Journal of Analytical Atomic Spectrometry最新文献

{"title":"Quantitative elemental analysis of human leukemia K562 single cells by inductively coupled plasma mass spectrometry in combination with a microdroplet generator†","authors":"Yu-ki Tanaka, Hinano Katayama, Risako Iida and Yasumitsu Ogra","doi":"10.1039/D4JA00364K","DOIUrl":"https://doi.org/10.1039/D4JA00364K","url":null,"abstract":"<p >Single-cell inductively coupled plasma mass spectrometry (scICP-MS) is an emerging technique for the determination of elemental contents in individual cells. No standardized system for the introduction of cultured mammalian cells has been established owing to difficulties in cell transport and detection. The transport efficiency of human chronic myelogenous leukemia K562 cells (hereinafter “K562 cells”) in a conventional sample introduction system comprising a pneumatic nebulizer and a total consumption spray chamber is low owing to cell damage. To improve cell transport efficiency, we installed a piezo-actuator-driven microdroplet generator (μDG) into the sample introduction system of an ICP-MS for fast time-resolved analysis. Cell transport efficiency was drastically improved by using a μDG. For the determination of elemental contents, calibration curves were created by analyzing microdroplets of ionic standard solutions generated by the μDG. The pulsed signals originating from the microdroplets were analyzed and the sensitivity (<em>i.e.</em>, signal intensity per elemental mass) was calculated for each element. The quantification protocol was validated using silver nanoparticles, titanium dioxide nanoparticles, and dried yeast cells. Finally, we introduced intact K562 cells and detected signals with high throughput. The average masses of five essential elements in single K562 cells were precisely determined as follows: 270 ± 100 fg for Mg, 23.0 ± 2.0 fg for Zn, 7684 ± 675 fg for P, 2136 ± 165 fg for S, and 14.4 ± 1.2 fg for Fe. These values are consistent with the values obtained by solution nebulization ICP-MS analysis after the acid digestion of K562 cells.</p>","PeriodicalId":81,"journal":{"name":"Journal of Analytical Atomic Spectrometry","volume":" 1","pages":" 216-225"},"PeriodicalIF":3.1,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ja/d4ja00364k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vacuum degree detection performance improvement of vacuum switches based on NELIBS","authors":"Jiaqi Liu, Xiaokang Ding, Feilong Zhang, Huan Yuan, Xiaohua Wang, Aijun Yang, Jifeng Chu and Mingzhe Rong","doi":"10.1039/D4JA00219A","DOIUrl":"https://doi.org/10.1039/D4JA00219A","url":null,"abstract":"<p >The measurement of vacuum degree and electrification in vacuum switches has been a critical issue constraining the development of vacuum switches for over half a century, remaining unresolved. In recent years, our team has proposed the use of laser-induced breakdown spectroscopy (LIBS) for the non-contact measurement of vacuum switch pressure. However, its application is hindered by relatively high detection limits, low sensitivity, and susceptibility to background noise interference, which result in suboptimal precision. Extensive research has indicated that metal nanoparticles can effectively enhance signal detection capabilities, however, their enhancement effects under low-pressure conditions remain unclear. This study aimed to investigate the enhancement effects of silver nanoparticles (AgNPs) on signals under low-pressure conditions. By analyzing spectral data, plasma images, and radiation integral intensity, we seek to improve the accuracy of vacuum level measurements in vacuum switches. Results showed that in low-pressure environments, AgNPs enhanced spectral signals by up to 7.17-fold, increasing vacuum detection accuracy from 95.7% to 98.05% and extending the detection range by an order of magnitude to 10<small>⁻³</small> Pa. This enhancement was regulated by particle size and concentration, with 10 nm AgNPs exhibiting better enhancement effects than 5 nm particles. The optimal concentration varied with both particle size and pressure. Nanoparticle-enhanced LIBS (NELIBS) increased the drop in plasma radiation integral intensity, prolonging the pre-expansion state of the plasma when excited and improving the accuracy of vacuum level measurements. This explores the potential of applying nanomaterials to conduct electrical detection in vacuum conditions and lays a theoretical and experimental foundation for optimizing spectroscopic analysis technologies.