Antimicrobial Resistance and Infection Control最新文献

{"title":"Hand hygiene knowledge, glove use misconceptions, and determinants among healthcare workers in Addis Ababa hospitals: a mixed-method cross-sectional study.","authors":"Abayneh Melaku, Tesfaye Admassu, Argaw Ambelu","doi":"10.1186/s13756-026-01792-x","DOIUrl":"10.1186/s13756-026-01792-x","url":null,"abstract":"<p><strong>Background: </strong>Hand hygiene is a cornerstone of infection prevention, yet compliance among healthcare workers remains low. Despite multiple national initiatives, adherence in Ethiopian hospitals continues to be sub-optimal. This challenge is partly due to knowledge gaps and misconceptions, particularly regarding the WHO \"Five Moments\" and the appropriate use of gloves. This study aimed to assess the knowledge and misconceptions of healthcare workers concerning hand hygiene practices and glove use in hospitals in Addis Ababa.</p><p><strong>Methods: </strong>A mixed-methods cross-sectional study was conducted from December 2024 to January 2025 among 493 healthcare workers from public and private hospitals. Data were collected using the WHO Hand Hygiene Knowledge Questionnaire and in-depth interviews. Knowledge was assessed with a 33-item tool, categorized as good (> 75%), moderate (50-74%), or poor (< 50%). Quantitative data were analyzed using descriptive statistics, and Chi-squared Automatic Interaction Detection (CHAID) decision tree analysis, while qualitative data analyzed to contextualize and enrich the findings.</p><p><strong>Results: </strong>While 86% of respondents were aware of the WHO 'Five Moments,' detailed understanding remained inconsistent, with a moderate mean knowledge score of 71%. Nearly half (48.2%) believed hand hygiene was unnecessary when gloves were worn. Institutional factors strongly influenced knowledge: visible instructions (χ² = 15.62, df = 1, p < 0.001), functional IPC committees (χ² = 34.55, df = 1, p < 0.001), hospital ownership (χ² = 5.15, df = 1, p = 0.023), and working unit type (χ² = 15.63, df = 1, p = 0.010) were significantly associated with better knowledge. Individual factors such as younger age and higher educational attainment also predicted better knowledge. Qualitative findings revealed limited protocol adherence, reliance on routine habits over guidelines, insufficient training, inadequate institutional support, and misconceptions about glove use, all of which undermined healthcare workers' knowledge and practice.</p><p><strong>Conclusion: </strong>Moderate hand hygiene knowledge and significant misconceptions about hand hygiene and appropriate glove use persist among healthcare workers in Addis Ababa, undermining infection prevention efforts. Targeted and continuous education, visible instructions, strengthening Infection Prevention and Control (IPC) committees, and improved institutional support are essential to foster effective hand hygiene practices and reduce healthcare-associated infections.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148443764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A machine learning-driven multitask framework for antibiotic resistance prediction in Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae bloodstream infections among hematological malignancy patients.","authors":"Yuqing Cui, Xiaomeng Feng, Ruonan Shao, Lining Zhang, Xueyuan Li, Qingsong Lin, Jieru Wang, Li Liu, Ling Pan, Sisi Zhen, Yuping Fan, Tingting Zhang, Yingchang Mi, Zhijian Xiao, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Xin Chen, Sizhou Feng","doi":"10.1186/s13756-026-01790-z","DOIUrl":"10.1186/s13756-026-01790-z","url":null,"abstract":"<p><strong>Background: </strong>Inappropriate empirical antimicrobial therapy (IEAT) significantly increases mortality in patients with resistant Gram-negative bacteremia. We developed a multitask machine learning framework to predict carbapenem resistance (CR), β-lactam/β-lactamase inhibitor combinations resistance (BL/BLI-R), and third-/fourth-generation cephalosporins resistance (3GC/4GC-R) in HM patients with monomicrobial BSIs caused specifically by Escherichia coli, Klebsiella pneumoniae, or Enterobacter cloacae.</p><p><strong>Methods: </strong>Using retrospective data from 1,353 HM patients with three specific Enterobacterales BSIs (2017-2023), we trained support vector machines, eXtreme Gradient Boosting, and logistic regression models through 5-fold cross-validation with hyperparameter tuning and conducting internal validation via bootstrap. Model thresholds were optimized via Pareto front analysis to minimized IEAT and carbapenem use while maximizing sensitivity.