Annals of Surgical Treatment and Research最新文献

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Analysis of prognostic factors for postoperative complications and mortality in elderly patients undergoing emergency surgery for intestinal perforation or irreversible intestinal ischemia. 老年肠穿孔或不可逆性肠缺血急诊手术患者术后并发症和死亡率的预后因素分析。
IF 1.4 4区 医学
Annals of Surgical Treatment and Research Pub Date : 2023-10-01 Epub Date: 2023-09-27 DOI: 10.4174/astr.2023.105.4.198
Hyung Suk Kim, Hyun Il Kim, Young Joon Yoon, Jong Hoon Yeom, Min Gyu Kim
{"title":"Analysis of prognostic factors for postoperative complications and mortality in elderly patients undergoing emergency surgery for intestinal perforation or irreversible intestinal ischemia.","authors":"Hyung Suk Kim,&nbsp;Hyun Il Kim,&nbsp;Young Joon Yoon,&nbsp;Jong Hoon Yeom,&nbsp;Min Gyu Kim","doi":"10.4174/astr.2023.105.4.198","DOIUrl":"https://doi.org/10.4174/astr.2023.105.4.198","url":null,"abstract":"<p><strong>Purpose: </strong>Because the global geriatric population continues to increase, the assessment of emergency surgical outcomes in elderly patients with acute peritonitis will become more important.</p><p><strong>Methods: </strong>A retrospective review was conducted on the data of 174 elderly patients who underwent emergency surgery for intestinal perforation or intestinal infarction between June 2010 and November 2022. We conducted an analysis of the risk factors associated with postoperative complications and mortality by evaluating the characteristics of patients and their surgical outcomes.</p><p><strong>Results: </strong>In our study, most patients (94.3%) had preexisting comorbidities, and many patients (84.5%) required transfer to the intensive care unit following emergency surgery. Postoperative complications were observed in 84 individuals (48.3%), with postoperative mortality occurring in 29 (16.7%). Multivariate analysis revealed preoperative acute renal injury, hypoalbuminemia, and postoperative ventilator support as significant predictors of postoperative mortality.</p><p><strong>Conclusion: </strong>When elderly patients undergo emergency surgery for intestinal perforation or infarction, it is important to recognize that those with preoperative acute renal injury, hypoalbuminemia, and a need for postoperative ventilator support have a poor prognosis. Therefore, these patients require intensive care from the early stages of treatment.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the efficacy and safety of conversion from the tacrolimus capsule to tablet in stable liver transplant recipients with maintenance therapy: a 24-week, open-label, single-center, phase IV exploratory clinical study. 从他克莫司胶囊转为片剂对稳定肝移植受者进行维持治疗的疗效和安全性评估:一项24周、开放标签、单中心、IV期探索性临床研究。
IF 1.4 4区 医学
Annals of Surgical Treatment and Research Pub Date : 2023-10-01 Epub Date: 2023-09-27 DOI: 10.4174/astr.2023.105.4.228
Jae-Yoon Kim, Sukyoung Chang, Jiyoung Kim, Hyun Hwa Choi, Jaewon Lee, Su Young Hong, Jeong-Moo Lee, Suk Kyun Hong, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
{"title":"Evaluation of the efficacy and safety of conversion from the tacrolimus capsule to tablet in stable liver transplant recipients with maintenance therapy: a 24-week, open-label, single-center, phase IV exploratory clinical study.","authors":"Jae-Yoon Kim,&nbsp;Sukyoung Chang,&nbsp;Jiyoung Kim,&nbsp;Hyun Hwa Choi,&nbsp;Jaewon Lee,&nbsp;Su Young Hong,&nbsp;Jeong-Moo Lee,&nbsp;Suk Kyun Hong,&nbsp;YoungRok Choi,&nbsp;Nam-Joon Yi,&nbsp;Kwang-Woong Lee,&nbsp;Kyung-Suk Suh","doi":"10.4174/astr.2023.105.4.228","DOIUrl":"https://doi.org/10.4174/astr.2023.105.4.228","url":null,"abstract":"<p><strong>Purpose: </strong>The tablet form of tacrolimus is more convenient for drug ingestion than the capsule form. We examined the efficacy and safety of tacrolimus tablets and a satisfaction survey after formula conversion in liver transplant (LT) recipients.