Tomás Cerdó, Ana Nieto-Ruíz, José Antonio García-Santos, Anna Rodríguez-Pöhnlein, María García-Ricobaraza, Antonio Suárez, Mercedes G Bermúdez, Cristina Campoy
{"title":"Current Knowledge About the Impact of Maternal and Infant Nutrition on the Development of the Microbiota-Gut-Brain Axis.","authors":"Tomás Cerdó, Ana Nieto-Ruíz, José Antonio García-Santos, Anna Rodríguez-Pöhnlein, María García-Ricobaraza, Antonio Suárez, Mercedes G Bermúdez, Cristina Campoy","doi":"10.1146/annurev-nutr-061021-025355","DOIUrl":"10.1146/annurev-nutr-061021-025355","url":null,"abstract":"<p><p>The prenatal and early postnatal periods are stages during which dynamic changes and the development of the brain and gut microbiota occur, and nutrition is one of the most important modifiable factors that influences this process. Given the bidirectional cross talk between the gut microbiota and the brain through the microbiota-gut-brain axis (MGBA), there is growing interest in evaluating the potential effects of nutritional interventions administered during these critical developmental windows on gut microbiota composition and function and their association with neurodevelopmental outcomes. We review recent preclinical and clinical evidence from animal studies and infant/child populations. Although further research is needed, growing evidence suggests that different functional nutrients affect the establishment and development of the microbiota-gut-brain axis and could have preventive and therapeutic use in the treatment of neuropsychiatric disorders. Therefore, more in-depth knowledge regarding the effect of nutrition on the MGBA during critical developmental windows may enable the prevention of later neurocognitive and behavioral disorders and allow the establishment of individualized nutrition-based programs that can be used from the prenatal to the early and middle stages of life.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"251-278"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gluconeogenesis Flux in Metabolic Disease.","authors":"Ankit Shah, Fredric E Wondisford","doi":"10.1146/annurev-nutr-061121-091507","DOIUrl":"10.1146/annurev-nutr-061121-091507","url":null,"abstract":"<p><p>Gluconeogenesis is a critical biosynthetic process that helps maintain whole-body glucose homeostasis and becomes altered in certain medical diseases. We review gluconeogenic flux in various medical diseases, including common metabolic disorders, hormonal imbalances, specific inborn genetic errors, and cancer. We discuss how the altered gluconeogenic activity contributes to disease pathogenesis using data from experiments using isotopic tracer and spectroscopy methodologies. These in vitro, animal, and human studies provide insights into the changes in circulating levels of available gluconeogenesis substrates and the efficiency of converting those substrates to glucose by gluconeogenic organs. We highlight ongoing knowledge gaps, discuss emerging research areas, and suggest future investigations. A better understanding of altered gluconeogenesis flux may ultimately identify novel and targeted treatment strategies for such diseases.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"153-177"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2023-08-21Epub Date: 2023-05-19DOI: 10.1146/annurev-nutr-062220-112240
Judith Storch, Betina Corsico
{"title":"The Multifunctional Family of Mammalian Fatty Acid-Binding Proteins.","authors":"Judith Storch, Betina Corsico","doi":"10.1146/annurev-nutr-062220-112240","DOIUrl":"10.1146/annurev-nutr-062220-112240","url":null,"abstract":"<p><p>Fatty acid-binding proteins (FABPs) are small lipid-binding proteins abundantly expressed in tissues that are highly active in fatty acid (FA) metabolism. Ten mammalian FABPs have been identified, with tissue-specific expression patterns and highly conserved tertiary structures. FABPs were initially studied as intracellular FA transport proteins. Further investigation has demonstrated their participation in lipid metabolism, both directly and via regulation of gene expression, and in signaling within their cells of expression. There is also evidence that they may be secreted and have functional impact via the circulation. It has also been shown that the FABP ligand binding repertoire extends beyond long-chain FAs and that their functional properties also involve participation in systemic metabolism. This article reviews the present understanding of FABP functions and their apparent roles in disease, particularly metabolic and inflammation-related disorders and cancers.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"25-54"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10909404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2023-08-21Epub Date: 2023-05-28DOI: 10.1146/annurev-nutr-061121-094908
Ajita Jadhav, Aditya Bajaj, Yang Xiao, Manasvini Markandey, Vineet Ahuja, Purna C Kashyap
