Annals of Medical Research最新文献

{"title":"Comparison via Simulation of Association Coefficients Calculated between Categorical Variables","authors":"Sinem Sensoy, Yeliz Arici","doi":"10.5455/annalsmedres.2023.08.206","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.206","url":null,"abstract":"Aim: The aim of this study was to compare the robustness of some association coefficients used to determine the relationships between categorical variables under different experimental conditions. Material and Methods: A simulation study was conducted where random numbers were generated from a bivariate standard normal distribution with correlations of 0.5 and 0.9. Sample sizes were set at 30, 50, 100, 150 and 200. Random numbers were equally spaced and coded as 3×3, 4×4 and 5×5 cross-tabulations, respectively. The robustness of Pearson’s, Spearman's rank, Kendall's tau-b, Kendall's tau-c, Goodman-Kruskal’s gamma and Somer's d coefficients were compared under different experimental conditions consisting of combinations of specified population correlation degrees, table dimensions and sample sizes. Results: The Goodman-Kruskal’s gamma coefficient gave the closest result to the relationship levels set at the beginning of the study in all experimental conditions. However, after a certain level, it was negatively affected by the increase in table dimension and sample size. Kendall's tau-b and tau-c coefficients were furthest from the actual degree of the association. Spearman's rank correlation was more robust than Kendall's tau-b, Kendall's tau-c and Somer's d coefficients. Conclusion: The results of the study showed that the dimension of the contingency tables and sample size were effective factors in the robustness of association coefficients for categorical variables. Therefore, researchers should consider the table dimension and sample size as well as the type of variable when selecting the association coefficient to be calculated.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135800286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship with Disease Severity of Ischemia-Modified Albumin Levels in Diabetic Nephropathy","authors":"G ENER, Cihan kun, Esra lu, Ba Can, Bet Evran","doi":"10.5455/annalsmedres.2023.08.232","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.232","url":null,"abstract":"Background: While type 2 diabetes (T2DM) is increasing rapidly, developing diabetic complications are the leading cause of morbidity and mortality. Biochemical markers are important for early diagnosis and treatment of nephropathy, which is a common complication. The aim of this study is to evaluate serum ischemia-modified albumin (IMA) levels in the development of diabetic nephropathy in T2DM patients and to determine the effectiveness of this parameter in predicting the presence and severity of nephropathy. Materials and Methods: 68 adult patients diagnosed with T2DM and 30 healthy controls were included in this study. The T2DM group consisted of 34 patients without microalbuminuria (<30 mg/g) and 34 patients with microalbuminuria (30–300 mg/g) according to albumin/creatinine ratio (UACR). Biochemical data and serum IMA levels of the patient and control groups were measured and compared. Results: In terms of IMA levels, the difference between T2DM patients with microalbuminuria (0.55 ± 0.08 ABSU) and without microalbuminuria (0.42 ± 0.05 ABSU) and control (0.37 ± 0.08 ABSU) groups was significant (p<0.0001). The T2DM group with microalbuminuria had the highest glucose, HbA1c, UACR, and IMA levels. There was a positive correlation between IMA levels and UACR (r = 0.541, p < 0.001). IMA had a weak correlation with HbA1c (r = 0.345, p = 0.002). ROC analysis was performed and the IMA test had a high diagnostic value in the diagnostic differentiation of T2DM patients with microalbuminuria. According to multiple logistic regression analysis, IMA levels were an independent risk factor for DN (p = 0.003). Conclusions: Our data showed that IMA values increased significantly in diabetic patients, especially in those with microalbuminuria, and this increase was correlated with UACR levels. This study has shown that increased IMA levels are an important marker for the presence and severity of microalbuminuria in diabetic patients and therefore may be important in the early detection of renal dysfunction in T2DM. We even think that it can be used as an important marker in the follow-up of diabetic patients, even before the development of microalbuminuria.