Antimicrobial Resistance and Infection Control最新文献

{"title":"Management and microbial monitoring of final rinse water for flexible endoscopes in 290 hospitals in Jiangsu Province, China: a multicenter cross-sectional study.","authors":"Zhanjie Li, Bo Liu, Qingtang Zhu, Zijun Ge, Feng Zang, Wensen Chen, Yongxiang Zhang, Xiafen Ding, Jing Ding, Weihong Zhang","doi":"10.1186/s13756-025-01560-3","DOIUrl":"https://doi.org/10.1186/s13756-025-01560-3","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of a universally accepted standard or guideline for the frequency of disinfection in purified water pipelines. Furthermore, there is no standardized method for detecting microorganisms in the final rinse water utilized for endoscope cleaning.This study aims to examine the current management and microbial monitoring practices concerning the final rinse water used for flexible endoscope cleaning in medical institutions.</p><p><strong>Methods: </strong>A questionnaire was designed using a convenience sampling method to gather data on the maintenance and microbial monitoring of final rinse water for flexible endoscopes in 290 medical institutions across Jiangsu Province, China.</p><p><strong>Results: </strong>Purified water is used for endoscope rinsing by 93.45% of institutions, with 78.62% employing centralized water supply. Membrane filtration devices at the terminal are installed by 82.07%, mainly with a 0.2μm pore size (76.47%), and are replaced quarterly (32.77%). Disinfection devices are present at 52.76% of terminals, with varied disinfection frequencies; chlorine-containing disinfectants (48.15%) and peracetic acid (34.92%) are predominant. Inadequate disinfection, filter membrane neglect, sampling contamination, and biofilm formation are identified as reasons for non-compliant final rinse water. Actions include filter replacement, pipeline disinfection, and flushing. Microbial mornitoring occurs quarterly (70.96%), with faucet outlets as primary sampling sites. Standards are based on 10cfu/100ml (87.58%), using membrane filtration (40.81%) and nutrient agar plates (82.72%). A cultivation period of 2 days predominated (72.43%), with a temperature range of 35-37°C (76.47%).</p><p><strong>Conclusion: </strong>While purified water and terminal filters are common for final rinsing of endoscopes, there is variation in maintenance and supply line disinfection. Current microbiological methods' reliability is considered low, necessitating further research to establish unified standards for effective endoscope final rinse water management and monitoring.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"40"},"PeriodicalIF":4.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration of hospitalization increases the risk for long-term carriage of linezolid-resistant enterococci in critically ill patients.","authors":"Vera Rauschenberger, Heike Claus, Charlotte Polzin, Vera Blaschke, Stefanie Kampmeier","doi":"10.1186/s13756-025-01551-4","DOIUrl":"https://doi.org/10.1186/s13756-025-01551-4","url":null,"abstract":"<p><strong>Background: </strong>Enterococci are gut commensal microorganisms, which can however cause life-threatening infections especially in patients suffering from intestinal barrier disorders. Treatment of these enterococcal infections is challenging due to a variety of intrinsic and acquired antibiotic resistances. In this context, linezolid is applied as last-resort antibiotic. Our study aimed at determining linezolid-resistant enterococci (LRE) long-term carriage (≥ 10 weeks), since this is a risk factor for the development of LRE infection.</p><p><strong>Methods: </strong>In a one-year cohort study, all patients on hemato-oncology, intensive and intermediate care units were screened for LRE. To determine the molecular epidemiology, all detected LRE isolates were subjected to whole genome sequencing-based typing to investigate whether in-host selection or pathogen transmission was causative for LRE occurrence. Clinical and demographic data were recorded to identify risk factors for LRE clearance and persistence.</p><p><strong>Results: </strong>Long-term LRE carriage was identified in 7 of 46 (15%) patients. Duration of hospitalization differed significantly between LRE persistence (mean: 110 days; range 28-225 days) and clearance group (mean: 53 days; range 5-213 days). LRE strains mostly exhibited a high genetic core genome diversity, indicating that transmission events played a minor role.</p><p><strong>Conclusions: </strong>Our study shows that the duration of hospitalization increases the risk for long-term carriage of LRE. In contrast to other multi drug resistant bacteria, LRE carriage was rarely caused by transmission events. Thus, future infection prevention measures should focus on antimicrobial stewardship approaches next to classical hygiene strategies.