[实验中鲁霉素对血液系统的作用]。

Antibiotiki Pub Date : 1984-07-01
T P Svinogeeva, E K Berezina, L I Raĭko
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引用次数: 0

摘要

研究了抗肿瘤抗生素雷霉素对白化大鼠外周血循环系统及骨髓的影响。以25 mg/kg /天的剂量腹腔注射,连续30天。结果表明,鲁霉素对外周血循环系统和造血功能的毒性作用较低。它诱导短暂性贫血的迹象,并没有抑制骨髓的再生能力。药物重复使用后,血小板计数和凝血率增加。这些症状在疗程结束一个月后消失。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Action of reumycin on the blood system in an experiment].

The effect of reumycin, an antitumor antibiotic on the peripheral circulatory system and bone marrow was studied on albino rats. The drug was injected intraperitoneally in a dose of 25 mg/kg daily for 30 days. It was shown that reumycin had a comparatively low toxic effect on the peripheral circulatory system and hemopoiesis. It induced the signs of transitory anemia and did not suppress the regenerative capacity of the bone marrow. After the drug repeated use there was an increase in the platelet count and in the rate of blood coagulation. These signs vanished a month after the end of the treatment course.

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