Annals of Medical Research最新文献

{"title":"Boric acid's cytotoxic effect on CD133+ cancer stem cells in H460 cell line","authors":"M. Acar","doi":"10.5455/annalsmedres.2023.02.045","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.02.045","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77357659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of teacher smoking and copd awareness: The case of Sanliurfa","authors":"G. Lu, erif Kurtulu, Remzi Can, Hamdiye Turan, Z. Sak, Mahmut lger","doi":"10.5455/annalsmedres.2023.04.082","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.04.082","url":null,"abstract":"Objective: This study aims to investigate the smoking status of teachers, the relationship between smoking and COPD, and teachers' awareness of COPD. Material and Method: 504 teachers participated in this cross-sectional study. The data was obtained through an online questionnaire utilizing a 22-question form designed by the researchers. Results: The mean age of the participants was 38.677.70 years, 47.8% of them were female, and 81.5% worked in public schools. 28% of teachers reported smoking. 24.4% of teachers reported living with a COPD patient, with 86.5% citing smoking as the major risk factor for COPD. 88.3% of participants indicated that avoiding tobacco products is crucial in preventing COPD. The majority of participants (92.7%) provided the correct response when asked about the symptoms of COPD. While 67.7% responded that PFT is used for diagnosis, 50.6% reported that it is a treatable disease, and 25% reported that inhaler medicines are used for treatment. There was a statistically significant distinction between the frequency of hearing about COPD and the specialties of the teachers. It was shown that 91.1% of smokers were aware of COPD, however, no statistical correlation was found between smoking and awareness. Conclusion: This study revealed that the prevalence of smoking among teachers in Sanliurfa was lower than previously reported in the literature. The level of awareness that COPD is a lung disease was found to be higher than in previous studies of a similar sort. It was established that awareness of the risk factors for COPD, its symptoms, preventive strategies, and the fact that COPD is a treatable disease was high. We believe that this awareness will play a crucial role in protecting students from smoking and various smoking-related diseases, such as COPD.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77768545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TWO DIFFERENT CHARACTERISTICS AND PROGNOSIS OF GRADE 3 GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS:\u0000Erciyes Multidisiplinary Neuroendocrine Tumor (NET) Group Experience","authors":"E. Doğan, M. Ozkan, M. Inanc, U. Abdulrezzak, A. Tutuş, F. Ozturk, E. Sozuer, G. Sezgin, S. Gursoy, A. Yurçi, F. Bayram","doi":"10.5455/annalsmedres.2023.01.017","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.01.017","url":null,"abstract":"Grade 3 gastroenteropancreatic neuroendocrine tumors (GEPNETs) are not a homogenous group. We aimed to determine clinicopathologic, survival and prognostic differences in metastatic grade 3 GEPNETs with the help of ki67 and GA68PET CT/octreoscan. We divided patients diagnosed metastatic grade 3 GEPNETs into two groups based on the ki67 cut-off point 47 as ki67 low and high. And we divided into 2 groups again according to scan positivity. And we compared all four groups according to clinicopathologic characteristics, survival and prognostic factors. We included 26 patients into our study. The median overall survival in low group was 20 and 10 months in high group (p=0,321). Lower ki67 scan positive group had longer overall survival than lower ki67 scan negative group (NR vs 3 months, respectively, p=0.067) and in high ki67 group the median overall survival was longer in scan positive than negative group (10 vs 9,respectively, p=0.956). The median overall survival was longer in patients with low ki67 levels compared to high ki67 levels. The best overall survival was in low ki67 and scan positive group.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82776561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Psychosocial Well-being of Children with Fragile X Syndrome: Psychopathology, Autism Spectrum Disorder Comorbidity and the Role of Caregivers' Perceived Social Support","authors":"A. M. Res, Hicran Doğru, Yuce Kahraman","doi":"10.5455/annalsmedres.2022.09.297","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.09.297","url":null,"abstract":"Objective: Fragile X syndrome (FXS) is a rare genetic disease that can have several intellectual and developmental disabilities. Here, we aim to examine psychopathology in children with FXS and investigate the relationship between children's psychosocial well-being and socio-demographic factors, autism spectrum disorder (ASD) comorbidity, and the type and level of caregivers' perceived social support. Materials and Method: Twenty-six children aged 5-18 years with FXS and 26 age- and sex-matched healthy controls (HC) were included. DSM-5-based clinical interviews were conducted with all participants. We also collected parent ratings of health-related quality of life indexes and perceived social support levels and types. Results: The mean