</p><p><strong>Methods: </strong>This study was an open-label, prospective clinical trial for tacrolimus formula 1:1 conversion from capsule to tablet in 41 adult LT recipients with tacrolimus maintenance therapy of more than 1 month. The primary endpoint was incidence of biopsy-proven acute rejection (BPAR) within 24 weeks. Surveys 1 week before and 4 weeks after formula conversion were conducted for total daily dose of medication, number, scale of discomfort and satisfaction.</p><p><strong>Results: </strong>The overall incidence of BPAR was 0% and there was no graft loss or patient death. The incidence of adverse effects was 34.1% (n = 14) after formula conversion. The most common severe adverse effect was abnormal liver function test (n = 5): biliary complications (n = 4) and alcoholic recidivism (n = 1). Total daily dose and number of tacrolimus doses were significantly lower after formula conversion (P < 0.05) without changes in trough level. According to survey analysis, there was no significant difference in discomfort and satisfaction scales from capsule to tablet conversion (P < 0.05).</p><p><strong>Conclusion: </strong>The present study suggests that the new tablet formula can be a useful treatment option to maintain a consistent level of tacrolimus with a lower total daily dose and number in adult LT recipients.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specialty impact on residents' perceived quality of life, stress, and job satisfaction: a comparative study. 专业对居民感知生活质量、压力和工作满意度的影响:一项比较研究。
IF 1.4 4区 医学
Annals of Surgical Treatment and Research Pub Date : 2023-10-01 Epub Date: 2023-09-27 DOI: 10.4174/astr.2023.105.4.188
Bo Young Kim, Inah Yoon, Seong John Han, Suk-Kyung Hong, Sehoon Choi, Hyo-Jin Kwon, Eun Key Kim
{"title":"Specialty impact on residents' perceived quality of life, stress, and job satisfaction: a comparative study.","authors":"Bo Young Kim,&nbsp;Inah Yoon,&nbsp;Seong John Han,&nbsp;Suk-Kyung Hong,&nbsp;Sehoon Choi,&nbsp;Hyo-Jin Kwon,&nbsp;Eun Key Kim","doi":"10.4174/astr.2023.105.4.188","DOIUrl":"https://doi.org/10.4174/astr.2023.105.4.188","url":null,"abstract":"<p><strong>Purpose: </strong>Specialty choice in residency training has a significant impact on an individual's career and satisfaction, as well as the supply-demand imbalance in the healthcare system. The current study aimed to investigate the quality of life (QOL), stress, self-confidence, and job satisfaction of residents, and to explore factors associated with such variables, including postgraduate year, sex, and especially specialty, through a cross-sectional survey.</p><p><strong>Methods: </strong>An online survey was administered to residents at 2 affiliated teaching hospitals. The survey had a total of 46 items encompassing overall residency life such as workload, QOL, stress, confidence, relationship, harassment, and satisfaction. Related survey items were then reconstructed into 4 key categories through exploratory factor analysis for comparison according to group classification.</p><p><strong>Results: </strong>The weekly work hours of residents in vital and other specialties were similar, but residents in vital specialties had significantly more on-call days per month. Residents in vital specialties had significantly lower scores for QOL and satisfaction. Specifically, vital-surgical residents had significantly lower QOL scores and higher stress scores than the other specialty groups. Satisfaction scores were also lowest among vital-surgical residents, with a marginal difference from vital-medical, and a significant difference from other-surgical residents. Female residents had significantly lower satisfaction scores than their male counterparts.