Annual review of chemical and biomolecular engineering最新文献_第8页

Small-Scale Phenomena in Reactive Bubbly Flows: Experiments, Numerical Modeling, and Applications. 反应性气泡流中的小尺度现象:实验、数值模拟和应用。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2021-06-07 DOI: 10.1146/annurev-chembioeng-092220-100517

Michael Schlüter, Sonja Herres-Pawlis, Ulrich Nieken, Ute Tuttlies, Dieter Bothe

{"title":"Small-Scale Phenomena in Reactive Bubbly Flows: Experiments, Numerical Modeling, and Applications.","authors":"Michael Schlüter, Sonja Herres-Pawlis, Ulrich Nieken, Ute Tuttlies, Dieter Bothe","doi":"10.1146/annurev-chembioeng-092220-100517","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-092220-100517","url":null,"abstract":"Improving the yield and selectivity of chemical reactions is one of the challenging tasks in paving the way for a more sustainable and climate-friendly economy. For the industrially highly relevant gas-liquid reactions, this can be achieved by tailoring the timescales of mixing to the requirements of the reaction. Although this has long been known for idealized reactors and time- and space-averaged processes, considerable progress has been made recently on the influence of local mixing processes. This progress has become possible through joint research between chemists, mathematicians, and engineers. We present the reaction systems with adjustable kinetics that have been developed, which are easy to handle and analyze. We show examples of how the selectivity of competitive-consecutive reactions can be controlled via local bubble wake structures. This is demonstrated for Taylor bubbles and bubbly flows under technical conditions. Highly resolvednumerical simulations confirm the importance of the bubble wake structure for the performance of a particular chemical reaction and indicate tremendous potential for future process improvements.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39071349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Wearable and Implantable Soft Bioelectronics: Device Designs and Material Strategies. 可穿戴与植入式软体生物电子学:装置设计与材料策略。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2021-06-07 DOI: 10.1146/annurev-chembioeng-101420-024336

Sung-Hyuk Sunwoo, Kyoung-Ho Ha, Sangkyu Lee, Nanshu Lu, Dae-Hyeong Kim

{"title":"Wearable and Implantable Soft Bioelectronics: Device Designs and Material Strategies.","authors":"Sung-Hyuk Sunwoo, Kyoung-Ho Ha, Sangkyu Lee, Nanshu Lu, Dae-Hyeong Kim","doi":"10.1146/annurev-chembioeng-101420-024336","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-101420-024336","url":null,"abstract":"High-performance wearable and implantable devices capable of recording physiological signals and delivering appropriate therapeutics in real time are playing a pivotal role in revolutionizing personalized healthcare. However, the mechanical and biochemical mismatches between rigid, inorganic devices and soft, organic human tissues cause significant trouble, including skin irritation, tissue damage, compromised signal-to-noise ratios, and limited service time. As a result, profuse research efforts have been devoted to overcoming these issues by using flexible and stretchable device designs and soft materials. Here, we summarize recent representative research and technological advances for soft bioelectronics, including conformable and stretchable device designs, various types of soft electronic materials, and surface coating and treatment methods. We also highlight applications of these strategies to emerging soft wearable and implantable devices. We conclude with some current limitations and offer future prospects of this booming field.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39071351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Introduction. 介绍。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2021-06-07 DOI: 10.1146/annurev-ch-12-033021-100001

Rachel A Segalman, Michael F Doherty

引用次数: 0

Tough Double Network Hydrogel and Its Biomedical Applications. 强韧双网水凝胶及其生物医学应用。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2021-06-07 Epub Date: 2021-03-26 DOI: 10.1146/annurev-chembioeng-101220-080338

Takayuki Nonoyama, Jian Ping Gong

引用次数: 43

RNA Engineering for Public Health: Innovations in RNA-Based Diagnostics and Therapeutics. 公共卫生的RNA工程:基于RNA的诊断和治疗的创新。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2021-06-07 DOI: 10.1146/annurev-chembioeng-101420-014055

Walter Thavarajah, Laura M Hertz, David Z Bushhouse, Chloé M Archuleta, Julius B Lucks

