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[Effect of aeration conditions on carbon dioxide mass transfer in antibiotic biosynthetic processes]. [曝气条件对抗生素生物合成过程中二氧化碳传质的影响]。
Antibiotiki Pub Date : 1984-10-01
N N Falkov, T S Sherstobitova
{"title":"[Effect of aeration conditions on carbon dioxide mass transfer in antibiotic biosynthetic processes].","authors":"N N Falkov,&nbsp;T S Sherstobitova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of the aeration conditions on the mass exchange according to carbon dioxide in biosynthesis of various antibiotics was studied. On the basis of the results an equation for its estimation was developed. It was also shown that the effect of the aeration conditions on the intensity of the mass exchange according to carbon dioxide was much higher than that of the mass exchange according to oxygen.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 10","pages":"740-3"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17496981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Doxycycline in experimental rickettsial infection]. [强力霉素在实验性立克次体感染中的应用]。
Antibiotiki Pub Date : 1984-10-01
N G Kekcheeva
{"title":"[Doxycycline in experimental rickettsial infection].","authors":"N G Kekcheeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of doxycycline on R. prowazekii and R. sibirica was studied in comparison with that of tetracycline on two infection models, i. e. chick embryos and guinea pigs. The activity of doxycycline in the experiments with chick embryos was higher than that of tetracycline, the drug being more active against R. prowazekii than R. sibirica. The use of doxycycline in the treatment of the guinea pigs infected with R. prowazekii resulted in very rapid and stable decrease of the temperature. When used within the incubation period the drug prevented the infection development. Doxycycline was less effective in infections caused by R. sibirica.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 10","pages":"775-80"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17498385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Electron microscopy-cytochemical study of human leukocytes after interferon induction]. 电子显微镜-干扰素诱导后人白细胞的细胞化学研究
Antibiotiki Pub Date : 1984-10-01
V M Frolova, D L Beliaeva, V P Kuznetsov, V V Rogovin
{"title":"[Electron microscopy-cytochemical study of human leukocytes after interferon induction].","authors":"V M Frolova,&nbsp;D L Beliaeva,&nbsp;V P Kuznetsov,&nbsp;V V Rogovin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 10","pages":"781-4"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17162753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Oxidation of anthracycline antibiotics]. [蒽环类抗生素的氧化]。
Antibiotiki Pub Date : 1984-10-01
V S Orlov, G N Bogdanov
{"title":"[Oxidation of anthracycline antibiotics].","authors":"V S Orlov,&nbsp;G N Bogdanov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The quantum-chemical estimation of the highest occupied molecular orbital energy for the aglycons of carminomycin, rubomycin, adriamycin and aclacinomycin A in the neutral and ionized states was performed with a semiempirical method. It was shown that the aglycon ionization amplified the electron donor properties of the antibiotics. On the basis of the difference in the absorption spectra of the neutral and ionized chromophores their ionization constants were determined spectrophotometrically. For comparison of the electron donor properties of the anthracyclines at the physiological pH value the reaction of their oxidation with potassium ferricyanide accompanied by decoloration of the solutions was studied. On the basis of the quantum-chemical and experimental data it was concluded that the electron donor properties amplified as follows: aclacinomycin A less than adriamycin-rubomycin less than carminomycin. At the same time their acute toxicity increased (a decrease in the LD50). Therefore, the toxicity of the anthracycline antibiotics could be also due to formation of the radicals with high reactivity on the monoelectronic oxidation.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 10","pages":"748-51"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17652318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Substrate specificity of the beta-lactamases found in a number of clinical strains of gram-negative bacteria]. [在一些临床革兰氏阴性菌菌株中发现的-内酰胺酶的底物特异性]。
Antibiotiki Pub Date : 1984-09-01
A Iu Sazykin, S M Navashin
{"title":"[Substrate specificity of the beta-lactamases found in a number of clinical strains of gram-negative bacteria].","authors":"A Iu Sazykin,&nbsp;S M Navashin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The substrate profiles of beta-lactamases defected in 46 clinical polyresistant strains of gram-negative bacteria were determined. By the substrate profile and sensitivity to inhibitors (dicloxacillin and p-CMB) beta-lactamases were considered to belong to classes I, II, III, IV and V of the Richmond classification. The molecular weights of the enzymes were measured. Enterobacter aerogenes 6803, Enterobacter aerogenes 11030 and Klebsiella pneumoniae 970 produced simultaneously two beta-lactamases belonging to different classes. beta-Lactamases of classes I and III were detected in the cells of Enterobacter aerogenes 6803. The cells of Enterobacter aerogenes 11030 contained beta-lactamases of classes V and III and the cells of Klebsiella pneumonia 970 beta-lactamases of classes II and III. Therefore, in all the cases one of beta-lactamases belonged to the class III enzyme close to TEM beta-lactamases by its substrate profile, molecular weight and sensitivity to the inhibitors. Cephalexin and dicloxacillin were most frequently stable to the effect of the above beta-lactamases. The enzymes from 26 strains did not hydrolyse or hydrolysed slightly cephalexin and the enzymes from 19 strains did not hydrolyse of hydrolysed slightly dicloxacillin.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 9","pages":"657-61"},"PeriodicalIF":0.0,"publicationDate":"1984-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17395437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[R plasmids of Pseudomonas aeruginosa]. [R]铜绿假单胞菌质粒。
Antibiotiki Pub Date : 1984-09-01
A M Boronin, L A Anisimova
