Antimicrobial Resistance and Infection Control最新文献

{"title":"Assessment of the risk of aerosol transmission of CRKP during bronchoscopy in the intensive care unit.","authors":"Junlin Yang, Zhuhong Zha, Lingzhu Li","doi":"10.1186/s13756-025-01603-9","DOIUrl":"10.1186/s13756-025-01603-9","url":null,"abstract":"<p><strong>Background: </strong>The potential for aerosol generation during bronchoscopy to facilitate the transmission of multidrug-resistant bacteria remains incompletely understood. This study aimed to assess the risk of carbapenem-resistant Klebsiella pneumoniae (CRKP) transmission via aerosols during bronchoscopy in an intensive care unit (ICU).</p><p><strong>Methods: </strong>We collected eight samples from the ICU of a tertiary general hospital, including bronchoalveolar lavage fluid (BALF) samples from one patient with community-acquired pneumonia and one patient with hospital-acquired CRKP infection, as well as air samples collected at 1, 2, and 3 m from the patients' bedsides. The gene sequences of the isolates were determined using Sanger sequencing, and the sequence type (ST) of the strains was identified through multilocus sequence typing (MLST). Phylogenetic and evolutionary analyses were performed using the MEGA program to construct maximum likelihood trees.</p><p><strong>Results: </strong>All samples tested positive for CRKP, with consistent antibiotic susceptibility profiles showing resistance to first-line antibiotics commonly used in clinical practice. All isolates were identified as ST11-type CRKP, and phylogenetic analysis revealed high homology among the eight CRKP isolates.</p><p><strong>Conclusions: </strong>This study demonstrates that CRKP can be transmitted through aerosols up to 3 m during bronchoscopy in the ICU, leading to hospital-acquired infections in patients in adjacent beds. These findings underscore the need for enhanced infection control measures during aerosol-generating procedures in high-risk settings.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"81"},"PeriodicalIF":4.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adequacy and implications of antimicrobial prophylaxis for elective surgeries in a tertiary hospital: a cross sectional and retrospective cohort study (ADEQUAP).","authors":"Marco Piscaglia, Dolores Martín Sierra, Antonio Huelva Millán, Maria Teresa Garcia Poo, Jesús Rodríguez Baño, Maria Dolores Del Toro López","doi":"10.1186/s13756-025-01601-x","DOIUrl":"10.1186/s13756-025-01601-x","url":null,"abstract":"<p><strong>Background: </strong>Surgical antimicrobial prophylaxis (SAP) is essential for preventing surgical site infections (SSI) but is often improperly administered. This study assessed SAP adequacy and its association with SSI and other nosocomial infections (NI) to identify areas for improvement.</p><p><strong>Methods: </strong>This cross-sectional and retrospective cohort study included adults undergoing elective cardiovascular, orthopaedic, colorectal surgeries and cystectomy in 2022 at a teaching hospital. SAP was considered adequate if it met all local guideline criteria: indication, drug, dose, timing of administration, redosing and duration. Associations between SAP adequacy and SSI were analyzed using generalized mixed models.</p><p><strong>Results: </strong>Among 723 patients included (median age 68 years; 57.7% male), 714 (98.8%) received SAP. Overall multidomain adherence to SAP guidelines was 34.6%, with high compliance for regimen (92.8%), dose (97.5%), and timing (98.3%), but lower compliance for redosing (63.4%) and duration (53.9%). Regimen adequacy was significantly lower in patients with beta-lactam allergies (55.6% vs. 94.8%, p < 0.001) and in cystectomy cases compared to other procedures (41.2% vs. 94.1%, p < 0.001). Non-compliant regimens were independently associated with a higher SSI rate (adjusted OR 3.4; 95% CI: 1.8-8.3; p = 0.003), but not with non-SSI NIs. Inadequate SAP was also associated with a length of stay (LOS) exceeding 10 days (RR 4.61; p < 0.001) and higher 90-day mortality (RR 3.37; p = 0.007). Patients who developed an SSI were significantly more likely to develop additional non-SSI NIs (adjusted OR 6.1; 95% CI: 2.8-13.4; p < 0.001). Median LOS was longer in patients with SSI (16.5 vs. 7 days, p < 0.001), and SSI was also associated with increased 90-day mortality (14.7% vs. 2.7%; RR 5.42; p < 0.001).</p><p><strong>Conclusion: </strong>Non-adherence to SAP guidelines was associated with an increased risk of SSI, prolonged LOS, and greater crude mortality. Key areas for improvement include regimen selection, appropriate redosing, and limiting SAP duration. Patients with beta-lactam allergies were specially at risk of receiving inadequate SAP. Although SAP non-compliance was not independently associated with other NIs, SSIs significantly increased their occurrence.