</p><p><strong>Conclusion: </strong>Residents in vital specialties, particularly vital-surgical specialties, experience significantly worse working conditions across multiple dimensions. It is necessary to improve not only the quantity but also the quality of the system in terms of resource allocation and prioritization.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Donor sex and donor-recipient sex disparity do not affect hepatocellular carcinoma recurrence after living donor liver transplantation. 供体性别和供体-受体性别差异不影响肝移植术后肝细胞癌复发。
IF 1.4 4区 医学
Annals of Surgical Treatment and Research Pub Date : 2023-09-01 DOI: 10.4174/astr.2023.105.3.133
Rak Kyun Oh, Shin Hwang, Gi-Won Song, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Dong-Hwan Jung, Gil-Chun Park, Young-In Yoon, Woo-Hyoung Kang
{"title":"Donor sex and donor-recipient sex disparity do not affect hepatocellular carcinoma recurrence after living donor liver transplantation.","authors":"Rak Kyun Oh,&nbsp;Shin Hwang,&nbsp;Gi-Won Song,&nbsp;Chul-Soo Ahn,&nbsp;Deok-Bog Moon,&nbsp;Tae-Yong Ha,&nbsp;Dong-Hwan Jung,&nbsp;Gil-Chun Park,&nbsp;Young-In Yoon,&nbsp;Woo-Hyoung Kang","doi":"10.4174/astr.2023.105.3.133","DOIUrl":"https://doi.org/10.4174/astr.2023.105.3.133","url":null,"abstract":"<p><strong>Purpose: </strong>Studies have yielded contradictory results on whether donor sex and donor-recipient sex disparity affect hepatocellular carcinoma (HCC) recurrence after living donor liver transplantation (LDLT). The present study assessed whether donor sex or donor-recipient sex disparity affects HCC recurrence after LDLT at a high-volume center.</p><p><strong>Methods: </strong>This study included 772 HCC patients who underwent LDLT between January 2006 and December 2015 at Asan Medical Center. Patients were divided into 4 groups based on the sex of the donor and recipient: male-to-male (n = 490, 63.5%), male-to-female (n = 75, 9.7%), female-to-male (n = 170, 22.0%), and female-to-female (n = 37, 4.8%).</p><p><strong>Results: </strong>Disease-free survival (DFS; P = 0.372) and overall survival (OS; P = 0.591) did not differ significantly among the 4 groups. DFS also did not differ significantly between LDLT recipients with male and female donors (P = 0.792) or between male and female recipients (P = 0.084). After patient matching with an α-FP/des-γ-carboxy prothrombin/tumor volume score cutoff of 5logs, donor-recipient sex disparity did not significantly affect DFS (P = 0.598) or OS (P = 0.777). There were also no differences in DFS in matched LDLT recipients with male and female donors (P = 0.312) or between male and female recipients (P = 0.374).</p><p><strong>Conclusion: </strong>Neither donor sex nor donor-recipient sex disparity significantly affected posttransplant HCC recurrence.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/01/astr-105-133.PMC10485355.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10276582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new risk scoring system for early prediction of surgical need in patients with adhesive small bowel obstruction: a single-center retrospective clinical study. 粘连性小肠梗阻患者手术需求早期预测的新风险评分系统:一项单中心回顾性临床研究
IF 1.4 4区 医学
Annals of Surgical Treatment and Research Pub Date : 2023-09-01 DOI: 10.4174/astr.2023.105.3.165
Evren Besler, Emre Teke, Doğukan Akkuş, Mahmut Hüdai Demir, Sebahat Aksaray, Sibel Aydın Aksu, Meryem Günay Gürleyik