</p>","PeriodicalId":81,"journal":{"name":"Journal of Analytical Atomic Spectrometry","volume":" 1","pages":" 248-258"},"PeriodicalIF":3.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An accurate quantitative method for NdFeB magnetism based on laser-induced breakdown spectroscopy","authors":"Guanyu Chen, Jing Chen, Dongming Qu, Guang Yang and Huihui Sun","doi":"10.1039/D4JA00342J","DOIUrl":"https://doi.org/10.1039/D4JA00342J","url":null,"abstract":"<p >NdFeB magnetic materials are widely used in daily life, such as in permanent magnet motors, loudspeakers and computer disks. The NdFeB magnetic material has excellent magnetic properties, and its magnetic properties are also the key to judge the production quality of NdFeB. Therefore, the precise quantification of the magnetic properties of NdFeB magnetic materials is crucial. Laser induced breakdown spectroscopy (LIBS) is a technique to obtain the spectrum of chemical elements by excitation of plasma on the surface of a sample with a high energy laser. In this paper, a precise classification and magnetic quantification method for NdFeB magnetic materials based on laser-induced breakdown spectroscopy is designed, which is different from the traditional direct magnetic property detection method and uses element detection to quantitatively analyze the magnetic properties indirectly. A laser-induced breakdown spectroscopy system was used to collect the characteristic spectrum of NdFeB magnetic materials, and the sliding window minimum removal base method was independently designed to further optimize the detection accuracy. A classification model and quantitative analysis method model were further established and optimized. The random forest method was used to preliminarily classify NdFeB magnetic materials, and the GA-ELM method was used to conduct quantitative analysis of magnetic properties. Quantitative magnetic properties include Br, Hcj, Hcb and (BH)max. The error analysis of the final quantitative analysis is as follows: RMSE of Br reaches 0.0001526, RMSE of Hcj reaches 0.0001937, RMSE of Hcb reaches 0.00197, and RMSE of (BH)max reaches 0.00785. It is verified that the magnetic quantification method for NdFeB magnetic materials based on laser-induced breakdown spectroscopy can effectively conduct accurate quantitative analysis of the magnetic properties of NdFeB magnetic materials and provide a fast, convenient, accurate and economical detection method for the quality control of magnetic materials workshops.</p>","PeriodicalId":81,"journal":{"name":"Journal of Analytical Atomic Spectrometry","volume":" 1","pages":" 297-305"},"PeriodicalIF":3.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ copper isotope analysis by femtosecond laser ablation multicollector inductively coupled plasma mass spectrometry (fs-LA-MC-ICP-MS) on historical gold coins†","authors":"Louise de Palaminy, Franck Poitrasson, Christophe Pécheyran, Gaëlle Barbotin, Pascale Louvat, Sylvain Bérail, Anne-Laure Ronzani, Luc Robbiola and Sandrine Baron","doi":"10.1039/D4JA00217B","DOIUrl":"https://doi.org/10.1039/D4JA00217B","url":null,"abstract":"<p >This study investigates the potential of femtosecond laser ablation coupled with multicollector inductively coupled plasma mass spectrometry (fs-LA-MC-ICP-MS) for copper isotopic analysis in gold matrices applied to cultural heritage. Elemental analyses, which have commonly been used so far, provide information on the circulation of metal stocks based on elemental signatures but fail to pinpoint the precise source of gold. In contrast, isotopic analyses can offer a more accurate means of identifying the source of the metal, yet their application to gold matrices remains a challenge. For the first time, we successfully determined copper isotope ratio in gold matrices and achieved repeatabilities of 0.12‰ to 0.26‰ (2SD) for <em>δ</em><small>⁶⁵</small>Cu analyses carried out over up to 8 days, demonstrating the feasibility of copper isotopic analyses in gold coins at the micron-scale. This work was conducted using isotopically characterised in-house matrix-matched gold standard with copper concentrations varying from 4.5 wt% to 9.6 wt%. Our results open new avenues of research for provenance studies of precious museum artefacts and archaeological finds, with potential applications in authentication analyses on similar gold materials. The micro-sampling performed by femtosecond laser ablation minimises the damages on such ancient artifacts. However, the Cu concentrations had to be of at least 4 wt% with our analytical set up and a special care must be taken on the laser beam focusing in order to obtain accurate <em>δ</em><small>⁶⁵</small>Cu measurements in gold matrices.