{"title":"Role of Diet-Microbiome Interaction in Gastrointestinal Disorders and Strategies to Modulate Them with Microbiome-Targeted Therapies.","authors":"Ajita Jadhav, Aditya Bajaj, Yang Xiao, Manasvini Markandey, Vineet Ahuja, Purna C Kashyap","doi":"10.1146/annurev-nutr-061121-094908","DOIUrl":"10.1146/annurev-nutr-061121-094908","url":null,"abstract":"<p><p>Diet is an important determinant of health and consequently is often implicated in the development of disease, particularly gastrointestinal (GI) diseases, given the high prevalence of meal-related symptoms. The mechanisms underlying diet-driven pathophysiology are not well understood, but recent studies suggest that gut microbiota may mediate the effect of diet on GI physiology. In this review, we focus primarily on two distinct GI diseases where the role of diet has been best studied: irritable bowel syndrome and inflammatory bowel disease. We discuss how the concurrent and sequential utilization of dietary nutrients by the host and gut microbiota determines the eventual bioactive metabolite profiles in the gut and the biological effect of these metabolites on GI physiology. We highlight several concepts that can be gleaned from these findings, such as how distinct effects of an individual metabolite can influence diverse GI diseases, the effect of similar dietary interventions on multiple disease states, and the need for extensive phenotyping and data collection to help make personalized diet recommendations.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"355-383"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10044027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2023-08-21Epub Date: 2023-05-19DOI: 10.1146/annurev-nutr-061121-091234
Helen J Jones, Claire D Bourke, Jonathan R Swann, Ruairi C Robertson
{"title":"Malnourished Microbes: Host-Microbiome Interactions in Child Undernutrition.","authors":"Helen J Jones, Claire D Bourke, Jonathan R Swann, Ruairi C Robertson","doi":"10.1146/annurev-nutr-061121-091234","DOIUrl":"10.1146/annurev-nutr-061121-091234","url":null,"abstract":"<p><p>Childhood undernutrition is a major global health burden that is only partially resolved by nutritional interventions. Both chronic and acute forms of child undernutrition are characterized by derangements in multiple biological systems including metabolism, immunity, and endocrine systems. A growing body of evidence supports a role of the gut microbiome in mediating these pathways influencing early life growth. Observational studies report alterations in the gut microbiome of undernourished children, while preclinical studies suggest that this can trigger intestinal enteropathy, alter host metabolism, and disrupt immune-mediated resistance against enteropathogens, each of which contribute to poor early life growth. Here, we compile evidence from preclinical and clinical studies and describe the emerging pathophysiological pathways by which the early life gut microbiome influences host metabolism, immunity, intestinal function, endocrine regulation, and other pathways contributing to child undernutrition. We discuss emerging microbiome-directed therapies and consider future research directions to identify and target microbiome-sensitive pathways in child undernutrition.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"327-353"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2023-08-21Epub Date: 2023-06-12DOI: 10.1146/annurev-nutr-061021-022648
Michal K Handzlik, Christian M Metallo
{"title":"Sources and Sinks of Serine in Nutrition, Health, and Disease.","authors":"Michal K Handzlik, Christian M Metallo","doi":"10.1146/annurev-nutr-061021-022648","DOIUrl":"10.1146/annurev-nutr-061021-022648","url":null,"abstract":"<p><p>Amino acid dysregulation has emerged as an important driver of disease progression in various contexts. l-Serine lies at a central node of metabolism, linking carbohydrate metabolism, transamination, glycine, and folate-mediated one-carbon metabolism to protein synthesis and various downstream bioenergetic and biosynthetic pathways. l-Serine is produced locally in the brain but is sourced predominantly from glycine and one-carbon metabolism in peripheral tissues via liver and kidney metabolism. Compromised regulation or activity of l-serine synthesis and disposal occurs in the context of genetic diseases as well as chronic disease states, leading to low circulating l-serine levels and pathogenesis in the nervous system, retina, heart, and aging muscle. Dietary interventions in preclinical models modulate sensory neuropathy, retinopathy, tumor growth, and muscle regeneration. A serine tolerance test may provide a quantitative readout of l-serine homeostasis that identifies patients who may be susceptible to neuropathy or responsive to therapy.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"123-151"},"PeriodicalIF":12.6,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10400346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2023-08-21Epub Date: 2023-05-31DOI: 10.1146/annurev-nutr-062222-023359
Hilary K Seligman, Ronli Levi, Victoria O Adebiyi, Alisha Coleman-Jensen, Joanne F Guthrie, Edward A Frongillo
{"title":"Assessing and Monitoring Nutrition Security to Promote Healthy Dietary Intake and Outcomes in the United States.","authors":"Hilary K Seligman, Ronli Levi, Victoria O Adebiyi, Alisha Coleman-Jensen, Joanne F Guthrie, Edward A Frongillo","doi":"10.1146/annurev-nutr-062222-023359","DOIUrl":"10.1146/annurev-nutr-062222-023359","url":null,"abstract":"<p><p>The US Department of Agriculture's Economic Research Service leads the federal government in data development and research on food security in US households. Nutrition security is an emerging concept that, although closely related, is distinct from food security. No standard conceptualization or measure of nutrition security currently exists. We review the existing research on nutrition security and how it is informed by the more robust literature on food security and diet quality. Based on this review, we propose a conceptual framework for understanding nutrition security and its relationship to food security. We identify two constructs (healthy diets and nutritional status) and multiple subconstructs that form the basis of nutrition security. The proposed framework and corresponding constructs are intended to provide (<i>a</i>) understanding of how nutrition security arises and how it differs from food security, (<i>b</i>) background on why assessment and monitoring of nutrition security is important, and (<i>c</i>) guidance for a research agenda that will further clarify the meaning of nutrition security and its measurement.