age of children with FXS was 10.9 ± 3.5 years, and the mean age of healthy comparisons (HC, n= 26) was 11.8 ± 2.6 years. In the FXS group, 84.6% had comorbid psychiatric disorders, and 65.3% had intellectual disability. FXS group displayed lower psychosocial and total quality of life scores than the HC group. Also, there was significant positive correlations between childrens' psychosocial well-being and \"significant others\" (rp = 0.502, p = 0.009) and total perceived support scores (rp = 0.448, p = 0.022). The most influential factor related to the psychosocial well-being in children with FXS was ASD comorbidity (F= 30.6, R2, 0.543, p<0.001). Conclusion: Providing support to mothers of children with FXS may positively affect the children's health outcomes, especially psychosocial well-being.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85740682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OUR RESULTS OF TOTAL HIP ARTROPLASTY WITH ANTEROLATERAL APPROACH","authors":"Enes z, R. Sevimli, Harun se","doi":"10.5455/annalsmedres.2023.01.013","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.01.013","url":null,"abstract":"Aim: It was aimed to compare the clinical and radiological results of total hip arthroplasty performed with the anterolateral approach with the literature. Material and Method: 65 patients who underwent total hip arthroplasty with anterolateral approach between 2016-2021 were included. Preoperative and postoperative functional status evaluations of the patients were performed using the Harris hip score. In the clinical evaluation of the patients, thigh pain, wound infection, length of hospital stay, body mass index, duration of surgery and complications were also evaluated. In the radiological evaluation, the acetabular and femoral relaxation zones, the presence and amount of vertical and horizontal migration of the acetabular component, the presence and amount of femoral vertical migration, the position of the femoral component, the femoral dorr classification, the angle of inclination of the acetabular component and the presence of heterotrophic ossification were examined. Results: Of the patients, 29 (44.6%) were male and 36 (55.4%) were female. The mean age of the patients was 61.65 and the mean follow-up period was 40.2 months. Considering the diagnoses of the patients, THA was applied to 51 (70.8%) patients for coxarthrosis, 14 (19.4%) for avascular necrosis, 5 (6.9%) patients for fractures, and 2 (2.8%) patients for septic arthritis. The mean preoperative Harris Hip Score of the patients was 34.2 (18.1-59.9). The mean postoperative Harris Hip score was 88.5 (68.8-96). When the postoperative Harris Hip Score of the patients was evaluated, 53 (73.6%) were evaluated as excellent results, 18 (25%) as very good results, and 1 (1.4%) as good result. Findings: In our study, the results of total hip arthroplasty performed with the anterolateral approach were found to be a successful and satisfactory surgery when performed with appropriate indications and planning.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89404136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audiovestibular Findings in Celiac Patients","authors":"Tu lar, Berna n","doi":"10.5455/annalsmedres.2022.08.233","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.233","url":null,"abstract":"Objective: Celiac is a small intestine disease that occurs in susceptible individuals with a cellular and humoral immunological response that develops against gluten, a cereal protein. There are few studies evaluating the audiovestibular system in celiac patients. This study aims to evaluate audiovestibular findings in celiac patients. Materials and Methods: 40 patients with celiac disease and 40 healthy volunteers were enrolled in this sudy. Each subject underwent a neurotologic examination including pure tone audiometry (PTA), Transient Evoked Otoacoustic Emission (TEOAE) with 1000 Hz, 1500 Hz, 2000 Hz, 3000 Hz and 4000 Hz, Videonystagmography (VNG), and binaural bithermal caloric test. It was evaluated whether the test results indicated significant differences between the celiac patient and control group. Results: Sensorineural hearing loss was detected in the right and left ear of the 7 patients. In the pure tone audiometry (PTA) test, there was no statistically significant difference between celiac patients and controls in both air conducted and bone conducted hearing thresholds (p=0,389 for the right ear, p=0,083 for the left ear). Speech reception thresholds of celiac patients were significantly higher than the controls (p= 0,000 for right ear, p=0,001 for the left ear) While OAE response was obtained in the right ear of 24 patients and in the left ear of 23 patients; OAE response was obtained in all of the control group. In the OAE test, in response to 2000 Hz stimuli, there was no significant difference in the right ear responses, although there was a lower signal-to-noise ratio in patients compared to the control group. At all other frequencies, a statistically significant lower signal-to-noise ratio was found in the patient group. Statistically significant pathological differences were found in spontaneaus nystagmus, gaze, saccade, smooth pursuit, optokinetic nystagmus and caloric tests in celiac patients compared to the control group (p < 0.05). Conclusion: Pure tone audiometry, otoacoustic emision, oculomotor and caloric tests findings indicated that auditory system, periphral and central vestibular system may be affected in individuals with celiac disease.