</p>","PeriodicalId":81,"journal":{"name":"Journal of Analytical Atomic Spectrometry","volume":" 1","pages":" 226-237"},"PeriodicalIF":3.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of anode geometry on the analytical performance of solution-cathode glow discharge for alkali metal detection by atomic emission spectroscopy","authors":"Jinmei Wang, Wei Li, Peichao Zheng, Biao Li, Biyong Zhang, Lianbo Guo, Hongwu Tian and Daming Dong","doi":"10.1039/D4JA00335G","DOIUrl":"https://doi.org/10.1039/D4JA00335G","url":null,"abstract":"<p >The effect of anode geometries on the analytical performance of the solution-cathode glow discharge (SCGD) source was investigated using tungsten rods with varying diameters and conical angles for atomic emission spectroscopy (AES). Under optimal operational parameters (electrolyte solution: HNO<small>₃</small> at pH 1.0, discharge current: 65 mA, solution flow rate: 1.9 mL min<small>⁻¹</small>, and discharge distance: 2.0 mm), the highest emission intensity and stability for Na, Rb, K, Li, and Cs were obtained at the tungsten rod with a diameter of 2.4 mm, with relative standard deviations (RSD) of 1.14%, 0.93%, 1.01%, 1.25%, and 0.94%, respectively, while achieving the best detection limits (DLs). Additionally, when the anode tip had a conical angle of less than 30°, thermal melting resulted in discharge instability. A conical angle greater than 90° induced thermal spreading, leading to instability. Higher emission intensity stability and lower DLs were achieved with a conical angle of 60°. These results may provide new insights for enhancing the performance of SCGD systems.</p>","PeriodicalId":81,"journal":{"name":"Journal of Analytical Atomic Spectrometry","volume":" 2","pages":" 346-353"},"PeriodicalIF":3.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A portable smartphone platform with FeNPs@g-C3N4 nano-enzyme for visual and on-site sensing of F− and Al3+ in tea†","authors":"Yanyang Wang, Shanshan Gao, Gege Yang, Wenyi Zhu, Ying Lu, Mengyuan Tan, Yuancheng Peng, Hua Yang and Chunxia Song","doi":"10.1039/D4JA00338A","DOIUrl":"https://doi.org/10.1039/D4JA00338A","url":null,"abstract":"<p >A portable platform for the visual determination of F<small>⁻</small> and Al<small>³⁺</small> was developed by combining FeNPs@g-C<small>₃</small>N<small>₄</small> nano-enzyme and a smartphone. The FeNPs@g-C<small>₃</small>N<small>₄</small> nano-enzyme with excellent peroxidase activity was synthesized through the <em>in situ</em> growth of Fe nanoparticles (FeNPs) on graphite-phase carbon nitride nanosheets (g-C<small>₃</small>N<small>₄</small>), which could catalyze H<small>₂</small>O<small>₂</small> to oxidize TMB to blue oxide (oxTMB). The peroxidase activity of the FeNPs@g-C<small>₃</small>N<small>₄</small> nano-enzyme could be inhibited by F<small>⁻</small>, and then restored by Al<small>³⁺</small> because of the coordination reaction between Fe<small>³⁺</small>/Al<small>³⁺</small> and F<small>⁻</small>. Furthermore, the solution color could be dynamically manipulated by changing the concentrations of F<small>⁻</small> and Al<small>³⁺</small>. Under optimal conditions, the developed method gave low detection limits of 2.43 nM for F<small>⁻</small> and 7.66 μM for Al<small>³⁺</small>. The cooperation of nano-enzyme and smartphone has greatly shortened the detection time and reduced the cost of detection, providing a new strategy for the on-site and convenient detection of F<small>⁻</small> and Al<small>³⁺</small> in tea, and showed significant application potential in food safety evaluation.</p>","PeriodicalId":81,"journal":{"name":"Journal of Analytical Atomic Spectrometry","volume":" 2","pages":" 402-410"},"PeriodicalIF":3.