IF 2.2 4区医学

Apmis Pub Date : 2025-07-15 DOI: 10.1111/apm.70047

Agim Osmani, Sema Askın Keceli, Doganhan Kadir Er, Huseyin Uzuner, Feriha Ercan, Ayca Karagoz Koroğlu

{"title":"In Vitro Activity of Antifungals in Combination With Meropenem or Daptomycin Against Dual Candida albicans–Bacterial Biofilms","authors":"Agim Osmani, Sema Askın Keceli, Doganhan Kadir Er, Huseyin Uzuner, Feriha Ercan, Ayca Karagoz Koroğlu","doi":"10.1111/apm.70047","DOIUrl":"https://doi.org/10.1111/apm.70047","url":null,"abstract":"The objective was to investigate the effectiveness of anidulafungin (ANI), voriconazole (VOR), and amphotericin (AMB) combined with meropenem against dual biofilms of Candida albicans and Pseudomonas aeruginosa, as well as with daptomycin against dual biofilms of C. albicans–Staphylococcus epidermidis. MIC values of antifungals were determined by CLSI M27-A3 method. The effectiveness of antifungals in combination with antibiotics against biofilms was tested by Checkerboard analysis. Biofilm quantifications were tested by the XTT method. The biofilm images were captured using SEM. The quantity of C. albicans–S. epidermidis and C. albicans–P. aeruginosa was lower (83.2% and 56.3%, respectively) than that of single Candida biofilm. The SMIC50 values for single C. albicans biofilms were 32-fold higher for AMB and VOR, and 128-fold higher for ANI when compared to dual Candida biofilms. Daptomycin combined with ANI or VOR showed antagonistic effects against C. albicans–S. epidermidis biofilms, while meropenem in combination with all antifungals was found to be additive against C. albicans–P. aeruginosa biofilms. Antifungals and their combinations resulted in a decrease in blastospore and bacterial density, as observed through SEM. In C. albicans–P. aeruginosa biofilms, using meropenem alongside antifungals would be beneficial due to its additive effect. Daptomycin combined with ANI or VOR may not be effective in C. albicans–S. epidermidis coinfections.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Anti-CMV TCR CDR3s via Blood and Tumor Exome Files Correlates With Increased Survival for Stomach Adenocarcinoma and Soft Tissue Sarcoma 通过血液和肿瘤外显子组文件检测抗cmv TCR CDR3s与胃腺癌和软组织肉瘤的生存率增加相关

IF 2.2 4区医学

Apmis Pub Date : 2025-07-13 DOI: 10.1111/apm.70053

Utsav Kapoor, Michael T. Aboujaoude, Konrad J. Cios, Andrea Chobrutskiy, Boris I. Chobrutskiy, George Blanck

{"title":"Detection of Anti-CMV TCR CDR3s via Blood and Tumor Exome Files Correlates With Increased Survival for Stomach Adenocarcinoma and Soft Tissue Sarcoma","authors":"Utsav Kapoor, Michael T. Aboujaoude, Konrad J. Cios, Andrea Chobrutskiy, Boris I. Chobrutskiy, George Blanck","doi":"10.1111/apm.70053","DOIUrl":"https://doi.org/10.1111/apm.70053","url":null,"abstract":"<div>\u0000 \u0000 While the role of anti-cytomegalovirus (CMV) T-cell responses in the cancer setting is becoming increasingly recognized, the association between CMV and survival outcomes has not been subject to study through more recent immunogenomic approaches. Thus for this study, we extracted T-cell receptor (TCR) recombination reads from whole exome sequencing (WXS) and RNA sequencing (RNAseq) files of stomach adenocarcinoma (STAD) and soft tissue sarcoma (SARC) samples from the Cancer Genome Atlas (TCGA) and matched the corresponding TCR complementarity determining region-3 (CDR3) amino acid (AA) sequences represented by these reads to known anti-CMV CDR3 sequences. Results indicated that the recovery of both TRA and TRB recombination reads from WXS files, from either blood or tumor samples, which corresponded to AA sequences matching anti-CMV CDR3s, correlated with better survival probabilities for both STAD and SARC. However, TCR CDR3s represented by recombination reads recovered from RNAseq files and matching anti-CMV TCR CDR3 AA sequences correlated with lower survival probabilities. These results raise the question of whether exposure to CMV prior to onset or progression of cancer may lead to better survival probability whereas a potentially active T-cell response to CMV during cancer onset or progression could represent an ongoing comorbidity? In conclusion, TCR CDR3s may be an important indicator of prognosis for stomach cancer and soft tissue sarcoma and may support further research into anti-CMV CDR3s as a tool for development of immunotherapy for these cancers.\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Value of lncRNA NEAT1 in Patients With Hidradenitis Suppurativa lncRNA - NEAT1在化脓性汗腺炎中的临床价值

