{"title":"The Role of Artificial Intelligence in Deciphering Diet-Disease Relationships: Case Studies.","authors":"Yotam Cohen, Rafael Valdés-Mas, Eran Elinav","doi":"10.1146/annurev-nutr-061121-090535","DOIUrl":"https://doi.org/10.1146/annurev-nutr-061121-090535","url":null,"abstract":"<p><p>Modernization of society from a rural, hunter-gatherer setting into an urban and industrial habitat, with the associated dietary changes, has led to an increased prevalence of cardiometabolic and additional noncommunicable diseases, such as cancer, inflammatory bowel disease, and neurodegenerative and autoimmune disorders. However, while dietary sciences have been rapidly evolving to meet these challenges, validation and translation of experimental results into clinical practice remain limited for multiple reasons, including inherent ethnic, gender, and cultural interindividual variability, among other methodological, dietary reporting-related, and analytical issues. Recently, large clinical cohorts with artificial intelligence analytics have introduced new precision and personalized nutrition concepts that enable one to successfully bridge these gaps in a real-life setting. In this review, we highlight selected examples of case studies at the intersection between diet-disease research and artificial intelligence. We discuss their potential and challenges and offer an outlook toward the transformation of dietary sciences into individualized clinical translation.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"225-250"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2023-08-21Epub Date: 2023-05-17DOI: 10.1146/annurev-nutr-011923-020327
Regan L Bailey, Shinyoung Jun, Alexandra E Cowan, Heather A Eicher-Miller, Jaime J Gahche, Johanna T Dwyer, Terryl J Hartman, Diane C Mitchell, Rebecca A Seguin-Fowler, Raymond J Carroll, Janet A Tooze
{"title":"Major Gaps in Understanding Dietary Supplement Use in Health and Disease.","authors":"Regan L Bailey, Shinyoung Jun, Alexandra E Cowan, Heather A Eicher-Miller, Jaime J Gahche, Johanna T Dwyer, Terryl J Hartman, Diane C Mitchell, Rebecca A Seguin-Fowler, Raymond J Carroll, Janet A Tooze","doi":"10.1146/annurev-nutr-011923-020327","DOIUrl":"10.1146/annurev-nutr-011923-020327","url":null,"abstract":"<p><p>Precise dietary assessment is critical for accurate exposure classification in nutritional research, typically aimed at understanding how diet relates to health. Dietary supplement (DS) use is widespread and represents a considerable source of nutrients. However, few studies have compared the best methods to measure DSs. Our literature review on the relative validity and reproducibility of DS instruments in the United States [e.g., product inventories, questionnaires, and 24-h dietary recalls (24HR)] identified five studies that examined validity (<i>n</i> = 5) and/or reproducibility (<i>n</i> = 4). No gold standard reference method exists for validating DS use; thus, each study's investigators chose the reference instrument used to measure validity. Self-administered questionnaires agreed well with 24HR and inventory methods when comparing the prevalence of commonly used DSs. The inventory method captured nutrient amounts more accurately than the other methods. Reproducibility (over 3 months to 2.4 years) of prevalence of use estimates on the questionnaires was acceptable for common DSs. Given the limited body of research on measurement error in DS assessment, only tentative conclusions on these DS instruments can be drawn at present. Further research is critical to advancing knowledge in DS assessment for research and monitoring purposes.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"179-197"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11078263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10034461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Placenta: A Maternofetal Interface.","authors":"Kimberly O'Brien, Yiqin Wang","doi":"10.1146/annurev-nutr-061121-085246","DOIUrl":"https://doi.org/10.1146/annurev-nutr-061121-085246","url":null,"abstract":"<p><p>The placenta is the gatekeeper between the mother and the fetus. Over the first trimester of pregnancy, the fetus is nourished by uterine gland secretions in a process known as histiotrophic nutrition. During the second trimester of pregnancy, placentation has evolved to the point at which nutrients are delivered to the placenta via maternal blood (hemotrophic nutrition). Over gestation, the placenta must adapt to these variable nutrient supplies, to alterations in maternal physiology and blood flow, and to dynamic changes in fetal growth rates. Numerous questions remain about the mechanisms used to transport nutrients to the fetus and the maternal and fetal determinants of this process. Growing data highlight the ability of the placenta to regulate this process. As new technologies and omics approaches are utilized to study this maternofetal interface, greater insight into this unique organ and its impact on fetal development and long-term health has been obtained.