</p><p><strong>Results: </strong>The models achieved AUCs of 0.81 (95% CI, 0.78-0.85) for CR model, 0.81 (95% CI, 0.77-0.84) for BL/BLI-R model, and 0.72 (95% CI, 0.68-0.76) for 3GC/4GC-R model before optimization. Threshold optimization improved sensitivity for CR prediction increased from 0.10 to 0.77, for BL/BLI-R prediction from 0.19 to 0.94, and for 3GC/4GC-R prediction from 0.54 to 0.98. SHAP analysis identified key predictors including prolonged neutropenia, prior carbapenem exposure, and tumor consolidation stage. Integrating pathogen species enhanced 3GC/4GC-R prediction (AUC 0.72 vs. 0.76). Clinically, by employing the threshold optimization strategy, the model successfully reduced empirical carbapenem use from 71.7% to 32.1% without increasing the rate of IEAT compared to clinical practice (4.0% vs. 6.11%).</p><p><strong>Conclusion: </strong>This multitask framework supports resistance prediction in HM patients with monomicrobial BSIs due to three specific Enterobacterales species, mainly used to assist clinical decision-making after pathogen identification and strongly suspected infection with one of the three pathogens. Prospective validation is required before clinical application.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing antibiotic use for cesarean section in anticipation of the diagnosis-related groups payment system: a retrospective cohort study on the impact of clinical pharmacist intervention.","authors":"Ting Chen, Ranran Wang, Fenfen Gu, Jinlian Zhang, Chao Li, Lei Jin, Lixia Li","doi":"10.1186/s13756-026-01789-6","DOIUrl":"https://doi.org/10.1186/s13756-026-01789-6","url":null,"abstract":"<p><strong>Background: </strong>In anticipation of the nationwide implementation of the Diagnosis-Related Groups (DRG) 2.0 payment system in China, scheduled to take effect in 2025, hospitals are proactively seeking strategies to enhance care quality while optimizing resource utilization. Perioperative antibiotic stewardship for cesarean sections represents a key focus for these preparatory initiatives.</p><p><strong>Objectives: </strong>To evaluate whether a structured clinical pharmacist-led intervention pathway, implemented in anticipation of the DRG payment reform, improves antibiotic appropriateness and reduces adverse outcomes and costs.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study involving 640 women who underwent cesarean section at a tertiary hospital. The control group (n = 314) received standard care (January-June 2024); the intervention group (n = 326) received care guided by a pharmacist-led pathway (July-December 2024), encompassing preoperative assessment, intraoperative support, and postoperative monitoring.</p><p><strong>Results: </strong>The intervention significantly increased the rate of rational antibiotic use (94.8% vs. 89.2%, P = 0.009) and reduced postoperative infection rates (22.7% vs. 31.8%, P < 0.01). Multivariate analysis identified pharmacist intervention as an independent protective factor against infection (OR = 0.642, 95% CI: 0.449-0.918, P = 0.015). Additionally, the intervention group exhibited significantly lower total hospitalization costs, drug costs, and antibiotic costs (all P < 0.01).</p><p><strong>Conclusion: </strong>In this real-world, before-and-after study, the implementation of a standardized clinical pharmacist-led antimicrobial stewardship pathway-anticipating China's forthcoming DRG payment system- was associated with more rational antibiotic use, reduced postoperative infection rates, shorter hospital stays, and lower total costs among women undergoing cesarean sections. These findings underscore the potential value of integrating clinical pharmacists into perioperative care teams as a proactive, real-world strategy to enhance quality and efficiency in high-risk obstetric populations prior to the nationwide implementation of DRG.