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135802051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETERMINATION OF THE OPTIMUM PLATELET-RICH PLASMA METHOD FOR THE ESSENTIAL AMOUNT OF PLATELETS","authors":"ESMA KIRIMLIOGLU, AHMET YAPICI","doi":"10.5455/annalsmedres.2023.07.164","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.07.164","url":null,"abstract":"Objective: Platelet-rich plasma (PRP) is the cellular plasma component containing a higher platelet concentration obtained by centrifugation of autologous peripheral blood. PRP has an auxiliary role in regenerative medicine treatment. Current treatment protocols for tissue repair strategies may be globally insufficient. PRP treatment via Platelet-released growth factors (GF) supports inflammation, proliferation, and wound healing. PRP studies have progressed and have proposed different formulations in recent years. Although various methods and devices are used, there are few and different standardized protocols to obtain PRP with the highest platelet concentration. Although anticoagulants containing citrate are primarily preferred in PRP production To provide effective platelet concentration in PRP, we noticed differences in the literature regarding PRP tube volumes, anticoagulant-citrate, and blood amounts. We aimed to obtain the most appropriate platelet concentration in PRP treatment by using different concentration ratios of Acid Citrate dextrose (ACD) solution A and different blood amounts and introducing a new treatment method to the literature. Methods: The blood of 30 individuals aged between 30 and 75 was taken into 10cc laboratory tubes, and 15cc and 18cc hourglass-shaped PRP tubes containing 8% ACD-solution A. Blood fractions were separated by centrifugation, buffy coat area was collected, and count platelet amount by Hematology Analyzer. Results: The platelet amount per µl was statistically significantly higher in 18cc blood compared to 15cc and 10cc. Platelet amounts obtained from 15 and 18cc peripheral blood with 8% ACD-solution A were above the effective treatment amount recommended in the literature. Conclusion: It was observed that the amount of used blood volume was correlated with the amount of obtained platelets.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF RADIOFREQUENCY ELECTROMAGNETIC RADIATION ON RAT LIVER TISSUE AND SERUM PARAOXONASE (PON1)","authors":"Mehmet YAVA, Asuman T","doi":"10.5455/annalsmedres.2023.08.210","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.210","url":null,"abstract":"Aim: The development of technology increases the rate of everyone having a smartphone. Therefore, the possible biological effects of these devices are of concern. In this study, we aimed to investigate the effect of 2100 MHz radiofrequency electromagnetic radiation on rat liver tissue and serum paraoxonase 1 level.\u0000Materials and Methods: Within the scope of the study, a 2100 MHz radiofrequency electromagnetic radiation model was created. In our study, we used Sprague Dawley male rats. Two groups were made as sham-control and exposure group (5 h a day for 2 weeks). Liver tissue and serum paraoxonase were studied.\u0000Results: The paraoxonase 1 value of the exposure group was higher than the sham control group, and did not have statistically important difference in the comparison of exposure and sham control groups (p>0.05). Did not have important difference in histopathological parameters of rat liver tissue (p>0.05). \u0000Conclusion: Although it seems that radiofrequency radiation does not cause liver damage, more detailed studies with short- and long-term exposure are needed.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pandemic process in children","authors":"Ferda enol, ilkay eci, Altay Babacan, Nuray Arslan, Zulal Toraman","doi":"10.5455/annalsmedres.2023.01.033","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.01.033","url":null,"abstract":"Aim: When compared to adults, it is seen that the COVID-19 disease in children has a milder course. However, considering that there are cases with severe course and even death, it is aimed to analyze the COVID-19 PCR positivity in children according to age and gender. Materials and Methods: Between March 7, 2020 and August 18, 2021, throat and nose swab samples from children with clinical complaints or a history of contact were evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) and the distribution of positive children by age and gender classified. Results: The PCR test was positive in 3,181 (30.74%) out of 10,342 children, the highest positivity rate was 33.52% in male and in the 15-18 age range, while this rate was 36.77% in female in the 15-18 age range. Conclusion: In this study, it was determined that the prevalence of the COVID19 pandemic, which affected the whole world, in childhood age groups was highest in male and between the ages of 15-18.