[Influence of prodigiozan, methyluracil and levamisole on the anti-inflammatory effect of nonsteroid antiphlogistics].

Abstract

The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation. Noninbred albino mice of both sexes were used in the experiments. It was shown that prodigiosan as a therapeutic agent had a pronounced anti-inflammatory action. It potentiated the effect of voltaren used in a dose lower than the ED50 and did not change the anti-inflammatory activity of naproxen, indomethacin and acetylsalicylic acid used in the doses equal to the ED50. The potentiating effect of prodigiosan on voltaren was statistically significant Methyluracil used as a prophylactic agent had an anti-inflammatory effect. Levamisole used as a prophylactic agent or a therapeutic agent did not decrease the edema level. The anti-inflammatory effect of naproxen, indomethacin, acetylsalicylic acid and voltaren did not change, when the drugs were administered to the animals treated with methyluracil and levamisole.