Annual review of pharmacology and toxicology最新文献_第7页

Pharmacological Interventions in Labor and Delivery. 分娩中的药物干预。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI: 10.1146/annurev-pharmtox-051921-122822

Susan Wray, Sarah Arrowsmith, Andrew Sharp

引用次数: 3

Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review. 了解胎儿发育和幼儿期化学物质暴露:综述。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI: 10.1146/annurev-pharmtox-051922-113350

Magdaléna Krausová, Dominik Braun, Tina Buerki-Thurnherr, Claudia Gundacker, Eva Schernhammer, Lukas Wisgrill, Benedikt Warth

{"title":"Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review.","authors":"Magdaléna Krausová, Dominik Braun, Tina Buerki-Thurnherr, Claudia Gundacker, Eva Schernhammer, Lukas Wisgrill, Benedikt Warth","doi":"10.1146/annurev-pharmtox-051922-113350","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-051922-113350","url":null,"abstract":"Early human life is considered a critical window of susceptibility to external exposures. Infants are exposed to a multitude of environmental factors, collectively referred to as the exposome. The chemical exposome can be summarized as the sum of all xenobiotics that humans are exposed to throughout a lifetime. We review different exposure classes and routes that impact fetal and infant metabolism and the potential toxicological role of mixture effects. We also discuss the progress in human biomonitoring and present possiblemodels for studying maternal-fetal transfer. Data gaps on prenatal and infant exposure to xenobiotic mixtures are identified and include natural biotoxins, in addition to commonly reported synthetic toxicants, to obtain a more holistic assessment of the chemical exposome. We highlight the lack of large-scale studies covering a broad range of xenobiotics. Several recommendations to advance our understanding of the early-life chemical exposome and the subsequent impact on health outcomes are proposed.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":"63 ","pages":"517-540"},"PeriodicalIF":12.5,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10564763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment. 与精神分裂症相关的认知障碍:从病理生理学到治疗。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI: 10.1146/annurev-pharmtox-051921-093250

Daniel C Javitt

{"title":"Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment.","authors":"Daniel C Javitt","doi":"10.1146/annurev-pharmtox-051921-093250","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-051921-093250","url":null,"abstract":"Cognitive impairment is a core feature of schizophrenia and a major contributor to poor functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are now well established. In addition, there has been increasing appreciation in recent years of the additional role of social cognitive impairment in driving functional outcomes and of the contributions of sensory-level dysfunction to higher-order impairments. At the neurochemical level, acute administration of N-methyl-d-aspartate receptor (NMDAR) antagonists reproduces the pattern of neurocognitive dysfunction associated with schizophrenia, encouraging the development of treatments targeted at both NMDAR and its interactome. At the local-circuit level, an auditory neurophysiological measure, mismatch negativity, has emerged both as a veridical index of NMDAR dysfunction and excitatory/inhibitory imbalance in schizophrenia and as a critical biomarker for early-stage translational drug development. Although no compounds have yet been approved for treatment of cognitive impairment associated with schizophrenia, several candidates are showing promise in early-phase testing.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":"63 ","pages":"119-141"},"PeriodicalIF":12.5,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10570682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Biased Agonism: Lessons from Studies of Opioid Receptor Agonists. 偏倚激动作用:阿片受体激动剂研究的启示。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI: 10.1146/annurev-pharmtox-052120-091058

Eamonn Kelly, Alexandra Conibear, Graeme Henderson

引用次数: 14

Introduction to the Theme "Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care". 介绍主题“新药的发展:从实验室到床边，改善病人护理”。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI: 10.1146/annurev-pharmtox-091222-022612

Terrence F Blaschke, Paul A Insel, Susan G Amara, Urs A Meyer

{"title":"Introduction to the Theme \"Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care\".","authors":"Terrence F Blaschke, Paul A Insel, Susan G Amara, Urs A Meyer","doi":"10.1146/annurev-pharmtox-091222-022612","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-091222-022612","url":null,"abstract":"Investigations in pharmacology and toxicology range from molecular studies to clinical care. Studies in basic and clinical pharmacology and in preclinical and clinical toxicology are all essential in bringing new knowledge and new drugs into clinical use. The 30 reviews in Volume 63 of the Annual Review of Pharmacology and Toxicology explore topics across this spectrum. Examples include \"Zebrafish as a Mainstream Model for In Vivo Systems Pharmacology and Toxicology\" and \"Artificial Intelligence and Machine Learning for Lead-to-Candidate Decision-Making and Beyond.\" Other reviews discuss components important for drug discovery and development and the use of pharmaceuticals in a variety of diseases. Air pollution continues to increase globally; accordingly, \"Air Pollution-Related Neurotoxicity Across the Life Span\" is a timely and forward-thinking review. Volume 63 also explores the use of contemporary technologies such as electronic health records, pharmacogenetics, and new drug delivery systems that help enhance and improve the utility of new therapies.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":"63 ","pages":"15-18"},"PeriodicalIF":12.5,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10741368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Roadmap for Achieving Universal Antiretroviral Treatment. 实现普及抗逆转录病毒治疗的路线图。

