Annals of Surgical Treatment and Research最新文献

{"title":"Improving prediction of ypT0-1N0 response in rectal cancer: the added value of gross tumor type to magnetic resonance tumor regression grade after chemoradiotherapy in a retrospective cohort study.","authors":"Kyong-Min Kang, Mi-Jeong Choi, Hong-Min Ahn, Heung-Kwon Oh, Duck-Woo Kim, Jungheum Cho, Won Chang, Young Hoon Kim, Kyoung Ho Lee, Yu Kyung Jun, Yonghoon Choi, Sung-Bum Kang","doi":"10.4174/astr.2026.110.4.237","DOIUrl":"10.4174/astr.2026.110.4.237","url":null,"abstract":"<p><strong>Purpose: </strong>While MRI-based tumor regression grade (mrTRG) has shown promise in evaluating pathologic response to concurrent chemoradiotherapy (CCRT) in rectal cancer, its ability to predict pathologic complete response remains limited. This study aimed to enhance mrTRG's diagnostic performance in predicting ypT0-1N0 status, a key factor in considering non-radical management after CCRT for locally advanced rectal cancer (LARC).</p><p><strong>Methods: </strong>This retrospective study included 430 patients with LARC who underwent radical resection following CCRT at a single referral hospital between April 2018 and September 2024. Multivariable logistic regression was used to identify predictive factors associated with achieving ypT0-1N0 status. The diagnostic performances of mrTRG1-2 alone and in combination with other factors were assessed by comparing sensitivity, specificity, positive-predictive value (PPV), negative-predictive value, and area under the curve (AUC).</p><p><strong>Results: </strong>Ninety-three patients (21.6%) achieved ypT0-1N0. In the multivariable analysis, fungating type, cT1-2, and mrTRG1-2 were independent predictors for ypT0-1N0. Integrating mrTRG with gross tumor type yielded the highest AUC of 0.689 among the combined models. For predicting ypT0-1N0, the combination of mrTRG and gross tumor type improved PPV (79.2% <i>vs.</i> 41.5% for mrTRG alone) while also demonstrating enhanced sensitivity compared with ycT0-1N0, the conventional MRI-based predictor (40.9% <i>vs.</i> 22.6%).</p><p><strong>Conclusion: </strong>This study demonstrated that combining mrTRG and gross tumor type improved the PPV of mrTRG in predicting ypT0-1N0 after CCRT in LARC. Further studies are warranted to validate the role of gross tumor type in refining predictive systems for selecting candidates for non-radical treatment.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"110 4","pages":"237-245"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are the long-term oncologic outcomes different between appendiceal cancer and right-sided colon cancer? An exact matching analysis of a 10-year institutional cohort.","authors":"Gunwoo Lee, Eun Jung Park, Soo Young Oh, Young Il Kim, Min Hyun Kim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu","doi":"10.4174/astr.2026.110.4.246","DOIUrl":"10.4174/astr.2026.110.4.246","url":null,"abstract":"<p><strong>Purpose: </strong>Due to its rarity, treatment guidelines for appendiceal cancer have traditionally followed those established for colorectal cancer, despite showing distinct histologic and clinical features. This study aimed to compare the clinicopathologic characteristics and long-term oncologic outcomes of appendiceal cancer with those of right-sided colon cancers.</p><p><strong>Methods: </strong>We retrospectively reviewed the records of patients with stage I-III appendiceal, cecal, or ascending colon cancer who underwent curative resection between 2010 and 2020 at our center. A 1:3:3 exact matching for age, sex, TNM stage, and adjuvant chemotherapy was performed. Survival outcomes were analyzed using the Kaplan-Meier and Cox regression methods.</p><p><strong>Results: </strong>Overall, 245 patients with appendiceal cancer (n = 35), ascending colon cancer (n = 105), and cecal cancer (n = 105) were analyzed. Appendiceal cancer exhibited a higher proportion of T4 tumors and fewer harvested lymph nodes compared with ascending or cecal cancers. The mean follow-up duration was 9.5 years. The 5- and 10-year overall survival rates were lower in appendiceal cancer (66.2% and 52.9%) than in ascending (91.2% and 78.4%) or cecal cancer (88.5% and 78.3%). Similarly, the 10-year disease-free survival rate was lower in appendiceal cancer (59.2%) compared with ascending (83.1%) and cecal cancers (78.4%). Cox regression analysis identified age (≥65 years), perforation, nodal metastasis, and lymphovascular invasion as independent predictors of poor prognosis.