IF 2.2 4区医学

Apmis Pub Date : 2025-07-13 DOI: 10.1111/apm.70049

Li Zeng, Xiaoshuang Liao, Peng Guo, Xiaojiao Rong, Bo Yang, Jialin Zou

{"title":"Clinical Value of lncRNA NEAT1 in Patients With Hidradenitis Suppurativa","authors":"Li Zeng, Xiaoshuang Liao, Peng Guo, Xiaojiao Rong, Bo Yang, Jialin Zou","doi":"10.1111/apm.70049","DOIUrl":"https://doi.org/10.1111/apm.70049","url":null,"abstract":"<div>\u0000 \u0000 Hidradenitis suppurativa (HS) is characterized by chronic inflammation. LncRNA NEAT1 has been implicated in inflammatory skin conditions. This study aimed to investigate NEAT1 expression and its potential clinical implications in HS patients. A total of 182 individuals participated in this research, comprising 80 individuals in the control group and 102 HS patients in the HS group. QRT-PCR quantified the expression of NEAT1. Concentrations of inflammatory cytokines, including IL-1β, IL-6, IL-17, and TNF-α, were measured by ELISA. The association between NEAT1 level and these inflammatory markers was assessed by Pearson's correlation analysis. Multivariate logistic regression analysis was employed to estimate potential risk factors for HS. NEAT1 expression was elevated in HS patients compared to controls, with an area under the ROC curve measuring 0.8904, yielding a sensitivity of 69.61% and a specificity of 97.5%. Inflammatory factors IL-1β, IL-6, IL-17, and TNF-α were increased in HS patients and positively related to NEAT1 expression. The analysis identified smoking, ESR, CRP, and NEAT1 as risk factors for HS. In conclusion, increased NEAT1 in HS patients correlated with the disease severity. The expression level of NEAT1 was positively correlated with inflammatory factors, highlighting the role of smoking, ESR, CRP, and NEAT1 as key risk factors in HS.\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Analysis of White Blood Cell Trajectories and 30-Day Mortality in Ventilator-Associated Pneumonia Patients: A Cohort Study Based on the MIMIC-IV Database 呼吸机相关肺炎患者白细胞轨迹与30天死亡率的关联分析：基于MIMIC-IV数据库的队列研究

