Applied Radiation and Isotopes最新文献

{"title":"Accelerator based-BNCT facilities worldwide and an update of the Buenos Aires project","authors":"M.E. Capoulat ,&nbsp;D. Cartelli ,&nbsp;M. Baldo ,&nbsp;J.C. Suarez Sandín ,&nbsp;M.F. Del Grosso ,&nbsp;A. Bertolo ,&nbsp;P. Gaviola ,&nbsp;M. Igarzábal ,&nbsp;G. Conti ,&nbsp;M. Gun ,&nbsp;A.A. Valda ,&nbsp;D.M. Minsky ,&nbsp;F. Sala ,&nbsp;S. Incicco ,&nbsp;J. Erhardt ,&nbsp;A.J. Kreiner","doi":"10.1016/j.apradiso.2025.111723","DOIUrl":"10.1016/j.apradiso.2025.111723","url":null,"abstract":"<div><div>Globally, there are several AB-BNCT facilities, either operational and already treating patients and others still under development. These facilities range from high-energy 30 MeV cyclotrons using the ⁹Be(p,n) reaction, medium-energy RFQ-DTL accelerators operating at 8–10 MeV with the same reaction, low-energy electrostatic machines (Tandem and single-ended) using the ⁷Li(p,n) reaction at approximately 2.5 MeV. Additionally, the low-energy ESQ accelerator developed in Argentina, employs the ⁹Be(d,n) or the ¹³C(d,n) reactions at 1.45 MeV. This paper presents updated insights into Argentina's AB-BNCT project while also providing a global overview of AB-BNCT developments.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111723"},"PeriodicalIF":1.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of dose distribution with and without reflecting heterogeneous boron distribution using 18F-BPA positron emission tomography in boron neutron capture therapy","authors":"Yuta Kobayashi ,&nbsp;Satoshi Nakamura ,&nbsp;Mihiro Takemori ,&nbsp;Tetsu Nakaichi ,&nbsp;Yasunori Shuto ,&nbsp;Kimiteru Ito ,&nbsp;Kana Takahashi ,&nbsp;Tairo Kashihara ,&nbsp;Miki Yonemura ,&nbsp;Hana Endo ,&nbsp;Kouji Kunito ,&nbsp;Hiroyuki Okamoto ,&nbsp;Takahito Chiba ,&nbsp;Hiroki Nakayama ,&nbsp;Riki Oshika ,&nbsp;Hironori Kishida ,&nbsp;Jun Itami ,&nbsp;Hiroaki Kurihara ,&nbsp;Hiroshi Igaki","doi":"10.1016/j.apradiso.2025.111720","DOIUrl":"10.1016/j.apradiso.2025.111720","url":null,"abstract":"<div><div>This study investigated the dosimetric impact of implementing heterogeneous boron distribution into dose evaluations on tumors in BNCT. The study involved 27 patients who underwent ¹⁸F-BPA PET/CT scans. Dose evaluations were performed using various methods reflecting boron concentrations on CT images. The conventional dose evaluations, which reflected uniform boron concentration in blood of 25 ppm and a constant tumor-to-blood (T/B) ratio of 3.5, were compared with individual dose evaluations, which reflected the blood boron concentration and T/B ratio calculated from ¹⁸F-BPA in each patient. The heterogeneous tumoral dose distribution was also compared, revealing the dosimetric impact of the boron distribution calculated from each voxel of ¹⁸F-BPA. The spatial correspondence between ¹⁸F-BPA and dose distribution was compared using metabolic tumor volume (MTV) from ¹⁸F-BPA and isodose volume from the heterogeneous dose distribution. Results showed that the median blood boron concentration and T/B ratio calculated from ¹⁸F-BPA were 25.57 (23.90–27.84) ppm and 3.75 (2.54–4.59), respectively, comparable to those in the conventional dose evaluations. All dose indices in the heterogeneous tumoral dose evaluations were significantly lower than those in the conventional dose evaluations (p &lt; 0.01). However, the spatial correspondence between the ¹⁸F-BPA and the dose distribution was not observed in the dice similarity coefficients of both MTV40-40% isodose volume and MTV50-50% isodose volume. In conclusion, the study confirmed the validity of applying the boron concentration calculated from ¹⁸F-BPA to the dose evaluation for a patient in BNCT. The differences might be associated with non-inter-patient variations of ¹⁸F-BPA, but the conventional dose evaluations mainly focused on the high boron concentration area within the tumor. Furthermore, the discrepancies in the patients were also observed between the ¹⁸F-BPA distribution and the heterogeneous dose distribution. Therefore, this study suggested that the indications for BNCT should consider not only ¹⁸F-BPA but also the dose distributions, which could reflect the heterogeneous tumoral boron distribution.