Annals of Surgical Treatment and Research最新文献

{"title":"Epigenetic modulation inhibits epithelial-mesenchymal transition-driven fibrogenesis and enhances characteristics of chemically-derived hepatic progenitors.","authors":"Michael Adisasmita, Hyomin K Lee, Yohan An, Myounghoi Kim, Michael Girma Mamo, Junho K Hur, Dongho Choi, Ji Hyun Shin, Yun Kyung Jung","doi":"10.4174/astr.2024.106.5.274","DOIUrl":"10.4174/astr.2024.106.5.274","url":null,"abstract":"<p><strong>Purpose: </strong>One of the novel cell sources of cell-based liver regenerative medicine is human chemically-derived hepatic progenitors (hCdHs). We previously established this cell by direct hepatocyte reprogramming with a combination of small molecules (hepatocyte growth factor, A83-01, CHIR99021). However, there have been several issues concerning the cell's stability and maintenance, namely the occurrences of epithelial-mesenchymal transition (EMT) that develop fibrotic phenotypes, resulting in the loss of hepatic progenitor characteristics. These hepatic progenitor attributes are thought to be regulated by SOX9, a transcription factor essential for hepatic progenitor cells and cholangiocytes.</p><p><strong>Methods: </strong>To suppress the fibrotic phenotype and improve our long-term hCdHs culture technology, we utilized the epigenetic modulating drugs DNA methyltransferase inhibitor (5-azacytidine) and histone deacetylase inhibitor (sodium butyrate) that have been reported to suppress and revert hepatic fibrosis. To confirm the essential role of SOX9 to our cell, we used clustered regularly interspaced short palindromic repeats-interference (CRISPRi) to repress the SOX9 expression.</p><p><strong>Results: </strong>The treatment of only 5-azacytidine significantly reduces the fibrosis/mesenchymal marker and EMT-related transcription factor expression level in the early passages. Interestingly, this treatment also increased the hepatic progenitor markers expression, even during the reprogramming phase. Then, we confirmed the essential role of SOX9 by repressing the SOX9 expression with CRISPRi which resulted in the downregulation of several essential hepatic progenitor cell markers.</p><p><strong>Conclusion: </strong>These results highlight the capacity of 5-azacytidine to inhibit EMT-driven hepatic fibrosis and the significance of SOX9 on hepatic progenitor cell stemness properties.</p>","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"106 5","pages":"274-283"},"PeriodicalIF":1.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Prognosis according to the timing of recurrence in breast cancer\" (Ann Surg Treat Res 2023;104:1-9).","authors":"Dominik Hlauschek, Michael Gnant","doi":"10.4174/astr.2024.106.4.237","DOIUrl":"https://doi.org/10.4174/astr.2024.106.4.237","url":null,"abstract":"","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"106 4","pages":"237-238"},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10995837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply on \"Prognosis according to the timing of recurrence in breast cancer\" (Ann Surg Treat Res 2023;104:1-9).","authors":"Seung Pil Jung, Young Joo Lee, Soo Youn Bae","doi":"10.4174/astr.2024.106.4.239","DOIUrl":"https://doi.org/10.4174/astr.2024.106.4.239","url":null,"abstract":"","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"106 4","pages":"239-240"},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10995842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative profiling by data-independent acquisition mass spectrometry reveals featured plasma proteins in breast cancer: a pilot study.","authors":"Kyung-Hwak Yoon, Hyosub Chu, Hyeonji Kim, Sunghyun Huh, Eun-Kyu Kim, Un-Beom Kang, Hee-Chul Shin","doi":"10.4174/astr.2024.106.4.195","DOIUrl":"https://doi.org/10.4174/astr.2024.106.4.195","url":null,"abstract":"Breast cancer is known to be influenced by genetic and environmental factors, and several susceptibility genes have been discovered. Still, the majority of genetic contributors remain unknown. We aimed to analyze the plasma proteome of breast cancer patients in comparison to healthy individuals to identify differences in protein expression profiles and discover novel biomarkers.","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"25 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRIGENDUM: Correction of the ethical statements. Training efficacy of robotic duct-to-mucosa pancreaticojejunostomy simulation using silicone models for surgical fellows.","authors":"Mirang Lee, Youngmin Han, Jae Seung Kang, Yoo Jin Choi, Hee Ju Sohn, Wooil Kwon, Jin-Young