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89328519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of lifestyle change on autonomic nervous system dysfunction in patients with \u0000metabolic syndrome","authors":"A. Birant, G. Kozdağ, D. Ural, A. Ağır","doi":"10.5455/annalsmedres.2022.04.150","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.04.150","url":null,"abstract":"Study Design: A prospective clinical cohort study. Objective: In this study, it was aimed to examine the effects of metabolic syndrome, which affects many organs, on the autonomic nervous system and to observe the changes after treatment. Materials and Methods: Heart rate variability values of 101 metabolic syndrome patients who were treated at the Kocaeli University Cardiology Outpatient Clinic included in the study. All patients were offered lifestyle change suggestions in addition to their medical treatments. At the end of three months, the heart rate variability parameters of the patients were re-evaluated. Results: Heart rate variability values were found to be significantly lower in metabolic syndrome patients compared to the control group. It was observed that the heart rate variability values improved significantly in half of the patients who applied the given treatment with lifestyle changes. A decrease in heart rate change parameters was found in the group that did not implement lifestyle changes compared to the beginning of the study. Conclusions: Autonomic nervous system functions evaluated by heart rate variability decreased in patients with metabolic syndrome, and the treatment and lifestyle changes had a positive effect on these parameters.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87400379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hyperchloremia with acute kidney injury in children with major trauma","authors":"A. M. Res, Kübra Çeleğen, M. Çeleğen","doi":"10.5455/annalsmedres.2022.11.347","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.11.347","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90185021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Dose-Dependent Effect of Carminic Acid on Brain and Peripheral Tissues","authors":"G. Akcay","doi":"10.5455/annalsmedres.2022.12.360","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.360","url":null,"abstract":"In recent years, there has been an increase in the frequency of use of food additives and colorants to extend the life of food and to color it. Excessive consumption of these additives can lead to attention deficit hyperactivity disorder and learning disorder, especially in children. Uncontrolled additives whose dosage is not specified can cause an allergic reaction, cause damage to the neurological system and cause cancer. There are not many studies showing the dose-dependent effect of carminic acid. It was aimed to determine the dose-dependent changes of carminic acid, a food additive, in liver, kidney, blood and brain tissues (hippocampus, brain, brain stem) and to investigate the effects of these doses on hyperactivity behaviorally. In our study, dose-dependent effects of 500 mg, 1500 mg and 3000 mg carminic acid (CA) used as a colorant in hippocampus, brain, brain stem, liver, kidney and blood samples were investigated. 32 Wistar albino male rats weighing 150-200 g were divided into 4 groups as control, CA-500, CA-1500 and CA-3000. The locomotor activities of the rats were evaluated in the open field test, and their anxiety behaviors were evaluated in the elevated plus maze test. Carminic acid levels in hippocampus, brain, brain stem, liver, kidney and blood were measured by high performance liquid chromatography (HPLC) method. Locomotor activity and anxiety behavior test results of CA-1500 and CA-3000 groups were increased compared to the control group. In the results of HPLC analysis, 500 mg, 1500 mg and 3000 mg doses administered to rats were not detectable in hippocampus, brain and brain stem tissues, while a dose-dependent increase was found in liver, kidney and blood samples (p<0.5). It was concluded that since carminic acid could not cross the blood-brain barrier, it was not detected in hippocampus, brain and brain stem tissues, and increased dose-dependently in peripheral tissues such as liver, kidney and blood. Although it cannot be detected in the brain, it has been observed that hyperactivity, which may increase locomotor activity and anxiety, may lead to behavioral changes.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"422 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84928109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete Title: Assessment of optic disc and macula in fasting period during Ramadan by optical coherence tomography angiography\u0000Running Title: Evaluating the effect of fasting by OCT-A","authors":"N. Bilen, Meltem l","doi":"10.5455/annalsmedres.2022.08.228","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.228","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78553308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}