the most appropriate treatment for the type of fracture should be applied as soon as possible.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84032126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An evaluation of rapid antigen tests diagnostic performance in the detection of SARS-CoV-2 infection 快速抗原试验在检测SARS-CoV-2感染中的诊断效果评价

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.10.311

A. M. Res, G. Bayram, Harun Gulbudak, Taylan Bozok, G. Aslan

{"title":"An evaluation of rapid antigen tests diagnostic performance in the detection of SARS-CoV-2 infection","authors":"A. M. Res, G. Bayram, Harun Gulbudak, Taylan Bozok, G. Aslan","doi":"10.5455/annalsmedres.2022.10.311","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.10.311","url":null,"abstract":"Aim: The study aimed simultaneously compare the diagnostic performance of the rapid antigen test (CoVard COVID-19 Rapid Antigen Test Kit, Turkey) and the RT-PCR test used in the detection of SARS-CoV-2 infection. Materials and Methods: In this study, the results of rapid antigen tests and RT-PCR tests applied simultaneously to the diagnosis of SARS-CoV-2 infection on nasopharyngeal swab specimens taken from patients applying to the …… University Hospital Emergency Unit with various symptoms were retrospectively analyzed. The study included 308 patients with or without respiratory tract infection symptoms who underwent COVID-19 rapid antigen and RT-PCR testing. Results: It was observed that 157 (51.0%) of the patients had symptoms related to COVID-19. A total of 50 (16.2%; 95%CI: 12.0-20.5%) of the patients' rapid antigen test and 97 (31.5%; 95%CI: 26.3-37.0) of the patients' RT-PCR test were positive. The rapid antigen test for 41 (42.3%; 95%CI: 32.0-52.9) out of 97 specimens with a positive RT-PCR test was also positive. The rapid antigen test was positive in nine (18%; 95%CI: 8.6-28.6) specimens while the RT-PCR test was negative. The concordance between the rapid antigen test and the RT-PCR was intermediate (k=0.437, p<0.0005). Conclusion: Compared to nucleic acid-based tests, rapid antigen tests are practical and fast, as well as not requiring experienced personnel and special laboratory infrastructure. It was concluded that the use of rapid antigen tests will help provide rapid triage in emergency services, especially during the times when cases with COVID-19 are on the rise.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77780098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Hysterosalpingography Diagnostic Value with Laparoscopy and Hysteroscopy Findings in Infertility Research 子宫输卵管造影与腹腔镜、宫腔镜诊断不孕症的价值比较

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.03.073

A. K., Muradiye m

{"title":"Comparison of Hysterosalpingography Diagnostic Value with Laparoscopy and Hysteroscopy Findings in Infertility Research","authors":"A. K., Muradiye m","doi":"10.5455/annalsmedres.2023.03.073","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.03.073","url":null,"abstract":"Objective: To compare hysterosalpingography (HSG) findings with laparoscopy (LS) and hysteroscopy (HS) findings in infertile patients and evaluate their adequacy in diagnosis Materials and Methods: The presented retrospective study was conducted on 106 patients diagnosed with primary and secondary infertility. LS-HS procedure was applied to the cases who could not get pregnant at the end of six months after HSG. Sociodemographic data and tubal, uterine, endometrial, and pelvic findings were compared. Sensitivity, specificity, and positive and negative predictive values were calculated. Results: Primary infertility was observed at a higher rate. (n=68, 64.2%). Most of the patients were in the 24-29 age group. The maximum duration of infertility has been observed in the range of 1-4 years. Compared with LS in tubal patency, the sensitivity of HSG was 85%, specificity 65%, positive predictivity 88.3%, and negative predictivity 58.6%. Compared with HS in detecting uterine pathologies, the sensitivity of HSG was 94.9%, specificity 53.3%, positive predictivity 72.7%, and negative predictivity 89.7%. Conclusion: In evaluating infertile patients, HSG is reliable in detecting tubal blockade. Due to its low specificity, invasive methods can be applied, especially in unexplained infertility whose pathology is not seen in HSG. These methods are complementary rather than the alternative.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87766473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the relationship between the PaO₂/FiO₂ ratio and Wells score in patients diagnosed with acute pulmonary embolism 对确诊为急性肺栓塞患者的 PaO₂/FiO₂比值与威尔斯评分之间关系的研究

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2022.10.321

Fatma Tortum, A. Gur

引用次数: 0

Audiologic follow up results of child with NGLY1 deficiency NGLY1缺乏症患儿听力学随访结果

Annals of Medical Research Pub Date : 2023-01-01 DOI: 10.5455/annalsmedres.2023.01.022

Oğulcan Gundogdu, Cem Yeral, Oğuz Yılmaz, Y. Bayazıt

引用次数: 0