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"39"},"PeriodicalIF":4.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of standard precautions and unrestricted movements of carbapenemase-producing Enterobacterales (CPE) carriers on CPE transmission in a nursing home in Singapore: a prospective cohort study.","authors":"Kyaw Zaw Linn, Xiaowei Huan, Pei Yun Hon, Sharifah Farhanah Syed Husen, Natascha May Thevasagayam, Oon Tek Ng, Shawn Vasoo, Moi Lin Ling, Dale Fisher, Kalisvar Marimuthu","doi":"10.1186/s13756-025-01554-1","DOIUrl":"https://doi.org/10.1186/s13756-025-01554-1","url":null,"abstract":"<p><strong>Background: </strong>In 2018, Singapore's National Infection Prevention & Control Committee (NIPC) recommended standard precautions and unrestricted movements for CPE carriers in nursing homes.</p><p><strong>Objective: </strong>This study investigates the short-term impact of this intervention on CPE transmission in a nursing home in Singapore.</p><p><strong>Methods: </strong>We conducted a prospective cohort study between 1st April and 11th July 2019 in a 255-bedded nursing home in Singapore. Stool samples from residents and environmental samples from sink strainers in the residents' bedrooms, bathrooms, and lavatories, and shower drain traps in bathrooms were collected at baseline, week 2, week 8, and week 12 and tested for CPE. We performed whole genomic sequencing (WGS) to find out if there was any bacterial or plasmid linkage among the residents and between the residents and environment.</p><p><strong>Results: </strong>A total of 32 residents, including six known CPE carriers, were recruited and completed the three-month follow-up visits. Of the six known CPE carriers, five tested negative for CPE, while one consistently tested positive for CPE throughout the study. Of the 28 sink strainers, six (21.43%) were positive for CPE. CPE was not detected in any shower drain trap throughout the study. Only one resident acquired CPE at week 12. WGS analysis of available CPE isolates showed no bacterial or plasmid linkage between residents or between residents and the environment.</p><p><strong>Conclusions: </strong>Standard precautions and unrestricted movement of CPE carriers may be sufficient to control CPE transmission in the nursing home setting. Larger studies with more extensive environmental sampling and longer follow-up periods are needed to confirm this.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"38"},"PeriodicalIF":4.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Antimicrobial stewardship in the community setting: a qualitative exploratory study.","authors":"Rose I Okonkwo, Henry Ndukwe, Gary Grant, Sohil Khan","doi":"10.1186/s13756-025-01556-z","DOIUrl":"https://doi.org/10.1186/s13756-025-01556-z","url":null,"abstract":"","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"35"},"PeriodicalIF":4.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of fungi and their antifungal and disinfectant resistance in hospital environments: insights into combating nosocomial mycoses.","authors":"Soudabeh Ghodsi, Mahnaz Nikaeen, Shima Aboutalebian, Rasoul Mohammadi, Hossein Mirhendi","doi":"10.1186/s13756-025-01558-x","DOIUrl":"https://doi.org/10.1186/s13756-025-01558-x","url":null,"abstract":"<p><strong>Background: </strong>Fungal infections are increasingly recognized as a global health concern, contributing to considerable morbidity and mortality in hospital settings. This underscores the urgent need for infection prevention and control in healthcare facilities to protect vulnerable patients from the risk of acquiring invasive fungal diseases (IFDs). Given the critical role of transmission-based precautions in limiting the spread of filamentous fungi responsible for IFDs, this study was conducted to explore the potential role of the hospital environment in the dissemination of these infections.</p><p><strong>Methods: </strong>A total of 83 samples were collected from the air and surface of exhaust vents in the intensive care units (ICUs) of hospitals in Isfahan, Iran, to assess the presence and diversity of fungal species. Susceptibility testing against antifungal agents, including commonly used drugs and disinfectants, was performed on the identified fungal isolates. Furthermore, the antifungal resistance profiles of isolates from clinical IFD cases were compared with those of environmental isolates.