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE IMPORTANCE OF OBSTRUCTIVE SLEEP APNEA SCORE AND END-TIDAL CO2 LEVEL IN ADOLESCENT CHILDREN WHO UNDERWENT OROPHARYNGEAL SURGERY","authors":"Hayel zer, lker m, Tolga zl","doi":"10.5455/annalsmedres.2023.09.240","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.09.240","url":null,"abstract":"Aim Children with obstructive sleep apnea have an increased postoperative risk of adverse respiratory events. In our study, we calculated Obstructive Sleep Apnea Scores using the modified STOP-Bang questionnaire in children undergoing oropharyngeal surgery. The groups determined according to this score were compared in terms of mask ventilation levels in the intraoperative period, postoperative complications and postoperative ETCO2 levels. Methods A total of 90 patients, aged 7-15 years, who will undergo oropharyngeal surgery, classified as ASA I-II, and who have undergone a modified STOP-Bang questionnaire at the preoperative examination, were included in the study. Obstructive sleep apnea score (OSAs) was determined according to the modified STOP-Bang questionnaire, and the patients were divided into 3 groups as low, medium, and high-risk. Difficult mask ventilation level was noted in the intraoperative period. At the end of the operation, end-tidal carbon dioxide concentration (ETCO2) values at 0, 3, 5, 10, and 15 minutes after the patient was extubated and whether the patient had spasms were recorded. Results Among the 8 parameters in the modified STOP-Bang questionnaire, it was found that there was a significant difference between the groups for the other 6 parameters except for snoring and learning disability. Diffucult mask ventilation increased significantly from Group I to Group III. There is a significant difference between Group I and II, Group II and III, and Group I and Group III (p= 0.001). Although there were small differences within the groups and between the measurements of ETCO2 at different minutes, these differences were not statistically significant (p≥0.05) Conclusion In conclusion, associations between the results of the modified STOP-Bang questionnaire and the level of intervention required for difficult mask ventilation, this information could serve as a useful indicator for a higher level of care in the perioperative period for future patients","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134981038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could SCUBE be used as a therapeutic target in rheumatoid arthritis?","authors":"NUR YAVUZ, ERHAN APKIN, ASIM REM, AHMET E, D ALTAY","doi":"10.5455/annalsmedres.2023.07.165","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.07.165","url":null,"abstract":"Objective: To investigate the levels of signal peptide-CUB-EGF domain-containing protein(SCUBE 1 and 3) in rheumatoid arthritis (RA). Materials and Methods: Twenty eight RA patients and 28 healthy volunteers were included in the study. SCUBE-1, SCUBE-3, Vascular Endothelial Growth Factor (VEGF), Matrix Metalloproteinase-9 (MMP-9), CD-40L, Interleukin-6 (IL-6) levels, which are important markers in angiogenesis, were measured twice, at baseline and after the treatment. Results: Compared to the healthy group, only MMP-9, one of the angiogenesis markers, was elevated in the patient group (p>0.05). After treatment, a significant decrease was observed in VEGF levels (p<0.05), while SCUBE-1, SCUBE-3, IL-6, CD-40 and MMP-9 levels remained at similar levels (p>0.05). Conclusion: In our study, RA patients responded to treatment with clinical improvements. Although there were differences in the levels of MMP and VEGF, there was no association with the disease in SCUBE.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135159964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Demographic Characteristics of Patients with Neuro-ophthalmological Disorders Starting Later in Life","authors":"Sevim KAVUNCU, Pinar Nalcacioglu","doi":"10.5455/annalsmedres.2022.12.374","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.374","url":null,"abstract":"Objectives: To determine the demographic, etiological and clinical features as well as treatment modalities of patients with neuro-ophthalmological disorders starting at a later age. Materials and Methods: We retrospectively reviewed the clinical data related to the neuro-ophthalmology patients who presented at the age of ≥ 65 years at two tertiary eye care referral centers from 2004 to 2022. Results: Of the 2,127 patients who applied to the Neuro-Ophthalmology Department during this period, 162 (7.6%) were ≥ 65 years old at the time of diagnosis and their data were analyzed. The mean age at the onset of disease was 73.2 ± 6.7 (65–95) years, and mean follow-up time was 1.1±0.4 (1-3) years. Non-arteritic anterior ischemic optic neuropathy (NAAION) (n=85, 52.5%), isolated cranial nerve palsies (n=28, 17.3%), and cerebral vascular disorders (CVD) (n=14, 8.6%) were the most frequent diagnosis. The most common symptoms were as follows: sudden visual loss in 79 (48.8%), diplopia in 31 (19.1%), and blurred vision in 21 (13%) cases. The most common accompanying systemic disease was hypertension (HT) and diabetes mellitus (DM) in 31 (27.4%), followed by HT in 29 (25.7%) cases. There was no accompanying systemic disease in 49 (30.2%) patients. The diagnosis of NAAION and AAION resulted in poor visual outcomes, while CVD presented with homonymous hemianopsia. Conclusion: NAAION and CVD were the most common age-related neuro-ophthalmological disorders that cause visual acuity loss and a visual field defect at an advanced age. Identifying these disorders and managing the visual problems are essential to preserve the protection of the patient's quality of life.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136303079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial anomalous pulmonary venous connection: diagnosis, management, and outcomes","authors":"Fatma Sengul, Perver Arslan, Ensar Duras, Pelin Ayyildiz, Hacer Kamali, Okan Yildiz, smihan Onan, Alper Guzeltas","doi":"10.5455/annalsmedres.2023.06.144","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.06.144","url":null,"abstract":"Aim: Partial anomalous pulmonary venous connection (PAPVC) is a rare congenital cardiovascular anomaly characterized by one or more, but not all, pulmonary veins draining into the right atrium. This condition can occur in isolation or in conjunction with other cardiac abnormalities such as an atrial septal defect (ASD). In this study we aimed to investigate the clinical presentation, diagnostic approaches, management options, and outcomes of patients with PAPVC. Materials and methods: This retrospective study included 140 patients diagnosed with isolated or ASD-associated PAPVC between January 2010 and December 2022. Results: The median age at presentation was 5 years (1 month to 39 years). Isolated PAPVC was observed in 36 patients (25.7%), while 104 patients (74.3%) had an atrial septal defect (ASD). In our patient cohort, 119 patients (85%) exhibited partially affected anomalous PVs, while the remaining 21 patients (15%) presented with anomalous pulmonary veins involving the entire lung. Right-sided PVs were involved in 116 patients (82.8%), left-sided PVs in 20 patients (14.3%), and both right and left PVs in 4 patients (2.9%). Malposition of primum septum was detected in 8 patients (5.8%), and scimitar syndrome was present in 7 patients (5%). Surgical treatment was performed in 71.4% (n=100) of the patients, while catheter angiography with vertical vein occlusion was performed in 2 patients with dual drainage. Conclusion: Despite the infrequency and complexity of PAPVC, timely identification and customized surgical intervention can help avert serious complications. The application of advanced imaging technologies in diagnosis and surgical planning is crucial.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136303080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of implant locations and overdenture designs on the implants and bone stress: a finite element analysis","authors":"Elifnur zelce, E. Tokar, zg Karacaer","doi":"10.5455/annalsmedres.2022.08.235","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.235","url":null,"abstract":"Objective The effects of implant locations and prosthesis design (palate less, full palate) on stress values of the implant and bone in maxillary overdenture prostheses were examined and compared with finite element analysis. Material and Methods Full palate and palate less four implant supported finite element overdenture models have created with different implant locations (M1: bilateral lateral 1. premolar, M2: canine 2. premolar, M3: 1. premolar 1. Molar). Static loads have applied with food stuff method on 1. Molar region. Von mises stress on implants and implant parts, maximum and minimum principal stress generated in peri-implant bone have calculated with finite element analysis method (FEA). Results As a result, it was observed that the palate less design creates more stress on the implants and bone compared to the full palate design. In addition, stress formation was observed to be higher in models with implant positions are posterior. Conclusion In implant supported overdentures (ISO), palatal coverage ensures more balanced distribution of stresses occurring around the implants and implant parts, regardless of the location of the supporting implants.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88015670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}