Applied Radiation and Isotopes最新文献

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A simple and efficient method for separation of 99mTc from 100Mo targets 从 100Mo 靶件中分离 99mTc 的简单高效方法。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-09-25 DOI: 10.1016/j.apradiso.2024.111531
Desheng Chen , Qinggang Huang , Shiwei Cao , Xiaolei Wu , Wei Tian , Cunmin Tan , Jieru Wang , Mu Lin , Zhi Qin
{"title":"A simple and efficient method for separation of 99mTc from 100Mo targets","authors":"Desheng Chen ,&nbsp;Qinggang Huang ,&nbsp;Shiwei Cao ,&nbsp;Xiaolei Wu ,&nbsp;Wei Tian ,&nbsp;Cunmin Tan ,&nbsp;Jieru Wang ,&nbsp;Mu Lin ,&nbsp;Zhi Qin","doi":"10.1016/j.apradiso.2024.111531","DOIUrl":"10.1016/j.apradiso.2024.111531","url":null,"abstract":"<div><div><sup>99m</sup>Tc is regarded as the most important medical isotope, and its supply issues have garnered significant attention. A simple and efficient separation method was performed for the production of <sup>99m</sup>Tc from <sup>100</sup>Mo target in this study. The entire process involves accelerator irradiation, <sup>99m</sup>Tc/<sup>100</sup>Mo separation, and target material recovery. The key aspect is separation process, which including the high-temperature conversion of metal molybdenum targets and the selective solution of <sup>99m</sup>Tc with normal saline. This method can separate highly pure <sup>99m</sup>Tc within 1.5 h, with a separation efficiency exceeding 80%. The reagents used in the separation process are minimal, resulting in less radioactive waste. Additionally, the target material is easy to reclaim, with a recovery rate of over 95%.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"214 ","pages":"Article 111531"},"PeriodicalIF":1.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical-stimulated luminescence properties of undoped and Eu-doped LiCl transparent ceramics synthesized by spark plasma sintering method 火花等离子烧结法合成的未掺杂和掺杂 Eu 的氯化锂透明陶瓷的光激发发光特性
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-09-24 DOI: 10.1016/j.apradiso.2024.111528
Kensei Ichiba , Hiromi Kimura , Yuma Takebuchi , Takumi Kato , Daisuke Nakauchi , Noriaki Kawaguchi , Takayuki Yanagida
{"title":"Optical-stimulated luminescence properties of undoped and Eu-doped LiCl transparent ceramics synthesized by spark plasma sintering method","authors":"Kensei Ichiba ,&nbsp;Hiromi Kimura ,&nbsp;Yuma Takebuchi ,&nbsp;Takumi Kato ,&nbsp;Daisuke Nakauchi ,&nbsp;Noriaki Kawaguchi ,&nbsp;Takayuki Yanagida","doi":"10.1016/j.apradiso.2024.111528","DOIUrl":"10.1016/j.apradiso.2024.111528","url":null,"abstract":"<div><div>The undoped and Eu-doped LiCl transparent ceramics were synthesized, and their photoluminescence (PL) and optical stimulated luminescence (OSL) properties were evaluated. The PL properties of the undoped sample revealed as emission band due to a defect center. Additionally, the Eu-doped samples exhibited an emission band due to the 5d–4f transitions of Eu<sup>2+</sup> ions. The OSL phenomenon was observed only in the Eu-doped samples and was not present in the undoped sample. The OSL spectra of the Eu-doped samples showed as emission band at 430 nm under stimulated at 490 nm, which was due to the 5d–4f transitions of Eu<sup>2+</sup> ions. Based on the dose response functions, the lower detection limits of the Eu-doped samples were indicated as 10 mGy (0.1% Eu) and 1 mGy (0.5% and 1.0% Eu), and the 0.5% Eu-doped sample exhibited the highest OSL intensity among the Eu-doped samples.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"214 ","pages":"Article 111528"},"PeriodicalIF":1.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse reactions to therapeutic radiopharmaceuticals 放射性治疗药物的不良反应
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-09-24 DOI: 10.1016/j.apradiso.2024.111527
Mine Silindir-Gunay, Nur Ozolmez
