Antimicrobial Resistance and Infection Control最新文献

{"title":"Trends of antibiotic use for acute upper respiratory infections in Chinese emergency departments and the impact of COVID-19: a cross-sectional study.","authors":"Tingxi Wu, Tongxu Li, Heng Guo, Bin Zhu, Yang Zhang, Zhigang Zhao","doi":"10.1186/s13756-025-01567-w","DOIUrl":"10.1186/s13756-025-01567-w","url":null,"abstract":"<p><strong>Background: </strong>The emergence of Coronavirus Disease 2019 (COVID-19) has impacted antibiotic use; however, studies on antibiotic use for acute upper respiratory infections (AURIs) in Chinese emergency department (ED) settings are still scarce.</p><p><strong>Objective: </strong>This study aimed to explore trends and patterns in antibiotic use and the impact of COVID-19 in Chinese ED settings.</p><p><strong>Methods: </strong>A cross-sectional, retrospective analysis was conducted using prescriptions for ED visits due to AURIs through the Hospital Prescription Analysis Cooperative Project Database between 2018 and 2023. We examined patterns of antibiotic use for AURIs and employed an interrupted time series analysis to assess the impact of the COVID-19 pandemic on antibiotic use. The proportion of antibiotic prescriptions adhering to first-line guideline recommendations was also evaluated.</p><p><strong>Results: </strong>A total of 1,972,270 prescriptions for AURIs from 108 hospitals in EDs were extracted. The antibiotic prescription rate (APR) was 58.44%. The predominant antibiotics prescribed for AURIs were second- and third-generation cephalosporins and azithromycin. Among these prescriptions, only 22.26% adhered to first-line guideline recommendations, while 83.82% involved Watch-group antibiotics. A substantial decrease in antibiotic consumption was observed at the onset of the pandemic, but no significant changes were found in the APR. After the relaxation of anti-COVID-19 measures, both antibiotic consumption and the APR exhibited an upward trend. However, neither returned to pre-pandemic levels.</p><p><strong>Conclusion: </strong>Antibiotic use for AURIs was prevalent in ED settings, with a predominant use of broad-spectrum and Watch-group antibiotics. After the lifting of pandemic control measures, both antibiotic consumption and the APR exhibited an upward trend, underscoring the need to reinforce antimicrobial stewardship, particular targeting broad-spectrum and Watch-group antibiotic use.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"51"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quick and dirty: improper glove use increases infection risk and has global consequences.","authors":"Alexandra Peters, Martina Močenić, Alberto Spitilli, Sally Bloomfield, Mahmood F Bhutta","doi":"10.1186/s13756-025-01563-0","DOIUrl":"10.1186/s13756-025-01563-0","url":null,"abstract":"<p><p>The development of disposable gloves and the discovery that good hand hygiene are essential for protecting patients are among the most important developments in the history of infection prevention and control, and are both essential for protecting patients and healthcare workers. Although there are international-level guidelines for glove use and hand hygiene during patient care, there are major issues concerning compliance. The overuse of gloving does not only contribute to reduced patient safety and increased healthcare-associated infections, but leads directly to environmental degradation and labor rights abuses.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"52"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between heuristic and deliberative thinking: a multi-center qualitative study of physicians' decision-making in infection prevention practice.","authors":"Miriam Schutte, Mireille Dekker, Jonne Sikkens, Rosa van Mansfeld","doi":"10.1186/s13756-025-01572-z","DOIUrl":"10.1186/s13756-025-01572-z","url":null,"abstract":"<p><strong>Background: </strong>Application of standard infection prevention and control (IPC) measures is crucial to prevent hospital-acquired infections, but compliance by physicians is suboptimal. Interventions aimed to improve compliance are often generic and lack sustained effects. A better understanding of physicians' trade-offs regarding application of IPC and influences on their behavior is needed to develop effective behavior change interventions. We aimed to understand physicians' decision-making processes around application of IPC and the factors that influence their behavior.</p><p><strong>Methods: </strong>This qualitative study involved semi-structured interviews with 18 physicians and 7 nurses from five different hospitals in the Netherlands. Reflexive thematic analysis involved inductive coding followed by deductive analysis using mechanisms of action, including the Theoretical Domains Framework, that link to behavior change techniques.