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111720"},"PeriodicalIF":1.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of photon beam skyshine studies from medical megavoltage accelerators","authors":"Mikaeil Molazadeh ,&nbsp;Hosein Ghiasi","doi":"10.1016/j.apradiso.2025.111716","DOIUrl":"10.1016/j.apradiso.2025.111716","url":null,"abstract":"<div><div>This review examines the literature on the assessment of photon beam skyshine dose rates in medical accelerator radiotherapy with an energy range of 4-25 MV. The selected studies focus on medical accelerators within radiotherapy facilities and employ various methodologies for calculating photon beam skyshine dose rates. Researchers utilized Monte Carlo (MC) simulations, direct measurements, and empirical methods outlined in NCRP Reports 151 and 51 for skyshine estimations. These NCRP reports have established empirical approaches for calculating skyshine dose rates in linac-based radiotherapy settings. The methodologies adopted by different researchers and their findings were compared and discussed. Among these methods, the one that aligns best with measurements across various studies was identified as the gold standard. Notably, the conclusion drawn from multiple papers indicates that NCRP 151 tends to overestimate skyshine dose rates. Various studies were conducted under different geometries and distances from the X-ray source, and comparisons with other works showed consistent results. However, some discrepancies were noted in the results of skyshine characterization studies. This review encompasses publications related to photon beam skyshine from medical accelerators, highlighting that the primary approaches, NCRP 151 empirical methods, MC simulations, and direct measurements, yield reasonable results when multiple methods are employed.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111716"},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a measurement method for neutron energy spectrum in the low-energy range by combining activation foils and position-sensitive proportional counter -numerical study-","authors":"Yu Fujiwara,&nbsp;Shingo Tamaki,&nbsp;Sachie Kusaka,&nbsp;Fuminobu Sato,&nbsp;Isao Murata","doi":"10.1016/j.apradiso.2025.111719","DOIUrl":"10.1016/j.apradiso.2025.111719","url":null,"abstract":"<div><div>Boron Neutron Capture Therapy (BNCT) is a promising form of radiotherapy expected to be effective in treating refractory cancers such as glioblastoma. A key factor in BNCT is the neutron energy spectrum in the epithermal range (0.5 eV–10 keV), which is challenging to evaluate due to its broad and low-energy characteristics. This study proposes a novel measurement method for the neutron energy spectrum in the epithermal range, utilizing a combination of activation foils and a position-sensitive proportional counter to capture the full energy range of neutrons in BNCT. A prototype of the spectrometer was developed, and numerical validation was performed. The results of the numerical study demonstrated that the proposed spectrometer can accurately evaluate the neutron energy spectrum across a broader energy range compared to existing methods.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111719"},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristic comparison between two different neutron spectrometers for boron neutron capture therapy irradiation field developed at Heavy Water Neutron Irradiation Facility of Kyoto University Research Reactor","authors":"Jakkrit Prateepkaew ,&nbsp;Nishiki Matsubayashi ,&nbsp;Takushi Takata ,&nbsp;Hiroki Tanaka ,&nbsp;Yoshinori Sakurai","doi":"10.1016/j.apradiso.2025.111717","DOIUrl":"10.1016/j.apradiso.2025.111717","url":null,"abstract":"<div><div>The neutron energy spectrum at the beam port has been measured at many boron neutron capture therapy (BNCT) facilities worldwide. At Heavy Water Neutron Irradiation Facility of Kyoto University Research Reactor (KUR-HWNIF), two types of neutron spectrometers—the Simple Multilayer Spectrometer (SMS) and the Cylindrical Hemisphere-Accurate Remote Multilayer Spectrometer (CHARMS)—were recently developed to measure the neutron energy spectrum. This paper investigates the characteristics of each neutron spectrometer in measuring the neutron energy spectrum at BNCT irradiation field, with a focus on their dependence on the angular distribution of the incident neutron beam. Additionally, an overview of the CHARMS prototype designed to verify online and remote operation from outside the irradiation room is provided.