{"title":"A new risk scoring system for early prediction of surgical need in patients with adhesive small bowel obstruction: a single-center retrospective clinical study.","authors":"Evren Besler,&nbsp;Emre Teke,&nbsp;Doğukan Akkuş,&nbsp;Mahmut Hüdai Demir,&nbsp;Sebahat Aksaray,&nbsp;Sibel Aydın Aksu,&nbsp;Meryem Günay Gürleyik","doi":"10.4174/astr.2023.105.3.165","DOIUrl":"https://doi.org/10.4174/astr.2023.105.3.165","url":null,"abstract":"<p><strong>Purpose: </strong>Cases of adhesive small bowel obstruction are a nuisance to surgeons. There have been years of ongoing discussions, and various guidelines have been published for the management of this disease. Both surgical and conservative approaches can have their own complications. It is often difficult to decide which treatment to apply to which patient. We aimed to create a multiparametric scoring system for the optimal management of adhesive small bowel obstruction patients.</p><p><strong>Methods: </strong>The retrospective laboratory, clinical and radiological records of 100 patients who were hospitalized and followed-up/treated for adhesive small bowel obstruction secondary to surgery in the General Surgery Clinic of Haydarpaşa Numune Education and Research Hospital (Istanbul) between 2011 and 2021 were reviewed and statistically analyzed.</p><p><strong>Results: </strong>Admittance CRP and the largest diameter of the small intestine in the horizontal section of the admittance CT scans were significantly higher (P = 0.006 and P = 0.007), and the admittance albumin and sodium values were significantly lower (P < 0.001 and P = 0.031) in patients operated on for adhesive small bowel obstruction than in patients not operated on. Free intraperitoneal fluid in CT scans was detected at a higher rate in the operated group. An adhesive small bowel obstruction surgery score above 3.5 points out of 7 was found to be significant (P < 0.001).</p><p><strong>Conclusion: </strong>With this easy and applicable scoring system, complications of existing disease may be avoided by considering earlier surgical intervention in patients with a score of 4 and above.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/10/astr-105-165.PMC10485350.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracorporeal modified delta-shaped gastroduodenostomy during 2-port distal gastrectomy: technical aspects and short-term outcomes. 2端口远端胃切除术中改良的体内三角型胃十二指肠造口术:技术方面和短期结果。
IF 1.4 4区 医学
Annals of Surgical Treatment and Research Pub Date : 2023-09-01 DOI: 10.4174/astr.2023.105.3.172
Sejin Lee, Jeong Ho Song, Sung Hyun Park, Minah Cho, Yoo Min Kim, Woo Jin Hyung, Hyoung-Il Kim
{"title":"Intracorporeal modified delta-shaped gastroduodenostomy during 2-port distal gastrectomy: technical aspects and short-term outcomes.","authors":"Sejin Lee,&nbsp;Jeong Ho Song,&nbsp;Sung Hyun Park,&nbsp;Minah Cho,&nbsp;Yoo Min Kim,&nbsp;Woo Jin Hyung,&nbsp;Hyoung-Il Kim","doi":"10.4174/astr.2023.105.3.172","DOIUrl":"https://doi.org/10.4174/astr.2023.105.3.172","url":null,"abstract":"<p><strong>Purpose: </strong>Surgeons have become increasingly interested in reduced-port gastrectomy to minimize trauma while maintaining oncologic safety. Although gastroduodenostomy has the benefits of better nutritional outcomes and fewer postoperative complications than other types of reconstruction, gastroduodenostomy is not a preferred option for reduced-port distal gastrectomy because of technical difficulties. In this study, we describe our intracorporeal modified delta-shaped gastroduodenostomy technique, which is easily applicable during 2-port distal gastrectomy.</p><p><strong>Methods: </strong>We retrospectively reviewed our database of 30 consecutive patients with gastric cancer who underwent 2-port distal gastrectomy with intracorporeal modified delta-shaped gastroduodenostomy from October 2016 to May 2021. In this reduced-port approach, we used a Tropian Single port (TROPIAN TECH) via a 25-mm transumbilical incision and a 12-mm port at the right flank. All anastomoses were performed using a 60-mm endolinear stapler. We used 3 additional sutures to provide proper traction and support for the anastomosis.