</p><p><strong>Conclusion: </strong>Appendiceal cancer exhibited significantly worse long-term survival compared to cecal or ascending colon cancer. Tumor perforation, nodal metastasis, and lymphovascular invasion were adverse prognostic factors for overall and disease-free survival.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"110 4","pages":"246-258"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Enhanced Recovery After Surgery in high-risk patients undergoing colon cancer surgery: a retrospective cohort study.","authors":"Reem Mohammed H Alshiakh, In Kyeong Kim, Jung Hoon Bae, Yoon Suk Lee, In Kyu Lee","doi":"10.4174/astr.2026.110.4.205","DOIUrl":"10.4174/astr.2026.110.4.205","url":null,"abstract":"<p><strong>Purpose: </strong>Enhanced Recovery After Surgery (ERAS) protocols have demonstrated significant benefits, but their safety and effectiveness in high-risk patients remain unclear. This study evaluated clinical postoperative outcomes in elderly patients and those with comorbidities undergoing colon cancer surgery.</p><p><strong>Methods: </strong>This retrospective cohort study included 1,035 patients who underwent elective colon cancer surgery from 2017 to 2022. A standardized 25-element ERAS protocol was implemented across all groups. Patients were categorized into a control group (aged <70 years without comorbidities, n = 534) and high-risk groups including elderly patients (≥70 years, n = 312) and those with cardiac (n = 60), pulmonary (n = 81), renal (n = 24), or hepatic disease (n = 24).</p><p><strong>Results: </strong>ERAS compliance rates were significantly lower in all high-risk groups compared to controls (79.39% ± 10.9%), with renal disease patients showing the most pronounced reduction (69.69% ± 17.0%). <i>Post-hoc</i> analysis revealed that only renal disease patients demonstrated significantly higher complication rates (45.8% <i>vs.</i> 18.9%, P < 0.01). Despite lower compliance, multivariate analysis revealed ERAS compliance ≥70% as the strongest independent predictor of both length of stay (odds ratio [OR], 0.139; P < 0.001) and complications (OR, 0.298; P < 0.001), substantially outweighing patient risk factors. After adjusting for treatment factors, patient comorbidity groups showed no independent association with clinical outcomes.</p><p><strong>Conclusion: </strong>ERAS protocols can be successfully implemented in high-risk patients with appropriate attention to compliance optimization. Treatment factors, particularly ERAS adherence, consistently outweigh patient risk factors in determining outcomes, and well-tailored ERAS implementation should be considered with high-risk patients for perioperative care.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"110 4","pages":"205-215"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of surgical outcomes after robotic gastrectomy with conventional multiport, single-site, and single-port surgical system for gastric cancer.","authors":"Ki-Yoon Kim, Jawon Hwang, Sung Hyun Park, Minah Cho, Yoo Min Kim, Woo Jin Hyung, Hyoung-Il Kim","doi":"10.4174/astr.2026.110.4.216","DOIUrl":"10.4174/astr.2026.110.4.216","url":null,"abstract":"<p><strong>Purpose: </strong>Technological advancements have enabled reduced-port robotic systems, enhancing the benefits of robotic surgery. This study compared the surgical outcomes of conventional multiport (5 ports), single-site (2 ports), and single-port (2 ports) robotic gastrectomy for gastric cancer.</p><p><strong>Methods: </strong>A prospectively collected database was retrospectively reviewed for patients who underwent robotic distal subtotal gastrectomy between January 2010 and August 2022 at Severance Hospital, Yonsei University Health System. The initial 20 cases from each group (multiport, single-site, and SP) were analyzed, focusing on demographics, surgical procedures, pathological results, and postoperative outcomes. The \"textbook outcome\" metric was employed to assess surgical quality.</p><p><strong>Results: </strong>The SP group showed lower visual analog pain scale compared to the multiport and single-site groups (3.5, 4.4, and 4.3, respectively, P = 0.017), faster time to first flatus (2.0, 2.7, and 2.8 days, respectively; P < 0.001), and shorter hospital stays (3.5, 6.2, and 5.5 days, respectively; P < 0.001). No significant differences were observed in major complications, unplanned intensive care unit care, readmission, or mortality between the groups. The rate of patients achieving textbook outcomes were 85.0% for the multiport group, 100% for the single-site group, and 95.0% for the SP group (P = 0.310).