IF 2.2 4区医学

Apmis Pub Date : 2025-07-13 DOI: 10.1111/apm.70042

Jian Fang, Liang Liao

{"title":"Association Analysis of White Blood Cell Trajectories and 30-Day Mortality in Ventilator-Associated Pneumonia Patients: A Cohort Study Based on the MIMIC-IV Database","authors":"Jian Fang, Liang Liao","doi":"10.1111/apm.70042","DOIUrl":"https://doi.org/10.1111/apm.70042","url":null,"abstract":"<div>\u0000 \u0000 Abnormal white blood cell (WBC) counts have been associated with ventilator-associated pneumonia (VAP). However, the prognostic value of WBC trajectory changes in VAP patients remains understudied. This study aimed to explore the correlation between WBC trajectory changes and the 30-day mortality rate in VAP patients. Data from VAP patients in the MIMIC-IV database were included. Group-based trajectory analysis was used to categorize patients based on their WBC patterns within 7 days of ICU admission. Cox proportional hazards regression analysis was conducted to assess the association between WBC trajectories and 30-day mortality. A total of 1194 eligible VAP patients were included. Five distinct WBC trajectories were identified. Compared to the trajectory group with continuously normal WBC levels (Class 5), the group with initially high levels but subsequent decrease (Class 2) and the group with continuously increasing WBC levels (Class 3) showed independent associations with increased mortality (OR > 1, p < 0.05). Additionally, restricted cubic splines (RCS) results indicated a possible linear relationship between WBC counts on the 6th and 7th days and the 30-day survival status of VAP patients. Within the first week of ICU admission, both the group with initially low levels but persistently increasing WBC trajectories and the group with initially high levels but continuously decreasing WBC trajectories were associated with increased 30-day mortality in VAP patients. This finding offers insights into predicting short-term mortality risks related to VAP and aids clinicians in early identification of high-risk patients.\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Report of Actinomyces odontolyticus Pansinusitis in a Leflunomide-Treated Patient With Psoriatic Arthritis: A Rare Opportunistic Infection 在来氟米特治疗的银屑病关节炎患者中首次报道放线菌溶牙性全鼻窦炎：罕见的机会性感染

IF 2.2 4区医学

Apmis Pub Date : 2025-07-11 DOI: 10.1111/apm.70048

Angelo Nigro

引用次数: 0

miR-143 and miR-145 in Colorectal Cancer: A Digital Pathology Approach on Expressions and Protein Correlations miR-143和miR-145在结直肠癌中的表达和蛋白相关性的数字病理学方法

IF 2.2 4区医学

Apmis Pub Date : 2025-07-11 DOI: 10.1111/apm.70051

Erik Nesje Wiik, Henrik Sahlin Pettersen, Haakon Skogseth, Jostein Halgunset, Arne Wibe

{"title":"miR-143 and miR-145 in Colorectal Cancer: A Digital Pathology Approach on Expressions and Protein Correlations","authors":"Erik Nesje Wiik, Henrik Sahlin Pettersen, Haakon Skogseth, Jostein Halgunset, Arne Wibe","doi":"10.1111/apm.70051","DOIUrl":"https://doi.org/10.1111/apm.70051","url":null,"abstract":"<div>\u0000 \u0000 miR-143 and miR-145 have been reported as downregulated in colorectal cancer (CRC) compared to normal mucosa, with regulatory effects on proteins involved in carcinogenesis. These findings primarily derive from tissue homogenate analyses and experimental models. The present study employs in situ methodology to reassess miR-143 and miR-145 expression in CRC and their associations with validated protein targets within the native tumor microenvironment. Expression patterns of miR-143, miR-145, and eight previously experimentally validated target proteins were analyzed in clinical samples from 100 CRC patients using in situ hybridization, immunohistochemistry, and deep learning-based epithelial segmentation. Expression levels of miR-143 and miR-145 showed no significant difference between CRC and normal mucosa, though considerable inter-patient variability was observed. Among 11 examined miRNA-protein relationships, only four showed significant correlations, exhibiting positive associations that contrast with previously reported inverse relationships. Subgroup analyses revealed no statistically significant association between miRNA expression variability and examined clinicopathological parameters. These findings highlight the importance of in situ validation for results obtained from tissue homogenates and in vitro experiments. Additional research is warranted to determine the prognostic significance of miR-143 and miR-145 in clinical outcomes.\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Gum Kondagogu Stabilized Zinc Oxide Nanoparticles and Its Application as an Antibacterial Agent Against Wastewaterborne Bacteria 孔大谷胶稳定氧化锌纳米颗粒的合成、表征及其对废水细菌的抗菌作用