</p><p><strong>Results: </strong>Mean ± standard deviation of operation time was 148.9 ± 34.7 minutes; reconstruction time was 13.2 ± 4.6 minutes; estimated blood loss was 29.3 ± 44.4 mL; and length of hospital stay was 4.5 ± 1.2 postoperative days. A total of 11 patients (36.7%) had a Clavien-Dindo grade I or grade II complication, and there were no grade IIIa or higher complications.</p><p><strong>Conclusion: </strong>Intracorporeal modified delta-shaped gastroduodenostomy was safely performed via a 2-port approach, resulting in acceptable surgical outcomes and no major complications.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/08/astr-105-172.PMC10485356.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prognostic and predictive value of plasma D-dimer in children with neuroblastoma: a 7-year retrospective analysis at a single institution. 血浆d -二聚体对神经母细胞瘤患儿的预后和预测价值:一项单一机构的7年回顾性分析
IF 1.4 4区 医学
Annals of Surgical Treatment and Research Pub Date : 2023-09-01 DOI: 10.4174/astr.2023.105.3.148
Zhen-Ni Wang, Yao Zhang, Jian Sun, Zhen-Zhen Zhao, Shan Wang, Chao Yang
{"title":"The prognostic and predictive value of plasma D-dimer in children with neuroblastoma: a 7-year retrospective analysis at a single institution.","authors":"Zhen-Ni Wang,&nbsp;Yao Zhang,&nbsp;Jian Sun,&nbsp;Zhen-Zhen Zhao,&nbsp;Shan Wang,&nbsp;Chao Yang","doi":"10.4174/astr.2023.105.3.148","DOIUrl":"https://doi.org/10.4174/astr.2023.105.3.148","url":null,"abstract":"<p><strong>Purpose: </strong>Elevated plasma D-dimer level is a poor prognostic factor for many solid tumors. However, limited research has been conducted on D-dimer in children with neuroblastoma (NB), and its clinical significance remains unclear. The present study investigated the clinical and prognostic significance of D-dimer in pediatric NB patients.</p><p><strong>Methods: </strong>A retrospective analysis of all newly admitted NB patients was conducted from January 2014 to December 2020. Baseline clinicopathological features, preoperative laboratory parameters, and follow-up information were collected. Univariate and multivariate analyses were performed to determine the relationship between D-dimer level, clinical features, and the prognostic value.</p><p><strong>Results: </strong>Among 266 patients, the median value of D-dimer was 2.98 ng/mL, of which 132 patients showed elevated D-dimer levels before surgery (>2.98 ng/mL). Univariate analysis revealed that elevated D-dimer was significantly associated with age, hemoglobin, neutrophil-to-lymphocyte ratio, neuron-specific enolase, 24-hour vanillylmandelic acid, overall survival, and so on (P < 0.05). Patients with elevated D-dimer levels had shorter median overall survival time when compared with normal D-dimer levels (P = 0.01). The prognosis was better in patients with normal D-dimer levels when combined with lower age, ganglioneuroblastoma tumor type, lower stage on International Neuroblastoma Staging System, low-risk group, and without bone metastasis or bone marrow metastasis. The continuous increase of D-dimer level after treatment indicated tumor recurrence or progression.</p><p><strong>Conclusion: </strong>A high D-dimer level is associated with low overall survival, and an elevated D-dimer level after treatment indicates tumor recurrence and progression. D-dimer can be used as one of the evaluation factors for NB treatment or prognosis.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/bb/astr-105-148.PMC10485353.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ventilator support in the pretransplant period predisposes early graft failure after deceased donor liver transplantation. 移植前呼吸机支持易导致死亡供肝移植后早期移植衰竭。