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"82"},"PeriodicalIF":4.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An economic evaluation of a hospital-wide bundle intervention to reduce hospital-acquired infections and bladder distension among hip fracture patients in Sweden.","authors":"Sneha Abdul Jabbar, Maria Frödin, Ewa Wikström, Brigid M Gillespie, Hanna Gyllensten, Annette Erichsen","doi":"10.1186/s13756-025-01573-y","DOIUrl":"10.1186/s13756-025-01573-y","url":null,"abstract":"<p><strong>Background: </strong>A theory-driven knowledge translation program was established to co-create and implement evidence-based practices to prevent urinary catheter-associated urinary tract infections (UC-UTIs) and bladder distension (BD). This study investigates the cost-effectiveness of implementing the Safe Hands and Safe Bladder bundle intervention compared to standard care for patients undergoing hip fracture surgery in Sweden.</p><p><strong>Method: </strong>The study included outcomes from a quality register of patients who underwent hip fracture surgery at a Swedish hospital from 2015 to 2020. Adopting a healthcare perspective, estimates for the implementation cost were derived using activity-based costing, while the bundle's cost-effectiveness was estimated using a decision tree model. Health outcomes were evaluated based on adverse events, specifically UC-UTI and BD. Analyses included calculating the incremental cost-effectiveness ratio (ICER), which denotes the incremental cost per added infection rate expressed as a percentage. Additionally, sensitivity analyses were conducted to test the robustness of the results under alternative cost assumptions.</p><p><strong>Results: </strong>The likelihood of avoiding BD or UC-UTI increased from 50 to 87% over the course of the intervention year. The discounted implementation cost was SEK 890,389 (corresponding to Int$ 102,721). However, the implementation cost was offset by costs for a prolonged hospital stay due to these adverse events, resulting in an overall cost savings of SEK - 7,334 per patient (Int$ -846) in 2020 compared to before the intervention was introduced. Consequently, the intervention proved to be cost-effective, leading to savings and a decrease in the occurrence of adverse events.</p><p><strong>Conclusion: </strong>Implementing the bundle intervention in units providing care for patients with acute hip fractures proved cost-effective. This offers decision makers valuable insights and demonstrates that implementation programs incorporating collaboration, facilitation and co-creation processes can effectively use limited resources. Further research should determine the generalizability of the findings to other settings and populations.</p><p><strong>Clinicaltrials: </strong></p><p><strong>Gov registration: </strong>NCT02983136 and ISRCTN 17,022,695, retrospectively registered after data collection were completed.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"80"},"PeriodicalIF":4.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farmer field schools as interventions to reduce the need for antimicrobials in agrifood systems: a longitudinal analysis of layer farmer field school graduates and non-graduates in Kenya.","authors":"Mark A Caudell, Stella Kiambi, Tabitha Kimani, Anica Buckel, Ruth Omani, Junxia Song, Markus Lipp, Emmanuel Kabali","doi":"10.1186/s13756-025-01580-z","DOIUrl":"10.1186/s13756-025-01580-z","url":null,"abstract":"","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"79"},"PeriodicalIF":4.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter exploration of microbial communities in hospital toilets reveals: antibiotic exposure in a nosocomial settings selects for coEnterococcus over commensal taxa.","authors":"Claudio Neidhöfer, Marcel Neuenhoff, Esther Sib, Anna Rehm, Lúcia Ribeiro Dias, Bernd Neumann, Jörg Steinmann, Manuel Döhla, Yousra Kherabi, Ana Budimir, Crystel Hajjar, Rouba Khatib, Katharina Axtmann, Katjana Schwab, Peter Brossart, Steffen Engelhart, Nico T Mutters, Gabriele Bierbaum, Stefan Janssen, Marijo Parčina","doi":"10.1186/s13756-025-01600-y","DOIUrl":"10.1186/s13756-025-01600-y","url":null,"abstract":"<p><strong>Background: </strong>Excessive antibiotic utilization in hospital settings catalyzes the emergence and dissemination of multidrug resistant (MDR) bacteria, with sanitary facilities serving as critical vectors for their propagation. This study investigated the impact of patient antibiotic exposure on microbial diversity in hospital sanitary facilities, as well as the emergence of uniform communities and prospering taxa under antibiotic pressure.