Annals of Pediatric Cardiology最新文献

{"title":"Cryoablation for the Para-Hisian accessory pathway: Early Indian experience.","authors":"Nayani Makkar, Jyothi Vijay, P Abhilash Sreevilasam, Narayanan Namboodiri","doi":"10.4103/apc.apc_182_23","DOIUrl":"10.4103/apc.apc_182_23","url":null,"abstract":"","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":"17 1","pages":"88-90"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it time to consider a population health approach and health policy planning in pediatric cardiac workforce planning?","authors":"Bistra Zheleva, Veeralakshmi Rajasekhar","doi":"10.4103/apc.apc_171_23","DOIUrl":"10.4103/apc.apc_171_23","url":null,"abstract":"","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":"16 6","pages":"481-482"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling post-MIS-N cardiomyopathy by longitudinal multimodality global cardiac assessment from neonatal insult to 16-month follow-up.","authors":"Maitri Chaudhuri, Munesh Tomar, Balasubramanyam Shankar","doi":"10.4103/apc.apc_114_23","DOIUrl":"10.4103/apc.apc_114_23","url":null,"abstract":"<p><p>A full-term male neonate presented on the 11^th day of life with late-onset multisystem inflammatory syndrome-neonate (MIS-N) (cardioneurological compromise). Immediate anti-inflammatory modulation led to a gradual recovery of neurological and coronary lesions. However, temporal evaluation unmasked silent myocardial dysfunction in echocardiography validated further by elevated biomarkers, myocardial fibrosis in cardiac magnetic resonance imaging, and abnormal strain study persisting till 16 months of follow-up. This revealed a hitherto unknown and rare progression of MIS-N into dilated cardiomyopathy.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":"16 6","pages":"463-467"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal pulmonary venous drainage in the setting of total anomalous pulmonary venous connection.","authors":"Saikiran Kakarla, Deepa Sasikumar, Harikrishnan K N Kurup, Jineesh Valakkada","doi":"10.4103/apc.apc_183_21","DOIUrl":"10.4103/apc.apc_183_21","url":null,"abstract":"<p><p>Total anomalous pulmonary venous connection (TAPVC) and anomalous pulmonary venous drainage are not synonymous. This has been described in the setting of right isomerism (bilateral right sidedness) where the pulmonary veins are connected anomalously but drain normally to the left-sided morphological right atrium. We describe another situation in right isomerism where normal pulmonary venous drainage is present in the setting of TAPVC.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":"16 6","pages":"478-480"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in outcomes between surgical pericardial window and pericardiocentesis in children with postpericardiotomy syndrome.","authors":"Joshua T Fields, Conor P O'Halloran, Paul Tannous, Brock A Karolcik, Scott M Bradley, Minoo N Kavarana, John F Rhodes, Eric M Graham, John M Costello","doi":"10.4103/apc.apc_108_23","DOIUrl":"10.4103/apc.apc_108_23","url":null,"abstract":"<p><p>Children with postpericardiotomy syndrome may develop hemodynamically significant pericardial effusions warranting drainage by surgical pericardial window or pericardiocentesis. The optimal approach is unknown. We performed a retrospective observational study at two pediatric cardiac centers. We included 42 children aged <18 years who developed postpericardiotomy syndrome following cardiac surgery between 2014 and 2021. Thirty-two patients underwent pericardial window and 10 underwent pericardiocentesis. Patients in the pericardial window group presented with postpericardiotomy syndrome sooner than those who underwent pericardiocentesis (median 7.5 days vs. 14.5 days, <i>P</i> = 0.03) and tended to undergo earlier intervention (median 8 days vs. 16 days, <i>P</i> = 0.16). No patient required subsequent drainage. There were no differences between groups in days of pericardial tube duration (median 4 days), complications, and subsequent days of intensive care or hospitalization. For children with postpericardiotomy syndrome with a pericardial effusion warranting drainage, these data suggest that pericardial window and pericardiocentesis have similar efficacy, safety, and resource utilization.