</p><p><strong>Results: </strong>Fungi were detected in 45% of air samples and 100% of exhaust vent samples, with Aspergillus species being the most commonly identified genus. Mucorales were also found in 17% of exhaust vent samples. Aspergillus spp. and Rhizopus spp. showed the highest resistance to Amphotericin B, and a considerable proportion of these isolates exhibited simultaneous resistance to disinfectants. A similar antifungal resistance profile was noted between A. flavus and some R. arrhizus isolates from both environmental and clinical samples.</p><p><strong>Conclusions: </strong>The findings of this study indicate that the hospital environment, particularly exhaust vents, may act as a significant reservoir for causative agents of IFDs. This highlights the importance of environmental surveillance in preventing and controlling nosocomial fungal infections.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"37"},"PeriodicalIF":4.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing bedding hygiene in long-term care facilities: investigating the impact of multilevel antimicrobial polymers (MAP-1) on bacterial and MDRO reduction.","authors":"Awais Farid, Wei Han, Joseph K C Kwan, King Lun Yeung","doi":"10.1186/s13756-025-01555-0","DOIUrl":"https://doi.org/10.1186/s13756-025-01555-0","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the bactericidal efficacy of Multilevel Antimicrobial Polymer (MAP-1) on standard bedsheets in Long-term care facility (LTCF). The research quantifies total viable bacteria and MRSA counts and evaluates the percentage difference between treated and control bedding material over a one-week period.</p><p><strong>Design: </strong>A double-blind interventional, double cross-over study.</p><p><strong>Setting: </strong>Haven of Hope Woo Ping Care and Attention Home in Sai Kung, Hong Kong.</p><p><strong>Methods: </strong>Over an 8-week period, bedding materials from residents' rooms were sampled, totalling 288 samples from 96 bedsheets, with half treated with MAP-1 and the remaining serving as controls. MAP-1, developed at The Hong Kong University of Science and Technology, incorporates USFDA and USEPA-approved polymers. Sampling procedures adhered to standardized protocols, and bacterial counts were determined using culture methods. Data analysis employed t-tests and ANOVA to compare microbial loads between the control and treatment groups, with statistical significance set at p < 0.05.</p><p><strong>Results: </strong>The study revealed a significant reduction in total viable bacteria and MRSA counts on bedsheets treated with MAP-1. Noteworthy reductions of 80.37% for total bacteria and 87.31% for MRSA at the end of seven-day use, in the intervention group compared to the control. These reductions were statistically significant across all four observation periods and among both male and female residents.</p><p><strong>Conclusion: </strong>The study establishes the bactericidal efficacy of MAP-1 on standard bedsheets, showcasing its potential in diminishing total bacterial counts and MRSA contamination. These results hold promise for enhancing infection control practices and promoting improved sanitary conditions within healthcare settings.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"36"},"PeriodicalIF":4.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of a national repository of Fourier-transform infrared spectroscopy spectra enables fast detection of silent outbreaks and prevention of spread of new antibiotic-resistant sequence types.","authors":"Mor N Lurie-Weinberger, Elizabeth Temkin, Ophir Kastel, Moshe Bechor, Darya Bychenko-Banyas, Reut Efrati-Epchtien, Gabrielle D Levi, Nadya Rakovitsky, Alona Keren-Paz, Yehuda Carmeli","doi":"10.1186/s13756-025-01546-1","DOIUrl":"https://doi.org/10.1186/s13756-025-01546-1","url":null,"abstract":"<p><strong>Background: </strong>The reference microbiology laboratory of Israel's National Institute for Antibiotic Resistance and Infection Control has established a national repository of isolates analyzed by Fourier-transform infrared (FTIR) spectroscopy and their spectra. Healthcare institutions send antibiotic-resistant isolates as part of outbreak investigation, periodic nation-wide collection of specific species, or point prevalence studies. Here, we describe the use of a national FTIR repository to detect the emergence and spread of new sequence types and resistance mechanisms.</p><p><strong>Methods: </strong>Using FTIR, we produced dendrograms of outbreaks and periodic country-level dendrograms of isolates from selected species. When FTIR identified new clusters that were distinct from previously characterized clusters, they were investigated further by whole genome sequencing.