Pharmacogenomics Beyond Single Common Genetic Variants: The Way Forward.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Volker M Lauschke, Yitian Zhou, Magnus Ingelman-Sundberg
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引用次数: 0

Abstract

Interindividual variability in genes encoding drug-metabolizing enzymes, transporters, receptors, and human leukocyte antigens has a major impact on a patient's response to drugs with regard to efficacy and safety. Enabled by both technological and conceptual advances, the field of pharmacogenomics is developing rapidly. Major progress in omics profiling methods has enabled novel genotypic and phenotypic characterization of patients and biobanks. These developments are paralleled by advances in machine learning, which have allowed us to parse the immense wealth of data and establish novel genetic markers and polygenic models for drug selection and dosing. Pharmacogenomics has recently become more widespread in clinical practice to personalize treatment and to develop new drugs tailored to specific patient populations. In this review, we provide an overview of the latest developments in the field and discuss the way forward, including how to address the missing heritability, develop novel polygenic models, and further improve the clinical implementation of pharmacogenomics.

药物基因组学超越单一常见基因变异:前进之路。
编码药物代谢酶、转运体、受体和人类白细胞抗原的基因的个体间变异对患者在疗效和安全性方面对药物的反应有重大影响。在技术和概念进步的推动下,药物基因组学领域正在迅速发展。全息分析方法的重大进展使得对患者和生物库进行新的基因型和表型特征描述成为可能。与此同时,机器学习也取得了进展,使我们能够解析大量数据,并建立新的遗传标记和多基因模型,用于药物选择和剂量。最近,药物基因组学在临床实践中越来越广泛地应用于个性化治疗和开发针对特定患者群体的新药。在这篇综述中,我们概述了该领域的最新进展,并讨论了未来的发展方向,包括如何解决遗传率缺失问题、开发新型多基因模型以及进一步改善药物基因组学的临床应用。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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