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of nanoparticle-enhanced LIBS (NELIBS) for the analysis of archaeological metallic artifacts: a critical assessment†","authors":"Rosalba Gaudiuso, Aya Taleb, Marcella Dell'Aglio, Immacolata Concetta Tommasi and Alessandro De Giacomo","doi":"10.1039/D4JA00349G","DOIUrl":"https://doi.org/10.1039/D4JA00349G","url":null,"abstract":"<p >Nanoparticle-Enhanced Laser-Induced Breakdown Spectroscopy (NELIBS) is a LIBS variant that, in its original implementation, is based on intensifying the emission intensity of the sample under investigation by depositing nanoparticles on its surface. In this work, we evaluated the feasibility of this approach for the analysis of historical samples by carrying out NELIBS of a bronze archaeological object. Our purpose was exploiting the emission enhancement to perform single-shot analysis of ancient metallic samples and to improve the LOD (Limit Of Detection) of minor and trace elements while also reducing the sample damage. To this end, we carried out LIBS and NELIBS analysis of one bronze helmet fragment (VII century BCE), and we adopted two different analytical approaches <em>i.e.</em>, calibration lines drawn with a set of copper-based standard alloys, and Calibration-Free (CF). When depositing NPs on the surface of the archaeological sample, some critical issues arose, which have the potential to limit the applicability of NELIBS to metallic samples with surfaces altered by corrosion and burial deposits, such as those of ancient artifacts. We discussed these issues and proposed experimental and analytical approaches to mitigate their detrimental effects on the analysis. Our results showed that the LOD decreased for all the elements analyzed in the standard alloys and in the archaeological sample, though not in the same extent, and confirmed that, while requiring some special care for experimental optimization and data analysis, NELIBS can be a powerful approach in heritage science studies.</p>","PeriodicalId":81,"journal":{"name":"Journal of Analytical Atomic Spectrometry","volume":" 2","pages":" 354-364"},"PeriodicalIF":3.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finding a needle in a haystack: quantitative HERFD-XRF imaging and HERFD-XANES characterization of trace platinum in gold solidi from the Late Roman and Byzantine Empires","authors":"Lisa L. Van Loon, Y. Zou Finfrock, Debora M. Meira, R. W. Burgess, George Bevan and Neil R. Banerjee","doi":"10.1039/D4JA00281D","DOIUrl":"https://doi.org/10.1039/D4JA00281D","url":null,"abstract":"<p >High-Energy Resolution Fluorescence Detection X-Ray Fluorescence (HERFD-XRF) imaging and HERFD X-ray Absorption Near Edge Structure (XANES) spectroscopy are used to quantify and characterize trace platinum (Pt) in gold solidi from the Late Roman and Byzantine Empires. Historically, the elemental analysis of coins has been pivotal in distinguishing authentic artifacts from forgeries, elucidating minting practices, and understanding economic shifts. Notably, a new gold source with high platinum content appeared in the fourth century CE, transforming the Roman economy. Traditional methods struggled to detect platinum due to the overwhelming gold matrix. This study demonstrates the effectiveness of HERFD techniques in resolving this challenge. Three gold solidi, minted between 654 and 659 CE, were analyzed alongside reference gold materials with known Pt concentrations. The HERFD-XRF imaging revealed spatial distributions of platinum, highlighting non-uniformities within the coins. Additionally, HERFD-XANES spectroscopy identified the oxidation states and chemical speciation of platinum. Results demonstrate that platinum in the solidi primarily exists as metallic Pt, with some surface oxidation. The findings align with previous measurements but reveal higher Pt concentrations and significant inhomogeneities. This research confirms the reliability of HERFD methods for quantifying trace elements and provides new insights into the raw material sources and minting techniques of ancient gold coins. The non-destructive nature of this approach allows for extensive analyses, offering valuable data for historical, economic, and archaeological studies. This innovative application of HERFD-XRF imaging and XANES in cultural heritage research underscores the potential for detailed material characterization and conservation, enhancing our understanding of ancient economies and trade patterns.</p>","PeriodicalId":81,"journal":{"name":"Journal of Analytical Atomic Spectrometry","volume":" 1","pages":" 137-145"},"PeriodicalIF":3.