磺胺类药物和青霉素类药物联合给药后在大鼠血液和器官中的分布。

Antibiotiki Pub Date : 1984-12-01

V I Bobrov, G T Beletskaia

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摘要

青霉素和氨苄青霉素与磺胺或磺胺二甲氧嘧啶联合使用可增加大鼠某些器官和组织中青霉素和磺胺的水平。这伴随着药物浓度梯度的上升。由此得出结论，青霉素类和磺胺类药物的联合使用决定了它们从血液进入宿主其他器官和组织的渗透性增加。

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[Distribution of sulfanilamides and penicillins in the blood and organs of rats after their combined administration].

The use of benzylpenicillin and ampicillin in combination with sulfalen or sulfadimethoxine increased the levels of the penicillins and sulfalen in some organs and tissues of rats. This was accompanied by a rise in the concentration gradients of the drugs. It is concluded that the combined use of the penicillins and sulfanilamides determines their increased penetration from the blood into other organs and tissues of the host.

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Antibiotiki

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