Applied Radiation and Isotopes最新文献

{"title":"Boron neutron capture therapy (BNCT) for left axillary lymph node metastasis of recurrent breast cancer","authors":"Takuya Fujimoto ,&nbsp;Yoko Maekawa ,&nbsp;Shinichi Hori ,&nbsp;Atsushi Oguro ,&nbsp;Atsushi Hori ,&nbsp;Ikuo Fujita ,&nbsp;Yoshinori Sakurai ,&nbsp;Hiroki Tanaka ,&nbsp;Tatsuya Ito ,&nbsp;Shunsuke Yahiro ,&nbsp;Toshiko Sakuma ,&nbsp;Minoru Suzuki","doi":"10.1016/j.apradiso.2025.111715","DOIUrl":"10.1016/j.apradiso.2025.111715","url":null,"abstract":"<div><div>Here described for the first time is the efficacy of <em>p</em>-boronophenylalanine (BPA)-based BNCT in the clinical treatment of metastatic breast cancer. The patient was diagnosed with left axillary lymph node metastasis from breast cancer with comorbidity of neuropathy. Although several treatment strategies for suppressing the progression of the cancer were unavailing, BPA-based BNCT impeded the progression. This clinical case suggests the applicability of this new method of treatment to not only metastatic but also primary breast cancer.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111715"},"PeriodicalIF":1.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of 18F-FDG absorbed dose ratios in percent in adult and pediatric reference phantoms using DoseCalcs Monte Carlo platform","authors":"Tarik El Ghalbzouri ,&nbsp;Tarek El Bardouni ,&nbsp;Jaafar El Bakkali ,&nbsp;Hicham Satti ,&nbsp;Abdelhamid Nouayti ,&nbsp;Iman Berriban ,&nbsp;Randa Yerrou ,&nbsp;Assia Arectout ,&nbsp;Maryam Hadouachi","doi":"10.1016/j.apradiso.2025.111705","DOIUrl":"10.1016/j.apradiso.2025.111705","url":null,"abstract":"<div><div>This study investigates the field of radiation exposure in nuclear medicine, which might have implications for exposure to ionizing radiation in pediatric cases. To demonstrate the difference in radiosensitivity between younger patients and adults and to highlight the need for individualized radiation protection procedures when investigating medical imaging and therapy, this study examines the absorbed dose ratios in percent (ADR%) for ¹⁸F-FDG. This parameter is an important indicator, illustrating the percentage of radiation dose absorbed by specific organs/tissues concerning the emitted radiation from different body regions.</div><div>The methodology involves calculating ADR% in twelve voxel-based models for adults, children, and newborns, as referenced by International Commission on Radiological Protection (ICRP) Publications 110 and 143. The simulations used the ¹⁸F positron spectrum from ICRP Publication 107 and Livermore models. These simulations were performed using the DoseCalcs Monte Carlo platform.</div><div>We have calculated the S-values and ADR% using the DoseCalcs simulations of the ¹⁸F positrons and provided a comprehensive dataset of ADR% results. This dataset evaluates the impact of anatomical variation on absorbed dose in target regions. It consists of 141 target regions and 8 different source regions.</div><div>Significant differences in radiosensitivity were observed in ADR% values among various source–target combinations for each age and sex group. The self-irradiation ADR% reaches up to 95%, while the cross-irradiation ADR% varies, ranging approximately from 0.1% to 12%, depending on the mass of the target organ, the distance between it and the source organ, and the chemical composition of these organs. Also, the variations observed across different age and sex phantoms highlight the importance of personalized internal dosimetry, especially for pediatric cases with heightened radiosensitivity. Healthcare practitioners can use the dataset of ADR% values as the first stage to illustrate variability and optimize nuclear medicine imaging with ¹⁸F-FDG while reducing radiation risks.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"218 ","pages":"Article 111705"},"PeriodicalIF":1.