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical site infection prevention among surgical healthcare workers in Syria: a nationwide cross-sectional study.","authors":"Mais Alreem Mohaisen, Mohammad Atia, Bushra Mohammad Motaz Al-Noufi, Bshr Ibrahim Suliman, Rahaf Mohammad Kheir Aljalam, Raghad Darwish Ghilan, Abdulrahman Muhammad Alahmad, Hamzah Ali Saadoun, Jana Wafek Khaddour, Ahmad Muhammad Zaher Harba, Esraa Gehad Ghazali, Mohammad Wisam Al-Nahas, Zaidan Hazam Zaidan, Tamim Abo Obaid, Ahmad Abdul Hakim Alhamid, Allaith Abo Ghabra, Hebatallah Nasser Fadhl, Badr Mohammed Baras, Afia Tahsin Shobnom, Golam Moktadir, Muhammad Taha Zaman, Saralees Nadarajah, Alhussien Abdelbagi Mohamed Elfaki, Alhasan Abdelbagi Mohamed Elfaki, Mohammed Ali Saghir, Zahin Zeima, Amjad Suliman Almezaal, Reham Almukbel","doi":"10.1186/s13756-026-01783-y","DOIUrl":"10.1186/s13756-026-01783-y","url":null,"abstract":"<p><strong>Background: </strong>Surgical site infections (SSIs), infections at or near surgical incisions, represent 20-30% of nosocomial infections globally, with higher prevalence in low- and middle-income countries such as Syria. This study assessed SSI prevalence in two Syrian hospitals alongside a nationwide evaluation of surgical healthcare workers' knowledge, practices, compliance, and barriers to WHO/CDC SSI prevention guidelines.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among 375 healthcare workers in surgical settings across Syria. A structured questionnaire collected data on demographics, educational background, work experience, self-reported practices, knowledge of WHO guidelines, and perceived barriers to implementation. Composite knowledge and practice scores were calculated. Data were analyzed using descriptive statistics, Pearson correlation, and ANOVA.</p><p><strong>Results: </strong>Adherence to basic preventive practices was high, including hand preparation (89.33%) and intraoperative sterilization (91.47%). However, gaps persisted in avoiding preoperative shaving, appropriate antibiotic prophylaxis timing and duration, and postoperative antibiotic discontinuation. Major barriers included lack of role models (68%), inadequate training (63%), and staff shortages. Pearson analysis revealed positive correlations between compliance and practice scores (r = 0.5203, p < 0.001) and compliance and knowledge scores (r = 0.3372, p < 0.001). Crucially, the weakest correlation was found between knowledge and practice scores (r = 0.2662, p < 0.001), highlighting a prominent know-do gap. Hospital-reported SSI prevalence was 9.5% in one hospital and 1.47% in the other.</p><p><strong>Conclusion: </strong>This study identified suboptimal knowledge and inconsistent implementation of high-impact SSI prevention practices among Syrian surgical healthcare workers despite strong adherence to basic aseptic measures. Targeted training, improved surveillance systems, and institutional support are needed to strengthen guideline adherence and reduce preventable SSIs.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice model of unit-based clinical pharmacists' individualized daily antimicrobial use density monitoring report on antimicrobial stewardship in intensive care unit of a tertiary hospital in Guangxi, China: an interrupted time series analysis.","authors":"Tianmin Huang, Donglan Zhu, Jun Luo, Hongliang Zhang, Yue Qiu, Yan Wen, Guoping Liu, Hanchun Wen, Taotao Liu","doi":"10.1186/s13756-026-01786-9","DOIUrl":"10.1186/s13756-026-01786-9","url":null,"abstract":"<p><strong>Background: </strong>High antimicrobial exposure and antimicrobial resistance in intensive care units (ICUs) remain major challenges to patient safety. This study evaluated whether a unit-based clinical pharmacist (UBCP) model supported by an individualized daily antimicrobial use density monitoring report (IAUD-RP) could improve antimicrobial stewardship in an ICU.</p><p><strong>Methods: </strong>This single-center, retrospective, quasi-experimental study used interrupted time series analysis in a 12-bed ICU of a tertiary teaching hospital in Guangxi, China. Adult patients admitted between April 1, 2023, and October 31, 2025, were included. The intervention, initiated in August 2024, consisted of UBCP-led daily ward-wide screening, real-time risk stratification, and targeted pharmacist interventions using the individualized monitoring report. The primary outcome was antimicrobial use measured as defined daily doses (DDDs) per 100 patient-days. Secondary outcomes included average antimicrobial cost per hospitalization, multidrug-resistant organism healthcare-associated infection incidence density, clinical outcomes, and changes in specific antimicrobial agents or classes.