{"title":"Adverse reactions to therapeutic radiopharmaceuticals","authors":"Mine Silindir-Gunay,&nbsp;Nur Ozolmez","doi":"10.1016/j.apradiso.2024.111527","DOIUrl":"10.1016/j.apradiso.2024.111527","url":null,"abstract":"<div><div>Radiopharmaceuticals are drugs used in treatment or diagnosis that contain a radioactive part, usually a pharmaceutical part in their structure. Adverse drug reactions are harmful and unexpected responses that occur when administered at normal doses. Although radiopharmaceuticals are regarded as safe medical products, adverse reactions should not be ignored. More serious adverse reactions such as myelosuppression, pleural effusion, and death may develop in therapeutic radiopharmaceuticals due to their use at higher doses than those used in diagnosis. Therefore, monitoring adverse reactions and reporting them to health authorities is important. This review aims to provide information about adverse reactions that may be related to radiopharmaceuticals used in treatment.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"214 ","pages":"Article 111527"},"PeriodicalIF":1.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conceptual design of sandwich walls for shielding against secondary neutrons using MC simulations with FLUKA 利用 FLUKA 进行 MC 模拟,设计用于屏蔽二次中子的夹层墙的概念设计
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-09-23 DOI: 10.1016/j.apradiso.2024.111525
Redona Bexheti , Mimoza Ristova
{"title":"Conceptual design of sandwich walls for shielding against secondary neutrons using MC simulations with FLUKA","authors":"Redona Bexheti ,&nbsp;Mimoza Ristova","doi":"10.1016/j.apradiso.2024.111525","DOIUrl":"10.1016/j.apradiso.2024.111525","url":null,"abstract":"<div><div>FLUKA Monte-Carlo transport code was employed to evaluate the secondary neutron spectra emerging from spherical sandwich shielding configurations composed of concrete and soil, similar to that used at the particle therapy facility MedAustron. This study provides a comparative analysis of neutron spectra attenuated by a concrete-soil-concrete (CSC) sandwich wall shielding configuration versus a full concrete wall design (CCC). Furthermore, we enhanced the shielding performance of the CSC configuration by adding an additional concrete layer (CCSC) to achieve results comparable to the CCC shielding. Two scenarios were tested for shielding performance: (1) primary protons at 100 MeV, and (2) primary carbon ions (C-ions) at 190 MeV/u. Our simulations with primary protons of 100 MeV showed that adding additional internal concrete wall to the CSC configuration, therefore designing the CCSC configuration, the RP performance becomes slightly improved – the HE-peak drops from (1.43 ± 0.11)10<sup>−11</sup> to (5.62 ± 0.3)10<sup>−12</sup>, about 2.5 times. Still, the HE-peak of the exiting neutron spectrum from CCC -(6.29 ± 1.87) 10<sup>−13</sup> is about 9 times lower than that exiting CCSC - (5.62 ± 0.3) 10<sup>−12</sup>.</div><div>Our simulations with primary C-ions showed that by placing an additional internal concrete wall to the CSC configuration (CCSC) the RP performance becomes slightly improved – the exiting HE peak can be further attenuated from (6.92 ± 0.40)10<sup>−9</sup> for CSC to (3.79 ± 0.15)10<sup>−9</sup>, becoming comparable to the one exiting the CCC configuration, (0.92 ± 0.04)10<sup>−9</sup>, only 4 times higher. Future research should be focused on improvements of the RP performance of the CCSC, by increasing the soil layer thickness and taking into consideration the humidity (water content) in the soil and concrete and also improve the number of primaries to 10<sup>9</sup> or even 10<sup>10</sup> for better statistical outcome.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"214 ","pages":"Article 111525"},"PeriodicalIF":1.6,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility of new polymeric matrices in the production of ferrous sulphate dosimeters 新型聚合物基质用于生产硫酸亚铁剂量计的可行性
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-09-20 DOI: 10.1016/j.apradiso.2024.111526
Ângela Moreira Marques dos Santos , Amir Zacarias Mesquita , Rita de Cássia-Oliveira Sebastião , Telma Cristina Ferreira Fonseca
