Archives of Clinical Neuropsychology最新文献

{"title":"Depression Symptoms Moderate Associations between Daily Functioning and Neuropsychological Performance in Mexican American Adults.","authors":"Lisa V Graves, Jennifer Lozano, Lorraine Vergonia, Paola Ortega","doi":"10.1093/arclin/acae100","DOIUrl":"10.1093/arclin/acae100","url":null,"abstract":"<p><strong>Objective: </strong>The influence of depression on the relationship between cognition and daily living in aging Mexican American adults requires further investigation, given projected trends in general growth as well as prevalence of depression and Alzheimer's disease and related dementias (ADRD) in this population.</p><p><strong>Method: </strong>In the present study, we examined the extent to which depression (assessed using the Geriatric Depression Scale - 15 item version) moderated the association between reported daily functioning (assessed using the Functional Activities Questionnaire [FAQ]) and objective neuropsychological performance in aging Mexican American adults in the National Alzheimer's Coordinating Center cohort.</p><p><strong>Results: </strong>Worse reported daily functioning (higher FAQ scores) was associated with worse memory and language performance among participants without elevated depression symptoms (ps < .05), but no associations were observed among those with elevated symptoms (ps > .05). Moreover, depression did not moderate associations of reported daily functioning with performance in attention and working memory or executive functioning and processing speed (ps > .05).</p><p><strong>Conclusions: </strong>Aging Mexican American adults with elevated depression symptoms may have subjective informant reports of daily functioning that are discrepant from their objective performance on formal tests of memory and language. Within the context of neuropsychological evaluations for ADRD, failure to adequately assess mood to inform the nature of cognitive and/or functional changes could result in misdiagnosis and lead to delayed, premature, and/or improper intervention with this population.</p>","PeriodicalId":8176,"journal":{"name":"Archives of Clinical Neuropsychology","volume":" ","pages":"822-832"},"PeriodicalIF":2.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Language and Cognitive Impairments in Multiple Sclerosis: a Comparative Study of RRMS and SPMS Patients.","authors":"Maria Martzoukou, Anastasia Nousia, Lambros Messinis, Kostas Konstantopoulos, Grigorios Nasios","doi":"10.1093/arclin/acae110","DOIUrl":"10.1093/arclin/acae110","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies have reported that patients with Multiple Sclerosis (MS) face cognitive difficulties. Much less, however, is known about their language abilities. The present study aims to provide a clear view of the language abilities of adults with MS, considering their cognitive skills and the type of the disorder.</p><p><strong>Method: </strong>Specifically, 20 patients with Relapsing-Remitting MS, 17 patients with Secondary Progressive MS, and two healthy control groups demographically matched with the clinical groups, took part in the study. Their language abilities were examined using the Adult Language Abilities Test, which explores morpho-syntactic and semantic phenomena of the Greek language in both comprehension and production modes.</p><p><strong>Results: </strong>Our results did not reveal statistically significant differences between the two clinical groups on any cognitive or language subtest. Both groups, however, performed poorer than the control groups in producing the correct form of verbs, possessive and weak personal pronouns, and in comprehending relative and passive clauses. Participants' performance in morphosyntax was found to be related to their processing speed.</p><p><strong>Conclusion: </strong>Mapping the cognitive and language abilities of patients with MS is crucial for designing effective targeted interventions, which can help them adopt strategies to manage their specific cognitive and language symptoms.</p>","PeriodicalId":8176,"journal":{"name":"Archives of Clinical Neuropsychology","volume":" ","pages":"775-782"},"PeriodicalIF":2.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIH Toolbox Cognition Performance in Older Adults with Normal Cognition, Mild Cognitive Impairment, and Mild Dementia of the Alzheimer's Type: Results from the ARMADA Study.","authors":"Emily H Ho, Tatiana Karpouzian-Rogers, Ezgi Ayturk, Katy Bedjeti, Sandra Weintraub, Richard Gershon","doi":"10.1093/arclin/acaf035","DOIUrl":"https://doi.org/10.1093/arclin/acaf035","url":null,"abstract":"<p><strong>Objective: </strong>Efficient and early detection of cognitive impairment may be facilitated using the NIH Toolbox (NIHTB), a computerized suite of assessments measuring multiple aspects of neurological functioning.</p><p><strong>Methods: </strong>The Advancing Reliable Measurement in Alzheimer's Disease and cognitive Aging study validated the NIHTB across a geographically diverse cognitive aging sample. Participants aged >64 with normal cognition (NC), mild cognitive impairment (MCI), and dementia of the Alzheimer type (DAT) across nine research sites completed the NIHTB. One-way ANOVAs captured differences in performance on the Cognition Battery and effect sizes were calculated.