</p><p><strong>Results: </strong>A total of 657 patients were included (295 before, 362 after). UBCP recommendations achieved a 91.7% acceptance rate. Interrupted time series analysis showed a significant immediate reduction in antimicrobial use (level change, - 29.0 DDDs/100 patient-days; P = 0.038), following a significant pre-intervention upward trend (+ 2.5 per month; P = 0.005). Interrupted time series analysis showed a significant immediate reduction in average antimicrobial cost per hospitalization (level change, - 8304 CNY; P = 0.035), consistent with the crude reduction (25,568 to 14,926 CNY; P < 0.001). Total antimicrobial consumption decreased by 11.9%. Tigecycline, quinolones, and carbapenems decreased by 52.1%, 39.7%, and 15.8%, respectively, whereas WHO Access-group antibacterial agents increased by 67.8%. After excluding patients with indeterminate ('Others') outcomes, clinical failure was lower post-intervention (13.0% vs. 19.2%; adjusted OR 0.62, 95% CI 0.39-0.99; P = 0.045).</p><p><strong>Conclusion: </strong>The UBCP-led IAUD-RP model was associated with a significant and sustained reduction in antimicrobial use density, a directionally favorable change in antimicrobial cost and prescribing pattern, and a directionally favorable but non-confirmatory signal for reduced clinical failure.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13411574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National surveillance of healthcare-associated infections in the UAE: first multisector report and benchmark analysis (2023).","authors":"Joseph Tannous, Elias Tannous, Husna Nazar, Najiba Abdulrazzaq","doi":"10.1186/s13756-026-01785-w","DOIUrl":"10.1186/s13756-026-01785-w","url":null,"abstract":"<p><strong>Background: </strong>Healthcare-associated infections (HAIs) are a major global patient safety concern, yet comprehensive national surveillance data remain limited in many regions, including the Middle East. In the United Arab Emirates (UAE), prior efforts were restricted to selected surgical site infections (SSIs), with no unified framework capturing the full spectrum of HAIs. We aimed to establish the first national benchmark for HAIs across multiple healthcare sectors and infection types.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of national HAI surveillance data from 92 hospitals with ≥ 20 beds across the UAE in 2023. Data were reported through a standardized electronic reporting system using Centers for Disease Control and Prevention/National Healthcare Safety Network (CDC/NHSN) definitions. Outcomes included rates of central line-associated bloodstream infection (CLABSI), catheter-associated urinary tract infection (CAUTI), ventilator-associated events (VAE), and SSIs, alongside causative organisms, multidrug-resistant organisms (MDROs), and hand hygiene compliance. Device-associated infection rates were expressed per 1,000 device-days and SSI rates per 100 procedures. Comparisons with NHSN pooled mean rates were descriptive.</p><p><strong>Results: </strong>Across participating hospitals, 236 CLABSI, 225 CAUTI, 247 VAE, and 488 SSI events were identified. National rates were 0.95 per 1,000 central line-days for CLABSI and 0.84 per 1,000 catheter-days for CAUTI, both exceeding NHSN pooled mean rates (0.74 and 0.73, respectively). The VAE rate (2.85 per 1,000 ventilator-days) was lower than NHSN (8.04). SSI rates exceeded NHSN pooled mean rates for cesarean section (emergency 1.17%, elective 1.77%), appendectomy (0.37%), coronary artery bypass grafting (1.83%), laminectomy (2.02%), and craniotomy (2.11%), while rates were lower for knee (0.39%) and hip arthroplasty (0.20%). Among 464 causative isolates reported from Dubai and the Northern Emirates, 31.3% were multidrug-resistant, predominantly carbapenem-resistant Enterobacterales, methicillin-resistant Staphylococcus aureus, and Candida auris. Hand hygiene compliance was 91.3%.</p><p><strong>Conclusion: </strong>This first national HAI surveillance report in the UAE demonstrates the feasibility of multisector data integration and establishes a baseline for benchmarking. Elevated device-associated infection rates and substantial MDRO burden highlight priorities for prevention and antimicrobial stewardship. Comparisons with NHSN pooled mean rates should be interpreted cautiously due to differences in risk adjustment. Expansion of standardized surveillance and incorporation of patient-level data will be essential to refine benchmarking and guide targeted interventions.