IF 2.2 4区医学

Apmis Pub Date : 2025-07-10 DOI: 10.1111/apm.70046

Aruna Jyothi Kora, Venkata Balarama Krishna Mullapudi

{"title":"Synthesis and Characterization of Gum Kondagogu Stabilized Zinc Oxide Nanoparticles and Its Application as an Antibacterial Agent Against Wastewaterborne Bacteria","authors":"Aruna Jyothi Kora, Venkata Balarama Krishna Mullapudi","doi":"10.1111/apm.70046","DOIUrl":"https://doi.org/10.1111/apm.70046","url":null,"abstract":"Wastewater recycling is one of the viable options for attaining sustainable water management. In this scenario, gum stabilized zinc oxide nanoparticles (ZnO NP) were synthesized employing the alkaline precipitation method with gum kondagogu stabilizer. Synthesized NP were characterized using UV–vis, DLS, zeta potential, XRD, FTIR, and TEM. ZnO NP exhibited an absorption peak at 351 nm in UV–vis, a zeta potential value of–35 mV, and a z-average value of 254 nm in DLS. XRD pattern showed a characteristic hexagonal wurtzite crystal structure and FTIR data indicated the capping of NP by various gum functional groups. The size of spherical NP varied from 12.4 to 35.7 nm, and the mean particle size was 24.8 ± 5.1 nm. The in vitro antibacterial activity of ZnO NP against wastewaterborne bacteria, Escherichia coli (Gram- negative) and Bacillus subtilis (Gram-positive) was studied with the resazurin broth assay. MIC values of 900 μg/mL and 900 μg/mL and MBC values of 1800 μg/mL and 900 μg/mL of ZnO NP were recorded towards E. coli and B. subtilis. Notably, ZnO NP exhibited superior bactericidal activity against B. subtilis compared to previous studies. Thus, the current study on ZnO NP mediated bacterial disinfection has wide applications in wastewater treatment and remediation of microbially contaminated effluents.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterials and Candida auris: A Systematic Review of Emerging Strategies 纳米材料与耳念珠菌：新兴策略的系统综述

IF 2.2 4区医学

Apmis Pub Date : 2025-07-10 DOI: 10.1111/apm.70044

Sergio A. Alanís-Ríos, Celia N. Sánchez-Domínguez, Hiram Villanueva-Lozano, Neri A. Álvarez Villalobos, Rogelio de J. Treviño-Rangel

{"title":"Nanomaterials and Candida auris: A Systematic Review of Emerging Strategies","authors":"Sergio A. Alanís-Ríos, Celia N. Sánchez-Domínguez, Hiram Villanueva-Lozano, Neri A. Álvarez Villalobos, Rogelio de J. Treviño-Rangel","doi":"10.1111/apm.70044","DOIUrl":"https://doi.org/10.1111/apm.70044","url":null,"abstract":"<div>\u0000 \u0000 The alarming rise of multidrug-resistant Candida auris infections and the consequent scarcity of effective therapeutic options have spurred research into alternative strategies for their prevention and management. Nanomaterials have emerged as a promising avenue for the development of innovative antifungal approaches. A systematic search of MEDLINE, EMBASE, Web of Science, and Scopus databases up to January 3, 2024, was conducted to identify studies reporting on the antifungal efficacy of nanoparticles (NPs) against C. auris. This search included studies on metallic NPs, lipidic carriers, the use of chitosan as a matrix, and other nanoparticle synthesis methodologies, including green chemistry approaches. Of the 266 articles initially retrieved, 30 met the eligibility criteria. Metallic NPs, particularly silver nanoparticles, were the most extensively studied, whereas lipidic carriers were the least explored. All nanomaterials demonstrated antifungal activity, showing inhibition of fungal growth, biofilm disruption, reduced fungal burden, and significantly improved survival rates in animal models of C. auris candidemia. Ongoing research into innovative treatment and prevention strategies remains urgently needed to combat this growing public health threat.\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of miR-222-3p Alleviates Acute Pancreatitis by Negatively Regulating the Expression of SIRT1 抑制miR-222-3p通过负性调节SIRT1的表达缓解急性胰腺炎