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143369802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting (n,3n) nuclear reaction cross-sections using XGBoost and Leave-One-Out Cross-Validation","authors":"Yiğit Ali Üncü ,&nbsp;Taner Danışman ,&nbsp;Hasan Özdoğan","doi":"10.1016/j.apradiso.2025.111714","DOIUrl":"10.1016/j.apradiso.2025.111714","url":null,"abstract":"<div><div>Accurately predicting nuclear reaction cross-sections is crucial for advancing various fields, including nuclear medicine, energy production, and materials science. This study aims to address the challenges associated with predicting (n <span><math><mrow><mo>,</mo><mn>3</mn><mi>n</mi></mrow></math></span>) nuclear reaction cross-sections by developing a robust machine learning (ML) model based on the XGBoost (eXtreme Gradient Boosting) algorithm. By leveraging a comprehensive dataset of experimental cross-sectional values, the study demonstrates the potential of ML to overcome limitations in existing theoretical and empirical approaches. LOOCV (Leave-One-Out Cross-Validation) was employed for feature selection and hyperparameter optimization to ensure the reliability of the model. The dataset was meticulously prepared by normalizing values and addressing missing data, which contributed to robust model training. XGBoost's ability to handle complex, non-linear relationships enabled it to provide accurate predictions that closely align with experimental data, as evaluated through key metrics such as Mean Squared Error (MSE) and Mean Absolute Error (MAE), and reduced Chi-Square. To validate the model's accuracy, its predictions were compared with calculations from the TALYS 1.95 nuclear reaction code, TENDL and phenological model. The results highlight the efficacy of XGBoost in improving prediction accuracy, offering a novel approach to solving complex challenges in nuclear data analysis.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111714"},"PeriodicalIF":1.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A methodology study for sodium quantification in bone and soft tissue based on in vivo neutron activation analysis using a two-compartment model","authors":"Song Yue ,&nbsp;Mychaela Coyne ,&nbsp;Connie M. Weaver ,&nbsp;Cheryl AM. Anderson ,&nbsp;Linda H. Nie","doi":"10.1016/j.apradiso.2025.111712","DOIUrl":"10.1016/j.apradiso.2025.111712","url":null,"abstract":"<div><div>Sodium (Na) is an essential mineral for human health regulation and in excess has been associated with many diseases. Its storage has been found in rapidly (soft tissue) and slowly exchangeable pools (bone) in human body. However, Na concentration and metabolism information in human bone and soft tissue cannot be determined using conventional biological urine and blood samples. The aim of this study was to apply a transportable neutron generator based <em>in vivo</em> neutron activation analysis technique to separately quantify Na in bone and soft tissue. Two pigs were fed with low and high Na diet to investigate the effects of dietary Na intake on Na storage and metabolism. The emitted gamma rays from Na activated by thermal neutron capture reaction in pig leg were collected using a high purity germanium detector. A biokinetic model based on internal dosimetry theorem was developed to obtain the bone and soft tissue Na concentration, as well as half-life of Na retention in the two compartments. The results show that soft tissue Na concentration was significantly higher in the pig that received a high Na diet <span><math><mrow><mo>(</mo><mrow><mn>1057.08</mn><mspace></mspace><mo>±</mo><mn>43.62</mn><mspace></mspace><mi>p</mi><mi>p</mi><mi>m</mi><mspace></mspace><mi>v</mi><mi>s</mi><mspace></mspace><mn>704.46</mn><mspace></mspace><mo>±</mo><mn>45.60</mn><mspace></mspace><mi>p</mi><mi>p</mi><mi>m</mi><mo>,</mo><mi>p</mi><mo>=</mo><mn>0.007</mn></mrow><mo>)</mo></mrow></math></span>. In contrast, the bone sodium concentration was not affected by dietary intervention <span><math><mrow><mo>(</mo><mrow><mn>856.45</mn><mo>±</mo><mn>78.48</mn><mspace></mspace><mi>p</mi><mi>p</mi><mi>m</mi><mspace></mspace><mi>v</mi><mi>s</mi><mspace></mspace><mn>803.30</mn><mo>±</mo><mn>48.98</mn><mspace></mspace><mi>p</mi><mi>p</mi><mi>m</mi><mo>,</mo><mi>p</mi><mo>=</mo><mn>0.107</mn></mrow><mo>)</mo></mrow></math></span>. The developed methodology is capable of effectively measuring altered Na levels resulting from dietary Na consumption, with great potential in exploring the association between Na intake and health outcomes such as hypertension.