{"title":"Feasibility of new polymeric matrices in the production of ferrous sulphate dosimeters","authors":"Ângela Moreira Marques dos Santos ,&nbsp;Amir Zacarias Mesquita ,&nbsp;Rita de Cássia-Oliveira Sebastião ,&nbsp;Telma Cristina Ferreira Fonseca","doi":"10.1016/j.apradiso.2024.111526","DOIUrl":"10.1016/j.apradiso.2024.111526","url":null,"abstract":"<div><div>External beam radiotherapy is a treatment modality that employs high doses for curative or palliative purposes. Safety in such treatments, particularly with high-precision equipment, necessitates strict adherence to quality control protocols to ensure the efficacy of oncological treatments. In this context, chemical dosimeters, particularly the Fricke gel, have emerged as valuable tools for quantitatively analysing absorbed radiation doses. These dosimeters can be applied both as tissue-equivalent phantoms and as radiation detectors in radiotherapy centers. The objective of this study was to evaluate the feasibility of new gelling matrices, comprising common materials such as CMC, GGU, and PVA, for producing ferrous sulphate dosimeters aimed at the relative quantification of radiation dose. A rheological study was conducted for different Fricke gel dosimetric formulations. Initially, the performance of these dosimeters, produced at various gel concentrations, was evaluated in terms of their consistency at room temperature. This was achieved through the straightforward process of humidification the gels with glycerine. These matrices consist of both natural and synthetic polymers that are readily accessible, easy to handle, and can be easily incorporated into the acidic ferrous sulphate solution. Parameters such as the influence of gelling matrix concentration, linearity, and stability were assessed and correlated with those previously investigated for Fricke gel produced with bloom 300 pig skin gelatine (GEL). Ferrous sulphate dosimeters fabricated with sodium carboxymethylcellulose (CMC), guar gum (GGU), and polyvinyl alcohol (PVA) exhibited a coefficient of variation of less than 1% relative to the dose response evaluated in this study. By using readily available and easily manageable materials, it is possible to replicate dosimeters with a favourable dosimetric response for high-dose measurements.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"214 ","pages":"Article 111526"},"PeriodicalIF":1.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiolabeling and preclinical evaluation of technetium-99m labeled colistin 锝-99m标记的可乐定的放射性标记和临床前评估
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-09-14 DOI: 10.1016/j.apradiso.2024.111524
Pardeep Kumar , Nagesh C Shanbhag# , Pradip Chaudhari , Bhabani Mohanty , Riptee Thakur , Gopalakrishnan M Sasidharan
{"title":"Radiolabeling and preclinical evaluation of technetium-99m labeled colistin","authors":"Pardeep Kumar ,&nbsp;Nagesh C Shanbhag# ,&nbsp;Pradip Chaudhari ,&nbsp;Bhabani Mohanty ,&nbsp;Riptee Thakur ,&nbsp;Gopalakrishnan M Sasidharan","doi":"10.1016/j.apradiso.2024.111524","DOIUrl":"10.1016/j.apradiso.2024.111524","url":null,"abstract":"<div><h3>Introduction</h3><p>Antibiotic resistance is a burden on the healthcare system. In present study, we have labeled an antibiotic named Colistimethate sodium (CMS) with technetium-99m (<sup>99m</sup>Tc) to develop a SPECT based imaging tracer.</p></div><div><h3>Methods</h3><p>We standardised the labeling using 0.5–2 mg of CMS (in water) using stannous chloride dihydrate as a reducing agent followed by addition of 370 ± 74 MBq of <sup>99m</sup>Tc. A group of mice were injected intravenously (in tail vein) with 4–6 MBq of [<sup>99m</sup>Tc]Tc-CMS diluted with saline and euthanized at various time intervals. microSPECT Imaging (ϒ-eye) was acquired to study the biodistribution in the healthy mice.