IF 2.2 4区医学

Apmis Pub Date : 2024-08-13 DOI: 10.1111/apm.13460

Naji Naseef Pathoor, Pitchaipillai Sankar Ganesh

引用次数: 0

RE: Aetiological profile of acute encephalitis syndrome in Assam, India, during a 4-year period from 2019 to 2022 RE：2019年至2022年4年间印度阿萨姆邦急性脑炎综合征的病原学概况。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-13 DOI: 10.1111/apm.13461

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED 在 APECED 患者中，针对潜伏巨细胞病毒感染的 T 细胞反应降低与抗 IFN 自身抗体无关。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-07 DOI: 10.1111/apm.13458

Iivo Hetemäki, Nelli Heikkilä, Pärt Peterson, Eliisa Kekäläinen, Nick Willcox, Wolff Anette S. B., Hanna Jarva, T Petteri Arstila

{"title":"Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED","authors":"Iivo Hetemäki, Nelli Heikkilä, Pärt Peterson, Eliisa Kekäläinen, Nick Willcox, Wolff Anette S. B., Hanna Jarva, T Petteri Arstila","doi":"10.1111/apm.13458","DOIUrl":"10.1111/apm.13458","url":null,"abstract":"Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inborn error of immunity affecting both multiple endocrine organs and susceptibility to candidiasis, each with an autoimmune basis. Recently, high titer neutralizing anti-type I interferon (IFN) autoantibodies have been linked with increased severity of SARS-CoV-2 and varicella zoster virus infections in APECED patients. Examining immunity against cytomegalovirus (CMV), we found a higher prevalence of anti-CMV IgG antibodies in patients with APECED (N = 19) than in 44 healthy controls (90% vs 64%, p = 0.04); the similar difference in their IgG levels did not achieve significance (95 ± 74 vs 64 ± 35 IU/mL, ns.). In contrast, the frequency of CMV-specific T cells was lower (804 ± 718/million vs 1591 ± 972/million PBMC p = 0.03). We saw no correlations between levels of anti-CMV IgG and anti-IFN antibodies in APECED patients or in a separate cohort of patients with thymoma (n = 70), over 60% of whom also had anti-IFN antibodies. Our results suggest a dysregulated response to CMV in APECED patients and highlight immunodeficiency to viral infections as part of the disease spectrum.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 11","pages":"881-887"},"PeriodicalIF":2.2,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world data confirm elexacftor/tezacaftor/ivacaftor modulators halves sweat chloride concentration in eligible people with cystic fibrosis 真实世界的数据证实，elexacftor/tezacaftor/ivacaftor调节剂可将符合条件的囊性纤维化患者的汗液氯化物浓度减半。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-02 DOI: 10.1111/apm.13453

Thomas Bryrup, Daniel Faurholt-Jepsen, Tacjana Pressler, Esben Herborg Henriksen, Christian Leo-Hansen, Bibi Uhre Nielsen, Christine Højte, Inger Hee Mabuza Mathiesen, Terese L. Katzenstein, Majbritt Jeppesen, Søren Jensen-Fangel, Hanne Vebert Olesen, Marianne Skov, Tavs Qvist, Mette Frahm Olsen, the TransformCF Study Group

{"title":"Real-world data confirm elexacftor/tezacaftor/ivacaftor modulators halves sweat chloride concentration in eligible people with cystic fibrosis","authors":"Thomas Bryrup, Daniel Faurholt-Jepsen, Tacjana Pressler, Esben Herborg Henriksen, Christian Leo-Hansen, Bibi Uhre Nielsen, Christine Højte, Inger Hee Mabuza Mathiesen, Terese L. Katzenstein, Majbritt Jeppesen, Søren Jensen-Fangel, Hanne Vebert Olesen, Marianne Skov, Tavs Qvist, Mette Frahm Olsen, the TransformCF Study Group","doi":"10.1111/apm.13453","DOIUrl":"10.1111/apm.13453","url":null,"abstract":"Sweat chloride concentration, a diagnostic feature in cystic fibrosis (CF), reflects CF transmembrane conductance regulator (CFTR) activity. CFTR modulator therapies, especially elexacaftor/tezacaftor/ivacaftor (ETI), has improved CF outcomes. We report nationwide, real-world data on sweat chloride concentration in people with CF (pwCF) with and without modulator therapies. All Danish pwCF with a minimum of one F508del allele were included. Sweat chloride measurements were stratified by genotype and modulator treatment. Differences were assessed using mixed-effects models. We included 977 sweat chloride measurements from 430 pwCF, 71% of which were F508del homozygous. Heterozygous and homozygous ETI-treated pwCF had an estimated mean sweat chloride concentration of 43 mmol/L (95% confidence interval: 39; 48) and 43 mmol/L (39; 47), respectively—48% and 59% lower than those without treatment. High variation in concentrations remained regardless of treatment status. Despite ETI treatment, 27% heterozygous and 23% homozygous pwCF had elevated concentrations (≥60 mmol/L). These real-world data confirm a substantial decrease in sweat chloride concentration during modulator treatment, especially ETI, where mean concentrations halved. However, large variation remained, including persistently high concentrations. These findings emphasize the potential of sweat chloride concentration as a treatment response biomarker and the need to explore its heterogeneity and relationship with clinical outcomes.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 10","pages":"728-733"},"PeriodicalIF":2.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mathematical description of nonself for biallelic genetic systems in pregnancy, transfusion, and transplantation 妊娠、输血和移植中的双偶联遗传系统的非自我数学描述。