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI: 10.1146/annurev-pharmtox-052020-094321

Simiso Sokhela, Samanta Lalla-Edward, Mark J Siedner, Mohammed Majam, Willem Daniel Francois Venter

{"title":"Roadmap for Achieving Universal Antiretroviral Treatment.","authors":"Simiso Sokhela, Samanta Lalla-Edward, Mark J Siedner, Mohammed Majam, Willem Daniel Francois Venter","doi":"10.1146/annurev-pharmtox-052020-094321","DOIUrl":"10.1146/annurev-pharmtox-052020-094321","url":null,"abstract":"Modern antiretroviral therapy safely, potently, and durably suppresses human immunodeficiency virus (HIV) that, if left untreated, predictably causes acquired immunodeficiency syndrome (AIDS), which has been responsible for tens of millions of deaths globally since it was described in 1981. In one of the most extraordinary medical success stories in modern times, a combination of pioneering basic science, innovative drug development, and ambitious public health programming resulted in access to lifesaving, safe drugs, taken as an oral tablet daily, for most of the world. However, substantial challenges remain in the fields of prevention, timely access to diagnosis, and treatment, especially in pediatric and adolescent patients. As HIV-positive adults age, treating their comorbidities will require understanding the course of different chronic diseases complicated by HIV-related and antiretroviral toxicities and finding potential treatments. Finally, new long-acting antiretrovirals on the horizon promise exciting new options in both the prevention and treatment fields.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":"63 ","pages":"99-117"},"PeriodicalIF":11.2,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10807407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10731503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Duality of Arsenic Metabolism: Impact on Human Health. 砷代谢的二重性:对人体健康的影响。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI: 10.1146/annurev-pharmtox-051921-020936

Mahmoud A El-Ghiaty, Ayman O S El-Kadi

引用次数: 13

G Protein-Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications. G 蛋白偶联雌激素受体 GPER：分子药理学与治疗应用》。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI: 10.1146/annurev-pharmtox-031122-121944

Jeffrey B Arterburn, Eric R Prossnitz

{"title":"G Protein-Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications.","authors":"Jeffrey B Arterburn, Eric R Prossnitz","doi":"10.1146/annurev-pharmtox-031122-121944","DOIUrl":"10.1146/annurev-pharmtox-031122-121944","url":null,"abstract":"The actions of estrogens and related estrogenic molecules are complex and multifaceted in both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways that produce and respond to estrogens. Multiple receptors promulgate these responses, including the classical estrogen receptors of the nuclear hormone receptor family (estrogen receptors α and β), which function largely as ligand-activated transcription factors, and the 7-transmembrane G protein-coupled estrogen receptor, GPER, which activates a diverse array of signaling pathways. The pharmacology and functional roles of GPER in physiology and disease reveal important roles in responses to both natural and synthetic estrogenic compounds in numerous physiological systems. These functions have implications in the treatment of myriad disease states, including cancer, cardiovascular diseases, and metabolic disorders. This review focuses on the complex pharmacology of GPER and summarizes major physiological functions of GPER and the therapeutic implications and ongoing applications of GPER-targeted compounds.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":"63 ","pages":"295-320"},"PeriodicalIF":12.5,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9397068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Harnessing the Power of Electronic Health Records and Genomics for Drug Discovery. 利用电子健康记录和基因组学的力量进行药物研发。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI: 10.1146/annurev-pharmtox-051421-111324

Kristi Krebs, Lili Milani

引用次数: 1

Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable? 丝裂原活化蛋白激酶磷酸酶：不再不可救药？

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI: 10.1146/annurev-pharmtox-051921-121923

Shanelle R Shillingford, Anton M Bennett

{"title":"Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?","authors":"Shanelle R Shillingford, Anton M Bennett","doi":"10.1146/annurev-pharmtox-051921-121923","DOIUrl":"10.1146/annurev-pharmtox-051921-121923","url":null,"abstract":"Phosphatases and kinases maintain an equilibrium of dephosphorylated and phosphorylated proteins, respectively, that are required for critical cellular functions. Imbalance in this equilibrium or irregularity in their function causes unfavorable cellular effects that have been implicated in the development of numerous diseases. Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of protein substrates on tyrosine residues, and their involvement in cell signaling and diseases such as cancer and inflammatory and metabolic diseases has made them attractive therapeutic targets. However, PTPs have proved challenging in therapeutics development, garnering them the unfavorable reputation of being undruggable. Nonetheless, great strides have been made toward the inhibition of PTPs over the past decade. Here, we discuss the advancement in small-molecule inhibition for the PTP subfamily known as the mitogen-activated protein kinase (MAPK) phosphatases (MKPs). We review strategies and inhibitor discovery tools that have proven successful for small-molecule inhibition of the MKPs and discuss what the future of MKP inhibition potentially might yield.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":"63 ","pages":"617-636"},"PeriodicalIF":12.5,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9351418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5