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"301-325"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Causes and Clinical Sequelae of Riboflavin Deficiency.","authors":"Helene McNulty, Kristina Pentieva, Mary Ward","doi":"10.1146/annurev-nutr-061121-084407","DOIUrl":"https://doi.org/10.1146/annurev-nutr-061121-084407","url":null,"abstract":"<p><p>Riboflavin, in its cofactor forms flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), plays fundamental roles in energy metabolism, cellular antioxidant potential, and metabolic interactions with other micronutrients, including iron, vitamin B<sub>6</sub>, and folate. Severe riboflavin deficiency, largely confined to low-income countries, clinically manifests as cheilosis, angular stomatitis, glossitis, seborrheic dermatitis, and severe anemia with erythroid hypoplasia. Subclinical deficiency may be much more widespread, including in high-income countries, but typically goes undetected because riboflavin biomarkers are rarely measured in human studies. There are adverse health consequences of low and deficient riboflavin status throughout the life cycle, including anemia and hypertension, that could contribute substantially to the global burden of disease. This review considers the available evidence on causes, detection, and consequences of riboflavin deficiency, ranging from clinical deficiency signs to manifestations associated with less severe deficiency, and the related research, public health, and policy priorities.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"101-122"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10057258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Conversation with James Ntambi.","authors":"James M Ntambi, Patrick J Stover","doi":"10.1146/annurev-nutr-061021-020321","DOIUrl":"https://doi.org/10.1146/annurev-nutr-061021-020321","url":null,"abstract":"<p><p>An interview with James M. Ntambi, professor of biochemistry and the Katherine Berns Van Donk Steenbock Professor in Nutrition, College of Agricultural and Life Sciences, at the University of Wisconsin-Madison, took place via Zoom in April 2022. He was interviewed by Patrick J. Stover, director of the Institute for Advancing Health through Agriculture and professor of nutrition and biochemistry and biophysics at Texas A&M University. Dr. James Ntambi is a true pioneer in the field of nutritional biochemistry. He was among the very first to discover and elucidate the role that diet and nutrients play in regulating metabolism through changes in the expression of metabolic genes, focusing on the de novo lipogenesis pathways. As an African immigrant from Uganda, his love of science and his life experiences in African communities suffering from severe malnutrition molded his scientific interests at the interface of biochemistry and nutrition. Throughout his career, he has been an academic role model, a groundbreaking nutrition scientist, and an educator. His commitment to experiential learning through the many study-abroad classes he has hosted in Uganda has provided invaluable context for American students in nutrition. Dr. Ntambi's passion for education and scientific discovery is his legacy, and the field of nutrition has benefited enormously from his unique perspectives and contributions to science that are defined by his scientific curiosity, his generosity to his students and colleagues, and his life experiences. The following is an edited transcript.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"1-23"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10176067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Precision Nutrition: The Hype Is Exceeding the Science and Evidentiary Standards Needed to Inform Public Health Recommendations for Prevention of Chronic Disease.","authors":"Regan L Bailey, Patrick J Stover","doi":"10.1146/annurev-nutr-061021-025153","DOIUrl":"10.1146/annurev-nutr-061021-025153","url":null,"abstract":"<p><p>As dietary guidance for populations shifts from preventing deficiency disorders to chronic disease risk reduction, the biology supporting such guidance becomes more complex due to the multifactorial risk profile of disease and inherent population heterogeneity in the diet-disease relationship. Diet is a primary driver of chronic disease risk, and population-based guidance should account for individual responses. Cascading effects on evidentiary standards for population-based guidance are not straightforward. Precision remains a consideration for dietary guidance to prevent deficiency through the identification of population subgroups with unique nutritional needs. Reducing chronic disease through diet requires greater precision in (<i>a</i>) establishing essential nutrient needs throughout the life cycle in both health and disease; (<i>b</i>) considering effects of nutrients and other food substances on metabolic, immunological, inflammatory, and other physiological responses supporting healthy aging; and (<i>c</i>) considering healthy eating behaviors. Herein we provide a template for guiding population-based eating recommendations for reducing chronic diseases in heterogenous populations.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"385-407"},"PeriodicalIF":8.9,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11015823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10413353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annual review of nutritionPub Date : 2023-08-21Epub Date: 2023-05-30DOI: 10.1146/annurev-nutr-061021-030404
Veena Sangkhae, Allison L Fisher, Tomas Ganz, Elizabeta Nemeth