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"409-429"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10046681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Artificial Intelligence in Deciphering Diet-Disease Relationships: Case Studies.","authors":"Yotam Cohen, Rafael Valdés-Mas, Eran Elinav","doi":"10.1146/annurev-nutr-061121-090535","DOIUrl":"https://doi.org/10.1146/annurev-nutr-061121-090535","url":null,"abstract":"<p><p>Modernization of society from a rural, hunter-gatherer setting into an urban and industrial habitat, with the associated dietary changes, has led to an increased prevalence of cardiometabolic and additional noncommunicable diseases, such as cancer, inflammatory bowel disease, and neurodegenerative and autoimmune disorders. However, while dietary sciences have been rapidly evolving to meet these challenges, validation and translation of experimental results into clinical practice remain limited for multiple reasons, including inherent ethnic, gender, and cultural interindividual variability, among other methodological, dietary reporting-related, and analytical issues. Recently, large clinical cohorts with artificial intelligence analytics have introduced new precision and personalized nutrition concepts that enable one to successfully bridge these gaps in a real-life setting. In this review, we highlight selected examples of case studies at the intersection between diet-disease research and artificial intelligence. We discuss their potential and challenges and offer an outlook toward the transformation of dietary sciences into individualized clinical translation.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"225-250"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Placenta: A Maternofetal Interface.","authors":"Kimberly O'Brien, Yiqin Wang","doi":"10.1146/annurev-nutr-061121-085246","DOIUrl":"https://doi.org/10.1146/annurev-nutr-061121-085246","url":null,"abstract":"<p><p>The placenta is the gatekeeper between the mother and the fetus. Over the first trimester of pregnancy, the fetus is nourished by uterine gland secretions in a process known as histiotrophic nutrition. During the second trimester of pregnancy, placentation has evolved to the point at which nutrients are delivered to the placenta via maternal blood (hemotrophic nutrition). Over gestation, the placenta must adapt to these variable nutrient supplies, to alterations in maternal physiology and blood flow, and to dynamic changes in fetal growth rates. Numerous questions remain about the mechanisms used to transport nutrients to the fetus and the maternal and fetal determinants of this process. Growing data highlight the ability of the placenta to regulate this process. As new technologies and omics approaches are utilized to study this maternofetal interface, greater insight into this unique organ and its impact on fetal development and long-term health has been obtained.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"301-325"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2023-08-21Epub Date: 2023-05-17DOI: 10.1146/annurev-nutr-011923-020327
Regan L Bailey, Shinyoung Jun, Alexandra E Cowan, Heather A Eicher-Miller, Jaime J Gahche, Johanna T Dwyer, Terryl J Hartman, Diane C Mitchell, Rebecca A Seguin-Fowler, Raymond J Carroll, Janet A Tooze
{"title":"Major Gaps in Understanding Dietary Supplement Use in Health and Disease.","authors":"Regan L Bailey, Shinyoung Jun, Alexandra E Cowan, Heather A Eicher-Miller, Jaime J Gahche, Johanna T Dwyer, Terryl J Hartman, Diane C Mitchell, Rebecca A Seguin-Fowler, Raymond J Carroll, Janet A Tooze","doi":"10.1146/annurev-nutr-011923-020327","DOIUrl":"10.1146/annurev-nutr-011923-020327","url":null,"abstract":"<p><p>Precise dietary assessment is critical for accurate exposure classification in nutritional research, typically aimed at understanding how diet relates to health. Dietary supplement (DS) use is widespread and represents a considerable source of nutrients. However, few studies have compared the best methods to measure DSs. Our literature review on the relative validity and reproducibility of DS instruments in the United States [e.g., product inventories, questionnaires, and 24-h dietary recalls (24HR)] identified five studies that examined validity (<i>n</i> = 5) and/or reproducibility (<i>n</i> = 4). No gold standard reference method exists for validating DS use; thus, each study's investigators chose the reference instrument used to measure validity. Self-administered questionnaires agreed well with 24HR and inventory methods when comparing the prevalence of commonly used DSs. The inventory method captured nutrient amounts more accurately than the other methods. Reproducibility (over 3 months to 2.4 years) of prevalence of use estimates on the questionnaires was acceptable for common DSs. Given the limited body of research on measurement error in DS assessment, only tentative conclusions on these DS instruments can be drawn at present. Further research is critical to advancing knowledge in DS assessment for research and monitoring purposes.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"179-197"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11078263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10034461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}