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":"16 6","pages":"422-425"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision medicine in catecholaminergic polymorphic ventricular tachycardia: Recent advances toward personalized care.","authors":"Anthony Siu, Edelyne Tandanu, Brian Ma, Evbayekha Endurance Osas, Haipeng Liu, Tong Liu, Oscar Hou In Chou, Helen Huang, Gary Tse","doi":"10.4103/apc.apc_96_23","DOIUrl":"10.4103/apc.apc_96_23","url":null,"abstract":"<p><p>Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited cardiac ion channelopathy where the initial disease presentation is during childhood or adolescent stages, leading to increased risks of sudden cardiac death. Despite advances in medical science and technology, several gaps remain in the understanding of the molecular mechanisms, risk prediction, and therapeutic management of patients with CPVT. Recent studies have identified and validated seven sets of genes responsible for various CPVT phenotypes, including RyR2, CASQ-2, TRDN, CALM1, 2, and 3, and TECRL, providing novel insights into the molecular mechanisms. However, more data on atypical CPVT genotypes are required to investigate the underlying mechanisms further. The complexities of the underlying genetics contribute to challenges in risk stratification as well as the uncertainty surrounding nongenetic modifiers. Therapeutically, although medical management involving beta-blockers and flecainide, or insertion of an implantable cardioverter defibrillator remains the mainstay of treatment, animal and stem cell studies on gene therapy for CPVT have shown promising results. However, its clinical applicability remains unclear. Current gene therapy studies have primarily focused on the RyR2 and CASQ-2 variants, which constitute 75% of all CPVT cases. Alternative approaches that target a broader population, such as CaMKII inhibition, could be more feasible for clinical implementation. Together, this review provides an update on recent research on CPVT, highlighting the need for further investigation of the molecular mechanisms, risk stratification, and therapeutic management of this potentially lethal condition.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":"16 6","pages":"431-446"},"PeriodicalIF":0.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial anomalous systemic venous drainage, right superior vena cava to the left atrium in nonisomeric patient.","authors":"Salem Deraz, Olfat Alzaabi, Anshad Ummerkhan, Sidra Abdul Hakeem, Hamza Elnady, Ahmed Al Kamali","doi":"10.4103/apc.apc_93_23","DOIUrl":"10.4103/apc.apc_93_23","url":null,"abstract":"<p><p>The most encountered anomalous systemic venous drainage is a persistent left superior vena cava that drains into the right atrium through the coronary sinus. A much rarer anomalous systemic venous drainage is that of isolated anomalous drainage of a normally positioned right superior vena cava (RSVC) into the left atrium (LA). This has been reported in approximately 20 patients, with the diagnosis usually made by cardiac catheterization. We report the youngest case diagnosed at the age of 3 h after birth with hypoxemia resulting from anomalous drainage of a normal RSVC into the LA. This was diagnosed noninvasively by echocardiography and confirmed by cardiac computed tomography angiography.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":"16 6","pages":"468-471"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric cardiology in India - In search of a holistic solution.","authors":"Jaganmohan A Tharakan, Rajesh Sharma, Raghavan Subramanyan, Anita Saxena, Snehal M Kulkarni, Jay Relan, Sivasubramanian Ramakrishnan","doi":"10.4103/apc.apc_58_24","DOIUrl":"10.4103/apc.apc_58_24","url":null,"abstract":"<p><p>In response to the survey among early career pediatric cardiologists from India and the accompanying editorial, we invited comments and suggestions from thought leaders and senior functionaries in the field. We have summarized the thoughts and suggestions as a mini-symposium.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":"16 6","pages":"447-453"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter closure of large ostium secundum atrial septal defects in symptomatic small children: A single-center retrospective study.","authors":"Jahangir Ahmed Naseem, Mirza Shohiab Ur Riyaz, Shobhit Priyanshu Joseph, Jesu Krupa, Mayank Agarwal, Pratheesh George Mathen, Oommen K George, Paul V George, John Jose, Viji Samuel Thomson","doi":"10.4103/apc.apc_163_23","DOIUrl":"10.4103/apc.apc_163_23","url":null,"abstract":"<p><strong>Background: </strong>In general, the risks associated with transcatheter atrial septal defect (ASD) device closure are reported to be relatively low, but the evidence stems from trials involving adults and older children. Current guidelines do not recommend ASD device closure in children with defect sizes >20 mm due to limited data available in this group of patients. This retrospective study sought to determine the clinical and procedural characteristics of successful transcatheter ASD device closure in small children with large defects and assess the complication rates and reasons for unsuccessful device closure.