</p><p><strong>Conclusion: </strong>Reduced-port robotic gastrectomy, including single-site and SP, has shown surgical safety with a high proportion of patients meeting textbook outcomes. The SP system demonstrated less pain and faster recovery, aligning with minimally invasive surgical goals. Therefore, the SP system could be a reliable and safe option for robotic gastrectomy, offering enhanced recovery without compromising surgical quality.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"110 4","pages":"216-224"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of body composition and nutritional status with survival in stage IV colorectal cancer patients who underwent resection: a retrospective cohort study.","authors":"Jae Won Lee, Jae-Hoon Lee, Eun-Suk Cho, Su-Jin Shin, Hye Sun Lee, Kang Young Lee, Jeonghyun Kang","doi":"10.4174/astr.2026.110.3.170","DOIUrl":"10.4174/astr.2026.110.3.170","url":null,"abstract":"<p><strong>Purpose: </strong>Although host body composition, nutritional and systemic inflammatory status have been suggested to have an impact on prognosis in patients with colorectal cancer (CRC), their impact on patients with stage IV CRC remains unclear. This study investigated the prognostic effects of those parameters in patients initially diagnosed with stage IV CRC who underwent surgery.</p><p><strong>Methods: </strong>Patients with stage IV CRC who underwent surgery were selected. Preoperative computed tomography images were evaluated for skeletal muscle index, skeletal muscle density (SMD), visceral fat area (VFA), and subcutaneous fat area (SFA). For nutritional status and systemic inflammation, prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) were used. The Cox proportional hazard model was used to evaluate the prognostic significance of progression-free survival (PFS) after adjustment for the other covariates in the model.</p><p><strong>Results: </strong>Data of 134 patients with stage IV CRC who underwent surgery between January 2005 and February 2014 were included. SMD, VFA, SFA, PNI, NLR, LMR, and PLR were associated with PFS in the univariable analysis. In the multivariable analysis, SFA (hazard ratio [HR], 0.612; 95% confidence interval [CI], 0.389-0.961; P = 0.033), and PNI (HR, 0.536; 95% CI, 0.345-0.832; P = 0.005) were identified to be independent prognostic factors for PFS.</p><p><strong>Conclusion: </strong>SFA and PNI both demonstrated prognostic significance in patients with stage IV CRC. Accordingly, we believe further studies are warranted to determine whether incorporating these factors can aid in surgical decision-making for stage IV CRC patients.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"110 3","pages":"170-179"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suffocating neck hematoma in thyroidectomy: use of drains and perioperative risk factors in 1,334 surgeries.","authors":"Lucía Aragone, Paz Burbano, Adrian Cameron, Roque Adan, Daniel Pirchi","doi":"10.4174/astr.2026.110.3.144","DOIUrl":"10.4174/astr.2026.110.3.144","url":null,"abstract":"<p><strong>Purpose: </strong>A Suffocating Neck Hematoma (Snh) Is A Rare But Potentially Fatal Surgical Complication Of Thyroidectomy. In An Effort To Reduce Its Incidence, Many Surgeons Opt For The Selective Use Of Drains. However, There Are No Studies Demonstrating The Benefit Of This Strategy. Therefore, The Use Of Drains Remains Controversial. Our Primary Outcome Is To Analyze The Utility Of Drainage For Snh After Thyroidectomies.</p><p><strong>Methods: </strong>A comparative retrospective study with a prospective case registry was conducted. All adult patients who underwent total-thyroidectomy or hemi-thyroidectomy from January 2014 to December 2023 in a high-volume center were included. Drains were placed selectively, based on the surgeon's decision. Demographic and perioperative variables were compared between patients who presented with SNH and those who did not and outcomes were compared between patients with or without drains.</p><p><strong>Results: </strong>A total of 1,334 surgeries were recorded during the study period. Three hundred thirty-eight patients (25.3%) had drains placed. Only 4 patients (0.3%) presented SNH, all from the drain group and all of whom required surgical reintervention. It was observed that only the presence of drains was statistically significantly associated with SNH (P = 0.004) and with reoperations (P = 0.004). No other perioperative factors were found to be statistically significantly related to SNH in our series.