</p><p><strong>Methods: </strong>For this purpose a cross-sectional study was conducted between September 2022 and April 2023 from eight hospitals in seven cities across five countries, representing a diverse mix of tertiary care, military, oncological, psychiatric, and general teaching hospitals to analyze bacterial population differences in hospital toilets on wards with high versus minimal antibiotic administration using 16s rRNA amplicon sequencing.</p><p><strong>Results: </strong>PCoA analysis with Bray-Curtis and unweighted UniFrac metrics revealed microbial clustering influenced by antibiotic exposure and geography. Among all taxa analyzed, Enterococcus showed the strongest and most consistent association with high-exposure environments, making it one of the most striking findings in our dataset.</p><p><strong>Conclusion: </strong>Routine overuse of antimicrobial agents aimed at false patient safety promotes a high-risk environment in the sanitary facilities of respective wards. Hence, the issue of hospital acquired infections with MDR pathogens transcends mere pathogen spread, entailing significant changes to both environmental and microbial landscapes over time. The situation signals an emerging ecological problem within healthcare environments, and highlights the urgency for an integrated approach to antimicrobial stewardship. The low detection of key nosocomial Gram-negative genera likely reflects the focus on toilets rather than sinks or showers.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"78"},"PeriodicalIF":4.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 safe dental practices among a group of Egyptian students: a cross-sectional study.","authors":"Dena Ali Abozaid, Dina Hamed, Karim Mostafa Hindy, Mayar Moustafa Budair, Ziad Baher Hussein, Ziyad Islam Hegazy, Dina Nabih Kamel Boulos","doi":"10.1186/s13756-025-01591-w","DOIUrl":"10.1186/s13756-025-01591-w","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic has had a tremendous effect on dental practice. Dental practice during the pandemic has been associated with an increased risk of COVID-19 transmission. Adopting proper infection control measures in dentistry helps alleviate the risk of infection. The pandemic has created an even more challenging environment for dentists to perform their job safely, thus necessitating the adoption of very strict infection control measures for safe dental practice.</p><p><strong>Objectives: </strong>This study aimed to assess the knowledge, attitude, and practice (KAP) regarding COVID-19 safe dental measures among dentistry students currently in clinical training.</p><p><strong>Methods: </strong>A cross-sectional study was conducted. The study included a total of 104 dental students, who took clinical practical sessions in a nongovernmental dentistry school, in Egypt. Data collection was performed via an online questionnaire.</p><p><strong>Results: </strong>This study found that a total of 88.5% of the dental students had a satisfactory safe dental measures practice score. A total of 93.2% of the students had a positive attitude towards safe dental measures. Practice of hand hygiene was the most common safe dental practice among the students, and they practiced it all the time (82.7%), whereas checking patient temperature was the least common practice (28.8%). There was a statistically significant association between sex and hand hygiene (p = 0.023), checking patient temperature (p = 0.046). There was a positive moderate correlation between students' safe dental practice score and their attitude score (r = 0.470, p < 0.001). There was a weak inverse correlation between safe dental practice score and age (p = 0.029, r = (- 0.214)).</p><p><strong>Conclusions, and recommendations: </strong>This study highlights key strengths and gaps in dental education, reinforcing the importance of safety protocols in enhancing professional standards and safeguarding public health. The findings support the integration of pandemic-era measures into standard infection control practices. Nonetheless, specific domains-particularly temperature screening and knowledge regarding the application of HEPA filtration systems-require further emphasis and curricular enhancement.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"73"},"PeriodicalIF":4.