{"title":"RNA Engineering for Public Health: Innovations in RNA-Based Diagnostics and Therapeutics.","authors":"Walter Thavarajah, Laura M Hertz, David Z Bushhouse, Chloé M Archuleta, Julius B Lucks","doi":"10.1146/annurev-chembioeng-101420-014055","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-101420-014055","url":null,"abstract":"RNA is essential for cellular function: From sensing intra- and extracellular signals to controlling gene expression, RNA mediates a diverse and expansive list of molecular processes. A long-standing goal of synthetic biology has been to develop RNA engineering principles that can be used to harness and reprogram these RNA-mediated processes to engineer biological systems to solve pressing global challenges. Recent advances in the field of RNA engineering are bringing this to fruition, enabling the creation of RNA-based tools to combat some of the most urgent public health crises. Specifically, new diagnostics using engineered RNAs are able to detect both pathogens and chemicals while generating an easily detectable fluorescent signal as an indicator. New classes of vaccines and therapeutics are also using engineered RNAs to target a wide range of genetic and pathogenic diseases. Here, we discuss the recent breakthroughs in RNA engineering enabling these innovations and examine how advances in RNA design promise to accelerate the impact of engineered RNA systems.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714562/pdf/nihms-1849307.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9178826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Phagosome-Bacteria Interactions from the Bottom Up. 吞噬体与细菌自下而上的相互作用。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2021-06-07 Epub Date: 2021-03-29 DOI: 10.1146/annurev-chembioeng-090920-015024

Darshan M Sivaloganathan, Mark P Brynildsen

{"title":"Phagosome-Bacteria Interactions from the Bottom Up.","authors":"Darshan M Sivaloganathan, Mark P Brynildsen","doi":"10.1146/annurev-chembioeng-090920-015024","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-090920-015024","url":null,"abstract":"When attempting to propagate infections, bacterial pathogens encounter phagocytes that encase them in vacuoles called phagosomes. Within phagosomes, bacteria are bombarded with a plethora of stresses that often lead to their demise. However, pathogens have evolved numerous strategies to counter those host defenses and facilitate survival. Given the importance of phagosome-bacteria interactions to infection outcomes, they represent a collection of targets that are of interest for next-generation antibacterials. To facilitate such therapies, different approaches can be employed to increase understanding of phagosome-bacteria interactions, and these can be classified broadly as top down (starting from intact systems and breaking down the importance of different parts) or bottom up (developing a knowledge base on simplified systems and progressively increasing complexity). Here we review knowledge of phagosomal compositions and bacterial survival tactics useful for bottom-up approaches, which are particularly relevant for the application of reaction engineering to quantify and predict the time evolution of biochemical species in these death-dealing vacuoles. Further, we highlight how understanding in this area can be built up through the combination of immunology, microbiology, and engineering.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25529077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Engineering Advances in Spray Drying for Pharmaceuticals. 药品喷雾干燥的工程进展。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2021-06-07 Epub Date: 2021-03-29 DOI: 10.1146/annurev-chembioeng-091720-034106

John M Baumann, Molly S Adam, Joel D Wood

{"title":"Engineering Advances in Spray Drying for Pharmaceuticals.","authors":"John M Baumann, Molly S Adam, Joel D Wood","doi":"10.1146/annurev-chembioeng-091720-034106","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-091720-034106","url":null,"abstract":"Spray drying is a versatile technology that has been applied widely in the chemical, food, and, most recently, pharmaceutical industries. This review focuses on engineering advances and the most significant applications of spray drying for pharmaceuticals. An in-depth view of the process and its use is provided for amorphous solid dispersions, a major, growing drug-delivery approach. Enhanced understanding of the relationship of spray-drying process parameters to final product quality attributes has made robust product development possible to address a wide range of pharmaceutical problem statements. Formulation and process optimization have leveraged the knowledge gained as the technology has matured, enabling improved process development from early feasibility screening through commercial applications. Spray drying's use for approved small-molecule oral products is highlighted, as are emerging applications specific to delivery of biologics and non-oral delivery of dry powders. Based on the changing landscape of the industry, significant future opportunities exist for pharmaceutical spray drying.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25529079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Dynamic Interconversion of Metal Active Site Ensembles in Zeolite Catalysis. 沸石催化中金属活性位系群的动态相互转化。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2021-06-07 Epub Date: 2021-04-07 DOI: 10.1146/annurev-chembioeng-092120-010920