</p><p><strong>Conclusion: </strong>In our series, placement of drains after thyroidectomies did not prevent the development of SNH or its reoperation. No other perioperative variables were related to SNH. The selective use of drains after thyroidectomies has shown no clear benefit in our retrospective series.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"110 3","pages":"144-148"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical AI goes to the operating room: are we ready for the Surgical Data Factory?","authors":"Namkee Oh, Kyu-Hwan Jung, Gyu-Seong Choi","doi":"10.4174/astr.2026.110.3.135","DOIUrl":"10.4174/astr.2026.110.3.135","url":null,"abstract":"<p><p>The operating room remains a paradox: it is one of the most sensor-rich environments in the hospital, yet it produces largely underutilized data. While surgical artificial intelligence (AI) has achieved remarkable progress in recent years, the day-to-day practice of surgery has changed little, with most systems confined to passive decision support. This narrative review traces the evolution of surgical AI from perception to cognition to early forms of action, arguing that the next paradigm shift requires \"physical AI\"-systems capable of meaningful physical interaction and autonomous execution. The clinical motivation for pursuing physical AI is clear: surgical outcomes vary substantially across surgeons, access is constrained by workforce shortages, and high-quality care remains tied to the scarcity of human expertise. If reliable autonomous systems can be developed, surgery could become more standardized, scalable, and reproducible. However, a critical bottleneck persists: the scarcity of synchronized, multimodal training data. The fundamental barrier is environmental rather than algorithmic, as most operating rooms are not configured to measure surgical practice objectively. We propose reconceptualizing the operating room as a \"Surgical Data Factory\"-a closed-loop ecosystem designed to capture multimodal signals, structure them via consensus taxonomies linked to outcomes, and utilize them for training, validation, and monitoring. Surgeons must transition from passive users to active architects of this infrastructure. Investing in systematic data governance is the prerequisite for responsibly developing, validating, and scaling physical AI in surgery.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"110 3","pages":"135-143"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hungry bone syndrome after parathyroidectomy in secondary and tertiary hyperparathyroidism: a retrospective cohort study.","authors":"Douk Kwon, Byung-Chang Kim, Yu-Mi Lee, Tae-Yon Sung, Ki-Wook Chung, Won Woong Kim","doi":"10.4174/astr.2026.110.3.149","DOIUrl":"10.4174/astr.2026.110.3.149","url":null,"abstract":"<p><strong>Purpose: </strong>Hungry bone syndrome (HBS) is a common and critical postoperative complication in patients undergoing parathyroidectomy (PTX) for secondary hyperparathyroidism (SHPT) and tertiary hyperparathyroidism (THPT). We aimed to identify clinical predictors of HBS and assess its impact on bone mineral density (BMD) after PTX.</p><p><strong>Methods: </strong>We retrospectively analyzed data of patients with SHPT and THPT who underwent PTX at Asan Medical Center (2010-2022). Clinical characteristics, including biochemical markers and BMD, were investigated. HBS was defined as profound hypocalcemia of less than 8.4 mg/dL (2.1 mmol/L) or prolonged hypocalcemia for more than 4 days after PTX.</p><p><strong>Results: </strong>A total of 91 patients were included: 18 (19.8%) with SHPT and 73 (80.2%) with THPT. Subtotal PTX was performed in 80 patients (87.9%), while 11 patients (12.1%) underwent total PTX with autotransplantation (TPTX + AT). HBS occurred in 31 patients (34.1%), with a higher incidence in patients with SHPT (72.2%) and all patients who underwent TPTX + AT. Patients with HBS required more calcium supplementation and had higher ALP levels at all timepoints (P < 0.001). In the HBS group, BMD improved more significantly in the femur (P = 0.005) and showed a trend towards improvement in the spine (P = 0.059). Risk factors for HBS included younger age, SHPT, and elevated preoperative ALP and intact parathyroid hormone levels.</p><p><strong>Conclusion: </strong>HBS is characterized by severe hypocalcemia due to calcium reabsorption into bone after PTX. Identifying risk factors for HBS may promote early risk stratification and tailored perioperative management, including surgical approach, especially for high-risk patients.