</p></div><div><h3>Results</h3><p>We standardised the labeling using 0.5 mg of colistin in 0.5 ml of saline with addition of 30 μg stannous chloride dihydrate. The retention factor value was 0.1–0.3 as compared to 0.9–1.0 for free <sup>99m</sup>Tc by TLC and retention time was found to be 14.2 ± 1.3 min as evaluated by HPLC. The biodistribution data showed uptake in lungs, spleen, and liver at 30 min but the uptake decreased in lung at 60 min. The imaging data corroborated with the biodistribution data.</p></div><div><h3>Conclusions</h3><p>We could successfully label [<sup>99m</sup>Tc]Tc-CMS <sup>99m</sup>Tc and we could study its biodistribution in healthy mice.</p></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"214 ","pages":"Article 111524"},"PeriodicalIF":1.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thermoluminescence and optically stimulated luminescence studies of Gypsum for retrospective dosimetry 用于追溯剂量测定的石膏热致发光和光致发光研究
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-09-13 DOI: 10.1016/j.apradiso.2024.111523
Suchinder K. Sharma , Y.C. Nagar , A.K. Singhvi
{"title":"Thermoluminescence and optically stimulated luminescence studies of Gypsum for retrospective dosimetry","authors":"Suchinder K. Sharma ,&nbsp;Y.C. Nagar ,&nbsp;A.K. Singhvi","doi":"10.1016/j.apradiso.2024.111523","DOIUrl":"10.1016/j.apradiso.2024.111523","url":null,"abstract":"<div><p>This study examines the use of gypsum for radiation dosimetry using Thermoluminescence (TL) and Optically Stimulated Luminescence (OSL) techniques. It is observed that gypsum preserves the information of radiation dose despite the loss of water upon heating in a laboratory. Deconvolution of the thermoluminescence glow curve suggests thermoluminescence glow peaks at 125, 150, 280, 320, and 440 °C. The glow peak at 440 °C has a minimum detectable dose of 200 mGy, and it bleaches to approximately 50% with 300 min of daylight exposure. The Blue Light Stimulated Luminescence (BLSL) comprises a slow component and is correlated to 255 °C TL glow peak. The alpha efficiency of luminescence production per unit Gy of alpha dose with respect to the beta dose for the TL glow peaks at 440 °C is calculated at 0.18 ± 0.01. For BLSL, the value is calculated at 0.15 ± 0.01. A measurement protocol for the use of gypsum for retrospective dosimetry is also presented.</p></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"214 ","pages":"Article 111523"},"PeriodicalIF":1.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design of a mixed material moderator in a beam-shaping assembly for proton accelerator-based boron neutron capture therapy 设计基于质子加速器的硼中子俘获疗法的束流整形组件中的混合材料慢化剂
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-09-12 DOI: 10.1016/j.apradiso.2024.111515
Yulin Ge , Yao Zhong , Nan Yuan , Yanbing Sun , Liping Zou , Zhen Yang , Wei Ma , Liang Lu
{"title":"Design of a mixed material moderator in a beam-shaping assembly for proton accelerator-based boron neutron capture therapy","authors":"Yulin Ge ,&nbsp;Yao Zhong ,&nbsp;Nan Yuan ,&nbsp;Yanbing Sun ,&nbsp;Liping Zou ,&nbsp;Zhen Yang ,&nbsp;Wei Ma ,&nbsp;Liang Lu","doi":"10.1016/j.apradiso.2024.111515","DOIUrl":"10.1016/j.apradiso.2024.111515","url":null,"abstract":"<div><p>Boron Neutron Capture Therapy is being promoted with the development of accelerator neutron sources, and many new accelerator-based BNCT facilities are being built. In Particle Accelerator Facility project of Sun Yat-sen University, we plan to build a terminal for BNCT research based on an 8 MeV, CW 3 mA proton accelerator. In this paper, we present a beam-shaping assembly for this proton accelerator with such low 24 kW beam power, using composite moderator materials composed of five elements: Mg, Al, F, O, and Li. The calculation result of FLUKA with ENDF/B and JENDL libraries shows that the epithermal neutron beam flux is <span><math><mrow><mn>1.57</mn><mo>×</mo><msup><mn>10</mn><mn>9</mn></msup><mi>n</mi><mo>/</mo><msup><mtext>cm</mtext><mn>2</mn></msup><mo>/</mo><mi>s</mi></mrow></math></span> with the CW 3 mA proton beam. The fast neutron component and the gamma ray component under free-air condition are <span><math><mrow><mn>1.49</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>13</mn></mrow></msup><mspace></mspace><mtext>Gy</mtext><mo>∙</mo><msup><mtext>cm</mtext><mn>2</mn></msup></mrow></math></span> and <span><math><mrow><mn>8.12</mn><mo>×</mo><msup><mn>10</mn><mrow><mo>−</mo><mn>14</mn></mrow></msup><mspace></mspace><mtext>Gy</mtext><mo>∙</mo><msup><mtext>cm</mtext><mn>2</mn></msup></mrow></math></span> respectively, in line with IAEA-TECDOC-1223 design recommendations. The thermal analysis shows that the maximum temperature of beryllium target is 706.5 K, and the structure materials of BSA do not melt.</p></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"214 ","pages":"Article 111515"},"PeriodicalIF":1.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalized selection of unequal sub-arc collimator angles in VMAT for multiple brain metastases 在治疗多发性脑转移瘤的 VMAT 中个性化选择不等边弧下准直器角度
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-09-11 DOI: 10.1016/j.apradiso.2024.111513
Shi-Xiong Huang , Song-Hua Yang , Biao Zeng , Xiao-Hua Li
{"title":"Personalized selection of unequal sub-arc collimator angles in VMAT for multiple brain metastases","authors":"Shi-Xiong Huang ,&nbsp;Song-Hua Yang ,&nbsp;Biao Zeng ,&nbsp;Xiao-Hua Li","doi":"10.1016/j.apradiso.2024.111513","DOIUrl":"10.1016/j.apradiso.2024.111513","url":null,"abstract":"<div><h3>Purpose</h3><p>Investigating the effects of unequal sub-arc personalized collimator angle selection on the quality of Volumetric Modulated Arc Therapy (VMAT) plans for treating multiple brain metastases.</p></div><div><h3>Methods</h3><p>This study included 21 patients, each with 2–4 target volumes of multiple brain metastases. Two stereotactic radiotherapy (SRT) approaches were utilized: sub-arc collimator VMAT (SAC-VMAT) and fixed collimator VMAT (FC-VMAT). In the SAC-VMAT group, multi-leaf collimators (MLC) shaped the target area, dividing the full arc into four unequal sub-arcs under the beam's eye view (BEV). Each sub-arc had an appropriate collimator angle selected to mitigate ‘island blocking problems'. Conversely, the FC-VMAT group used a fixed collimator angle of 15° or 345°. A comparative analysis of the dosimetric parameters of the target volumes and normal tissues, along with the monitor units (MU), was conducted between the two groups.</p></div><div><h3>Results</h3><p>The mean dose and dose-volume to normal brain tissue (2–26 Gy, with a step of 2 Gy) were significantly lower in the SAC-VMAT group (P &lt; 0.01). There was no statistical difference between the two groups in dose to the target volumes, conformity index (CI), homogeneity index (HI), and other normal tissues (P &gt; 0.05). Compared with the FA-VMAT group, the SAC-VMAT group significantly reduced the gradient index (GI) (4.5 ± 0.59 vs 5.2 ± 0.75, P &lt; 0.001) and MU (1774.33 ± 181.77 vs 2001.0 ± 344.86, P &lt; 0.001). Notably, with an increase in the number of PTV, the SAC-VMAT group demonstrated more significant improvements in the dose-volume of normal brain tissue, GI, and MU.</p></div><div><h3>Conclusions</h3><p>In this study, personalized selection of the unequal sub-arc collimator angle ensured the prescribed dose to the PTV, CI, and HI, while significantly reducing the GI, MU, and the dose to normal brain tissue in the VMAT plan for multi-target brain metastases in the cohort of cases with 2–4 target volumes. Particularly as the number of targets increase, the advantages of this method become more pronounced.</p></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"214 ","pages":"Article 111513"},"PeriodicalIF":1.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thermoluminescence (TL) properties of Eu3+ incorporated with CaB4O7 phosphors prepared by solution-combustion process 溶液燃烧法制备的 Eu3+ 与 CaB4O7 荧光粉的热致发光 (TL) 特性
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2024-09-11 DOI: 10.1016/j.apradiso.2024.111522
Francis Birhanu Dejene, Habtamu Fekadu Etefa
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