</p><p><strong>Results: </strong>We found heterogeneity in physicians' approaches to decision-making around application of IPC. Some physicians relied on heuristics, while others applied logical reasoning. The latter group made an autonomous assessment of the risks for infection associated with a situation and traded off the costs and benefits of IPC application. The decision was further influenced by personal beliefs about the value of IPC and a supporting physical and social environment. Eighteen out of 26 mechanisms of action underlying the influences on IPC behavior were matched to our results; most important are \"memory, attention and decision processes\", \"behavioral cueing\", \"beliefs about consequences\", \"values\", \"norms\", \"social influences\", \"social learning/imitation\" and \"environmental context and resources\". These findings suggest that interventions are most likely to be beneficial if these focus on developing heuristics, changing risk beliefs, using social norms and imitation and generating a supportive environment.</p><p><strong>Conclusion: </strong>The heterogeneity in physicians' decision-making and autonomous risk assessment which is different from other healthcare professionals calls for tailored interventions targeting heuristic decision making, personal beliefs, social norms and the environmental context.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"50"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and outcome for bloodstream infections due to fluconazole-resistant Candida parapsilosis: a 22-year single-center retrospective study.","authors":"Cihan Semet, Esra Kazak, Beyza Ener, Seçil Ak, Güven Özkaya, Harun Ağca, Yasemin Heper, Emel Yılmaz, Halis Akalın","doi":"10.1186/s13756-025-01559-w","DOIUrl":"https://doi.org/10.1186/s13756-025-01559-w","url":null,"abstract":"<p><p>Candidemia ranks among the top causes of nosocomial bloodstream infections, significantly increasing hospital stays and costs. Rapid and effective empirical antifungal therapy is crucial. The Candida parapsilosis species complex, the second most common cause of candidemia, has shown rising fluconazole resistance globally and in our country. Additionally, echinocandins exhibit higher minimum inhibitory concentrations (MICs) for C. parapsilosis, complicating empirical treatment decisions. This retrospective study analyzed 173 C. parapsilosis candidemia cases over 22 years in a tertiary care hospital. We compared 88 fluconazole non-susceptible (minimum inhibitory concentration [MIC] = 4 µg/mL: susceptible dose dependent; MIC ≥ 8 µg/ml resistant) and 85 fluconazole susceptible cases, examining demographics, clinical characteristics, risk factors, and 28-day mortality. Independent risk factors for fluconazole non-susceptibilty included age ≥ 66 years (p = 0.016), central venous catheter use (p < 0.001), total parenteral nutrition (p = 0.003), and colostomy (p = 0.049). Fluconazole non-susceptible cases had lower microbiological cure rates and higher mortality. Mortality in this group was independently associated with microbiological cure failure (p < 0.001). This study highlights the importance of identifying risk factors to estimate the likelihood of resistant pathogens, initiating targeted antifungal therapy, and providing individualized management. Monitoring local resistance patterns is essential to guide empirical therapy. Further multicenter research is needed to validate findings and optimize treatment for fluconazole resistant candidemia. Clinical trial number: Not applicable.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"49"},"PeriodicalIF":4.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infection control interventions against carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an Iranian referral university hospital: A quasi-experimental study.","authors":"Mojtaba Akbari, Christian G Giske, Malihe Alenaseri, Ahmad Zarei, Narjes Karimi, Hamid Solgi","doi":"10.1186/s13756-025-01569-8","DOIUrl":"10.1186/s13756-025-01569-8","url":null,"abstract":"<p><strong>Background: </strong>In the past decades, the prevalence of carbapenem-resistant Gram-negative bacteria (CR-GNB) has increased on a global scale. Here, we outline the infection prevention and control (IPC) interventions for addressing the prevalence of carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Klebsiella pneumoniae (CRKP).