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"110 3","pages":"149-156"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-center experience with pediatric short bowel syndrome: clinical outcomes based on etiology and anatomical type in a retrospective cohort study.","authors":"Honam Hwang, Dayoung Ko, Joong Kee Youn, Hee-Beom Yang, Hyun-Young Kim","doi":"10.4174/astr.2026.110.3.194","DOIUrl":"10.4174/astr.2026.110.3.194","url":null,"abstract":"<p><strong>Purpose: </strong>Short bowel syndrome (SBS) is a critical condition in pediatric patients. It often results in dependence on parenteral nutrition (PN) and significant morbidity. This study aimed to review pediatric SBS patients from a single center and analyze clinical outcomes based on etiology and anatomical type.</p><p><strong>Methods: </strong>A total of 55 patients diagnosed with SBS at our institution from January 2004 to December 2018 were retrospectively analyzed. Clinical demographics and outcomes including growth and PN dependence were evaluated according to etiology and anatomical type.</p><p><strong>Results: </strong>The predominant cause of SBS was necrotizing enterocolitis (NEC). At the last follow-up, the mean weight-for-age (z-score) was -2.00 ± 2.07 and 52.7% of patients were weaned off PN. Catheter-related bloodstream infection and PN-associated liver disease occurred in 36.4% and 20.0% of cases, respectively. Patients with motility disorders exhibited lower weight-for-age and longer durations of PN than those with NEC or intestinal atresia. Additionally, outcomes varied significantly by anatomical type, with type I patients showing higher PN dependence and lower rates of successful weaning off PN than type III patients.</p><p><strong>Conclusion: </strong>The study suggests that clinical outcomes in pediatric SBS patients can vary depending on underlying etiology and anatomical type, indicating that tailored interventions might enhance patient outcomes. Further research is needed to identify independent prognostic factors for SBS and improve the quality of life of SBS children.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"110 3","pages":"194-201"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical response and prognosis of estrogen receptor-positive and human epidermal growth factor receptor-negative breast cancer patients after neoadjuvant chemotherapy: a retrospective cohort study.","authors":"Jin Ah Lee, Dooreh Kim, Young Joo Lee, Chang Ik Yoon, Woo-Chan Park, Soo Youn Bae","doi":"10.4174/astr.2026.110.3.157","DOIUrl":"10.4174/astr.2026.110.3.157","url":null,"abstract":"<p><strong>Purpose: </strong>Neoadjuvant chemotherapy (NAC) significantly revolutionized the management of locally advanced breast cancer, especially in human epidermal growth factor receptor 2 (HER2)-positive and triple-negative subtypes. However, its effectiveness is limited in estrogen receptor (ER)-positive, HER2-negative breast cancer. This study investigates the clinical response and prognosis of ER-positive, HER2-negative breast cancer after NAC.</p><p><strong>Methods: </strong>The clinicopathological characteristics and treatment responses of 149 patients with ER-positive, HER2-negative breast cancer treated with NAC and surgery at The Catholic University of Korea, Seoul St. Mary's Hospital between 2018 and 2023 were retrospectively analyzed. Pathologic complete response (pCR) was defined as the absence of invasive tumors (ypT0/is, ypN0). Disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier methods, stratified by age (≤50 years <i>vs.</i> >50 years).</p><p><strong>Results: </strong>Among 149 patients, 13 (8.7%) achieved pCR, 87 (58.4%) attained partial responses, 40 (26.8%) had stable disease, and 9 (6.0%) experienced progressive disease. RECIST responses differed significantly by age (P = 0.003). DFS (P = 0.011) and OS (P = 0.005) were significantly associated with clinical response in patients aged ≤50 years. Post-NAC Ki-67 was associated with DFS (P = 0.013) but not OS (P = 0.083) in patients aged ≤50 years. Clinical responses and post-NAC Ki-67 were not associated with DFS (P = 0.544) or OS (P = 0.569) in patients aged >50 years.</p><p><strong>Conclusion: </strong>In ER-positive, HER2-negative breast cancer, clinical responses and post-NAC Ki-67 were significant prognostic factors in patients aged ≤50 years but not in older patients. These findings highlight the need for tailored therapeutic approaches that consider age-specific prognostic differences.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"110 3","pages":"157-169"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}