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"218 ","pages":"Article 111712"},"PeriodicalIF":1.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143369801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Produced radioactive isotopes, ambient dose equivalent in TrueBeam room with flattening filter (FF) and Flattening Filter Free (FFF) modes: Monte Carlo simulation","authors":"Soai Dang Quoc ,&nbsp;Toshioh Fujibuchi ,&nbsp;Hiroyuki Arakawa ,&nbsp;Keisuke Hamada ,&nbsp;DongHee Han","doi":"10.1016/j.apradiso.2025.111704","DOIUrl":"10.1016/j.apradiso.2025.111704","url":null,"abstract":"<div><h3>Background</h3><div>High-energy linear accelerators used in radiotherapy produce unexpected neutrons that can activate materials in the treatment room.</div></div><div><h3>Materials and methods</h3><div>The research group used PHITS code to simulate TrueBeam Linac head with 10 MV photons. Then, PHITS codes connected Dchain code to calculate the variation of the induced radioactivity, the ambient dose equivalent during TrueBeam radiation 4 Gy with dose rate 400 MU (Monitor Unit)/minute in FF mode, 24 Gy with dose rate 2400 MU/minute in FFF mode, and cooling time (14 min).</div></div><div><h3>Results</h3><div>One minute of beam-on TrueBeam with 10 MV photon energy produced six mainly produced nuclides (183 mW, 24mNa, 185 mW, 28Al, 24mNa, and 187W). FFF mode had more activity of the produced isotopes than those in FF mode (1.60 × 1014 Bq compared with 1.57 × 1014 Bq—corresponding to ∼1.71% higher). The differences in the activity of isotopes and ambient dose between FF and FFF mode were mostly less than a few percent; however, considering that the MU per beam current is six times higher in the FFF mode than in the FF mode, the induced activities per MU can be reduced by roughly six times when using the FFF mode instead of the FF mode.</div></div><div><h3>Conclusion</h3><div>The isotope activities of the produced isotopes in the FF and FFF modes are essentially equivalent when normalized per beam current.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111704"},"PeriodicalIF":1.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calculation of double differential neutron cross-sections for the 115In(α,xn) reaction","authors":"Hasan Ozdogan ,&nbsp;Yigit Ali Uncu ,&nbsp;Mert Sekerci̇ ,&nbsp;Abdullah Kaplan","doi":"10.1016/j.apradiso.2025.111713","DOIUrl":"10.1016/j.apradiso.2025.111713","url":null,"abstract":"<div><div>The angle-dependent double differential cross-sections of neutrons scattered from an Indium-115 target bombarded by alpha particles at energies of 26.8 and 45.2 MeV, is analyzed using the TALYS 1.95 and PHITS 3.22 computer codes. Theoretical calculations through the TALYS code incorporated assessments of direct, compound, and pre-equilibrium nuclear reaction mechanisms. The computed results were compared with the experimental data sourced from the literature, providing a robust validation of the findings. The Monte Carlo results showed favorable correspondence with the experimental findings for 45.2 MeV alpha energy at 120° and 150°. The compound reaction mechanism was found to be the dominant interaction at energies below the neutron separation energy. With the increase in neutron emission energy, notable contributions from the pre-equilibrium mechanism to the cross-section calculations were observed.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111713"},"PeriodicalIF":1.