</p><p><strong>Methods: </strong>A quasi-experimental study design was performed during the seven periods of 6-months from September 2018 to September 2021 in a large ICU in an Iranian hospital. IPC interventions were implemented from period 2 onward, with the exception of period 4 (March-September 2020) due to COVID-19 pandemic-related service disruptions. CRKP and CRAB prevalence and antibiotic resistance of GNB were compared across the seven periods.</p><p><strong>Results: </strong>In total, 1,862 GNB isolates were identified across seven periods, with K. pneumoniae (41%) being the most prevalent pathogen, followed by Escherichia coli (24.6%) and A. baumannii (14%). The highest antibiotic resistance rates, including 65.5% for meropenem, were observed during the fourth period. From September 2019 to March 2022, 178 CRKP and 97 CRAB isolates were identified, with infection rates of 78.1% and 62.9%, respectively. Following IPC interventions, a significant reduction in CRKP and CRAB prevalence was noted in the second and third periods, although an increase occurred during the fourth period. By the seventh period, the lowest prevalence of CRKP (26 isolates) and CRAB (5 isolates) was observed. Finally, a moderate inverse correlation (-0.571) was found between hand hygiene compliance and mortality incidence.</p><p><strong>Conclusion: </strong>The implementation of targeted IPC interventions significantly reduced the prevalence of CRKP and CRAB infections in the ICU, demonstrating their effectiveness in controlling antibiotic-resistant pathogens. However, the resurgence of these infections during the COVID-19 pandemic highlights the need for continuous monitoring and adaptation of IPC strategies. Ongoing training and adherence to hygiene protocols are essential to sustain improvements and prevent future outbreaks. Our findings underscore the importance of proactive infection control measures in managing antibiotic resistance in critical care settings.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"48"},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-typhoidal Salmonella transmission reservoirs in Sub-Saharan Africa: a genomic assessment from a one health perspective.","authors":"Thorsten Thye, Ralf Krumkamp, John P A Lusingu, Linda Aurelia Ofori, Daniel T R Minja, Antje Flieger, Samwel Gesase, Richard Phillips, Sandra Simon, Kwasi Obiri-Danso, Charity Wiafe Akenten, Joyce Mbwana, Ellis Paintsil, Oumou Maiga Ascofare, Anna Jaeger, Maike Lamshöft, Daniel Eibach, Wibke Loag, Stefan Berg, Jürgen May, Denise Dekker","doi":"10.1186/s13756-025-01561-2","DOIUrl":"10.1186/s13756-025-01561-2","url":null,"abstract":"<p><strong>Background: </strong>In sub-Saharan Africa, invasive non-typhoidal Salmonella disease, characterized by bloodstream infections with high mortality rates, poses a significant public health burden. In Africa, Salmonella enterica, which are typically livestock- associated pathogens in industrialised countries, have genetically evolved and anthroponotic transmission has been proposed for S. Typhimurium ST313. In this study, we investigated the hypothesis of an exclusively anthroponotic transmission reservoir of Salmonella enterica ST313 and aimed to identify reservoirs for other Salmonella spp., shedding light on their occurrence in different ecological niches.</p><p><strong>Methods: </strong>This study used a One Health approach and Salmonella were isolated from humans, livestock and the environment, in Tanzania and in Ghana. Salmonella spp. were identified by biochemical methods and antibiotic susceptibility was tested. Isolates were subjected to whole genome sequencing.</p><p><strong>Results: </strong>Out of 9,086 collected samples, 222 Salmonella enterica were identified comprising 58 serovars. The highest level of antimicrobial resistance was found in humans with emerging fluroquinolone resistance and multidrug resistance being highest in isolates from blood cultures (24%, n/N = 11/46). For the invasive strains, the sequence types S. Typhimurium ST313 and ST19 were most common and ST313 was associated with multidrug resistance, followed by S. Enteritidis ST11 and ST147 and S. Dublin ST10. An overlap of sequence types amongst human-livestock and human-environmental strains was detected for S. Typhimurium ST19 but not found for ST313 and the two serovars Dublin and Enteritidis.