Siddarth H Krishna, Casey B Jones, Rajamani Gounder

{"title":"Dynamic Interconversion of Metal Active Site Ensembles in Zeolite Catalysis.","authors":"Siddarth H Krishna, Casey B Jones, Rajamani Gounder","doi":"10.1146/annurev-chembioeng-092120-010920","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-092120-010920","url":null,"abstract":"Catalysis science is founded on understanding the structure, number, and reactivity of active sites. Kinetic models that consider active sites to be static and noninteracting entities are routinely successful in describing the behavior of heterogeneous catalysts. Yet, active site ensembles often restructure in response to their external environment and even during steady-state catalytic turnover, sometimes requiring non-mean-field kinetic treatments to describe distance-dependent interactions among sites. Such behavior is being recognized more frequently in modern catalysis research, with the advent of experimental methods to quantify turnover rates with increasing precision, an expanding arsenal of operando characterization tools, and computational descriptions of atomic structure and motion at chemical potentials and timescales increasingly relevant to reaction conditions. This review focuses on dynamic changes to metal active site ensembles on zeolite supports, which are silica-based crystalline materials substituted with Al that generate binding sites for isolated and low-nuclearity metal site ensembles. Metal sites can become solvated and mobilized during reaction, facilitating interactions among sites that change their nuclearity and function. Such intersite communication can be regulated by the zeolite support, resulting in non-single-site and potentially non-mean-field kinetic behavior arising from mechanisms of catalytic action that combine elements of those canonically associated with homogeneous and heterogeneous catalysis.We discuss recent literature examples that document dynamic active site behavior in metal-zeolites and outline methodologies to identify and interpret such behavior. We conclude with our outlook on future research directions to develop this evolving branch of catalysis science and harness it for practical applications.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25567336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Polymer-Infiltrated Nanoparticle Films Using Capillarity-Based Techniques: Toward Multifunctional Coatings and Membranes. 基于毛细管技术的聚合物渗透纳米颗粒膜:迈向多功能涂层和膜。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2021-06-07 DOI: 10.1146/annurev-chembioeng-101220-093836

R Bharath Venkatesh, Neha Manohar, Yiwei Qiang, Haonan Wang, Hong Huy Tran, Baekmin Q Kim, Anastasia Neuman, Tian Ren, Zahra Fakhraai, Robert A Riggleman, Kathleen J Stebe, Kevin Turner, Daeyeon Lee

{"title":"Polymer-Infiltrated Nanoparticle Films Using Capillarity-Based Techniques: Toward Multifunctional Coatings and Membranes.","authors":"R Bharath Venkatesh, Neha Manohar, Yiwei Qiang, Haonan Wang, Hong Huy Tran, Baekmin Q Kim, Anastasia Neuman, Tian Ren, Zahra Fakhraai, Robert A Riggleman, Kathleen J Stebe, Kevin Turner, Daeyeon Lee","doi":"10.1146/annurev-chembioeng-101220-093836","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-101220-093836","url":null,"abstract":"Polymer-infiltrated nanoparticle films (PINFs) are a new class of nanocomposites that offer synergistic properties and functionality derived from unusually high fractions of nanomaterials. Recently, two versatile techniques,capillary rise infiltration (CaRI) and solvent-driven infiltration of polymer (SIP), have been introduced that exploit capillary forces in films of densely packed nanoparticles. In CaRI, a highly loaded PINF is produced by thermally induced wicking of polymer melt into the nanoparticle packing pores. In SIP, exposure of a polymer-nanoparticle bilayer to solvent vapor atmosphere induces capillary condensation of solvent in the pores of nanoparticle packing, leading to infiltration of polymer into the solvent-filled pores. CaRI/SIP PINFs show superior properties compared with polymer nanocomposite films made using traditional methods, including superb mechanical properties, thermal stability, heat transfer, and optical properties. This review discusses fundamental aspects of the infiltration process and highlights potential applications in separations, structural coatings, and polymer upcycling-a process to convert polymer wastes into useful chemicals.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39071348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Nature-Inspired Chemical Engineering for Process Intensification. 过程强化的自然启发化学工程。

IF 8.4 2区工程技术

Annual review of chemical and biomolecular engineering Pub Date : 2021-06-07 Epub Date: 2021-03-31 DOI: 10.1146/annurev-chembioeng-060718-030249

Marc-Olivier Coppens

{"title":"Nature-Inspired Chemical Engineering for Process Intensification.","authors":"Marc-Olivier Coppens","doi":"10.1146/annurev-chembioeng-060718-030249","DOIUrl":"https://doi.org/10.1146/annurev-chembioeng-060718-030249","url":null,"abstract":"A nature-inspired solution (NIS) methodology is proposed as a systematic platform for innovation and to inform transformative technology required to address Grand Challenges, including sustainable development. Scalability, efficiency, and resilience are essential to nature, as they are to engineering processes. They are achieved through underpinning fundamental mechanisms, which are grouped as recurring themes in the NIS approach: hierarchical transport networks, force balancing, dynamic self-organization, and ecosystem properties. To leverage these universal mechanisms, and incorporate them effectively into engineering design, adaptations may be needed to accommodate the different contexts of nature and engineering applications. Nature-inspired chemical engineering takes advantage of the NIS methodology for process intensification, as demonstrated here in fluidization, catalysis, fuel cell engineering, and membrane separations, where much higher performance is achieved by rigorously employing concepts optimized in nature. The same approach lends itself to other applications, from biomedical engineering to information technology and architecture.","PeriodicalId":8234,"journal":{"name":"Annual review of chemical and biomolecular engineering","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25549121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12