IF 2.2 4区医学

Apmis Pub Date : 2025-07-04 DOI: 10.1111/apm.70043

Tao Zhang, Jing Xiao, Wenzhao Chen

{"title":"Inhibition of miR-222-3p Alleviates Acute Pancreatitis by Negatively Regulating the Expression of SIRT1","authors":"Tao Zhang, Jing Xiao, Wenzhao Chen","doi":"10.1111/apm.70043","DOIUrl":"https://doi.org/10.1111/apm.70043","url":null,"abstract":"<div>\u0000 \u0000 The aim of this study is to explore the correlation between the levels of miR-222-3p and the onset of acute pancreatitis (AP) and further verify the role of miR-222-3p in the pathogenesis of AP through targeted regulation of Sirtuin 1 (SIRT1). This study encompassed a total of 160 AP patients, including 80 patients with mild and moderate AP (non-SAP) and 80 patients with severe AP (SAP). The levels of miR-222-3p and SIRT1 were detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR) technology, and the potential significance of miR-222-3p in the diagnosis of AP was evaluated by receiver operating characteristic curve. The proliferation activity of cerulein-induced HPDE6-C7 cells was investigated by Cell Counting Kit-8 method. Meanwhile, the changes in the levels of inflammatory factors were quantified using enzyme-linked immunosorbent assay (ELISA) kits. The result showed that miR-222-3p was elevated in AP patients, especially in SAP patients. Elevated miR-222-3p levels showed diagnostic significance for AP. Inhibiting miR-222-3p promoted the proliferation of cerulein-damaged HPDE6-C7 cells and reduced inflammatory factor increases induced by cerulein. SIRT1 inhibition reversed the effects of miR-222-3p on cerulein-induced HPDE6-C7 cells. Inhibition of miR-222-3p may alleviate the development of AP by targeting SIRT1.\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staphylococcus aureus From Prosthetic Joint Infections and Blood Cultures Display the Same Genetic Background 来自假体关节感染和血液培养的金黄色葡萄球菌显示相同的遗传背景

IF 2.2 4区医学

Apmis Pub Date : 2025-07-03 DOI: 10.1111/apm.70038

Bo Söderquist, Peter Wildeman, Marc Stegger, Bianca Stenmark

{"title":"Staphylococcus aureus From Prosthetic Joint Infections and Blood Cultures Display the Same Genetic Background","authors":"Bo Söderquist, Peter Wildeman, Marc Stegger, Bianca Stenmark","doi":"10.1111/apm.70038","DOIUrl":"https://doi.org/10.1111/apm.70038","url":null,"abstract":"Hematogenous prosthetic joint infections (PJIs) are primarily associated with Staphylococcus aureus, and there is a 30%–40% risk of contracting a hematogenous PJI following an S. aureus bacteremia. The aim of this study was to investigate whether identical strains of S. aureus were present in each patient from a cohort with both bacteremia and PJI and to explore the genomic differences between paired isolates obtained from blood cultures and tissue biopsies. All patients with a PJI and a temporally concomitant bacteremia due to S. aureus from 2005 to 2020 were included. Paired isolates of S. aureus from tissue biopsies and blood cultures were subjected to whole-genome sequencing. Twenty-four episodes of PJI were identified in 23 patients. All pairwise isolates from individual patients belonged to the same multilocus sequence type, clonal complex, and core genome multilocus sequence typing (cgMLST) complex type. The median number of single nucleotide polymorphisms (SNPs) in the conserved core genomes between the pairwise isolates was 3. In conclusion, identical cgMLST complex types and low levels of SNP differences between paired isolates of S. aureus from blood cultures and tissue biopsies suggest hematogenous seeding in all cases of PJI in this cohort.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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