[强力霉素在实验性立克次体感染中的应用]。

Antibiotiki Pub Date : 1984-10-01

N G Kekcheeva

{"title":"[强力霉素在实验性立克次体感染中的应用]。","authors":"N G Kekcheeva","doi":"","DOIUrl":null,"url":null,"abstract":"The effect of doxycycline on R. prowazekii and R. sibirica was studied in comparison with that of tetracycline on two infection models, i. e. chick embryos and guinea pigs. The activity of doxycycline in the experiments with chick embryos was higher than that of tetracycline, the drug being more active against R. prowazekii than R. sibirica. The use of doxycycline in the treatment of the guinea pigs infected with R. prowazekii resulted in very rapid and stable decrease of the temperature. When used within the incubation period the drug prevented the infection development. Doxycycline was less effective in infections caused by R. sibirica.","PeriodicalId":7959,"journal":{"name":"Antibiotiki","volume":"29 10","pages":"775-80"},"PeriodicalIF":0.0000,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Doxycycline in experimental rickettsial infection].\",\"authors\":\"N G Kekcheeva\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effect of doxycycline on R. prowazekii and R. sibirica was studied in comparison with that of tetracycline on two infection models, i. e. chick embryos and guinea pigs. The activity of doxycycline in the experiments with chick embryos was higher than that of tetracycline, the drug being more active against R. prowazekii than R. sibirica. The use of doxycycline in the treatment of the guinea pigs infected with R. prowazekii resulted in very rapid and stable decrease of the temperature. When used within the incubation period the drug prevented the infection development. Doxycycline was less effective in infections caused by R. sibirica.\",\"PeriodicalId\":7959,\"journal\":{\"name\":\"Antibiotiki\",\"volume\":\"29 10\",\"pages\":\"775-80\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Antibiotiki\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Antibiotiki","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

研究了强力霉素与四环素对鸡胚和豚鼠两种感染模型的影响。在鸡胚实验中，强力霉素的活性高于四环素，对鼠瘟热菌的活性高于西伯利亚鼠瘟热菌。多西环素治疗豚鼠感染普拉兹氏弧菌后，体温迅速稳定下降。在潜伏期内使用该药物可防止感染的发展。强力霉素对西伯利亚致病菌感染效果较差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Doxycycline in experimental rickettsial infection].

The effect of doxycycline on R. prowazekii and R. sibirica was studied in comparison with that of tetracycline on two infection models, i. e. chick embryos and guinea pigs. The activity of doxycycline in the experiments with chick embryos was higher than that of tetracycline, the drug being more active against R. prowazekii than R. sibirica. The use of doxycycline in the treatment of the guinea pigs infected with R. prowazekii resulted in very rapid and stable decrease of the temperature. When used within the incubation period the drug prevented the infection development. Doxycycline was less effective in infections caused by R. sibirica.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Antibiotiki

自引率

0.00%

发文量