{"title":"[头孢菌素和卡比西林在无菌性炎症大鼠组织中的渗透]。","authors":"I V Agapitova, V I Bobrov","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Two beta-lactam antibiotics with different serum protein binding were studied for penetration into the tissues of rats with aseptic inflammation. It was found that the pharmacokinetics of the drugs in the blood serum differed only in the elimination rate. The levels of the free fraction of cephaloridin were much higher than those of carbenicillin. The maximum concentrations of free cephaloridin in the inflammation exudate, intact and inflamed tissues and the areas under its pharmacokinetic curves were higher than those of carbenicillin. The elimination rate of both the drugs was the same for all the tissues studied.</p>","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 6","pages":"427-30"},"PeriodicalIF":0.0000,"publicationDate":"1984-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Cephalosporin and carbenicillin penetration into the tissues of rats with aseptic inflammation].\",\"authors\":\"I V Agapitova, V I Bobrov\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Two beta-lactam antibiotics with different serum protein binding were studied for penetration into the tissues of rats with aseptic inflammation. It was found that the pharmacokinetics of the drugs in the blood serum differed only in the elimination rate. The levels of the free fraction of cephaloridin were much higher than those of carbenicillin. The maximum concentrations of free cephaloridin in the inflammation exudate, intact and inflamed tissues and the areas under its pharmacokinetic curves were higher than those of carbenicillin. The elimination rate of both the drugs was the same for all the tissues studied.</p>\",\"PeriodicalId\":7959,\"journal\":{\"name\":\"Antibiotiki\",\"volume\":\"29 6\",\"pages\":\"427-30\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Antibiotiki\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Antibiotiki","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Cephalosporin and carbenicillin penetration into the tissues of rats with aseptic inflammation].
Two beta-lactam antibiotics with different serum protein binding were studied for penetration into the tissues of rats with aseptic inflammation. It was found that the pharmacokinetics of the drugs in the blood serum differed only in the elimination rate. The levels of the free fraction of cephaloridin were much higher than those of carbenicillin. The maximum concentrations of free cephaloridin in the inflammation exudate, intact and inflamed tissues and the areas under its pharmacokinetic curves were higher than those of carbenicillin. The elimination rate of both the drugs was the same for all the tissues studied.
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