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111717"},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutron relative biological effectiveness factors in boron neutron capture therapy: Estimation of their values from the secondary charged particles and evaluation of weighted kerma factors for a standard tissue","authors":"M. Pedrosa-Rivera ,&nbsp;J. Praena ,&nbsp;C. Ruiz-Ruiz ,&nbsp;M.J. Ruiz-Magaña ,&nbsp;I. Porras","doi":"10.1016/j.apradiso.2025.111722","DOIUrl":"10.1016/j.apradiso.2025.111722","url":null,"abstract":"<div><div>The average Relative Biological effectiveness (RBE) factors for neutron irradiation in the context of a BNCT treatment are studied. This research considers the various interactions and secondary particles of each process and estimates the RBE based on the damage induced in tissues by all of these particles. A novel concept of estimating the biological dose by means of weighted kerma factors is introduced. These weighted kerma factors include the RBE of each energy deposition based on an RBE-LET relationship for secondary charged particles and can be directly incorporated in weighted dose calculations from Monte Carlo simulations. Furthermore, the dependence of the neutron weighting factor on neutron energy for standard soft tissue is discussed.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111722"},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parameters of the neutron field at the Prizm-AN stand in the neutronic measurement laboratory","authors":"Sergey V. Bedenko ,&nbsp;Gennady N. Vlaskin ,&nbsp;Sergey D. Polozkov ,&nbsp;Nima Ghal-Eh ,&nbsp;Alexey S. Demin ,&nbsp;Dmitry G. Veretennikov ,&nbsp;Hector Rene Vega–Carrillo","doi":"10.1016/j.apradiso.2025.111729","DOIUrl":"10.1016/j.apradiso.2025.111729","url":null,"abstract":"<div><div>The present study focuses on the development of datasets characterizing the neutron field generated by the collimation channel of the Prizm-AN irradiation stand, which utilizes an internal bounded neutron (IBN) radioisotope capsule as a fast neutron source. It is aimed at supporting the prototyping of the proposed Thermal Neutron Imaging System (TENIS) diagnostics framework, currently in the feasibility assessment phase. To this end, comprehensive calculations of the radiation fields and dose characteristics associated with the Prizm-AN system—tailored to the operational specifics of the TENIS equipment—are presented. These insights will be valuable for developers in the preparatory stages leading to the creation of a demonstration version of the system. Additionally, the study explores the potential application of detection technologies for the real-time monitoring and control of parameters related to leaking deuterium-tritium (d−t) plasma.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111729"},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-photocatalytic electricity generation and thermoluminescence in natural hematite: Application in hydroelectric cell and dosimeter","authors":"Pragya Pandit ,&nbsp;Yatish R. Parauha ,&nbsp;Singarayan Michelraj ,&nbsp;S.J. Dhoble ,&nbsp;V. Ganesh ,&nbsp;Sanjeev Kimothi ,&nbsp;A.K. Singh","doi":"10.1016/j.apradiso.2025.111727","DOIUrl":"10.1016/j.apradiso.2025.111727","url":null,"abstract":"<div><div>Environmentally friendly hydroelectric power cells (HEC) and thermoluminescence dosimeters (TL) were manufactured using natural hematite. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) studies confirmed multimodal particle size range of 30–90 nm for natural hematite. Brunauer-Emmett-Teller (BET) analysis confirmed mesoporous and nanoporous structure with average pore size of 30 nm. X-ray Photoelectron Spectroscopy, photoluminescence, ultraviolet–visible spectral analyses confirmed the presence of oxygen vacancies on the surface of hematite. Surface area of natural hematite was considerable (33.48 m²/g), band gap was small (1.7 eV), and porosity was high (31%). A square hematite hydroelectric power cell with an area of 4.84 cm² generated electricity by redox reaction and produced an open circuit voltage of 0.98 V, a stable short circuit current of 7.0 mA, and open circuit power of 6.86 mW. The TL annealing curve is recorded using a hematite sample annealed at different temperatures (100 °C–700 °C) and irradiated with a⁶⁰Co gamma source with different radiation doses (100 Gy, 15 kGy). Deconvolution analysis of the TL glow curve reveals a prominent single emission band at 178 °C and high linearity in the dose range from 2 kGy to 9 kGy for sample annealed at 400 °C. Oxygen vacancies, which function as luminous traps, are thought to be the cause of the cause of the observed behaviour. Chen's peak method and initial rise method are used to calculate trapping factors such as activation energy, frequency factor and order of kinetics.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111727"},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new boron-doped gas microdosimeter for clinical Boron Neutron Capture Therapy","authors":"A. Selva ,&nbsp;A. Bianchi ,&nbsp;M. Rossignoli ,&nbsp;S. Bortolussi ,&nbsp;I. Postuma ,&nbsp;A. Pisent ,&nbsp;V. Vercesi ,&nbsp;V. Conte","doi":"10.1016/j.apradiso.2025.111721","DOIUrl":"10.1016/j.apradiso.2025.111721","url":null,"abstract":"<div><div>The Next Generation EU project ANTHEM (AdvaNced Technologies for Human-centrEd Medicine) aims at building a new accelerator-based BNCT facility in Caserta, Italy. In this framework, a new miniaturized Tissue-Equivalent Proportional Counter (mini-TEPC) with boron-doped cathode walls was designed and constructed, specifically developed to be used in BNCT clinical centres. The size of its sensitive cavity is only 1 mm to cope with the high intensity of BNCT neutron fields. The new detector was tested in reference fields where the thermal neutron component is negligible (photons, protons and fast neutrons), showing the same response as another mini-TEPC with identical design but for the boron doping. First tests were then performed at the thermal neutron column of the research reactor of the Laboratory for Applied Nuclear Energy in Pavia, Italy, with both detectors. Measured microdosimetric spectra were consistent with previous data taken at other thermal neutron sources. This paper presents the design of the new mini-TEPC and discusses the results of these first tests.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"220 ","pages":"Article 111721"},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annual effective dose assessment of radon concentration in spring and ground water for the population of Devprayag region in Uttarakhand Garhwal Himalayas","authors":"Sandeep Singh ,&nbsp;O.P. Nautiyal ,&nbsp;Prakhar Singh ,&nbsp;Ankur Kumar ,&nbsp;Devender Singh","doi":"10.1016/j.apradiso.2025.111728","DOIUrl":"10.1016/j.apradiso.2025.111728","url":null,"abstract":"<div><div>Radon measurement in the Himalayan region is crucial due to the unique geological composition that may lead to elevated radon levels in water sources, posing potential health risks to the local population. This study focuses on radon concentration in drinking water collected from 13 spring water samples and 13 groundwater samples (via hand pumps) across various locations in the Devprayag region. Radon levels were assessed using the SMART RnDuo continuous radon monitor. The concentration in spring water varied between 0.7 Bq/L and 64.4 Bq/L, while groundwater levels ranged from 0.6 Bq/L to 79.5 Bq/L. Although the radon levels in the samples fell within the safe limits set by the World Health Organization (WHO), the estimated annual effective dose from radon ingestion and inhalation surpassed the WHO's safety threshold of 100 μSv/year in several areas. These results highlight the necessity of ongoing radon monitoring in the region to reduce long-term health risks and guide safety standards for drinking water.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"219 ","pages":"Article 111728"},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}