葡萄糖依赖型胰岛素多肽-一种具有未开发代谢潜能的餐后激素。

IF 12.6 2区医学 Q1 NUTRITION & DIETETICS

Annual review of nutrition Pub Date : 2022-08-22 DOI:10.1146/annurev-nutr-062320-113625

Nunzio Guccio, Fiona M Gribble, Frank Reimann

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引用次数: 6

摘要

葡萄糖依赖的促胰岛素多肽(GIP)在食物摄入时从小肠上部释放，并有助于餐后控制营养配置，包括糖和脂肪。作为一个潜在的治疗靶点，GIPR轴长期被忽视，最近受到越来越多的关注，新出现的数据表明，在2型糖尿病和肥胖症患者中，在GLP-1受体激动剂中加入GIPR激动剂具有代谢有利的结果。本文综述了GIP轴的生理学，从肠道分泌GIP的机制到其对靶组织的作用和治疗发展。

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Glucose-Dependent Insulinotropic Polypeptide-A Postprandial Hormone with Unharnessed Metabolic Potential.

Glucose-dependent insulinotropic polypeptide (GIP) is released from the upper small intestine in response to food intake and contributes to the postprandial control of nutrient disposition, including of sugars and fats. Long neglected as a potential therapeutic target, the GIPR axis has received increasing interest recently, with the emerging data demonstrating the metabolically favorable outcomes of adding GIPR agonism to GLP-1 receptor agonists in people with type 2 diabetes and obesity. This review examines the physiology of the GIP axis, from the mechanisms underlying GIP secretion from the intestine to its action on target tissues and therapeutic development.

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来源期刊

Annual review of nutrition 医学-营养学

CiteScore

15.80

自引率

0.00%

发文量

期刊介绍： Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition