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[Determination of the content of the antibiotic cephalexin by alkalimetry]. [碱度法测定头孢氨苄的含量]。
Antibiotiki Pub Date : 1984-07-01
N Kane, K S Boparai
{"title":"[Determination of the content of the antibiotic cephalexin by alkalimetry].","authors":"N Kane, K S Boparai","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"500-1"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17542827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparative evaluation of the clinical effectiveness of 3 preparations of E. coli L-asparaginase]. 3种大肠杆菌l -天冬酰胺酶制剂的临床疗效比较。
Antibiotiki Pub Date : 1984-07-01
N A Kondrat'eva
{"title":"[Comparative evaluation of the clinical effectiveness of 3 preparations of E. coli L-asparaginase].","authors":"N A Kondrat'eva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Preparations of L-asparaginase made in the USSR, FRG and Japan were studied comparatively in 277 patients with acute lymphoblastic leukemia and lymphosarcomas. It was shown that the clinical characteristics of the preparation made in the USSR and the preparation (crasnitin) made in the FRG were identical. By the antileukemic action the preparation made in the USSR was superior to the preparation (leunase) made in Japan in the treatment of adult patients with such hemoblastosis forms. The effect of the three drugs in the treatment of children was analogous. The nature of the side effects of the three drugs was the same. However, their level was different. The allergenic effect of leunase on the patients was the most pronounced. L-Asparaginase made in the USSR and crasnitin are recommended for wide use in clinical practice.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"527-31"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17445284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Interrelation between the activity of the lytic enzyme producer Actinomyces recifensis var. lyticus 2435 and its population variability]. 裂解酶的产生者放线菌(Actinomyces recifensis var. lyticus 2435)的活性与其群体变异的相互关系。
Antibiotiki Pub Date : 1984-07-01
Iu S Babenko, T Ia Kulikova
{"title":"[Interrelation between the activity of the lytic enzyme producer Actinomyces recifensis var. lyticus 2435 and its population variability].","authors":"Iu S Babenko,&nbsp;T Ia Kulikova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Spontaneous variability of Actinomyces recifensis var. lyticus 2435 producing a complex of lytic enzymes was studied. A correlation between the strain activity and the content of the variants of the main morphological type in the population was shown. The carbon sources influenced the proportion of different type variants in the population. Strain 2435 was rather stable with respect to the level of the synthesis of yeast-like enzymes and showed a significant variation with respect to the level of the biosynthesis of the bacteriolytic complex. The population variation of strain 2435 with respect to the staphylolytic (synthesis of specific endopeptidases) and muramidase activity was most pronounced. The high activity levels of strain 2435 and wide lytic spectrum were provided by selection of the variants of the first morphological type with respect to the property of high staphylolytic activity.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"490-5"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17445281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antibiotic sensitivity of the microflora isolated from surgical patients with suppurative processes]. [化脓性手术患者分离菌群的抗生素敏感性]。
Antibiotiki Pub Date : 1984-07-01
N V Davydova, V G Riabtsev, E A Matveeva, E E Pogozheva, S A Dratvin
{"title":"[Antibiotic sensitivity of the microflora isolated from surgical patients with suppurative processes].","authors":"N V Davydova,&nbsp;V G Riabtsev,&nbsp;E A Matveeva,&nbsp;E E Pogozheva,&nbsp;S A Dratvin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pathological material from 77 surgical patients with purulent infections was assayed microbiologically and the properties of the pathogens were investigated. Multiple antibiotic resistance of the microflora monocultures and associations was shown. The aminoglycoside antibiotics and first of all gentamicin were the most effective.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"532-5"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17543607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Use of sodium nucleinate and its combinations with bacterial polysaccharides for preventing the nephrotoxic action of aminoglycoside antibiotics]. [使用核酸钠及其与细菌多糖联合预防氨基糖苷类抗生素的肾毒性作用]。
Antibiotiki Pub Date : 1984-07-01
R G Salakaia, N B Amirian
{"title":"[Use of sodium nucleinate and its combinations with bacterial polysaccharides for preventing the nephrotoxic action of aminoglycoside antibiotics].","authors":"R G Salakaia,&nbsp;N B Amirian","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Possible prevention of the nephrotoxic effect of different doses of aminoglycoside antibiotics, such as monomycin, kanamycin and gentamicin was studied experimentally on chinchilla rabbits. Substances increasing the cell resistance (sodium nucleinate, prodigiosan and pyrogenal alone and sodium nucleinate combinations with the bacterial polysaccharides) were used. It was shown that sodium nucleinate prevented nephrotoxicity of the aminoglycosides in the doses 2.5 times higher than the therapeutic ones. The combined use of sodium nucleinate with pyrogenal or prodigiosan was most effective. It prevented the nephrotoxic effect of the antibiotics in the doses 5 times higher than the therapeutic ones.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"507-9"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17542829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Action of the alkyl derivatives of amphotericin B on the conductivity of bilayer lipid membranes]. [两性霉素B的烷基衍生物对双层脂质膜导电性的作用]。
Antibiotiki Pub Date : 1984-07-01
Kh M Kasumov, O K Malafriev, V A Vaĭnshteĭn
{"title":"[Action of the alkyl derivatives of amphotericin B on the conductivity of bilayer lipid membranes].","authors":"Kh M Kasumov,&nbsp;O K Malafriev,&nbsp;V A Vaĭnshteĭn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Amphotericin B alkyl derivatives increased conductivity of bilayer membranes by formation of channels in them. The properties of such channels were studied. A new method for determination of the polyene antibiotic toxicity is described. The method is based on measurement of the constant of the relaxation time on the antibiotic removal from the membrane solution. It was shown that the amphotericin B alkyl derivatives had very low toxicity for the mammalian cells and were highly toxic for the fungal cells. These antibiotics may be used as new effective antifungal compounds.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"513-6"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17158773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Plasmids and the genome instability of Streptomyces]. 链霉菌的质粒和基因组不稳定性。
Antibiotiki Pub Date : 1984-07-01
L I Starodubtseva, V N Danilenko, S M Navashin
{"title":"[Plasmids and the genome instability of Streptomyces].","authors":"L I Starodubtseva,&nbsp;V N Danilenko,&nbsp;S M Navashin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"536-55"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17158775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regeneration of Nocardia orientalis protoplasts]. 【东方诺卡氏菌原生质体的再生】。
Antibiotiki Pub Date : 1984-07-01
A S Trenin, Iu V Dudnik
{"title":"[Regeneration of Nocardia orientalis protoplasts].","authors":"A S Trenin,&nbsp;Iu V Dudnik","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A method for effective regeneration of the protoplasts of N. orientalis, a vancomycin-producing organism into viable cells on a rich organic medium was developed. The dependence of the regeneration on the conditions of the protoplast plating out and the level of the regeneration medium dehydration was studied. The highest positive effect was observed when the protoplasts were suspended in the agarized medium and then plated out on the regeneration medium dehydrated by 2.5 per cent. The frequency of the protoplast regeneration increased on addition of bovine serum albumin to the regeneration medium. The effect of bovine serum albumin depended on its concentration. When the albumin concentration was optimal (0.01 per cent) the regeneration amounted to 100 per cent.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"495-500"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17542826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Action of reumycin on the blood system in an experiment]. [实验中鲁霉素对血液系统的作用]。
Antibiotiki Pub Date : 1984-07-01
T P Svinogeeva, E K Berezina, L I Raĭko
{"title":"[Action of reumycin on the blood system in an experiment].","authors":"T P Svinogeeva,&nbsp;E K Berezina,&nbsp;L I Raĭko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of reumycin, an antitumor antibiotic on the peripheral circulatory system and bone marrow was studied on albino rats. The drug was injected intraperitoneally in a dose of 25 mg/kg daily for 30 days. It was shown that reumycin had a comparatively low toxic effect on the peripheral circulatory system and hemopoiesis. It induced the signs of transitory anemia and did not suppress the regenerative capacity of the bone marrow. After the drug repeated use there was an increase in the platelet count and in the rate of blood coagulation. These signs vanished a month after the end of the treatment course.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"516-9"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17543606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A number of sorbents useful for the sorption of cephalosporin C]. [对头孢菌素C的吸收有用的一些吸附剂]。
Antibiotiki Pub Date : 1984-07-01
L M Kliueva, E S Vaĭsberg
{"title":"[A number of sorbents useful for the sorption of cephalosporin C].","authors":"L M Kliueva,&nbsp;E S Vaĭsberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The physicochemical and sorption properties of a number of sorbents made in the USSR and abroad were studied with respect to the recovery of cephalosporin C from a model solution. It was shown that the sorption capacity of a sorbent depended on its specific surface. The macroporous styrene divinylbenzene sorbents with a specific surface of more than 500 m2/g had the best sorption properties.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 7","pages":"488-90"},"PeriodicalIF":0.0,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17542825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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