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infection prevention and control measures for emerging infectious disease: lessons learned from the first case of imported Lassa fever in China.","authors":"Yalan Peng, Yantong Wang, Shiyu Li, Jing Huang, Wu Shi, Ruocheng Luo, Xianmou Pan, Wenzhi Huang, Fu Qiao, Yi Chen","doi":"10.1186/s13756-025-01597-4","DOIUrl":"10.1186/s13756-025-01597-4","url":null,"abstract":"<p><strong>Background: </strong>Lassa fever is an acute viral hemorrhagic disease prevalent in West Africa. West China Hospital of Sichuan University (WCHSCU) received China's first imported case of Lassa fever from overseas. We described the epidemiological investigation and infection prevention and control measures of this case following the confirmed diagnosis.</p><p><strong>Methods: </strong>An emergency epidemiological team defined close contacts and implemented infection prevention and control (IPC) measures: (1) isolation in a designated isolation room, (2) environmental disinfection for high-, medium-, and low-risk areas, (3) 21-day quarantine for contacts. Data were collected via field observations and medical records.</p><p><strong>Results: </strong>We identified 6 close contacts and 74 general contacts, who were subsequently quarantined for 21 days. The hospital environment was classified into high, medium, and low-risk areas, and corresponding cleaning and disinfection measures were implemented. Ultimately, no new infection cases emerged.</p><p><strong>Conclusion: </strong>Rapid risk stratification, strict isolation protocols, and multidisciplinary coordination effectively prevented transmission, underscoring the importance of preparedness in non-endemic regions.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"74"},"PeriodicalIF":4.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting whole-genome sequencing data during neonatal Klebsiella oxytoca complex outbreak management.","authors":"Chiara Minotti, Elena Robinson, Pascal Schlaepfer, Christian Pohl, Daniel Goldenberger, Sven M Schulzke, Peter Michael Keller, Julia Anna Bielicki","doi":"10.1186/s13756-025-01595-6","DOIUrl":"10.1186/s13756-025-01595-6","url":null,"abstract":"<p><strong>Background: </strong>K. oxytoca generally has a benign susceptibility profile and low virulence but can cause invasive infections in vulnerable populations, like preterm infants. We aim to describe how whole-genome sequencing (WGS) was used to inform management of a prolonged K. oxytoca outbreak on a neonatal intensive care unit (NICU) and implications for outbreak response involving similar organisms.</p><p><strong>Methods: </strong>We retrospectively reviewed outbreak-associated clinical and environmental isolates from a Swiss NICU. WGS was used to track evolution of resistance and highlighted multiple concurrent outbreaks. WGS was performed using a MiSeq or NextSeq 500 Illumina sequencer. The resulting genome sequences were analysed using Ridom SeqSphere. The current report conforms to ORION reporting guidelines.</p><p><strong>Results: </strong>Of 152 Klebsiella spp. patient-derived isolates, 83 were genotyped using WGS, along with six environmental isolates. This confirmed two outbreak waves (November 2021-February 2022, ST18 wildtype; July 2022-June 2023, main cluster ST18 KI β-lactamase hyperproducer), with multiple genotypically connected clusters during the second wave. Confirmed sepsis (K. oxytoca ST18 wildtype) occurred in four preterm or low birthweight infants. Twins presented a genotypically identical ST with a different susceptibility phenotype (ST18 wildtype vs. K1 OXY-hyperproducer). WGS combined with epidemiological investigation and environmental sampling identified an environmental source. There was a second outbreak wave after source removal, presumably due to the prolonged presence of colonised infants with typically long NICU stays and insufficient standard infection prevention and control measures to prevent transmission.</p><p><strong>Conclusion: </strong>WGS use in NICU outbreaks involving low-virulence bacteria can support identification and removal of potentiating environmental sources. These measures, however, will often be insufficient to contain the outbreak, and ongoing WGS surveillance of ubiquitous species may uncover multiple concurrent outbreaks, presumably driven by continuing transfer-transmission between different sources and infants in the NICU. Maximising standard infection prevention and control (IPC) measures is appropriate in this context.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"76"},"PeriodicalIF":4.