美国国立卫生研究院工具箱认知表现在老年人正常认知，轻度认知障碍，轻度痴呆的阿尔茨海默氏症类型：结果从ARMADA研究。

IF 2.1 4区心理学 Q2 PSYCHOLOGY

Archives of Clinical Neuropsychology Pub Date : 2025-05-14 DOI:10.1093/arclin/acaf035

Emily H Ho, Tatiana Karpouzian-Rogers, Ezgi Ayturk, Katy Bedjeti, Sandra Weintraub, Richard Gershon

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引用次数: 0

摘要

目的：使用NIH工具箱（NIHTB），一套测量神经功能多个方面的计算机化评估套件，可以促进有效和早期的认知障碍检测。方法：阿尔茨海默病和认知衰老的先进可靠测量研究在地理上不同的认知衰老样本中验证了NIHTB。来自9个研究地点的年龄在bb0 - 64岁、认知正常（NC）、轻度认知障碍（MCI）和阿尔茨海默型痴呆（DAT）的参与者完成了NIHTB。单因素方差分析（One-way anova）捕获了认知电池和效应大小的性能差异。结果：在人口统计学调整后，各组在所有认知测量中存在显著差异，总认知和流体认知存在较大差异。最大的区别是流体测量，特别是工作记忆和情景记忆。结论：NIHTB-CB可区分NC、MCI和DAT组。未来的研究将检查纵向差异和丰富的样本（非裔美国参与者，西班牙NIHTB， 85岁以上）的表现。

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NIH Toolbox Cognition Performance in Older Adults with Normal Cognition, Mild Cognitive Impairment, and Mild Dementia of the Alzheimer's Type: Results from the ARMADA Study.

Objective: Efficient and early detection of cognitive impairment may be facilitated using the NIH Toolbox (NIHTB), a computerized suite of assessments measuring multiple aspects of neurological functioning.

Methods: The Advancing Reliable Measurement in Alzheimer's Disease and cognitive Aging study validated the NIHTB across a geographically diverse cognitive aging sample. Participants aged >64 with normal cognition (NC), mild cognitive impairment (MCI), and dementia of the Alzheimer type (DAT) across nine research sites completed the NIHTB. One-way ANOVAs captured differences in performance on the Cognition Battery and effect sizes were calculated.

Results: Groups differed substantially across all cognition measures, with large differences in Total and Fluid Cognition, after demographic adjustment. The largest differentiators were in fluid measures, particularly for working and episodic memory.

Conclusions: NIHTB-CB differentiates NC, MCI, and DAT groups. Future studies will examine longitudinal differences and performance in enriched samples (African American participants, Spanish NIHTB, 85+ years old).

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来源期刊

Archives of Clinical Neuropsychology 医学-心理学

CiteScore

4.60

自引率

7.70%

发文量

358

审稿时长

6-12 weeks

期刊介绍： The journal publishes original contributions dealing with psychological aspects of the etiology, diagnosis, and treatment of disorders arising out of dysfunction of the central nervous system. Archives of Clinical Neuropsychology will also consider manuscripts involving the established principles of the profession of neuropsychology: (a) delivery and evaluation of services, (b) ethical and legal issues, and (c) approaches to education and training. Preference will be given to empirical reports and key reviews. Brief research reports, case studies, and commentaries on published articles (not exceeding two printed pages) will also be considered. At the discretion of the editor, rebuttals to commentaries may be invited. Occasional papers of a theoretical nature will be considered.