</p><p><strong>Results: </strong>FTIR analysis uncovered two clones new to Israel: NDM-5-producing E. coli ST650 harboring a novel plasmid, and NDM-producing K. pneumoniae ST307.</p><p><strong>Conclusions: </strong>Establishing regional or national FTIR repositories could serve as a simple and effective tool for early detection of new antibiotic-resistant clones.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"34"},"PeriodicalIF":4.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the feasibility, appropriateness, and acceptability of an environmental cleaning program improvement toolkit at a tertiary care hospital in Nigeria.","authors":"Cori Dennison, Matthew Hudson, Damilola Adeniyi, Folasade Ogunsola, Hanako Osuka, Lisa P Oakley, Paul Malpiedi, Amber Vasquez, Molly Patrick","doi":"10.1186/s13756-025-01550-5","DOIUrl":"https://doi.org/10.1186/s13756-025-01550-5","url":null,"abstract":"<p><strong>Background: </strong>Environmental cleaning is a key infection prevention and control (IPC) intervention in healthcare settings. The U.S. Centers for Disease Control and Prevention (CDC), with Infection Control Africa Network (ICAN), developed best practices for global healthcare environmental cleaning in resource-limited settings to help fill gaps in guidance in low- and middle-income countries (LMICs). We aimed to evaluate the feasibility, appropriateness, and acceptability of a quality improvement toolkit developed to assist with implementing the CDC/ICAN best practices at Lagos University Teaching Hospital in Nigeria.</p><p><strong>Methods: </strong>A mixed-methods approach was used to evaluate the implementation of the toolkit from March through September of 2021. A monitoring checklist assessed feasibility after three defined steps within the toolkit. Key informant interviews and electronic surveys were conducted with toolkit team members at three time points during implementation to assess appropriateness and acceptability. A deductive analytic process was used to code and analyze interview data based on constructs of appropriateness and acceptability. Additional codes and sub-themes that emerged during analysis followed an inductive process.</p><p><strong>Results: </strong>Within the interviews and surveys, themes identified for the appropriateness included concern related to (1) time commitment for the toolkit activities and (2) resources required to sustain improvements. Themes identified for acceptability included (1) perceived challenges with time commitment and resource requirements, (2) perceived effectiveness of toolkit structure and usability, (3) perceived benefits and success associated with knowledge gained about environmental cleaning and environmental cleaning staff, (4) perceived benefits and success associated with the training for cleaning staff undertaken during toolkit implementation, and (5) perceived benefits and success associated with the multidisciplinary team approach with the inclusion of facility leadership and a project coordinator.</p><p><strong>Conclusions: </strong>The results showed that the toolkit materials were feasible within the local context and highlighted perceived effectiveness, benefits, and success of the toolkit process and experience contributing to a high level of acceptability. Challenges relating to time commitment and concern for sustainability have implications for the appropriateness of this toolkit, similar approaches to quality improvement, and the need for strengthening support for IPC improvements at the facility and national levels in resource-limited healthcare settings in LMICs.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"33"},"PeriodicalIF":4.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated assessment of antimicrobial stewardship in carbapenem resistant Klebsiella pneumoniae prevalent hospitals in China: a multidisciplinary surveillance network-based survey.","authors":"Haishaerjiang Wushouer, Weibin Li, Junxuan Yu, Lin Hu, Xiaodong Guan, Xiaolin Liu, Anhua Wu, Xiaoqiang Yang, Minggui Wang, Yingchun Xu, Yanping Luo, Xun Huang, Luwen Shi","doi":"10.1186/s13756-025-01545-2","DOIUrl":"https://doi.org/10.1186/s13756-025-01545-2","url":null,"abstract":"<p><strong>Background: </strong>China has established an extensive multidisciplinary surveillance network encompassing antimicrobial utilisation, antimicrobial resistance, and nosocomial infections. We aimed to identify challenges and barriers in antimicrobial stewardship (AMS) development based on this national multidisciplinary surveillance network.