</p><p><strong>Methods: </strong>We retrospectively reviewed the data of all patients who underwent elective transcatheter closure of ostium secundum ASD in our department between September 2013 and February 2022. All children weighing <20 kg, requiring a device of size 20 mm or greater, were included. Major and minor complications were predefined and indications for referral were evaluated. Echocardiogram reports were reviewed from the time of referral, postcatheterization day 1, and at 1-year follow-up.</p><p><strong>Results: </strong>We identified 40 patients meeting inclusion criteria with a median (interquartile range [IQR]) procedural age of 5 (4-7) years and median (IQR) weight of 14 (12-18) kg. Successful device closure was achieved in 39 patients with a success rate of 97.5%. The total complication rate was 2.5% (95% confidence interval: 0.44%- I2.8%) with only 1 major complication. All children had right heart enlargement and exertional dyspnea, 30% of patients had recurrent lower respiratory tract infections, and 10% had failure to thrive. At 1-year follow-up, a transthoracic echocardiogram showed a well-endothelialized device in a stable position in all the patients, and none of the patients had a residual shunt.</p><p><strong>Conclusion: </strong>In experienced centers, percutaneous ASD closure of large defects in symptomatic small children can be done effectively and safely with a great degree of predictability and a low complication rate.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":"16 6","pages":"393-398"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between alveolar functional fraction and clinical outcomes in children during postoperative care after surgery for single-ventricular heart.","authors":"Dana Barry, Ellen A Spurrier, Jigar C Chauhan","doi":"10.4103/apc.apc_111_23","DOIUrl":"10.4103/apc.apc_111_23","url":null,"abstract":"<p><strong>Background: </strong>Optimization of pulmonary to systemic blood flow (Qp: Qs) is the key to postoperative care of children with a single-ventricular heart. The ratio of end-tidal CO2 to partial pressure of CO2 called alveolar functional fraction (AFF) has shown a strong relationship with Qp: Qs in the catheterization lab in this population (with Qp: Qs of 1 correlating with AFF of 0.7). As there are no studies to understand the relationship between AFF and clinical outcomes in the postoperative care of these children, this study was carried out.</p><p><strong>Methodology and results: </strong>This retrospective cohort study included 29 postoperative periods of children who underwent surgery for a single-ventricular heart. The average AFF was calculated for each early postoperative period. The primary clinical outcome was time in hours to normalize lactate. Other clinical outcomes included duration of mechanical ventilation, duration of milrinone infusion; presence of acute kidney injury (AKI), seizures and necrotizing enterocolitis (NEC); need for tracheostomy, need for extra-corporeal support, and mortality in the first 60 days postoperatively. The study population was divided into Group 1 with AFF ≤0.7 and Group 2 with AFF >0.7, to compare the outcome differences between the groups. Time to normalize the lactate had a modest negative correlation with the AFF, with Pearson's <i>r</i> = -0.49 (<i>P</i> = 0.007) for the entire cohort. The clinical outcomes were not statistically different for groups with AFF ≤0.7 and with AFF >0.7, although the group with AFF ≤0.7 had a higher incidence of NEC and higher mortality, whereas the group with AFF >0.7 had a higher incidence of AKI.</p><p><strong>Conclusions: </strong>In this small study, the AFF showed a modest negative correlation with the time to normalize lactate in postoperative care after surgery for a single-ventricle heart. There were the trends with some other important clinical outcomes but not statistically significant. A larger, multi-center study is needed to delineate these relationships further.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":"16 6","pages":"407-412"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}