{"title":"[R plasmids of Pseudomonas aeruginosa].","authors":"A M Boronin,&nbsp;L A Anisimova","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 9","pages":"678-95"},"PeriodicalIF":0.0,"publicationDate":"1984-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17162756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Stability of enzymes inactivating aminoglycoside antibiotics]. [氨基糖苷类抗生素失活酶的稳定性]。
Antibiotiki Pub Date : 1984-09-01
A S Taisova, N S Griaznova
{"title":"[Stability of enzymes inactivating aminoglycoside antibiotics].","authors":"A S Taisova,&nbsp;N S Griaznova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stability of aminoglycoside phosphotransferases, adenylyltransferases and acetyltransferases isolated from various sources was studied. The enzymes were characterized by different substrate profiles. They were stored at a temperature of -10 degrees C in the form of frozen solutions or at a temperature of 4 degrees C in the lyophilized form. It was shown that lyophilization markedly increased the stability of the enzymes inactivating aminoglycoside antibiotics. Aminoglycoside phosphotransferases and adenylyltransferases with streptomycin as substrate were less stable than aminoglycoside phosphotransferases with neomycin as substrate. Aminoglycoside acetyltransferases from Streptomyces fradiae 918 producing neomycin were least stable among the enzymes studied. Lyophilized enzymes as a possible stabilizer of ATP added to the preparations had no significant effect on their stability during storage.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 9","pages":"649-53"},"PeriodicalIF":0.0,"publicationDate":"1984-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17162754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Shifts in tissue respiration of the lung and liver in rabbits administered penicillin and streptomycin]. [给予青霉素和链霉素的家兔肺和肝脏组织呼吸的变化]。
Antibiotiki Pub Date : 1984-09-01
V I Vaĭchekonis
{"title":"[Shifts in tissue respiration of the lung and liver in rabbits administered penicillin and streptomycin].","authors":"V I Vaĭchekonis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The experiments were performed on intact rabbits weighing 2.5-3 kg. The animals were treated with penicillin or streptomycin injected intramuscularly in doses of 20 000 units or 17 000 micrograms a day per kg bw for 12 days. The concentrations of lactic and pyruvic acids, cytochrome c, activity of cytochrome c oxidase and thiol spectrum were investigated in the lungs and liver immediately after the antibiotic use in 10 rabbits of every experimental series. To follow the period of persisting of the antibiotic-induced changes the other 10 rabbits were killed 29 days after the last injection of the drugs. It was shown that penicillin induced significant changes in the concentrations of lactic and pyruvic acids in the lung tissue, activated cytochrome c oxidase and decreased the concentrations of free SH and S-S groups immediately after its administration. 29 days after discontinuation of penicillin the activity of cytochrome c oxidase returned to normal, while the other biochemical indices remained changed. Penicillin induced changes in the concentrations of lactic and pyruvic acids and the activity of cytochrome c oxidase in the liver. The concentrations of free masked SH and S-S groups also changed. 29 days after discontinuation of penicillin the enzymatic system of cytochrome c-cytochrome c oxidase alone returned to normal. Like penicillin, streptomycin induced changes in the tissue respiration of the lungs and liver. The character of the streptomycin-induced changes was more pronounced both immediately and 29 days after discontinuation of the drug use.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 9","pages":"662-6"},"PeriodicalIF":0.0,"publicationDate":"1984-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17566030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Action of bioglycans from marine invertebrates on macrophage functioning]. [海洋无脊椎动物生物聚糖对巨噬细胞功能的作用]。
Antibiotiki Pub Date : 1984-09-01
N N Besednova, R G Ovodova, T S Zaporozhets, V I Molchanova, N V Krylova
{"title":"[Action of bioglycans from marine invertebrates on macrophage functioning].","authors":"N N Besednova,&nbsp;R G Ovodova,&nbsp;T S Zaporozhets,&nbsp;V I Molchanova,&nbsp;N V Krylova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data on the absorption and bactericidal function of macrophages are presented. It was shown in vivo that bioglycans 42 and 106 had a stimulating action on phagocytosis of Y. pseudotuberculosis and S. typhimurium capable of persisting in macrophages for prolonged periods. Addition of the bioglycans to the cultures of the macrophages from intact animals increased the absorption activity of the macrophages and somewhat potentiated their bactericidal activity. Under the action of the bioglycans the level and rate of the carbon clearance in the blood flow increased. The results of the study are promising for adequate control of infections caused by intracellularly located pathogens.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 9","pages":"653-7"},"PeriodicalIF":0.0,"publicationDate":"1984-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17449839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparative effectiveness of immunomodulators in the therapy of bronchopulmonary diseases]. [免疫调节剂治疗支气管肺疾病的比较疗效]。
Antibiotiki Pub Date : 1984-09-01
A M Zemskov, V M Provotorov, A V Nikitin, V M Zemskov
{"title":"[Comparative effectiveness of immunomodulators in the therapy of bronchopulmonary diseases].","authors":"A M Zemskov,&nbsp;V M Provotorov,&nbsp;A V Nikitin,&nbsp;V M Zemskov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>One hundred and fifty-one patients with bronchopulmonary diseases were examined and it was shown that they had secondary immune deficiency mainly in the T-cells which could not be recovered with the routine therapeutic agents. The use of hemodez, levamisole or sodium nucleinate in the combined therapy promoted correction of the immune deficiency and increased the treatment efficacy. Sodium nucleinate proved to be the most efficient.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 9","pages":"673-6"},"PeriodicalIF":0.0,"publicationDate":"1984-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17566033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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