Annual review of nutrition最新文献_第6页

A Conversation with James Ntambi. James Ntambi访谈

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2023-08-21 Epub Date: 2023-05-30 DOI: 10.1146/annurev-nutr-061021-020321

James M Ntambi, Patrick J Stover

{"title":"A Conversation with James Ntambi.","authors":"James M Ntambi, Patrick J Stover","doi":"10.1146/annurev-nutr-061021-020321","DOIUrl":"10.1146/annurev-nutr-061021-020321","url":null,"abstract":"An interview with James M. Ntambi, professor of biochemistry and the Katherine Berns Van Donk Steenbock Professor in Nutrition, College of Agricultural and Life Sciences, at the University of Wisconsin-Madison, took place via Zoom in April 2022. He was interviewed by Patrick J. Stover, director of the Institute for Advancing Health through Agriculture and professor of nutrition and biochemistry and biophysics at Texas A&M University. Dr. James Ntambi is a true pioneer in the field of nutritional biochemistry. He was among the very first to discover and elucidate the role that diet and nutrients play in regulating metabolism through changes in the expression of metabolic genes, focusing on the de novo lipogenesis pathways. As an African immigrant from Uganda, his love of science and his life experiences in African communities suffering from severe malnutrition molded his scientific interests at the interface of biochemistry and nutrition. Throughout his career, he has been an academic role model, a groundbreaking nutrition scientist, and an educator. His commitment to experiential learning through the many study-abroad classes he has hosted in Uganda has provided invaluable context for American students in nutrition. Dr. Ntambi's passion for education and scientific discovery is his legacy, and the field of nutrition has benefited enormously from his unique perspectives and contributions to science that are defined by his scientific curiosity, his generosity to his students and colleagues, and his life experiences. The following is an edited transcript.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"1-23"},"PeriodicalIF":12.6,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10176067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Mechanisms of Iron and Heme Metabolism. 铁和血红素代谢的分子机制。

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062320-112625

Sohini Dutt, Iqbal Hamza, Thomas Benedict Bartnikas

引用次数: 24

Glucose-Dependent Insulinotropic Polypeptide-A Postprandial Hormone with Unharnessed Metabolic Potential. 葡萄糖依赖型胰岛素多肽-一种具有未开发代谢潜能的餐后激素。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2022-08-22 Epub Date: 2022-05-24 DOI: 10.1146/annurev-nutr-062320-113625

Nunzio Guccio, Fiona M Gribble, Frank Reimann

引用次数: 0

The Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease. 猪油以神秘的方式起作用:神经酰胺与营养相关的慢性疾病。

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062220-112920

Rebekah J Nicholson, Marie K Norris, Annelise M Poss, William L Holland, Scott A Summers

{"title":"The Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease.","authors":"Rebekah J Nicholson, Marie K Norris, Annelise M Poss, William L Holland, Scott A Summers","doi":"10.1146/annurev-nutr-062220-112920","DOIUrl":"https://doi.org/10.1146/annurev-nutr-062220-112920","url":null,"abstract":"Diet influences onset, progression, and severity of several chronic diseases, including heart failure, diabetes, steatohepatitis, and a subset of cancers. The prevalence and clinical burden of these obesity-linked diseases has risen over the past two decades. These metabolic disorders are driven by ectopic lipid deposition in tissues not suited for fat storage, leading to lipotoxic disruption of cell function and survival. Sphingolipids such as ceramides are among the most deleterious and bioactive metabolites that accrue, as they participate in selective insulin resistance, dyslipidemia, oxidative stress and apoptosis. This review discusses our current understanding of biochemical pathways controlling ceramide synthesis, production and action; influences of diet on ceramide levels; application of circulating ceramides as clinical biomarkers of metabolic disease; and molecular mechanisms linking ceramides to altered metabolism and survival of cells. Development of nutritional or pharmacological strategies to lower ceramides could have therapeutic value in a wide range of prevalent diseases.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"42 ","pages":"115-144"},"PeriodicalIF":8.9,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399075/pdf/nihms-1811128.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9759291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Obesity Dysregulates the Immune Response to Influenza Infection and Vaccination Through Metabolic and Inflammatory Mechanisms. 肥胖症通过代谢和炎症机制调节对流感感染和疫苗接种的免疫反应

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062320-115937

Saame Raza Shaikh, Nancie J MacIver, Melinda A Beck

{"title":"Obesity Dysregulates the Immune Response to Influenza Infection and Vaccination Through Metabolic and Inflammatory Mechanisms.","authors":"Saame Raza Shaikh, Nancie J MacIver, Melinda A Beck","doi":"10.1146/annurev-nutr-062320-115937","DOIUrl":"10.1146/annurev-nutr-062320-115937","url":null,"abstract":"The COVID-19 pandemic demonstrates that obesity alone, independent of comorbidities, is a significant risk factor for severe outcomes from infection. This susceptibility mirrors a similar pattern with influenza infection; that is, obesity is a unique risk factor for increased morbidity and mortality. Therefore, it is critical to understand how obesity contributes to a reduced ability to respond to respiratory viral infections. Herein, we discuss human and animal studies with influenza infection and vaccination that show obesity impairs immunity. We cover several key mechanisms for the dysfunction. These mechanisms include systemic and cellular level changes that dysregulate immune cell metabolism and function in addition to how obesity promotes deficiencies in metabolites that control the resolution of inflammation and infection. Finally, we discuss major gaps in knowledge, particularly as they pertain to diet and mechanisms, which will drive future efforts to improve outcomes in response to respiratory viral infections in an increasingly obese population.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"42 ","pages":"67-89"},"PeriodicalIF":8.9,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9346641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models. 性别作为营养研究中的生物变量:从人体研究到动物模型。

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062220-105852

Yilin Chen, Minhoo Kim, Sanjana Paye, Bérénice A Benayoun

引用次数: 7

The Origins, Evolution, and Future of Dietary Methionine Restriction. 膳食蛋氨酸限制的起源、演变和未来。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2022-08-22 Epub Date: 2022-05-19 DOI: 10.1146/annurev-nutr-062320-111849

Han Fang, Kirsten P Stone, Desiree Wanders, Laura A Forney, Thomas W Gettys

{"title":"The Origins, Evolution, and Future of Dietary Methionine Restriction.","authors":"Han Fang, Kirsten P Stone, Desiree Wanders, Laura A Forney, Thomas W Gettys","doi":"10.1146/annurev-nutr-062320-111849","DOIUrl":"10.1146/annurev-nutr-062320-111849","url":null,"abstract":"The original description of dietary methionine restriction (MR) used semipurified diets to limit methionine intake to 20% of normal levels, and this reduction in dietary methionine increased longevity by ∼30% in rats. The MR diet also produces paradoxical increases in energy intake and expenditure and limits fat deposition while reducing tissue and circulating lipids and enhancing overall insulin sensitivity. In the years following the original 1993 report, a comprehensive effort has been made to understand the nutrient sensing and signaling systems linking reduced dietary methionine to the behavioral, physiological, biochemical, and transcriptional components of the response. Recent work has shown that transcriptional activation of hepatic fibroblast growth factor 21 (FGF21) is a key event linking the MR diet to many but not all components of its metabolic phenotype. These findings raise the interesting possibility of developing therapeutic, MR-based diets that produce the beneficial effects of FGF21 by nutritionally modulating its transcription and release.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"42 ","pages":"201-226"},"PeriodicalIF":12.6,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936953/pdf/nihms-1854633.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10044735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprogramming of Hepatic Metabolism and Microenvironment in Nonalcoholic Steatohepatitis. 非酒精性脂肪性肝炎的肝脏代谢和微环境重编程。

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062220-105200

Liangyou Rui, Jiandie D Lin

引用次数: 15

National Food Intake Assessment: Technologies to Advance Traditional Methods. 国家食物摄入评估:改进传统方法的技术。

IF 8.9 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-062320-110636

Alanna J Moshfegh, Donna G Rhodes, Carrie L Martin

引用次数: 4

Folic Acid and the Prevention of Birth Defects: 30 Years of Opportunity and Controversies. 叶酸与预防出生缺陷：30年的机遇与争议。

IF 12.6 2区医学

Annual review of nutrition Pub Date : 2022-08-22 DOI: 10.1146/annurev-nutr-043020-091647

Krista S Crider, Yan Ping Qi, Lorraine F Yeung, Cara T Mai, Lauren Head Zauche, Arick Wang, Kelicia Daniels, Jennifer L Williams

{"title":"Folic Acid and the Prevention of Birth Defects: 30 Years of Opportunity and Controversies.","authors":"Krista S Crider, Yan Ping Qi, Lorraine F Yeung, Cara T Mai, Lauren Head Zauche, Arick Wang, Kelicia Daniels, Jennifer L Williams","doi":"10.1146/annurev-nutr-043020-091647","DOIUrl":"10.1146/annurev-nutr-043020-091647","url":null,"abstract":"For three decades, the US Public Health Service has recommended that all persons capable of becoming pregnant consume 400 μg/day of folic acid (FA) to prevent neural tube defects (NTDs). The neural tube forms by 28 days after conception. Fortification can be an effective NTD prevention strategy in populations with limited access to folic acid foods and/or supplements. This review describes the status of mandatory FA fortification among countries that fortify (n = 71) and the research describing the impact of those programs on NTD rates (up to 78% reduction), blood folate concentrations [red blood cell folate concentrations increased ∼1.47-fold (95% CI, 1.27, 1.70) following fortification], and other health outcomes. Across settings, high-quality studies such as those with randomized exposures (e.g., randomized controlled trials, Mendelian randomization studies) are needed to elucidate interactions of FA with vitamin B12 as well as expanded biomarker testing.","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"42 ","pages":"423-452"},"PeriodicalIF":12.6,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875360/pdf/nihms-1856824.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10398780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0