IF 1.4 4区 医学
Annals of Surgical Treatment and Research Pub Date : 2023-09-01 DOI: 10.4174/astr.2023.105.3.141
Nuri Lee, Sora Cha, Jongman Kim, Yunmi Lee, Enjin Kang, Hyun Jung Kim, Seung Hui Hong, Jinsoo Rhu, Gyu-Seong Choi, Jae-Won Joh
{"title":"Ventilator support in the pretransplant period predisposes early graft failure after deceased donor liver transplantation.","authors":"Nuri Lee,&nbsp;Sora Cha,&nbsp;Jongman Kim,&nbsp;Yunmi Lee,&nbsp;Enjin Kang,&nbsp;Hyun Jung Kim,&nbsp;Seung Hui Hong,&nbsp;Jinsoo Rhu,&nbsp;Gyu-Seong Choi,&nbsp;Jae-Won Joh","doi":"10.4174/astr.2023.105.3.141","DOIUrl":"https://doi.org/10.4174/astr.2023.105.3.141","url":null,"abstract":"<p><strong>Purpose: </strong>Deceased donor liver transplantation (DDLT) recipients in Korea are generally sicker due to an increasing organ shortage. In the present study, the risk factors for early 30-day liver graft failure after DDLT were identified.</p><p><strong>Methods: </strong>From August 2017 to February 2021, 265 adult DDLTs were performed. The characteristics of patients with and without 30-day graft failure were compared.</p><p><strong>Results: </strong>Liver graft failure occurred in 11 patients (17.7%) after DDLT. Baseline and perioperative characteristics of donors and recipients were not statistically significantly different between the 2 groups. The cumulative graft and overall survival rates at 6 months were 83.9% and 88.7%, respectively. Multivariate analysis showed ventilator support in the pretransplant period was a predisposing factor for 30-day graft failure after DDLT.</p><p><strong>Conclusion: </strong>Present study indicates that cautious decision is required when allocating DDLT in critically ill patients on mechanical ventilatory support.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/63/astr-105-141.PMC10485352.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suppressive role of vascular endothelial growth factor on intestinal apoptosis in induced necrotizing enterocolitis in rats. 血管内皮生长因子对大鼠坏死性小肠结肠炎肠细胞凋亡的抑制作用。
IF 1.4 4区 医学
Annals of Surgical Treatment and Research Pub Date : 2023-09-01 DOI: 10.4174/astr.2023.105.3.157
Hee-Beom Yang, Hyun-Young Kim, Soo-Hong Kim, So-Young Kim
{"title":"Suppressive role of vascular endothelial growth factor on intestinal apoptosis in induced necrotizing enterocolitis in rats.","authors":"Hee-Beom Yang,&nbsp;Hyun-Young Kim,&nbsp;Soo-Hong Kim,&nbsp;So-Young Kim","doi":"10.4174/astr.2023.105.3.157","DOIUrl":"https://doi.org/10.4174/astr.2023.105.3.157","url":null,"abstract":"<p><strong>Purpose: </strong>Necrotizing enterocolitis (NEC) is a devastating disease that can cause mortality in preterm babies. NEC may develop through an apoptotic pathway that is known to be inhibited by vascular endothelial growth factor (VEGF). This study determined whether VEGF exerted a protective effect against the development of NEC and apoptosis in rats.</p><p><strong>Methods: </strong>To determine the effect of VEGF in NEC rats, neonatal rats were randomized into 4 groups: the control group, the NEC group, the NEC + intraperitoneal VEGF (50 ng/kg) group (NEC + VEGF IP group), and the NEC + oral VEGF (50 ng/kg) group (NEC + VEGF OR group). NEC was induced by lipopolysaccharide/hypoxia and cold stress. The animals were sacrificed 72 hours later. After laparotomy, we obtained a region of the proximal small bowel from the ileocecal valve about 18 cm in length.