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148358938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The present and the future of antimicrobial resistance surveillance in Catalonia (Spain), 2024: from manual to automatic notification.","authors":"Marc Bach-Griera, Helios Gayà, Aurora Sabrià, Luca Basile, Nieves Larrosa, Cristina Pitart, Alba Rivera, Guillem López de Egea, Yuliya Poliakova, Mónica Ballestero-Téllez, Jun Hao Wang-Wang, Antonio Casabella-Pernas, Sandra Esteban-Cucó, Frederic Gómez-Bertomeu, Esther Clapés, Alba Bellés-Bellés, Inés Valle T-Figueras, José Domenico Stavola, Isabel Pujol-Bajador, Glòria Trujillo, Anna Vilamala, Araceli González-Cuevas, Mayuli Armas-Cruz, Mariona Xercavins, Virginia Plasencia, Natàlia Roca-Bau, Manel Monsónis, Núria Torrellas-Bertran, Karolina Romero-Vanegas, Esther Sanfeliu, Ester Comellas, Gemma Flores-Mateo, Fina Guimerà, Anna Llimós-Fàbregas, Maria Font-Font, Carles Alonso-Tarrés, Jacobo Mendioroz, Pilar Ciruela","doi":"10.1186/s13756-026-01781-0","DOIUrl":"10.1186/s13756-026-01781-0","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance (AMR) remains a major global public health concern requiring coordinated surveillance and technological innovation. In Catalonia, AMR surveillance is conducted through the Microbiological Reporting System of Catalonia (MRSC) and will be integrated into the Epidemiological Surveillance Information System (SIVEC), enabling automated and real-time monitoring. This study aimed to evaluate the current landscape of AMR surveillance and laboratory capacity across clinical microbiology laboratories (CMLs).</p><p><strong>Methods: </strong>All CMLs participating in the MRSC were invited to complete a structured survey assessing diagnostic capacity, resistance mechanism (RM) detection, laboratory information systems (LIS), and reporting practices. Surveillance data from invasive isolates (one per patient and episode) collected between 2016 and 2023 were analysed. CMLs were classified by complexity (L1-L3) according to phenotypic, molecular and genomic capabilities. Temporal trends in resistance were assessed using logistic regression models.</p><p><strong>Results: </strong>By 2023, 53 CMLs participated compared with 28 in 2016, reflecting a marked increase in coverage. A total of 87,556 invasive isolates and 694,289 susceptibility tests were reported. Escherichia coli was the most frequently notified microorganism (37,999 isolates), followed by Klebsiella pneumoniae (12,626) and methicillin-susceptible Staphylococcus aureus (10,464). All laboratories followed EUCAST criteria, although only 56.6% had implemented the 2023 version. Most CMLs (92.5%) detected RMs and 73.6% monitored multidrug resistance. Based on complexity, 18.9% were L1, 66.0% L2, and 15.1% L3; most notifications were reported by L2 (57.4%) and L3 laboratories (39.4%). Carbapenem resistance decreased in Pseudomonas aeruginosa (21.7 to 12.9%) and K. pneumoniae (6.3% to 3.2%), whereas E. coli increased (0.07 to 0.52%). Vancomycin resistance increased in Enterococcus faecium (0.27 to 2.30%) and remained low in E. faecalis. Third-generation cephalosporin resistance increased in E. coli (14.4 to 17.8%) and decreased in K. pneumoniae (36.0 to 26.6%), while MRSA declined (33.1 to 20.6%).</p><p><strong>Conclusions: </strong>AMR surveillance in Catalonia provides robust and representative data across a heterogeneous network. Further efforts are needed to ensure consistent EUCAST implementation and expand RM detection. The implementation of SIVEC will enable integrated, real-time surveillance and support timely, evidence-based public health decision-making.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148358964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a proprietary chlorine-stabilizing surface-coating formulation on healthcare environment disinfection in multidrug-resistant bacteria isolation rooms.","authors":"Yael Givon-Cohen, Nadav Abel, Tatiana Vander, Olga Libkind, Pasha Gur, Shahar Frechtman-Berger, Keren Anat Resnick, Jacob Moran-Gilad, Oren Zimhony","doi":"10.1186/s13756-026-01782-z","DOIUrl":"10.1186/s13756-026-01782-z","url":null,"abstract":"<p><strong>Objective: </strong>OxiLast™ is a surface coating formulation that extends the antimicrobial effect of chlorine-based disinfectants. We sought to test it in a healthcare environment.