</p><p><strong>Conclusions: </strong>Our study adds further evidence of S. Typhimurium ST313 being restricted to a human reservoir and linked to multidrug resistance. Additionally, our study provides comprehensive insights into Salmonella genetic diversity and distribution among humans, animals and the environment in Ghana and in Tanzania. This sheds light on other potential reservoirs for infections, all of which show antimicrobial resistance. Further research into stool carriage is warranted, encompassing patients with invasive disease and those with and without diarrhoea, to identify transmission reservoirs in particular for invasive disease-causing strains. These findings underscore the need for integrated One Health approaches to effectively monitor and manage salmonellosis and mitigate public health risks. Continued research into the spread of Salmonella spp. and its evolution is crucial for targeted interventions and disease control.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"46"},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global knowledge, attitudes, and practices towards antimicrobial resistance among healthcare workers: a systematic review and meta-analysis.","authors":"Abdolreza Sotoodeh Jahromi, Negin Namavari, Mohammad Jokar, Nader Sharifi, Samira Soleimanpour, Negin Naserzadeh, Vahid Rahmanian","doi":"10.1186/s13756-025-01562-1","DOIUrl":"10.1186/s13756-025-01562-1","url":null,"abstract":"<p><strong>Background: </strong>The rising prevalence of antimicrobial resistance (AMR) poses a critical global health challenge. Healthcare workers (HCWs) play a pivotal role in combating AMR by implementing effective preventive strategies and adhering to good practices. This study aimed to evaluate the global knowledge, attitudes, and practices (KAP) of HCWs towards AMR.</p><p><strong>Methods: </strong>A comprehensive search of PubMed/MEDLINE, ScienceDirect, Scopus, Web of Science, Cochrane Library, and Google Scholar was conducted for English-language articles published up to August 2024. Inclusion criteria were observational studies reporting KAP data among HCWs related to AMR. Study quality was assessed using the Joanna Briggs Institute critical appraisal checklist. Statistical analyses, including heterogeneity (I² statistic, Cochran Q), were conducted using STATA version 14. Random-effects models were applied for pooled estimates, and subgroup analyses, meta-regression, and sensitivity analyses were performed. Publication bias was assessed via Egger's test and adjusted using the trim-and-fill method. Geographical distribution was analyzed with ArcGIS 10.3 software, and evidence certainty was evaluated using the GRADE framework.</p><p><strong>Results: </strong>A meta-analysis of 108 studies involving 29,433 HCWs assessed their knowledge of AMR. Additionally, 51 studies with 13,660 HCWs evaluated attitudes, and 43 studies with 10,569 HCWs examined practices regarding AMR. The pooled proportion of HCWs with good knowledge of AMR was 56.5% (95% CI: 50.4-62.6%, I² = 99.5%), with the highest prevalence in Europe (70.3%) and the lowest in the Western Pacific (45.9%). Positive attitudes towards AMR were reported in 60.4% (95% CI: 48.5-72.3%, I² = 99.8%), with the highest prevalence in the Eastern Mediterranean Region (64.5%) and among those with less than five years of experience (77.8%). Good practices were observed in 48.5% (95% CI: 36.5-60.5%, I² = 99.7%), with the highest adherence in Europe (56.6%) and the lowest in Africa (39.1%). Subgroup analysis revealed that younger HCWs (under 30 years) showed better KAP scores across all domains.</p><p><strong>Conclusion: </strong>The findings underscore the need for targeted interventions to enhance the knowledge, attitudes, and practices of HCWs regarding AMR. Priority should be given to designing and implementing robust training programs tailored to the specific needs of HCWs in resource-constrained settings. Strengthening AMR-related education and practice among HCWs is crucial for combating the global AMR crisis effectively.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"47"},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digitalised measures for the prevention of central line-associated bloodstream infections: a scoping review.","authors":"Basilice Minka Obama, Rebecca Grant, Stephan Harbarth, Niccolò Buetti, Gaud Catho","doi":"10.1186/s13756-025-01549-y","DOIUrl":"10.1186/s13756-025-01549-y","url":null,"abstract":"<p><strong>Background: </strong>Central line-associated bloodstream infections (CLABSI) increase morbidity, mortality, and healthcare costs of hospitalised patients, despite being largely preventable. While evidence-based guidelines for preventing CLABSI are well-established, the implementation of these measures remain suboptimal. Digitalization presents a promising approach to improve guideline adherence, streamline implementation processes, and ultimately reduce CLABSI rates.