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[Effect of a modifying factor on the sensitivity of Crithidia oncopelti to levorin]. [一种修饰因子对石榴花对左旋甲素敏感性的影响]。
Antibiotiki Pub Date : 1984-07-01
N N Sukhareva-Nemakova, M V Chuenkova
{"title":"[Effect of a modifying factor on the sensitivity of Crithidia oncopelti to levorin].","authors":"N N Sukhareva-Nemakova,&nbsp;M V Chuenkova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The paper deals with possible discovery of ways for increasing sensitivity of trypanosomides to polyenic antibiotics. The following substances were tested: sodium pyruvate and acetate, calcium salts, ascorbic acid and 1-valine. The total number of the cells and the number of the viable cells in the culture and their morphological characteristics were used as the criteria for estimation of the C. oncopelti sensitivity. It was shown that sodium acetate most actively modified the levorin effect on C. oncopelti. Its addition in a concentration of 40 mg/ml to the cultivation medium with levorin in a concentration of 1 microgram/ml induced a trypanocidal effect. With the use of levorin alone such an effect was observed when the antibiotic was used in a concentration of 10 micrograms/ml. The growth rate of the protozoon was decreased by 60-80 per cent as compared to the control. The number of the viable cells was lowered 4 times. The morphology of the culture markedly changed. This indicates that the presence of sodium acetate as a modifier in the culture medium allowed one to decrease 10 times the dose of levorin and to preserve the trypanocidal effect.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"501-6"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17542828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mechanism of action of ectericide on opportunistic microbes]. 杀菌剂对机会微生物的作用机理
Antibiotiki Pub Date : 1984-07-01
I L Dikiĭ, E M Dikaia, G P Cherkas, A D Bazavluk
{"title":"[Mechanism of action of ectericide on opportunistic microbes].","authors":"I L Dikiĭ,&nbsp;E M Dikaia,&nbsp;G P Cherkas,&nbsp;A D Bazavluk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ectericide is a product of cod-liver oil oxidation (lower fatty acids, organic peroxides and aldehydes). Its antibacterial activity is based on the capacity for partial disintegration and extraction of the structural lipopolysaccharide of the microbial cell without any significant effect on the quantitative content of the structural proteins and nucleotides.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"510-2"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17445282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Action of the products of the vital activity of yeastlike fungi on the biosynthesis of levorin, levoristatin and fatty acids by a Streptomyces levoris culture]. [酵母样真菌生命活性产物对左旋链霉菌生物合成左旋素、左旋素和脂肪酸的作用]。
Antibiotiki Pub Date : 1984-07-01
O S Kuznetsova, E P Iakovleva, T P Efimova, V A Tsyganov
{"title":"[Action of the products of the vital activity of yeastlike fungi on the biosynthesis of levorin, levoristatin and fatty acids by a Streptomyces levoris culture].","authors":"O S Kuznetsova,&nbsp;E P Iakovleva,&nbsp;T P Efimova,&nbsp;V A Tsyganov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data on the effect of the products of vital activity of Candida tropicalis, a yeast-like fungus, on the biosynthesis of levorin, levoristatin and fatty acids by Streptomyces levoris are presented. It was shown that the effect of the biostimulators was not specific with respect to production of levorin, since in the presence of the products of vital activity of C. tropicalis an increase in the synthesis of levoristatin and fatty acids was also observed. The qualitative and quantitative composition of the fatty acids of the mycelium of S. levoris was studied. Interrelation between the biosynthesis of levorin and synthesis of unsaturated fatty acids and branched chain fatty acids was noted.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"483-7"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17272098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mechanisms of hemopoiesis inhibition and recovery after the administration of carminomycin and rubomycin in an experiment]. [carminomycin和rubomycin联合用药后造血功能抑制和恢复的实验机制]。
Antibiotiki Pub Date : 1984-06-01
V V Novitskiĭ, T V Pichugina, E D Gol'dberg
