Antibiotiki最新文献_第2页

[Various epidemiological aspects of the study of plasmids in Salmonella drug-resistance]. [沙门氏菌耐药性质粒研究的各个流行病学方面]。

Antibiotiki Pub Date : 1984-11-01

S Sh Rozhnova, V A Kilesso

引用次数: 0

[Sensitivity of Candida strains to polyenic antibiotics in the treatment of oral candidiasis]. 口腔念珠菌病治疗中念珠菌菌株对多药抗生素的敏感性。

Antibiotiki Pub Date : 1984-11-01

G I Boĭko, G P Sosnin, A A Adarchenko, G S Moroz

引用次数: 0

[Effect of various antibiotics on the circulation of proteins between the blood and lymph in macro-organisms]. [各种抗生素对大型生物血液和淋巴之间蛋白质循环的影响]。

Antibiotiki Pub Date : 1984-11-01

R G Polosova, V N Balashev

{"title":"[Effect of various antibiotics on the circulation of proteins between the blood and lymph in macro-organisms].","authors":"R G Polosova, V N Balashev","doi":"","DOIUrl":"","url":null,"abstract":"The effect of tetracycline, amphotericin B and kefzol on distribution of some proteins between the blood and lymph of the thoracic duct was studied on rabbits. Tetracycline was injected intramuscularly in the form of hydrochloride dissolved in 2% novocain in a dose of 25 mg/kg once or daily for 7 and 20 days. Kefzol (sodium cephazolin) was injected intramuscularly in a single dose of 100 mg/kg. Amphotericin B was injected intravenously in a dose of 1000 Units/kg once or for 5 days. The lymph samples were collected from the thoracic duct of rabbits treated with single doses of the antibiotics 1 and 24 hours after their injection. When the animals were treated with the antibiotics repeatedly the lymph samples were collected 24 hours after the last injection. The level of the total protein and the ratio of the protein fractions, i. e. albumins, alpha 1-, alpha 2-, beta- and gamma-globulins in the lymph and blood serum were determined. On the basis of these findings the protein coefficient (albumin/globulin) of the lymph and blood, the coefficients of the protein permeability of the blood vessels (R) and the constants of selective permeability of the blood capillaries (S) were calculated. It was shown that the shifts in the protein circulation between the blood and lymph had mainly the same trends independent of the antibiotics used and their retention time in the host. A significant decrease in the permeability of the blood vessel walls in respect to the total protein and gamma-globulins and a marked increase in their selectivity in passing of the protein molecules of different size were observed in all cases.","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 11","pages":"830-4"},"PeriodicalIF":0.0,"publicationDate":"1984-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17582661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Antitoxic properties of pantothenic acid derivatives, precursors of coenzyme A biosynthesis, with regard to kanamycin]. [泛酸衍生物，辅酶A生物合成前体，关于卡那霉素的抗毒性]。

Antibiotiki Pub Date : 1984-11-01

A G Moĭseenok, B F Dorofeev, V M Sheĭbak, T I Khomich

引用次数: 0

[Effect of amphotericin B on the diuretic action of diacarb and various indicators of water-salt metabolism in healthy and tumor-bearing animals]. [两性霉素B对健康及荷瘤动物地威利尿及水盐代谢各项指标的影响]。

Antibiotiki Pub Date : 1984-11-01

I A Bychkov, V G Pashinskiĭ, K V Iaremenko, G K Zoloev

{"title":"[Effect of amphotericin B on the diuretic action of diacarb and various indicators of water-salt metabolism in healthy and tumor-bearing animals].","authors":"I A Bychkov, V G Pashinskiĭ, K V Iaremenko, G K Zoloev","doi":"","DOIUrl":"","url":null,"abstract":"The experiments with albino rats, Wistar rats and SHK mice showed that the combined use of amphotericin B and diacarb markedly potentiated the effect of the latter: the amount of the urine excreted within 6 h and the renal excretion of sodium ions increased 1.8 and 1.5 times, respectively. Analogous trends were observed in the experiments with stabilization of the animal water balance by 2 per cent water loading. The studies on rats with Pliss lymphosarcoma showed that the diuresis level in the tumor-bearing animals was 3 times lower than that in healthy rats. The treatment with 5-fluorouracil lowered this index more significantly. With the use of amphotericin B, diacarb and their combination the urination level came to normal. The cyclophosphamide therapy of mice with sarcoma 180 was accompanied by accumulation of water in the tumor tissue. The combined use of the cytostatic with the polyenic antibiotic and diuretic resulted in a significant lowering of this index. In rats with Walker-256 carcinosarcoma, the treatment with the above three drugs lowered the sodium ion concentration and increased the calcium ion concentration in the tumor tissue. At the same time the electrolyte level in some organs not affected with malignant tumor (spleen, thymus, liver and adrenal glands) returned to normal.","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 11","pages":"837-40"},"PeriodicalIF":0.0,"publicationDate":"1984-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17606382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Seasonal characteristics of the effectiveness of vitamin E and sodium selenate in tetracycline-induced liver damage]. [维生素E和硒酸钠治疗四环素肝损伤疗效的季节性特征]。

Antibiotiki Pub Date : 1984-11-01

N P Skakun, I Iu Vysotskiĭ

{"title":"[Seasonal characteristics of the effectiveness of vitamin E and sodium selenate in tetracycline-induced liver damage].","authors":"N P Skakun, I Iu Vysotskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"The seasonal characteristics of the efficacy of vitamin E and sodium selenite in tetracycline affections of the liver were studied on 128 noninbred male albino rats. It was shown that in comparison to vitamin E sodium selenite more actively retarded activation of lipid peroxidation in the liver and activation of alanine aminotransferase and alkaline phosphatase in the blood serum in autumn and winter. A more pronounced inhibition of the increased levels of the dienic conjugates and alanine aminotransferase was observed in spring and summer and malonic dialdehyde and aspartate aminotransferase in summer by tocopherol acetate as compared to sodium selenite. The level of the thiol-disulfide equilibrium on the separate use of the drugs in spring and summer was higher than the control one. However, it did not reach the control level in autumn and winter. The combined use of sodium selenite and vitamin E prevented the toxic effect of tetracycline on the liver in autumn, spring and summer. Still, in the winter no such prevention was observed. The mechanisms of the seasonal differences in the tetracycline effect on the liver and the efficacy of the antioxidants in such affections are discussed.","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 11","pages":"856-61"},"PeriodicalIF":0.0,"publicationDate":"1984-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17580964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sensitivity of 56 strains of Streptococcus group B to 12 antibiotics: its determination by dilution and diffusion in agar]. [56株B群链球菌对12种抗生素的敏感性:琼脂稀释扩散法测定]。

Antibiotiki Pub Date : 1984-11-01

N I Giventel', S K Osmanov, L F Bogdanova, L S Vorob'eva, I A Bochkov

引用次数: 0

[Antitumor activity of doxorubicin in the treatment of hemocytoblastosis La and various ascites tumors in mice]. [阿霉素治疗小鼠成血细胞增多症La及多种腹水肿瘤的抗肿瘤活性]。

Antibiotiki Pub Date : 1984-11-01

L A Ul'ianova, V E Tarasova, V S Bazhanov, O I Iudina, L E Gol'dberg

引用次数: 0

[Pharmacodynamics of cephaloridine and cephalothin combined with sulfalene in rabbits]. [头孢啶、头孢肽联合磺胺在家兔体内的药效学]。

Antibiotiki Pub Date : 1984-11-01

V I Bobrov, G T Beletskaia, V P Iakovlev