生物活性随时间分布对站立式全身计数器计数效率的影响

IF 1.8 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-09-18 DOI:10.1016/j.apradiso.2025.112192

Rahul Roy , Rajesh Sankhla , Deepak K. Akar , Pramilla D. Sawant

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引用次数: 0

摘要

部分屏蔽系统，如快速扫描全身计数器（QSWBC）用于评估由于裂变和活化产物的内部污染。本研究旨在研究考虑131I， 137Cs和60Co在职业和环境暴露范围内计算幻影中的生物分布的QSWBC的计数效率（ce）。为此目的，使用放射性核素的年龄特异性生物动力学模型来计算生物动力学相关隔室中保留活性的分数。在FLUKA中进行蒙特卡罗模拟，以估计这些放射性核素的ce，同时考虑到时间依赖性生物分布和均匀分布，使用ICRP成人和儿童参考计算幻影（男性和女性）。推导了时间相关的效率校正因子（ECFs），以研究活性的生物分布对ce的影响。结果表明，ce在131I中最高，并且在位于身体前部的器官中最明显。ecf在采食第一天最高，随后下降，在采食~ 10天后趋于恒定值。131I、137Cs和60Co的ECFs分别为0.90 ~ 2.34、0.97 ~ 1.25和0.93 ~ 1.56。特定年龄和性别的ECFs将有助于减少放射性核素的生物分布对全身计数测量的影响，从而提高内部剂量评估的准确性。

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Influence of time-dependent biodistribution of activity on the counting efficiencies of standing-type whole body counter

Partially shielded systems such as Quick Scan Whole Body Counter (QSWBC) are used to assess internal contamination due to fission and activation products. The present work aims at studying the counting efficiencies (CEs) of the QSWBC taking into account the biodistribution of ¹³¹I, ¹³⁷Cs and ⁶⁰Co in computational phantoms within the scope of occupational and environmental exposures. For this purpose, the age-specific biokinetic models of the radionuclides were used to compute the fractional retained activities in biokinetically relevant compartments. Monte Carlo simulations were carried out in FLUKA to estimate the CEs for these radionuclides considering both time-dependent biodistribution and homogeneous distribution using ICRP adult and paediatric reference computational phantoms for both male and female. The time-dependent efficiency correction factors (ECFs) were derived to investigate the influence of biodistribution of activity on the CEs. The results highlight that CEs are highest for ¹³¹I and most pronounced in the case of organs located in the anterior regions of the body. The ECFs are highest on the first day of intake and then decline, tending towards constant values after ∼10 days of intake. For all the age groups, the ECFs vary between 0.90–2.34, 0.97–1.25 and 0.93–1.56 for ¹³¹I, ¹³⁷Cs and ⁶⁰Co respectively. The age and gender specific ECFs will be useful in reducing the impact of biodistribution of radionuclides on the whole body counting measurements, thereby enhancing the accuracy of internal dose assessment.

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.