{"title":"[Mechanisms of hemopoiesis inhibition and recovery after the administration of carminomycin and rubomycin in an experiment].","authors":"V V Novitskiĭ,&nbsp;T V Pichugina,&nbsp;E D Gol'dberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The experiments on 766 albino non-inbred rats and 270 mice BALB/c showed that when there were no basic differences in the mechanism of the anthracycline myeloinhibitory effect associated with a decrease in the number of the exogenic trunk hemopoietic cells, inhibition of the bone marrow proliferative activity and a decreased rate of the hemopoietic elements differentiation, carminomycin induced a more pronounced and persisting impairment of the hematopoietic tissue proliferation, as compared to rubomycin on their administration in doses equivalent by the total toxicity.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"437-41"},"PeriodicalIF":0.0,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17534041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Determination of beta-lactamase types of clinical strains of bacteria using a modified microiodometric method]. [改良微量量测法测定临床菌株β -内酰胺酶类型]。
Antibiotiki Pub Date : 1984-06-01
A Iu Sazykin, A S Krylov, S B Vakulenko, A N Abadzhieva, V G Nikishina
{"title":"[Determination of beta-lactamase types of clinical strains of bacteria using a modified microiodometric method].","authors":"A Iu Sazykin,&nbsp;A S Krylov,&nbsp;S B Vakulenko,&nbsp;A N Abadzhieva,&nbsp;V G Nikishina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The substrate profiles and sensitivity to dicloxacillin inhibition were studied in the enzymes of the clinical strains of Pseudomonas aeruginosa and the transconjugants of E. coli carrying the plasmids discovered earlier in P. aeruginosa. The study was performed with a modified microiodometric method for determination of the activity of beta-lactamases. According to the M. Richmond classification of beta-lactamases the enzymes detected in P. aeruginosa strains 4529, 5290 and 9902 may correspond to the 5th class, the enzymes of P. aeruginosa strain 8208 to the 2nd class and the beta-lactamases of the E. coli transconjugants to the 3rd class. Two different beta-lactamases were detected in P. aeruginosa strain 10294.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"413-7"},"PeriodicalIF":0.0,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17492612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparative effectiveness of immunomodulators in the therapy of rheumatic heart defects]. [免疫调节剂治疗风湿性心脏缺损的比较疗效]。
Antibiotiki Pub Date : 1984-06-01
A M Zemskov, V M Provotorov, E F Evstratova, V M Zemskov
{"title":"[Comparative effectiveness of immunomodulators in the therapy of rheumatic heart defects].","authors":"A M Zemskov,&nbsp;V M Provotorov,&nbsp;E F Evstratova,&nbsp;V M Zemskov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 166 patients with rheumatic heart diseases were examined. It was shown that the patients had secondary immune deficiency mainly with respect to the T-cells, which could not be eliminated with the routine therapeutic agents. The use of hemodes, decaris or sodium nucleinate in the combined therapy of such patients promoted correction of the immune deficiency and increased the treatment efficacy. Sodium nucleinate proved to be the most active.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"460-3"},"PeriodicalIF":0.0,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17392720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prevention of the formation of drug resistance in bacterial populations by using biologically active substances]. [通过使用生物活性物质预防细菌种群中耐药性的形成]。
Antibiotiki Pub Date : 1984-06-01
G E Afinogenov, T V Kopylova, N I Vladimirov, L N Briantseva
{"title":"[Prevention of the formation of drug resistance in bacterial populations by using biologically active substances].","authors":"G E Afinogenov,&nbsp;T V Kopylova,&nbsp;N I Vladimirov,&nbsp;L N Briantseva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The patients with infected wounds of the extremities were treated with kanamycin electrophoresis in combination with chlorhexidine bigluconate, an antiseptic. As compared to the patients treated with kanamycin alone, the rate of the wound size decrease in such patients was 2 times higher. The levels of microbial contamination in these patients were much lower. The contamination level with the aerobic flora was 4.8 times lower, including staphylococci, the level of contamination with which was 5.9 times lower. The contamination level with the kanamycin-resistant bacteria was 22 times lower. The treatment with kanamycin alone resulted in a 2.6-fold increase in the number of the antibiotic-resistant variants in the microbial populations of the wounds. In 48.2 per cent of the patients, this was accompanied by development of resistance to kanamycin in the whole microbial population of the wound. The development of the kanamycin resistance in the staphylococcal populations of 18.1 per cent of the patients was associated with changed sensitivity of the initial strains and in 81.9 per cent of the patients, with superinfection by the resistant strains. No changes in the kanamycin sensitivity of the initial gram-negative organisms during the treatment were observed. The use of chlorhexidine bigluconate, as a biologically active substance in combination with kanamycin potentiated the action of the antibiotic, prevented development and accumulation of the antibiotic-resistant variants in the microbial populations of the wounds and development of the drug resistance in these populations.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"417-21"},"PeriodicalIF":0.0,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17533279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antibacterial therapy of pyelonephritis in pregnant women]. 【孕妇肾盂肾炎的抗菌治疗】。