IF 2.2 4区医学

Apmis Pub Date : 2024-07-19 DOI: 10.1111/apm.13457

Klaus Rieneck

引用次数: 0

Exploring the role of mesenchymal stem cells in modulating immune responses via Treg and Th2 cell activation: insights from mouse model of multiple sclerosis 探索间充质干细胞在通过Treg和Th2细胞激活调节免疫反应中的作用：多发性硬化症小鼠模型的启示。

IF 2.2 4区医学

Apmis Pub Date : 2024-07-19 DOI: 10.1111/apm.13456

Abdolvahid Sadeghnejad, Alireza Pazoki, Esmaeil Yazdanpanah, Seyed-Alireza Esmaeili, Bahman Yousefi, Bijan Sadighi-Moghaddam, Rasoul Baharlou, Dariush Haghmorad

{"title":"Exploring the role of mesenchymal stem cells in modulating immune responses via Treg and Th2 cell activation: insights from mouse model of multiple sclerosis","authors":"Abdolvahid Sadeghnejad, Alireza Pazoki, Esmaeil Yazdanpanah, Seyed-Alireza Esmaeili, Bahman Yousefi, Bijan Sadighi-Moghaddam, Rasoul Baharlou, Dariush Haghmorad","doi":"10.1111/apm.13456","DOIUrl":"10.1111/apm.13456","url":null,"abstract":"Multiple sclerosis is a demyelinating neurodegenerative disease, and its animal model, experimental autoimmune encephalomyelitis (EAE), exhibits immunological and clinical similarities. The study aimed to examine mechanisms underlying therapeutic effects of mesenchymal stem cell administration in EAE. C57BL/6 mice were separated into control and treatment groups (T1, T2, and T3); EAE was induced in all animals. Clinical examinations were conducted daily, and on 25th day, animals were sacrificed, and spinal cord was stained for histological analysis. Additionally, spleen cell proliferation assay, assessments of cytokine, and gene expression in both spinal cord and spleen cells were performed. The results indicated a significant reduction in clinical symptoms among treatment groups compared to control group. Histological analyses revealed decreased infiltration of lymphocytes into the spinal cord and reduced demyelinated areas in treatment groups compared to control group. Cytokine production of IL-10, TGF-β, and IL-4 were significantly enhanced and IFN-γ and TNF-α in treatment groups were decreased relative to control group. Also, gene expression of CTLA-4, PD-1, IL-27, and IL-33 indicated a significant increase in treatment groups. The administration of MSCs significantly improved clinical symptoms, attenuated inflammation, and reduced spinal cord demyelination in EAE, suggesting a potential protective effect on disease progression.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 11","pages":"888-899"},"PeriodicalIF":2.2,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141730989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the intricacies of Porphyromonas gingivalis: virulence factors, lifecycle dynamics and phytochemical interventions for periodontal disease management 揭开牙龈卟啉单胞菌的神秘面纱：毒力因子、生命周期动态和牙周病管理的植物化学干预措施。

IF 2.2 4区医学

Apmis Pub Date : 2024-07-19 DOI: 10.1111/apm.13440

Rubeen Nadaf, Vijay M. Kumbar, Shridhar Ghagane

引用次数: 0

Immunohistochemical expression of SATB2 and PAX8 in differentiating primary from metastatic ovarian mucinous neoplasms SATB2 和 PAX8 在区分原发性和转移性卵巢黏液瘤中的免疫组化表达。

IF 2.2 4区医学

Apmis Pub Date : 2024-07-15 DOI: 10.1111/apm.13449

Rana Ahmed El Ghondakly, Salwa Ibrahim El Haddad, Magda Mohamed AbdelSalam, Ola Hassan Nada, Rola Mohamed Farid, Laila M. Farid