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ gamma radiometry of river bottom based on natural radioactivity measurements","authors":"H. Kasban,&nbsp;Elsayed H. Ali,&nbsp;H. Arafa","doi":"10.1016/j.apradiso.2025.111711","DOIUrl":"10.1016/j.apradiso.2025.111711","url":null,"abstract":"<div><div>Naturally occurring radioactive material (NORM) mapping at the bottom of rivers or seas is important for the environment, health, industry, and regulatory. NORM mapping procedure under the river bottom is complicated due to several technological, logistical, and environmental challenges. NORM mapping process normally carried out by taking samples from the location and analyzing it in the laboratory and hence it is time consuming especially if a large area is required to be scanned. This paper presents an efficient system for fast in situ mapping of NORM mapping under the river bottom. The system consists of a waterproof (NaI(Tl)) scintillation detector designed to immerge under water with a mechanical system to ensure that it is located on the surface under water. The detector is connected to Data Acquisition System (DAS) on the boat through waterproof coaxial cable. Globalization Positioning System (GPS) is used for determining the location of measurement. System Software provides a fast-mapping Gamma count rates in real time. The system has been tested at Rosetta branch of the river Nile in Egypt. The practical experiments, two navigations have been carried out with different boat speeds (2 km/h and 6 km/h). The measured data has been visualized and analyzed in situ and proved the efficiency of hardware and software. In addition, the obtained measurements show the different concentrations of NORM in the bottom of the river. The results indicate that the NORM is increased when moving toward the Mediterranean Sea direction which reflects that the composition of the soil material is changed at the intersection of the river Nile with the sea. The results also show that the longer sampling times allow more gamma counts to be recorded, the optimal scanning speed depends on the activity level of the source, the detector's sensitivity, and the objective of the NORM mapping.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111711"},"PeriodicalIF":1.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Based on the thickness equivalent basis effect decomposition method of ore separation by multi-energy X-ray transmission technology","authors":"Zi-Yan Yu ,&nbsp;Yan Zhang ,&nbsp;Xiong-Jie Zhang ,&nbsp;Hao-Ran Zhang ,&nbsp;Dong-Yang Wang ,&nbsp;Hong-Yu Duan ,&nbsp;Ren-Bo Wang ,&nbsp;Bin Tang","doi":"10.1016/j.apradiso.2025.111710","DOIUrl":"10.1016/j.apradiso.2025.111710","url":null,"abstract":"<div><div>The average grade of uranium ore in China is low and dispersed, positioning X-ray transmission technology as a promising method for enhancing uranium ore quality. However, the uneven thickness of the ore significantly affects the accuracy of the separation process. This paper introduces a method for mineral separation through base effect decomposition, leveraging the principle of thickness equivalence. This method exploits the characteristic of minimal variation in the linear attenuation coefficient of high-energy X-rays during transmission. By measuring reference samples, the sum of linear attenuation coefficients at selected energy intervals is calculated. This allows for the determination of the thickness equivalence values and corresponding equivalent linear attenuation coefficients for ore samples. Upon completion of thickness calibration, the average equivalent linear attenuation coefficient curves for different ore samples are analyzed using base effect formulas, resulting in the extraction of photoelectric effect coefficients and Compton effect coefficients, which serve as standards for uranium ore sorting. Monte Carlo simulations were performed on ore samples with varying thicknesses and uranium content, demonstrating a relative error in sample equivalent thickness of less than or equal to 7.08%. Following thickness correction, the base effect decomposition method demonstrates the capability to effectively differentiate uranium ore samples with a detection limit of 500 ppm, thereby fulfilling the industrial application requirements. This research not only provides a theoretical framework but also practical reference for the selective sorting of uranium ore, with significant implications for improving ore processing efficiency in actual uranium mining operations.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111710"},"PeriodicalIF":1.