</p><p><strong>Methods: </strong>This scoping review aims to synthesize the available evidence on digitalised interventions for the prevention of CLABSI. A systematic search was conducted using Medline to identify studies published between January 1, 2014, and March 20, 2024, that reported on the implementation of digitalised preventive measures for CLABSI and evaluated their impact on CLABSI rates. Data extraction included study characteristics, features of the digitalised preventive measures, effectiveness in reducing CLABSI rates, and relevant process outcomes.</p><p><strong>Results: </strong>A systematic search yielded 263 articles, of which six studies were included. Digitalised interventions were predominantly designed for use by nurses in tertiary-level hospitals (n = 6), primarily in intensive care units (n = 5) and targeted pediatric patient populations (n = 5). These measures were often implemented as part of multimodal strategies. The digital interventions included hospital dashboards (n = 2), mobile applications (n = 2), automatic notifications of catheter days (n = 1), and e-learning modules with electronic reminders (n = 1). The most common study design was quasi-experimental without an external control group. All included studies reported a reduction in CLABSI rates, ranging from 21 to 73%. Healthcare workers generally perceived these digital interventions positively.</p><p><strong>Discussion: </strong>Digitalised interventions for CLABSI prevention seem to be effective in reducing infection rates, likely because of increasing compliance to established guidelines for CLABSI prevention.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"45"},"PeriodicalIF":4.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018-2020.","authors":"Neris García-González, Beatriz Beamud, Jordi Sevilla-Fortuny, Victoria Sánchez-Hellín, Inmaculada Vidal, Juan Carlos Rodríguez, Begoña Fuster, Nuria Tormo, Carme Salvador, Concepción Gimeno, Barbara Gomila-Sard, Salvador Giner, Olalla Martínez, Javier Colomina, David Navarro, Victoria Domínguez, Fernando González-Candelas","doi":"10.1186/s13756-025-01553-2","DOIUrl":"https://doi.org/10.1186/s13756-025-01553-2","url":null,"abstract":"<p><strong>Background: </strong>The emergence and spread of third-generation cephalosporins (3GC) and carbapenem-resistant Klebsiella pneumoniae pose a global critical challenge. Understanding the transmission dynamics within and between hospital environments is crucial to develop effective control strategies.</p><p><strong>Methods: </strong>From 2017 to 2019, we conducted a genomic surveillance program in eight hospitals of the Comunitat Valenciana, Spain, collecting and sequencing 1,768 3GC- and carbapenem-resistant isolates. We quantified the overall transmission using core genomes and assessed the contribution of national and global isolates to the spread of AMR in the region by including 11,967 database genomes in the analysis.</p><p><strong>Results: </strong>The local collection was highly diverse, involving 188 lineages, including global high-risk clones such as ST307 and ST11, and 3GC and carbapenem resistance determinants. Half of the isolates were involved in transmission, with 70.5% occurring within hospitals.</p><p><strong>Conclusions: </strong>Different transmission patterns characterized the spread of 3GC- and carbapenem resistance in the region. While inter-hospital transmission played a significant role in the spread of 3GC-resistance, this was only sporadic for carbapenem resistance. Moreover, the factors behind inter-hospital spread for each type of resistance differed: while 3GC-resistance likely disseminated between hospitals through intermediate steps, carbapenem resistance was driven by more direct transmission routes. The burden of national and global cases on the ongoing regional AMR dissemination was low. Moreover, we revealed the rapid expansion in the region and globally of lineage ST307 carrying the bla_CTX-M-15 gene, a main driver of local transmissions, providing a deeper understanding of the successful spread of this high-risk clone.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"44"},"PeriodicalIF":4.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Healthcare workers' knowledge, attitude and practices on infection prevention and control in the context of the COVID-19 pandemic at the Faranah regional hospital and associated healthcare centers, Guinea.","authors":"Lena Landsmann, Anna Borodova, Carlos Rocha, Aziz Amadou Diallo, Kamis Mamadou Diallo, Matthias Borchert, Mardjan Arvand, Mamadou Diallo, Rebekah R Wood, Sophie A Müller","doi":"10.1186/s13756-025-01566-x","DOIUrl":"https://doi.org/10.1186/s13756-025-01566-x","url":null,"abstract":"","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"43"},"PeriodicalIF":4.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}