</p><p><strong>Results: </strong>Groups differed substantially across all cognition measures, with large differences in Total and Fluid Cognition, after demographic adjustment. The largest differentiators were in fluid measures, particularly for working and episodic memory.</p><p><strong>Conclusions: </strong>NIHTB-CB differentiates NC, MCI, and DAT groups. Future studies will examine longitudinal differences and performance in enriched samples (African American participants, Spanish NIHTB, 85+ years old).</p>","PeriodicalId":8176,"journal":{"name":"Archives of Clinical Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Response Bias Scale and Response Bias Scale-19 of the MMPI-2-RF: Cross Validation and Comparison in an Active-Duty Neuropsychological Sample.","authors":"Luke G Childers, Paul B Ingram, Adam T Schmidt, Brandy Piña-Watson","doi":"10.1093/arclin/acaf034","DOIUrl":"https://doi.org/10.1093/arclin/acaf034","url":null,"abstract":"<p><strong>Objective: </strong>Valid client performance is critical to effective psychological testing. The MMPI-2-RF includes the Response Bias Scale (RBS) as an effective over-reporting scale and was developed for such detection efforts. Emerging RBS research has evaluated modifications to improve the scale's reliability and validity, shortening it from 28 to 19-items. This study cross-validates RBS-19 in a large military sample using multiple Performance Validity Tests as outcome measures. It also examines the moderating effects of military rank.</p><p><strong>Methods: </strong>Active-Duty Service members (n = 587) seen at Walter Reed National Medical Center. Archival data were collected during referral-based post-deployment screenings for reported cognitive impairments. Analytic plan includes PVT mean difference testing, RBS/RBS19 and PVT Pass All / Fail Any strengths of association, and moderation analyses.</p><p><strong>Results: </strong>Results indicate a non-significant influence of rank at predicting PVT failure. RBS was generally equitable with RBS-19 but demonstrated some marginally better utility. Elevation frequency and differences in those rates (e.g., Chi Square and Phi Coefficient's) supported significant relationships between overall Pass All/Fail Any grouping.</p><p><strong>Conclusions: </strong>Clinical implications suggest differences in PVT detection when assessing response invalidity. Important moderator findings suggest rank does not influence response style. Inconsistency with previous literature suggests importance of context dependent testing (e.g., post-deployment, fitness for duty vs forensic/outpatient settings). Recommendations for future use in Active-Duty populations are provided.</p>","PeriodicalId":8176,"journal":{"name":"Archives of Clinical Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of In-person versus Remote Cognitive Assessment in Cognitively Unimpaired Older Adults via Regression-Based Change Analysis.","authors":"Lauren A Latham, Suzanne Craft, Stephen R Rapp, James R Bateman, Maryjo Cleveland, Samantha Rogers, Benjamin J Williams, Mia Yang, Bonnie C Sachs","doi":"10.1093/arclin/acaf033","DOIUrl":"https://doi.org/10.1093/arclin/acaf033","url":null,"abstract":"<p><strong>Objective: </strong>Compare the changes in neuropsychological test scores between remote and in-person follow-up assessment over a 1-year period using standardized regression-based (SRB) change indices.</p><p><strong>Method: </strong>Participants were from the Wake Forest Alzheimer's Disease Research Center (ADRC; N = 230) [mean age: 68.6 (7.8) years; education: 16.3 (2.3) years; 71% female; 86% White] and cognitively normal (as defined by a CDR of 0) at baseline and follow-up [mean days: 420.03 (48.53)]. Follow-up testing with the Uniform Data Set v3 Cognitive Battery was completed in person (n = 121) or remotely (n = 109) via phone (n = 61) or video (n = 48). SRB change scores were calculated using published formulas. Chi-square analysis compared the frequency of scores falling outside of an SRB cut-point +/-1.645 for follow-up assessments and mean SRB change scores were compared.</p><p><strong>Results: </strong>There were no significant differences in the frequency of SRB change scores for in-person versus remote follow-up assessments at the SRB cut-point. Similarly, one-way ANOVAs comparing mean SRB change scores revealed no significant differences between in-person, telephone, and video follow-up means for any of the tests.</p><p><strong>Conclusions: </strong>Telephone and video cognitive assessments performed similarly to in-person assessment and offer a valuable tool for research and clinical applications.</p>","PeriodicalId":8176,"journal":{"name":"Archives of Clinical Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An 18-Year Study of Changes in Neurocognitive Function and Associations with Repetitive Head Trauma among Former Collegiate American Football Players: A Case Series.","authors":"Samuel R Walton, Zachary Yukio Kerr, Jacob R Powell, Kelly S Giovanello, Michael A McCrea, Kevin M Guskiewicz, Benjamin L Brett","doi":"10.1093/arclin/acaf032","DOIUrl":"https://doi.org/10.1093/arclin/acaf032","url":null,"abstract":"<p><strong>Objectives: </strong>To assess changes in neurocognitive test scores among former collegiate American football players over 18 years and examine associations with head trauma history.