{"title":"Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms.","authors":"Veena Sangkhae, Allison L Fisher, Tomas Ganz, Elizabeta Nemeth","doi":"10.1146/annurev-nutr-061021-030404","DOIUrl":"10.1146/annurev-nutr-061021-030404","url":null,"abstract":"<p><p>Pregnancy entails a large negative balance of iron, an essential micronutrient. During pregnancy, iron requirements increase substantially to support both maternal red blood cell expansion and the development of the placenta and fetus. As insufficient iron has long been linked to adverse pregnancy outcomes, universal iron supplementation is common practice before and during pregnancy. However, in high-resource countries with iron fortification of staple foods and increased red meat consumption, the effects of too much iron supplementation during pregnancy have become a concern because iron excess has also been linked to adverse pregnancy outcomes. In this review, we address physiologic iron homeostasis of the mother, placenta, and fetus and discuss perturbations in iron homeostasis that result in pathological pregnancy. As many mechanistic regulatory systems have been deduced from animal models, we also discuss the principles learned from these models and how these may apply to human pregnancy.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"43 ","pages":"279-300"},"PeriodicalIF":12.6,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10723031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10044310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glucose-Dependent Insulinotropic Polypeptide-A Postprandial Hormone with Unharnessed Metabolic Potential.","authors":"Nunzio Guccio, Fiona M Gribble, Frank Reimann","doi":"10.1146/annurev-nutr-062320-113625","DOIUrl":"https://doi.org/10.1146/annurev-nutr-062320-113625","url":null,"abstract":"<p><p>Glucose-dependent insulinotropic polypeptide (GIP) is released from the upper small intestine in response to food intake and contributes to the postprandial control of nutrient disposition, including of sugars and fats. Long neglected as a potential therapeutic target, the GIPR axis has received increasing interest recently, with the emerging data demonstrating the metabolically favorable outcomes of adding GIPR agonism to GLP-1 receptor agonists in people with type 2 diabetes and obesity. This review examines the physiology of the GIP axis, from the mechanisms underlying GIP secretion from the intestine to its action on target tissues and therapeutic development.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"42 ","pages":"21-44"},"PeriodicalIF":8.9,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10106651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sohini Dutt, Iqbal Hamza, Thomas Benedict Bartnikas
{"title":"Molecular Mechanisms of Iron and Heme Metabolism.","authors":"Sohini Dutt, Iqbal Hamza, Thomas Benedict Bartnikas","doi":"10.1146/annurev-nutr-062320-112625","DOIUrl":"https://doi.org/10.1146/annurev-nutr-062320-112625","url":null,"abstract":"<p><p>An abundant metal in the human body, iron is essential for key biological pathways including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound to heme but it can also be incorporated into iron-sulfur clusters or bind directly to proteins. Iron's capacity to cycle between Fe<sup>2+</sup> and Fe<sup>3+</sup> contributes to its biological utility but also renders it toxic in excess. Heme is an iron-containing tetrapyrrole essential for diverse biological functions including gas transport and sensing, oxidative metabolism, and xenobiotic detoxification. Like iron, heme is essential yet toxic in excess. As such, both iron and heme homeostasis are tightly regulated. Here we discuss molecular and physiologic aspects of iron and heme metabolism. We focus on dietary absorption; cellular import; utilization; and export, recycling, and elimination, emphasizing studies published in recent years. We end with a discussion on current challenges and needs in the field of iron and heme biology.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"42 ","pages":"311-335"},"PeriodicalIF":8.9,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398995/pdf/nihms-1814241.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9813166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rebekah J Nicholson, Marie K Norris, Annelise M Poss, William L Holland, Scott A Summers
{"title":"The Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease.","authors":"Rebekah J Nicholson, Marie K Norris, Annelise M Poss, William L Holland, Scott A Summers","doi":"10.1146/annurev-nutr-062220-112920","DOIUrl":"https://doi.org/10.1146/annurev-nutr-062220-112920","url":null,"abstract":"<p><p>Diet influences onset, progression, and severity of several chronic diseases, including heart failure, diabetes, steatohepatitis, and a subset of cancers. The prevalence and clinical burden of these obesity-linked diseases has risen over the past two decades. These metabolic disorders are driven by ectopic lipid deposition in tissues not suited for fat storage, leading to lipotoxic disruption of cell function and survival. Sphingolipids such as ceramides are among the most deleterious and bioactive metabolites that accrue, as they participate in selective insulin resistance, dyslipidemia, oxidative stress and apoptosis. This review discusses our current understanding of biochemical pathways controlling ceramide synthesis, production and action; influences of diet on ceramide levels; application of circulating ceramides as clinical biomarkers of metabolic disease; and molecular mechanisms linking ceramides to altered metabolism and survival of cells. Development of nutritional or pharmacological strategies to lower ceramides could have therapeutic value in a wide range of prevalent diseases.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"42 ","pages":"115-144"},"PeriodicalIF":8.9,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399075/pdf/nihms-1811128.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9759291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}