Antibiotiki Pub Date : 1984-12-01

E G Shcherbakova, G A Rastunova, E K Alekhin, M M Medvedeva

{"title":"[Metabolism and function of phagocytes after combined administration of immunosuppressants and biologically active substances].","authors":"E G Shcherbakova, G A Rastunova, E K Alekhin, M M Medvedeva","doi":"","DOIUrl":"","url":null,"abstract":"Metabolism and function of mouse phagocytes were studied experimentally under conditions of immunosuppression with biologically active substances. It was shown by the cytochemical methods with the use of cytophotometry that strong immunosuppression with azathioprin, prednisolone, especially with their combination induced inhibition of the enzymatic systems responsible for synthetic and energy processes in macrophages. Prodigiosan, a bacterial lipopolysaccharide, and lysozyme promoted elimination of the unfavourable effect of the immunosuppressors on macrophage metabolism, normalizing the decreased activity of certain enzymes and markedly activating the enzymes involved in detoxification and phagocytosis. The lysozyme effect did not depend on the type of drug immunosuppression. The efficiency of prodigiosan was the highest after administration of prednisolone or its combination with azathioprin. Its effect was lower after immunosuppression with azathioprin alone. During allotransplantation, prodigiosan also promoted the recovery of the leukocyte adsorption and digestive capacity impaired by prednisolone and tis combination with azathioprin. The differential use of the biologically active substances is a promising trend in control of complications due to immunosuppression therapy.","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 12","pages":"907-13"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17580969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Structure of the antibiotic virenomycin]. [抗菌素的结构]。

Antibiotiki Pub Date : 1984-12-01

M G Brazhnikova, M K Kudinova, V V Kuliaeva, N P Potapova, L M Rubasheva

引用次数: 0

[Elimination of admixtures from antibiotic sediments during their treatment with solvents]. [在用溶剂处理抗生素沉积物过程中消除外加剂]。

Antibiotiki Pub Date : 1984-12-01

M A Sinitsyn, S A Zhukovskaia, S A Murav'eva

引用次数: 0

[Composition of cell walls of 2 mutant strains of Streptomyces chrysomallus]. [2株黄体链霉菌突变株细胞壁组成]。

Antibiotiki Pub Date : 1984-12-01

M Sh Zaretskaia, M V Nefelova, L A Baratova, A N Polin

引用次数: 0

[Oleandomycin content of mycelium and fermentation solution during cultivation of Streptomyces antibioticus]. [抗生素链霉菌培养过程中菌丝和发酵液中的油霉素含量]。

Antibiotiki Pub Date : 1984-12-01

S A Shukoliukov, I B Sokolova

{"title":"[Oleandomycin content of mycelium and fermentation solution during cultivation of Streptomyces antibioticus].","authors":"S A Shukoliukov, I B Sokolova","doi":"","DOIUrl":"","url":null,"abstract":"The time-course of the oleandomycin content in the mycelium and fermentation broth-filtrate was studied by the microbiological assay at different periods of cultivation of strains 471 and 961 in fermenters and flasks containing a rich soybean-corn medium. It was shown that centrifugation of the mycelium over the sucrose density gradient induced a 25-80 per cent decrease in its moist weight at the expense of removal of the admixture components of the rich medium. Addition of glucose (2 per cent) to the culture-grown in a lactose medium by the 72nd hour of fermentation had no effect on further increase of the cell biomass. However, it lowered the content of the mycelium-fixed and excreted antibiotic at all the subsequent fermentation periods. The content of oleandomycin in the untreated mycelium was only 0.36 per cent of its content in the fermentation broth filtrate. After centrifugation of the mycelium over the sucrose density gradient and its intensive washing with distilled water the content of the mycelium-fixed antibiotic decreased still more. The time-course of the content of the mycelium-fixed and excreted oleandomycin was characterized by the presence of two activity peaks; by the 80-110th and by the 140-170th hour of cultivation.","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 12","pages":"892-7"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17455782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Tolerance of group A streptococci to the bactericidal effect of various antibiotics]. [A群链球菌对各种抗生素杀菌作用的耐受性]。

Antibiotiki Pub Date : 1984-12-01

N I Givental', O A Krasil'nikova, L F Bogdanova, L S Vorob'eva, A S Labinskaia

引用次数: 0

[Distribution of sulfanilamides and penicillins in the blood and organs of rats after their combined administration]. 磺胺类药物和青霉素类药物联合给药后在大鼠血液和器官中的分布。

Antibiotiki Pub Date : 1984-12-01

V I Bobrov, G T Beletskaia

引用次数: 0

[Comparative study of the quantitative determination of kanamycin sulfate in ophthalmic films with a collagen base by microbiological and chemical methods]. 【微生物法与化学法测定胶原基眼膜中硫酸卡那霉素含量的比较研究】。

Antibiotiki Pub Date : 1984-12-01

L A Ivanova, T A Abramova, N M Levkovich, V F Okhotnikova, V S Kartashov

引用次数: 0

[Polyresistant Enterobacteriaceae strains and their plasmids in a hospital. Medical and theoretical aspects]. 某医院多耐药肠杆菌科菌株及其质粒。医学和理论方面]。

Antibiotiki Pub Date : 1984-12-01

S S Belokrysenko, L G Dugasheva

{"title":"[Polyresistant Enterobacteriaceae strains and their plasmids in a hospital. Medical and theoretical aspects].","authors":"S S Belokrysenko, L G Dugasheva","doi":"","DOIUrl":"","url":null,"abstract":"The properties and origin of multiple resistant strains of Enterobacteriaceae found in the intestine and nasopharynx of infants admitted to the hospital for premature infants were studied. The strains of E. coli of different serovars isolated at various periods contained similar conjugative R plasmids with a molecular weight of 80 Md belonging to the O incompatibility group controlling resistance to kanamycin and physically independent small plasmids controlling resistance to ampicillin (7 Md) and streptomycin-sulfanilamides (4 Md). Multiple drug resistance in the strains of K. pneumoniae was controlled by single large (100-120 Md) plasmid cointegrates with 6-8 resistance markers. Such cointegrates consisted of several potentially independent plasmids, sometimes dividing on transformation of plasmid DNA of the recipient strains of E. coli K12. The small plasmids controlling resistance to ampicillin and streptomycin-sulfanilamides similar to the respective plasmids of E. coli were the constant components of the plasmids cointegrates. The multiple drug resistance in the above strains was combined with high capacity for colonization in premature infants. The medical staff and mothers were the sources of bacterial strains with single plasmids controlling definite types of resistance. It is suggested that the multiple resistant strains of Enterobacteriaceae are formed in hospital as a result of accumulation of the plasmids or plasmid markers and selection. One of the conditions for successive acquisition of new plasmid markers by definite bacterial strains was their high capacity for colonization in patients, which provided constant contacts and genetic exchange of such strains with a wide range of immigrant strains during colonization in the newly admitted patients.","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 12","pages":"924-31"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17455783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Methods of determining the sensitivity of anaerobic bacteria to antibacterial drugs]. 厌氧菌对抗菌药物敏感性的测定方法

Antibiotiki Pub Date : 1984-12-01

T R Ponomareva, O M Dronova, A Z Smolianskaia

引用次数: 0

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