Antibiotiki最新文献_第10页

[Cytostatic action of N-ethyl-13-dihydrorubomycin on the cells of various tumor strains]. [n -乙基-13-二氢霉素对多种肿瘤细胞株的细胞抑制作用]。

Antibiotiki Pub Date : 1984-06-01

O P Volkolupova

引用次数: 0

[Growth of test microorganisms used in determining antibiotic activity on synthetic nutrient media]. [在合成营养培养基上测定抗生素活性的试验微生物的生长]。

Antibiotiki Pub Date : 1984-06-01

N G Vasil'eva, E M Bershteĭn, T A Fradkova, L S Golubkova, M S Poliak

引用次数: 0

[Interrelation of the antibiotic sensitivity (resistance) of staphylococci, clinical forms of the infection and production of protein A]. [葡萄球菌的抗生素敏感性(耐药性)、临床感染形式与蛋白A产生的相互关系]。

Antibiotiki Pub Date : 1984-06-01

G A Fomenko

{"title":"[Interrelation of the antibiotic sensitivity (resistance) of staphylococci, clinical forms of the infection and production of protein A].","authors":"G A Fomenko","doi":"","DOIUrl":"","url":null,"abstract":"Two hundred and thirty-two strains of Staph. aureus isolated from patients with staphylococcal infections were studied. The strains were isolated from the blood of patients with sepsis, from the purulent foci on the skin and in the subcutaneous fat, from the nasopharyngeal mucosa of patients with tonsillitis and inflammation of the upper respiratory tract, from the sputum of patients with the pneumonia signs and from the pus of patients with otitis. The pathogens were identified with the routine methods. The quantitative content of protein A in the strains was determined by the method of indirect hemagglutination with red blood cells sensitized with the hemolytic serum. The data obtained were analysed with regard to the strain group and characteristics of the strain resistance or sensitivity to benzylpenicillin, erythromycin, oleandomycin, chloramphenicol, streptomycin, neomycin, kanamycin, monomycin, ristomycin and furagin K. Statistically significant differences in the protein A content in certain strain groups were observed. These differences might be correlated with the strain antibiotic resistance but not sensitivity. Pronounced changes in the levels of protein A were detected in the staphylococcal hemocultures resistant to erythromycin and streptomycin. The cultures resistant to erythromycin were characterized by decreased content of protein A and those resistant to streptomycin were characterized by increased content of protein A. Comparison of the antibiotic sensitivity of the strains of 5 groups by variation statistics revealed significant differences in the levels of sensitivity to streptomycin, neomycin, kanamycin, monomycin, ristomycin and furagin K but not to erythromycin, oleandomycin and chloramphenicol in the strains of certain groups. The staphylococcal hemocultures isolated from patients with sepsis proved to be the most sensitive to the antibiotics.","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"421-7"},"PeriodicalIF":0.0,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17533280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Liver mono-oxygenases and the pharmacodynamics of carminomycin and rubomycin]. 肝单加氧酶与卡米霉素和红霉素的药效学研究。

Antibiotiki Pub Date : 1984-06-01

T A Bogush, S M Sitdikova

引用次数: 0

[Influence of prodigiozan, methyluracil and levamisole on the anti-inflammatory effect of nonsteroid antiphlogistics]. [prodigiozan、methyluracil和左旋咪唑对非甾体类消炎药抗炎作用的影响]。

Antibiotiki Pub Date : 1984-06-01

A Sh Bogdanova

引用次数: 0

[Effect of virazole on the antiviral activity of poly(G) X poly(C) and other polyribonucleotide interferonogens]. [病毒唑对poly(G) X poly(C)等多核苷酸干扰素抗病毒活性的影响]。

Antibiotiki Pub Date : 1984-06-01

L M Vil'ner, V A Lashkevich

引用次数: 0

[Interaction of salts of transition metals with gramicidin S in chloroform]. [在氯仿中过渡金属盐与革兰杀菌素S的相互作用]。