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technetium-99m-labeled stealth liposomes: A new Strategy to Identify metastasis in tumour model","authors":"Swapna J. Nabar ,&nbsp;Tanuja Shet ,&nbsp;Basant Malpani ,&nbsp;Puthusserickal Hassan ,&nbsp;Sandip Basu","doi":"10.1016/j.apradiso.2025.111709","DOIUrl":"10.1016/j.apradiso.2025.111709","url":null,"abstract":"<div><h3>Objective</h3><div>Stealth liposomes are useful carriers for delivering drugs to cancer sites. In this paper we describe the preparation and evaluation of ^99mTc labelled stealth liposomes (PEG-Liposomes) as potential radiopharmaceuticals for SPECT imaging of cancer. This study is first to describe targeted localisation of radiolabeled stealth liposomes in tumourous cells, sparing normal cells of various organs in metastatic L1210 mouse tumour model in BDF1 mice.</div></div><div><h3>Methods</h3><div>Glutathione encapsulated stealth liposomes were made using lipid film hydration technique followed by probe sonication. Liposomes were radiolabeled using a lipophilic technetium complex, ^99mTc-d,l-HMPAO. Labelled liposomes were purified by gel chromatography over sephadex G25 column. The tumour model was developed in immuno-competent BDF1 mice (F1DBA/2/C57-BL6 crosses) by injecting L1210 cells intraperitoneally. Biodistribution studies of the ^99mTc- stealth liposomes were done in both tumour induced and normal mice. Histopathologic studies were done by excising the organs and the radioactivity in various sections was detected by autoradiography.</div></div><div><h3>Results</h3><div>The stealth liposomes could be synthesized as per a reported procedure and it showed similar retention factor in thin layer chromatography. Liposomes could be radiolabelled by using ^99mTc-d,lHMPAO. Purification over sephadex G 25 column yielded radioachemical purity greater than 95%. Biodistribution studies and autoradiography studies showed significantly higher accumulation of ^99mTc labelled stealth liposomes in liver, pancreas and ascitic fluid of the tumour induced mice as compared to normal mice.</div></div><div><h3>Conclusions</h3><div>^99mTc labelled stealth liposomes having radiochemical purity greater than 95% could be prepared which showed higher uptake in tumour.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"218 ","pages":"Article 111709"},"PeriodicalIF":1.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143369798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production, radiochemical separation and electrochemical concentration of No-carrier-added 52Mn: An emerging PET radiometal","authors":"Sourav Patra ,&nbsp;Sanchita Ghosh ,&nbsp;Khajan Singh ,&nbsp;Suresh Chand Sharma ,&nbsp;Sanjay Vishwanath Thakare ,&nbsp;Rubel Chakravarty","doi":"10.1016/j.apradiso.2025.111707","DOIUrl":"10.1016/j.apradiso.2025.111707","url":null,"abstract":"<div><div>Recently, there has been significant interest in ⁵²Mn (T_½ = 5.6 d) as a relatively long lived radiometal for PET imaging of cancer. In this study, we have produced ⁵²Mn from natural Cr metallic powder target via ⁵²Cr (p, n) ⁵²Mn reaction in a particle accelerator. An efficient radiochemical separation method based on selective precipitation of Cr as Cr(OH)₃ followed by electrochemical purification and concentration of ⁵²Mn was developed for isolation of no-carrier-added (nca) ⁵²Mn from the irradiated target. The overall radiochemical separation yield of the process was &gt;75 %. After separation, ⁵²Mn was obtained with &gt;99.5 % radionuclidic purity and &gt;97 % radiochemical purity. The apparent molar activity of ⁵²Mn was determined to be 2.2 ± 0.1 MBq/nmol and it was found suitable for preparation of radiopharmaceuticals. As a proof of concept, [⁵²Mn]Mn-DOTA-E[c(RGDfK)]₂ was prepared with 98.8 ± 0.4 % radiolabeling yield and the radiochemical stability of the formulation was maintained over a period of 7 days under physiological conditions. Overall, this strategy is viable for obtaining nca ⁵²Mn in a suitable form for radiopharmaceutical preparation and would potentially increase the availability of this radiometal for clinical PET imaging in foreseeable future.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"218 ","pages":"Article 111707"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143369799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}