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bulk analysis of columbite ores by LA-ICP-MS: development of reference materials and investigation into matrix effects†","authors":"Subramaniyan Balachandar, Wen Zhang, Yongsheng Liu, Zhaochu Hu, Haihong Chen, Tao Luo, Tao He and Xianli Zeng","doi":"10.1039/D4JA00311J","DOIUrl":"https://doi.org/10.1039/D4JA00311J","url":null,"abstract":"<p >Determination of metal elements in columbite ores is of great importance in understanding the potential economic significance and the origin of deposits. LA-ICP-MS is recognized as a green and efficient method for the bulk analysis of trace elements in natural samples. However, a major issue is the lack of matrix-matched reference materials for columbite ores. In this study, we developed an advanced method to produce pressed ultrafine-powder pellets with appropriate concentrations by applying a wet-mill method. The optimized scheme achieves a typical grain size of <em>d</em><small>₉₀</small> = 1.74 μm, forming pressed powder pellets with great cohesion and homogeneity, suitable for LA-ICP-MS. The relative standard deviation (RSD) values obtained from repeated measurements are &lt;10% for more than 50 elements, comparable to those of homogeneous reference glasses. A systematic investigation of glass reference materials, commercial iron ore pellets, and our synthetic columbite ore pellets revealed significant matrix effects in various materials when using nanosecond laser ablation. Although the use of a femtosecond laser ablation system can partially suppress the matrix effect that occurs during the laser ablation process, the matrix effect in the ICP caused by differences in chemical composition remains challenging to resolve. The use of a “wet” plasma mode enhanced the matrix effect. Our results highlight the importance of matrix-matched reference materials in quantitative analysis of columbite ores and other ore samples. Utilizing the matrix-matched calibration method, we successfully determined trace elements in pressed powder pellets of iron ore (MAKR-NP) and columbite ore (LSC), with discrepancies of less than 10% for most elements.</p>","PeriodicalId":81,"journal":{"name":"Journal of Analytical Atomic Spectrometry","volume":" 1","pages":" 259-275"},"PeriodicalIF":3.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid 235U/238U determination by matrix assisted ionization–time-of-flight mass spectrometry†‡","authors":"Shelby Bowden, Kyle M. Samperton, Elizabeth D. LaBone, Haley B. Lawton, Abigail M. Waldron, Joseph M. Mannion, Matthew S. Wellons and Danielle R. Mannion","doi":"10.1039/D4JA00346B","DOIUrl":"https://doi.org/10.1039/D4JA00346B","url":null,"abstract":"<p >Matrix-assisted ionization (MAI) of inorganic analytes is a nascent research domain that holds promise for rapid, potentially facility-deployable analytical applications. We present results of MAI uranium isotopic analysis (<small>²³⁵</small>U/<small>²³⁸</small>U) obtained on the timescale of minutes utilizing simple sample preparation and an ambient ionization time-of-flight mass spectrometer (ToF MS). Experimental MAI-ToF MS characterization of uranium Certified Reference Materials (CRMs) was used to establish method calibration and validate quantitative <small>²³⁵</small>U/<small>²³⁸</small>U determination spanning depleted, natural, and low-enriched uranium isotopic compositions. Secondary standard analyses with total uranium mass loadings of 5–500 ng per analysis yield accurate calibrated <small>²³⁵</small>U/<small>²³⁸</small>U results and relative uncertainties of 4.7–17.2% (approx. ±95% confidence level), with weighted-mean uncertainties approaching 1.5%. This method permits accurate determination of uranium isotopic composition in a sample with uranium content as low as 200 pg for equal atom <small>²³⁵</small>U:<small>²³⁸</small>U. Instrument detection limits constrain the minimum uranium mass required to identify the presence of highly enriched uranium (HEU ≥20% <small>²³⁵</small>U) as only 500 pg using the method presented here. MAI-ToF MS quantitation of relatively extreme isotope ratios (<small>²³⁵</small>U/<small>²³⁸</small>U ≤ 0.01) is limited by detection of minor <small>²³⁵</small>U (LoD 100 pg <small>²³⁵</small>U/analysis ≈ 10 ng total U/analysis), and subsequent method optimization is anticipated to further reduce these limits. These findings underscore the potential of MAI-ToF MS for isotopic characterization of uranium and other inorganic species for both basic and applied science.</p>","PeriodicalId":81,"journal":{"name":"Journal of Analytical Atomic Spectrometry","volume":" 1","pages":" 195-201"},"PeriodicalIF":3.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}