{"title":"Immunohistochemical expression of SATB2 and PAX8 in differentiating primary from metastatic ovarian mucinous neoplasms","authors":"Rana Ahmed El Ghondakly, Salwa Ibrahim El Haddad, Magda Mohamed AbdelSalam, Ola Hassan Nada, Rola Mohamed Farid, Laila M. Farid","doi":"10.1111/apm.13449","DOIUrl":"10.1111/apm.13449","url":null,"abstract":"Accurate stratification of an ovarian mucinous neoplasm as primary or secondary is always challenging as they show overlapping histomorphological and immunohistochemical features. Immunohistochemical staining for SATB2 and PAX8 was performed on 80 cases of mucinous ovarian neoplasms subdivided into 53 primary [25 primary ovarian mucinous carcinomas (POMCs) and 28 mucinous borderline tumors (MBTs)] and 27 secondary (12 of colonic origin, 7 of appendiceal origin, and 8 of gastric origin). Expression was correlated with different clinicopathologic parameters. PAX8-positive immunostaining was detected in 38 out of 53 cases (71.69%) of primary ovarian mucinous neoplasms (POMNs) with null positivity in the secondary ovarian mucinous tumors (0/27). SATB2-positive expression was detected in 16 out of 27 cases (59.26%) of the secondary ovarian mucinous tumors. None of the studied POMNs showed any positive immunostaining for SATB2 (0/53). A profile of SATB2−/PAX8+ and SATB2+/PAX8− can be used to differentiate POMNCs from secondary ovarian mucinous tumors of GI origin, respectively, with 100% specificity. PAX8 expression is associated with some clinicopathologic parameters providing the basis for the possible usage of PAX8 as prognostic marker.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 10","pages":"706-717"},"PeriodicalIF":2.2,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteriophage therapy and infective endocarditis – is it realistic? 噬菌体疗法和感染性心内膜炎--现实吗？

IF 2.2 4区医学

Apmis Pub Date : 2024-07-15 DOI: 10.1111/apm.13455

Emilie C. Pedersen, Christian Johann Lerche, Franziska Angelica Schwartz, Oana Ciofu, Joana Azeredo, Kim Thomsen, Claus Moser

{"title":"Bacteriophage therapy and infective endocarditis – is it realistic?","authors":"Emilie C. Pedersen, Christian Johann Lerche, Franziska Angelica Schwartz, Oana Ciofu, Joana Azeredo, Kim Thomsen, Claus Moser","doi":"10.1111/apm.13455","DOIUrl":"10.1111/apm.13455","url":null,"abstract":"Infective endocarditis (IE) is a severe infection of the inner heart. Even with current standard treatment, the mean in-hospital mortality is as high as 15–20%, and 1-year mortality is up to 40% for left-sided IE. Importantly, IE mortality rates have not changed substantially over the past 30 years, and the incidence of IE is rising. The treatment is challenging due to the bacterial biofilm mode of growth inside the heart valve vegetations, resulting in antibiotic tolerance. Achieving sufficient antibiotic anti-biofilm concentrations in the biofilms of the heart valve vegetations is problematic, even with high-dose and long-term antibiotic therapy. The increasing prevalence of IE caused by antibiotic-resistant bacteria adds to the challenge. Therefore, adjunctive antibiotic-potentiating drug candidates and strategies are increasingly being investigated. Bacteriophage therapy is a reemerging antibacterial treatment strategy for difficult-to-treat infections, mainly biofilm-associated and caused by multidrug-resistant bacteria. However, significant knowledge gaps regarding the safety and efficacy of phage therapy impede more widespread implementation in clinical practice. Hopefully, future preclinical and clinical testing will reveal whether it is a viable treatment. The objective of the present review is to assess whether bacteriophage therapy is a realistic treatment for IE.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 10","pages":"675-687"},"PeriodicalIF":2.2,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13455","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the cross-protection of the Vero cell-derived attenuated influenza vaccines with compound adjuvant, through intranasal immunization 评估通过鼻内免疫接种含有复合佐剂的 Vero 细胞衍生减毒流感疫苗的交叉保护作用。

IF 2.2 4区医学

Apmis Pub Date : 2024-07-03 DOI: 10.1111/apm.13448

Liu Ze, Song Shaohui, Huang Jinhai, Gao Hui

{"title":"Evaluation of the cross-protection of the Vero cell-derived attenuated influenza vaccines with compound adjuvant, through intranasal immunization","authors":"Liu Ze, Song Shaohui, Huang Jinhai, Gao Hui","doi":"10.1111/apm.13448","DOIUrl":"10.1111/apm.13448","url":null,"abstract":"This study was to evaluate the sufficient safety and effect of the novel influenza vaccine program. It prepared new reassortant influenza virus, with high yield on Vero cells. According to the plaque counting, one dose LAIV was composed with 105 PFU of H1, H3, BY, and BV, respectively. Then mixed this LAIV with compound adjuvant, containing 500 μg/mL of carbopol971P and 50 μg/mL of tetanus toxin. That vaccination was called catt-flu. And it employed the GYZZ02 vaccine (commercialized freeze-dried LAIV, listed in China) as cohort analysis control. All mice received two doses of the vaccine, administered on days 0 and 14, respectively. That catt-flu program could induce more cross-protection with neutralizing antibody against heterogeneous types of influenza virus, not only based on HA but also NA protective antigen, through convenient nasal immunization, which had non-inferiority titter compared with the chicken embryo-derived GYZZ02 vaccine on safe and effect. The Vero cell-derived vaccine (LAIV) combined compound catt adjuvant (contain carbopol971P and tetanus toxin) could provide another safety and protective program of influenza vaccine by intranasal administration, as catt-flu program.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 10","pages":"741-753"},"PeriodicalIF":2.2,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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