</p><p><strong>Results: </strong>The NEC histological grade, apoptosis histological score, and caspase-3 activity were lower in the NEC + VEGF IP and OR groups than in the NEC group. In the NEC + VEGF IP and OR groups, the messenger RNA expression of apoptotic and inflammatory genes, such as <i>Bax</i>, <i>NF-κB</i>, <i>p53</i>, <i>Fas</i>, <i>FasL</i>, and <i>PAF-R</i>, but not that of <i>Bcl-2</i>, was decreased, as was the Bax/Bcl-2 protein ratio. Histological analysis revealed that the apoptosis-blocking effect of VEGF was more effective in the NEC + VEGF IP group than in the NEC + VEGF OR group.</p><p><strong>Conclusion: </strong>We identified apoptotic and inflammatory genes to confirm the preventive effect of VEGF pretreatment on NEC in rats. This study presents a novel approach to prevent apoptosis via VEGF pretreatment in rats with lipopolysaccharide/hypoxia-induced NEC.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/a1/astr-105-157.PMC10485351.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10276577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of public's perception of scar cosmesis after thyroidectomy: results of a survey of Turkish versus South Korean individuals. 评价公众对甲状腺切除术后疤痕美容的看法:土耳其与韩国个人的调查结果。
IF 1.4 4区 医学
Annals of Surgical Treatment and Research Pub Date : 2023-09-01 DOI: 10.4174/astr.2023.105.3.119
Erman Alci, Soo Young Kim, Hyeok Jun Yun, Seda Gozener, Murat Ozdemir, Yigit Turk, Hur Hassoy, Yong Sang Lee, Seok-Mo Kim, Gokhan Icoz, Hang-Seok Chang, Ozer Makay
{"title":"Evaluation of public's perception of scar cosmesis after thyroidectomy: results of a survey of Turkish versus South Korean individuals.","authors":"Erman Alci,&nbsp;Soo Young Kim,&nbsp;Hyeok Jun Yun,&nbsp;Seda Gozener,&nbsp;Murat Ozdemir,&nbsp;Yigit Turk,&nbsp;Hur Hassoy,&nbsp;Yong Sang Lee,&nbsp;Seok-Mo Kim,&nbsp;Gokhan Icoz,&nbsp;Hang-Seok Chang,&nbsp;Ozer Makay","doi":"10.4174/astr.2023.105.3.119","DOIUrl":"https://doi.org/10.4174/astr.2023.105.3.119","url":null,"abstract":"<p><strong>Purpose: </strong>Visible scars on the neck caused by thyroid surgery give rise to significant aesthetic, functional, and psychosocial problems. The objective of this study is to comparatively investigate the public perception of neck scar cosmesis in Turkish and South Korean populations.</p><p><strong>Methods: </strong>This survey was prepared to collect participants' demographic and socioeconomic data and determine their perception of scar cosmesis on the neck and consisted of 15 questions. One thousand thirty-nine individuals who did not undergo thyroid surgery completed the survey. The P-values of <0.05 were deemed to indicate statistical significance.</p><p><strong>Results: </strong>There were 1,039 respondents, of whom 525 (50.5%) were Turkish and 514 (49.5%) were South Korean. South Korean respondents stated that they would be significantly more uncomfortable with the thought of having a scar due to thyroid surgery, compared to the Turkish respondents (P < 0.001). The South Korean respondents stated that they would be significantly more concerned about the scar's length, thickness, and darkening color, compared to the Turkish respondents (P < 0.001 for all cases).</p><p><strong>Conclusion: </strong>Patients' expectations, which are affected by various sociodemographic factors and cultural characteristics, are as important as the medical condition when deciding on the type of thyroid surgery. The study findings clearly indicated that the South Korean population would be significantly more uncomfortable with having a scar on the neck, compared to the Turkish population. Therefore, in selected cases, a scarless thyroidectomy approach, such as transoral endoscopic thyroidectomy, vestibular approach may be preferable for societies like South Korea.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/cd/astr-105-119.PMC10485354.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10276583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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