Jang","doi":"10.4174/astr.2024.106.4.241","DOIUrl":"https://doi.org/10.4174/astr.2024.106.4.241","url":null,"abstract":"[This corrects the article on p. 45 in vol. 106, PMID: 38205096.].","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"25 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of bilateral axillo-breast approach robotic parathyroidectomy versus open parathyroidectomy for primary hyperparathyroidism: a single-institution retrospective study.","authors":"Jae Bong Choi, Jee-Hye Choi, Yoon Kong, Ja Kyung Lee, Woochul Kim, Hyeong Won Yu, Su-Jin Kim, Young Jun Chai, June Young Choi, Kyu Eun Lee","doi":"10.4174/astr.2024.106.4.203","DOIUrl":"https://doi.org/10.4174/astr.2024.106.4.203","url":null,"abstract":"Bilateral axillo-breast approach robotic parathyroidectomy (BABA-RP) aims to remove overactive or enlarged parathyroid glands with no visible neck collar incision. In this study, we compared the safety and surgical outcomes of BABA-RP <i>vs.</i> those of an open surgery group to ascertain whether BABA-RP is a safe and feasible surgical approach for patients with primary hyperparathyroidism (pHPT).","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"7 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High ligation with posterior wall repair for inguinal hernia repair in young adults: a nationwide cohort study.","authors":"Kil-Yong Lee, Jaeim Lee, Dongjae Kim, Seong Taek Oh","doi":"10.4174/astr.2024.106.4.231","DOIUrl":"https://doi.org/10.4174/astr.2024.106.4.231","url":null,"abstract":"This study evaluated the difference in the recurrence of inguinal hernia in young adult patients who underwent either high ligation alone or high ligation with posterior wall repair using nationwide data.","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"54 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of totally laparoscopic and laparoscopic-assisted approach in gastrectomy with D2 lymphadenectomy for advanced gastric cancer after neoadjuvant chemotherapy: a retrospective comparative study.","authors":"Zhenyu Chen, Guangyu Chen, Yan Li, Sha Kou, Tao Wang, Lin Zhang, Yongkuan Cao, Liye Liu","doi":"10.4174/astr.2024.106.4.218","DOIUrl":"https://doi.org/10.4174/astr.2024.106.4.218","url":null,"abstract":"Neoadjuvant chemotherapy is strongly recommended for advanced gastric cancer due to good local control and a high rate of R0 dissection with this strategy. Minimally invasive techniques such as laparoscopy-assisted or total laparoscopic approaches is becoming more and more acceptable in the treatment for gastric cancer. However, the safety and efficiency of total laparoscopic D2 gastrectomy (TLG) for advanced gastric cancer after neoadjuvant chemotherapy have not been well evaluated.","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"184 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fate of small remnant pancreatic tail in splenic hilum after laparoscopic spleen preserving distal pancreatectomy: a retrospective study.","authors":"Okjoo Lee, So Kyung Yoon, So Jeong Yoon, Hongbeom Kim, In Woong Han, Jin Seok Heo, Sang Hyun Shin","doi":"10.4174/astr.2024.106.4.211","DOIUrl":"https://doi.org/10.4174/astr.2024.106.4.211","url":null,"abstract":"When performing laparoscopic spleen-preserving distal pancreatectomy (LSPDP), sometimes, anatomically challenging patients are encountered, where the pancreatic tail is deep in the splenic hilum. The purpose of this study was to discuss the experience with the surgical technique of leaving the deep pancreatic tail of the splenic hilum in these patients.","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"8 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe and successful pregnancy following breast cancer treatment in young patients 35 years old or under without invasive fertility preservation: a retrospective study.","authors":"Ji Hye Kim, Yong Yeup Kim, Jai Hyun Chung, Woo Young Kim, Jae Bok Lee, Sang Uk Woo","doi":"10.4174/astr.2024.106.4.189","DOIUrl":"https://doi.org/10.4174/astr.2024.106.4.189","url":null,"abstract":"Recent advances in the treatment of breast cancer have led to the improvement of breast cancer patient's survival. With the prolonged survival of these patients, pregnancy became an important issue, especially in young cancer patient aged 35 years or under. Increased hormone levels during pregnancy, however, raise concerns about elevating the risk of cancer recurrence. The aim of this study was to validate the notion of increased risk associated with pregnancy after breast cancer treatment in young patients.","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"54 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}