</p><p><strong>Methods: </strong>Former collegiate American football players (n = 31; aged = 38.4 ± 1.3 years) self-reported their concussion history and repetitive head impact exposure (Head Impact Exposure Estimate). Neurocognitive testing was conducted at two time-points (during college [T1] and 18-year follow-up [T2]) via Hopkins Verbal Learning Test-Revised Immediate and Delayed Recall; Verbal fluency; Symbol Digit Modalities Test; and Trail-Making Test-B. Raw score changes were calculated, with accompanying Cohen's d effect sizes and coefficients of variation. Repeated-measures analyses of covariance models were fit to examine changes in test performance. Multivariable linear regression models tested associations of sport-related concussion history and repetitive head impact exposure with change scores.</p><p><strong>Results: </strong>No significant changes in cognitive test performance were observed (ps ≥ .06). Individual-level changes exhibited high variability (coefficients of variation ≥ 244%), and group-level effects were small to medium (d ≤ 0.41). Neither sport-related concussion history nor repetitive head impacts were related to change scores (ps > .05).</p><p><strong>Conclusions: </strong>Group-level test scores did not change over 18 years among former collegiate football players now in midlife, though individual-level variability was high. Sport-related concussion and head impact exposure estimates were not related to change. Longitudinal studies are essential to understand cognitive trajectories of former football players and factors influencing those trajectories.</p>","PeriodicalId":8176,"journal":{"name":"Archives of Clinical Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordance between the Noose and Boomerang Items of the Boston Naming Test in an Adult Clinical Sample.","authors":"Robert M Roth, Mike Almasri, Jared B Hammond, Angela R Waszkiewicz, Maurissa Abecassis, Anna C Graefe, Grant G Moncrief","doi":"10.1093/arclin/acaf031","DOIUrl":"https://doi.org/10.1093/arclin/acaf031","url":null,"abstract":"<p><strong>Objective: </strong>A publisher of the Boston Naming Test recently provided a boomerang item to replace the noose item. We examined response accuracy and speed for these items.</p><p><strong>Method: </strong>Participants were 300 patients seen for clinical neuropsychological evaluation. Noose and boomerang items were administered consecutively, in counterbalanced order.</p><p><strong>Results: </strong>Spontaneous response was correct for the noose in 91% and boomerang in 76.7%. Both responses were correct for 72.7% and incorrect for 5% (overall concordance of 77.7%), 18.3% had correct noose/incorrect boomerang, and 4% correct boomerang/incorrect noose. Time to spontaneous response was faster for the noose. Phonemic cues were more helpful in naming the boomerang.</p><p><strong>Conclusions: </strong>Spontaneous response to the noose and boomerang items showed lack of concordance in 22.3% of patients, and the items showed differences in time to response and benefit from phonemic cuing. These findings raise concern about using the boomerang as a replacement for the noose item.</p>","PeriodicalId":8176,"journal":{"name":"Archives of Clinical Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Cultural Adaptation and Spanish Validation of the Computerized Information Processing Assessment Battery (COGNITO).","authors":"Nieves Revert-Alcántara, María Jesús Funes-Molina, Carlos Porcel, Carmen Sáez-Zea","doi":"10.1093/arclin/acad075","DOIUrl":"10.1093/arclin/acad075","url":null,"abstract":"<p><strong>Introduction: </strong>Mild cognitive impairment (CI) has an exponential increase in its prevalence and causes functional deficits and dependence. Its early detection allows for timely treatment and greater therapeutic efficacy. However, mild cognitive impairment (MCI) is currently underdiagnosed. Although recent decades have seen a rise in computerized instruments for the detection and early diagnosis of MCI, showing numerous advantages over the classic paper-and-pencil methods, such as standardized stimulus presentation. However, their limitations include the use of self-administered application without professional supervision. Few of these instruments have Spanish-adapted versions.</p><p><strong>Objective: </strong>To translate, adapt, and validate the computerized Information Processing Assessment Battery (COGNITO) battery in the Spanish population and to develop a portable administration system that facilitates its application in different settings. COGNITO was then administered to 232 Spanish participants (18-89 years) without cognitive impairment, after which preliminary normative data were obtained.</p><p><strong>Results: </strong>Strong positive correlations were found between the main cognitive domains assessed by COGNITO and the variables of age, educational level, and MEC score. The gender variable only correlated with visuospatial skills, with men outperforming women. The test-retest correlations conducted after 4 weeks with 89 participants revealed adequate reliability coefficients ranging between.63 and.66 (visuospatial skills = 0.35). Internal consistency coefficients were satisfactory in Attention-Executive Functions and Memory domains.