Antibiotiki Pub Date : 1984-06-01

E V Komarov, G K Fomicheva

引用次数: 0

[Effectiveness of the rapid intravenous administration of rifampicin and isoniazid and of the intramuscular administration of streptomycin in disseminated destructive pulmonary tuberculosis in dogs]. [犬播散性破坏性肺结核快速静脉注射利福平和异烟肼及肌肉注射链霉素的效果]。

Antibiotiki Pub Date : 1984-06-01

I M Bondarev, V L Ivanov, V P Novoselova, L A Kovaleva, L A Shtegel'man

{"title":"[Effectiveness of the rapid intravenous administration of rifampicin and isoniazid and of the intramuscular administration of streptomycin in disseminated destructive pulmonary tuberculosis in dogs].","authors":"I M Bondarev, V L Ivanov, V P Novoselova, L A Kovaleva, L A Shtegel'man","doi":"","DOIUrl":"","url":null,"abstract":"Soluble rifampicin and isoniazid injected rapidly by the intravenous route and streptomycin injected intramuscularly to dogs with disseminated destructive tuberculosis of the lungs provided sterilization of the organs with respect to M. tuberculosis for the period of their use for 2 months. This was confirmed microbiologically. The treatment resulted in resolution of the dissemination foci in the organs and stimulation of immunomorphological and connective tissue reactions in the lungs until the foci cicatrized. The shifts in liver function (bilirubin, ALT and AST) and coagulograms during the treatment were temporary and came to normal by the end of the treatment. The organotropic effect of soluble rifampicin in combination with isoniazid injected rapidly by the intravenous route and streptomycin injected intramuscularly was not observed during the treatment of the dogs with disseminated destructive tuberculosis of the lungs. Rapid intravenous injection of rifampicin in combination with other antimicrobial drugs will provide a significant decrease in the periods of chemotherapy of patients with disseminated destructive tuberculosis of the lungs.","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"430-4"},"PeriodicalIF":0.0,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17534040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cephalosporin and carbenicillin penetration into the tissues of rats with aseptic inflammation]. [头孢菌素和卡比西林在无菌性炎症大鼠组织中的渗透]。

Antibiotiki Pub Date : 1984-06-01

I V Agapitova, V I Bobrov

引用次数: 0

[Effect of rubomycin and its paramagnetic analog on DNA synthesis]. [红霉素及其顺磁类似物对DNA合成的影响]。

Antibiotiki Pub Date : 1984-06-01

L Iu Dederer, L B Gorbacheva

{"title":"[Effect of rubomycin and its paramagnetic analog on DNA synthesis].","authors":"L Iu Dederer, L B Gorbacheva","doi":"","DOIUrl":"","url":null,"abstract":"Ruboxyl, a paramagnetic analog of rubomycin, was synthesized and subjected to a preliminary investigation at the Institute of Chemical Physics of the Academy of Sciences of the USSR. The drug is characterized by a higher antitumor activity, broader spectrum and lower general and cardiac toxicity. This is the first attempt of comparative biochemical investigation of rubomycin, ruboxyl and the nitroxyl radical at the level of DNA replication. The effect of these drugs on the synthesis of DNA in the cells of leukemia P-388, the bone marrow and heart of mice was studied. It was shown that the degree and duration of the DNA synthesis inhibition in the tumor cells correlated well with the antitumor activity of the drugs. On the 3rd day after administration rubomycin and ruboxyl induced stimulation of the DNA synthesis in the cells of the bone marrow. This might be explained by transfer of a part of the population of the bone marrow cells from Go phase due to the cytotoxic damages of the proliferating cells. The DNA synthesis stimulation in the bone marrow was most likely associated with the toxic effect of the drugs. No correlation between the cardiotoxicity and inhibition of the DNA synthesis in the heart cells of the mice was observed. The nitroxyl radical showed no biological activity on this model. The average lifespan of the mice treated with the nitroxyl radical was the same as that of the control animals. A decrease in the incorporation of 2-14C-thymidine into DNA of the tumor, bone marrow and heart was observed in the tumor carriers with development of the tumor.","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"442-5"},"PeriodicalIF":0.0,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17534042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0