</p><p><strong>Design: </strong>Controlled quasi-experimental study with parallel groups and repeated measures, conducted in isolation rooms of chronically ventilated patients, carriers of carbapenem-resistant Acinetobacter baumannii (CRAB).</p><p><strong>Methods: </strong>Standard sodium dichloroisocyanurate (NaDCC) disinfection was supplemented with OxiLast™ daily for 28 days at five patient stations, followed by twice-weekly application for 21 days. In parallel, six control stations were cleaned daily by NaDCC alone throughout the study. Environmental sampling targeted high touch surfaces adjacent to patient beds. Quantitative colony counts (CFU/cm2) and qualitative detection of CRAB and methicillin-resistant Staphylococcus aureus (MRSA) were performed at four time points: Day 0 (baseline), 21, 42, and 49. A decrease in environmental bioburden (target <5 CFU/cm²), CRAB and MRSA detection were defined as the primary outcomes. Achieving these benchmarks following twice-weekly application for three weeks was defined as the secondary outcome.</p><p><strong>Results: </strong>Baseline contamination averaged 1,272 CFU/cm² (median 800 CFU/cm²) and 17,172 CFU/cm² (median 756 CFU/cm²) in the control and intervention rooms, respectively. CRAB was detected in all stations of both groups, MRSA was detected in 4/6 and 5/5 of the control and intervention stations, respectively. On Day 21 following daily NaDCC-OxiLast™, all intervention stations dropped below 5 CFU/cm² (mean 2.07 CFU/cm²). The control group averaged 316 CFU/cm². CRAB and MRSA were detected in 5/6 of the control and in 1/5 and 0/5 in the intervention stations, respectively. Following twice-weekly NaDCC-OxiLast™ cleaning for 21 days, on Day 49, 4/5 intervention stations reached <5 CFU/cm² (averaging 1.33 CFU/cm²), CRAB was undetected and MRSA was detected in 1/5 stations. All control stations remained >5 CFU/cm², averaging 253 CFU/cm², CRAB and MRSA were detected in 5/6 and 6/6 stations, respectively. At Days 21 and 49, the odds ratio for both CRAB and MRSA contamination in intervention rooms, was 0.026 (95% CI 0.00-0.43; p = 0.008).</p><p><strong>Conclusions: </strong>These findings provide proof-of-concept for an extended-action protocol using OxiLast™ adjunct to NaDCC. The impact of this intervention on MDRO transmission and clinical infections should be further studied.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A message to Africa as Nigeria hosts the 5th Global High-Level Ministerial Conference on antimicrobial resistance.","authors":"Godwin Pius Ohemu, Babafela Awosile, Kome Otokunefor, Chizaram Onyeaghala","doi":"10.1186/s13756-026-01780-1","DOIUrl":"10.1186/s13756-026-01780-1","url":null,"abstract":"<p><p>The world is learning that no single nation can address the challenges posed by antimicrobial resistance (AMR) alone. For the first time, Africa is set to host the 5th Global High-Level Ministerial Conference on AMR, with Nigeria selected as the host country. For a continent where AMR causes more mortality per capita than anywhere else in the world, this is more than a diplomatic milestone; it is a call to action. This perspective examines what the conference aims to achieve, why Africa's AMR challenge demands a distinctly African response, and the seven priority areas African governments, communities, and health systems must urgently address to turn this historic moment into lasting change.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"15 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare-associated transmission and early IPC system vulnerabilities during the 2026 Bundibugyo Ebola outbreak in eastern Democratic Republic of the Congo.","authors":"Ben Bepouka, Mardoche Kafua","doi":"10.1186/s13756-026-01779-8","DOIUrl":"10.1186/s13756-026-01779-8","url":null,"abstract":"<p><p>The 2026 Bundibugyo Ebola outbreak in eastern DRC highlighted important early infection prevention and control (IPC) challenges, including healthcare-associated transmission, healthcare worker infections, unsafe triage systems, limited isolation capacity, and shortages of IPC supplies. This commentary argues that pathogen-specific preparedness may remain insufficient in settings characterized by diagnostic uncertainty and proposes an \"IPC-first\" outbreak response framework based on rapid syndromic IPC activation before definitive laboratory confirmation becomes available.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"15 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}