</p><p><strong>Conclusions: </strong>The Spanish adaptation of COGNITO shows adequate psychometric characteristics of validity and reliability. The preliminary normative data provided may contribute to the early detection of cognitive impairments associated with both normal aging and various types of neurological pathology. This tool has great utility and versatility for neuropsychological practice.</p>","PeriodicalId":8176,"journal":{"name":"Archives of Clinical Neuropsychology","volume":" ","pages":"591-603"},"PeriodicalIF":2.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41102424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative Data for the Alternating and Orthographic Constraint Semantic Fluency Tests in the Adult French-Quebec Population and Validation Study in Mild Cognitive Impairment and Alzheimer's Disease.","authors":"Joël Macoir, Carol Hudon","doi":"10.1093/arclin/acad065","DOIUrl":"10.1093/arclin/acad065","url":null,"abstract":"<p><p>Verbal fluency tests, known to elicit executive functions (EFs), have proven useful in distinguishing healthy individuals from those with cognitive impairment. The present study addresses two new tests of verbal fluency that elicit EFs, namely, extradimensional alternating fluency (EAF) and extradimensional orthographic constraint semantic fluency (EOCSF). The aim of Study 1 was to provide normative data in the adult and elderly population of French Québec for the two fluency tests. The aim of Study 2 was to determine their psychometric value. The normative sample consisted of 338 healthy controls (HCs) aged 50-89 years. Multiple linear regressions were used to generate equations for calculating Z-scores. Convergent validity was established by administering the two verbal fluency tests and the Letter-Number Sequence (LNS) subtest of the WAIS-III. To assess predictive validity, the performance of 19 HCs was compared with that of 19 participants with mild cognitive impairment (MCI) and 19 participants with Alzheimer's disease (AD). To determine test-retest reliability, the test was administered twice, 3 months apart, to a subsample of 20 HCs. Age and educational level were significantly related to performance in the EAF and the EOCSF. The two tests correlated significantly and positively with the LNS. The EAF and the EOCSF distinguished the performance of HCs from that of participants with MCI or AD. A test-retest analysis showed that scores on the two tests were stable over time. The norms and psychometric data for the EAF and the EOCSF will help clinicians and researchers better identify executive impairments associated with pathological conditions.</p>","PeriodicalId":8176,"journal":{"name":"Archives of Clinical Neuropsychology","volume":" ","pages":"662-672"},"PeriodicalIF":2.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10599195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Neuropsychology of Bilingual Mexican American Adults: Effect of Language Proficiency and Dominance.","authors":"Gabriela Ontiveros, Philip Gerard Gasquoine","doi":"10.1093/arclin/acad072","DOIUrl":"10.1093/arclin/acad072","url":null,"abstract":"<p><strong>Objective: </strong>To assess the association between language proficiency and absolute dominance on language versus visual-perceptual formatted and executive versus delayed memory neuropsychological measures in bilingual adults.</p><p><strong>Methods: </strong>Data from 55 bilingual, conversationally fluent, neurologically intact, Mexican American, consecutive, adults tested in separate sessions in Spanish and English in a counterbalanced order were analyzed. Age, years of education, self-reported language proficiency, Woodcock-Muñoz Language Survey-Revised (WMLS-R) picture vocabulary measures of language proficiency, and dominance (absolute Spanish-English WMLS-R difference scores) were correlated with 11 measures from La Batería Neuropsicólogica en Español and its original English language tests.</p><p><strong>Results: </strong>Self-reported and WMLS-R measures of language proficiency were significantly correlated in each language. Absolute language dominance was not significantly associated with any Spanish or English neuropsychological raw score. The WMLS-R language proficiency, but not age or years of education, was significantly correlated with language-formatted neuropsychological measures of California Verbal Learning Test delayed free recall number of words (both languages), letter fluency (both languages), delayed story memory (in English), and Stroop interference (Spanish). Linear regression models using age, years of education, and WMLS-R picture vocabulary scores as predictors were significant for all these measures excepting the last. The WMLS-R language proficiency was not significantly associated with raw scores on any visual-perceptual formatted measure.</p><p><strong>Conclusions: </strong>Monolingual neuropsychological test norms for language-formatted tests likely overestimate bilingual Mexican Americans' performance.</p>","PeriodicalId":8176,"journal":{"name":"Archives of Clinical Neuropsychology","volume":" ","pages":"456-466"},"PeriodicalIF":2.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41095120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}