Antibiotiki Pub Date : 1984-06-01
Z M Akhtamova, Z I Abramova, S D Voropaeva
{"title":"[Antibacterial therapy of pyelonephritis in pregnant women].","authors":"Z M Akhtamova,&nbsp;Z I Abramova,&nbsp;S D Voropaeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To determine the optimal schemes of rational antibacterial therapy of pyelonephritis gravidarum with ampicillin and cephuroxim, assays of the patient urine and studies on the pharmacokinetics of the drugs were performed. The bacteriurea levels were estimated in 264 women with Gould's method in modification of Ryabinsky and Rodoman. The causative agents of the disease were isolated from the urine of 92 pregnant women. Sensitivity of the isolates to 9 antibiotics was tested with the use of standard paper disks and the method of serial dilutions in solid media. The pharmacokinetics of ampicillin and cephuroxim in the blood and urine of 97 patients was studied for 6-8 hours after parenteral administration of the antibiotics in doses of 500 mg. Comparative analysis of the pharmacokinetic parameters of the antibiotics in the blood and urine of the patients, the antibiotic MICs for the disease causative agents and the clinical course of the disease suggests that pyelonephritis gravidarum should be treated with ampicillin and cephuroxim on doses of 500 mg injected intramuscularly 4 and 3 times a day respectively for 7-8 days in combination with antiinflammatory therapy.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"456-60"},"PeriodicalIF":0.0,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17534045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Adriablastin (doxorubicin) in the combined chemotherapy of patients with disseminated forms of breast cancer]. [阿达伐星(阿霉素)在弥散性乳腺癌患者联合化疗中的应用]。
Antibiotiki Pub Date : 1984-06-01
E K Voznyĭ, N S Besova, T V Kurkina, Iu B Al'tshtuller
{"title":"[Adriablastin (doxorubicin) in the combined chemotherapy of patients with disseminated forms of breast cancer].","authors":"E K Voznyĭ,&nbsp;N S Besova,&nbsp;T V Kurkina,&nbsp;Iu B Al'tshtuller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 119 patients were treated for disseminated cancer of the mammary gland according to two schemes with the use of adriablastin. It was shown that in the treatment of metastases into the bones adriablastin was the drug of choice. The treatment of such patients with it may be effective. The analgetic action of the drug was noted in 80 per cent of the patients. The roentgenologically observed objective effect of the drug was provided by the doses higher than 300 mg and the treatment period of not less than 4 months. In the treatment of patients with metastases of other localization the schemes with the use of adriablastin had no advantage over the Cooper scheme.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"463-8"},"PeriodicalIF":0.0,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17534046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Spectrophotometric determination of prodigiozan in ampule solutions]. 分光光度法测定安瓿溶液中神曲菌赞的含量。
Antibiotiki Pub Date : 1984-06-01
L E Shchedrina, L I Brutko, G A Rastunova, E G Shcherbakova
{"title":"[Spectrophotometric determination of prodigiozan in ampule solutions].","authors":"L E Shchedrina,&nbsp;L I Brutko,&nbsp;G A Rastunova,&nbsp;E G Shcherbakova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Based on a study of the absorption properties of prodigiosan it has been shown that its UV absorption spectrum is characterized by an arm at 250-260 nm with an inflection point at 260 nm. The concentration ranges within which the optical density of prodigiosan solution obeyed the Bouguer-Lambert-Beer law were measured. This allowed the development of a quantitative spectrophotometric method for determination of prodigiosan in ampouled solutions.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"410-3"},"PeriodicalIF":0.0,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17533278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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