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in 15 hospitals across China from July 2021 to April 2023. Purposeful sampling was employed to select the hospitals based on the rising prevalence of carbapenem-resistant Klebsiella pneumoniae. The survey consisted of three parts: a testing questionnaire was used to assess the awareness of clinical physicians regarding AMS; a scoring table was developed through the Delphi method to assess the hospitals' multidisciplinary management covering antibacterial usage surveillance, resistance surveillance, fungal surveillance, infectious disease management, and infection prevention and control; an on-site investigation based on case review and field inspection. Pearson correlation tests were used to examine the relationship between resistance levels and scores for various items. Theme analysis was applied to highlight key areas of focus in hospital multidisciplinary AMS from the on-site investigation.</p><p><strong>Results: </strong>Findings revealed that physicians of respiratory, infectious disease, and critical care were the top 3 specialists in AMS awareness scores, with an average of 70 points, 65 points and 62.5 points, respectively (a full mark of 100 points). Performance in infectious disease management, antibacterial surveillance, and infection prevention and control showed a scoring rate over 70%, with relatively low scores in resistance surveillance (49.1%) and fungal surveillance (36.0%). No significant correlation was found between any single scoring item and the resistance levels of focused drug-resistance pathogens. Five key areas were identified for improving multidisciplinary AMS: organizational structure, staffing and training, drug formulary and prescription management, laboratory testing and quality control, and clinical sampling and data reporting.</p><p><strong>Conclusions: </strong>The prevalence of focused drug-resistance pathogens could not attribute to any single factor. The following AMS activities should emphasise the establishment of sophisticated communication and collaboration mechanisms within multidisciplinary teams.</p><p><strong>Trial registration: </strong>Approval for this study was granted by the Ethics Committee of Peking University (reference number IRB00001052-22100).</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"32"},"PeriodicalIF":4.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of an outbreak of carbapenem resistant Acinetobacter baumannii in an intensive care unit during the COVID-19 epidemic.","authors":"Yi Kong, Ting Liu, Yanru Zhang, Hui Wang, Hongyi Lin","doi":"10.1186/s13756-025-01547-0","DOIUrl":"https://doi.org/10.1186/s13756-025-01547-0","url":null,"abstract":"<p><strong>Background: </strong>During the Coronavirus Disease 2019 (COVID-19) epidemic, the strain on intensive care units (ICUs) has increased, which made them more vulnerable to the threat of multidrug-resistant organism (MDRO).</p><p><strong>Aim: </strong>This study aims to investigate an outbreak of carbapenem resistant Acinetobacter baumannii (CRAB) infection in a general adult ICU of a tertiary hospital in China during the COVID-19 epidemic and evaluate the effectiveness of intervention measures.</p><p><strong>Methods: </strong>Demographic and clinical data of 37 patients were collected, and 230 environmental samples were collected. Whole genome sequencing (WGS) analysis was performed on clinical and environmental isolates. An evolutionary tree was constructed based on the WGS data. The infection control team implemented a bundle of MDRO interventions, including a termination of COVID-19 infection control measures and implementation of 'three-step' cleaning and disinfection method.</p><p><strong>Findings: </strong>There were 37 patients found to have CRAB infection or colonization in the ICU from December 2022 to April 2023, of whom 35 were hospital-acquired. 12 CRAB isolates were obtained from the environment and medical equipment. Through WGS analysis, the CRAB strains from the medical environment and bronchoscopes were found to be highly homologous to those from patients' clinical specimens. This demonstrated that the infection outbreak was caused by the lack of MDRO prevention and control measures. Following intervention, the CRAB detection rate gradually declined, with no positive samples for CRAB found in the ICU environment or on bronchoscopes.</p><p><strong>Conclusion: </strong>The infection control measures for COVID-19 conflicted with basic MDRO prevention and control strategies, likely contributing to the outbreak. Therefore, established infection prevention and control measures should be consistently followed, as they represent the most effective approach to preventing MDRO.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"30"},"PeriodicalIF":4.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}