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing outbreaks in burn units: the role of hygiene compliance and early warning systems.","authors":"Marie Lindblad, Fredrik Huss, Eva Tano, Birgitta Lytsy, Susanne Sütterlin","doi":"10.1186/s13756-025-01592-9","DOIUrl":"10.1186/s13756-025-01592-9","url":null,"abstract":"<p><strong>Background and objectives: </strong>To analyse observations of staff's hand hygiene, usage of gloves and plastic aprons, and dress code compliance at the Burn Centre, Uppsala University Hospital in Sweden, and to evaluate the association between hygiene non-compliance and outbreak periods. Furthermore, to explore the potential of using routine hygiene observations as an early warning tool for the risk of uncontrolled spread of (multidrug-resistant) bacteria.</p><p><strong>Methods: </strong>Direct observations of the personnel's compliance with hand hygiene, usage of gloves and plastic aprons, and dress code were studied in relation to two A. baumannii outbreaks in 2014 and 2020. Interrupted time series analyses were conducted from 2013 to 2017 and 2018 to 2022 to evaluate outbreak intervention measures. Rolling sums of observed hygiene errors and 90th percentiles were calculated for four-, five-, and six-month periods.</p><p><strong>Results: </strong>During the study, 13,216 direct observations showed hygiene compliance ranging from 70 to 100% per category. Infection control interventions significantly reduced non-compliance after both outbreaks, with sustained improvements for two years following the first outbreak. Rolling four- to six-month sums, using 90th percentile thresholds of seven, nine, and eleven non-compliances predicted A. baumannii outbreaks.</p><p><strong>Conclusion: </strong>In this setting, compliance levels above 97% were consistently observed during outbreak-free periods, suggesting a potential protective effect. Focus on non-compliance as a key metric and rolling sums of non-compliance, may support early detection of increased outbreak risk and guide preventive interventions.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"75"},"PeriodicalIF":4.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 pandemic on surgical site infections: a multi-center study evaluating incidence, pathogen distribution, and antimicrobial resistance patterns.","authors":"Şiran Keske, Elif Sargın Altunok, Emel Azak, Ezgi Gülten, Tuğba Arslan Gülen, Çiğdem Ataman Hatipoğlu, Ali Asan, Derya Korkmaz, Bahar Kaçmaz, Yeşim Kızmaz, Ayşe Batırel, Fethiye Akgül, Derya Yapar, Zehra Çağla Karakoç, Ayşe Serra Özel, Tuğba Yanık Yalçın, Deniz Özer, Özge Eren Korkmaz, Ahmet Şahin, Muhammed Fatih Karaşın, Tuba Turunç, Mehtap Aydın, Neşe Demirtürk, Alpay Azap, Önder Ergönül","doi":"10.1186/s13756-025-01542-5","DOIUrl":"10.1186/s13756-025-01542-5","url":null,"abstract":"<p><strong>Background: </strong>Surgical site infections (SSIs) are among the most significant concerns in healthcare settings, presenting challenges in patient management and healthcare outcomes. The emergence of the COVID-19 pandemic has further complicated the landscape of infectious disease epidemiology, impacting the distribution and resistance characteristics of pathogens responsible for SSIs. Understanding these dynamics is essential for improving infection prevention and treatment strategies.</p><p><strong>Methods: </strong>This retrospective multi-center study included 17 hospitals in Turkey, analyzing SSI cases from January 2019 to January 2023. The study was divided into three phases: pre-pandemic (January 2019 - March 2020), early pandemic (March 2020 - January 2022), and late pandemic (January 2022 - January 2023). We assessed demographic and clinical characteristics, pathogen distributions, and resistance rates, focusing on multidrug-resistant (MDR) pathogens.</p><p><strong>Results: </strong>A total of 2,058 patients with SSIs were included. The SSI rate increased from 0.79% in 2019 to 0.87% in 2020, then decreased to 0.46% in 2021 and 0.50% in 2022. The most prevalent pathogens were E. coli (21.9%) and K. pneumoniae (14.6%). Resistance to meropenem in K. pneumoniae rose from 23% pre-pandemic to 33% post-pandemic, while ceftazidime-avibactam resistance surged from 6 to 43%. P. aeruginosa showed increased quinolone resistance from 18 to 27%, with colistin resistance rising to 13% in the late pandemic phase.</p><p><strong>Conclusions: </strong>This study highlights the significant impact of the COVID-19 pandemic on SSIs in Turkey, revealing concerning trends in antibiotic resistance among key pathogens. Ongoing surveillance and enhanced infection control measures are essential to address these challenges and improve patient outcomes in the post-pandemic era.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"77"},"PeriodicalIF":4.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}