Annals of African Medicine最新文献

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Outcomes of Prophylactic Inguinal Lymph Node Dissection in Malignancies of Lower Limb. 下肢恶性肿瘤预防性腹股沟淋巴结清扫术的效果
IF 0.6
Annals of African Medicine Pub Date : 2024-10-01 Epub Date: 2024-09-14 DOI: 10.4103/aam.aam_164_22
Prabhat Bhaskarrao Nichkaode, Bijay Sharma, Sreemanth Reddy, Ramteja Inturi, Aditya Patil
{"title":"Outcomes of Prophylactic Inguinal Lymph Node Dissection in Malignancies of Lower Limb.","authors":"Prabhat Bhaskarrao Nichkaode, Bijay Sharma, Sreemanth Reddy, Ramteja Inturi, Aditya Patil","doi":"10.4103/aam.aam_164_22","DOIUrl":"10.4103/aam.aam_164_22","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the role of early prophylactic inguinal node dissection in patients with squamous cell cancer and melanoma of lower limb.</p><p><strong>Materials and methods: </strong>From 2008 to 2018, a Tertiary Care Hospital connected to a teaching institute served as the site of this retrospective observational study. Patient records were gathered with the purpose of gathering clinical, investigative, surgical, pathological and follow-up information.</p><p><strong>Results: </strong>We included 33 patients in this analysis out of the 47 patients we treated ourselves between 2008 and 2018; among these 33 patients, 21 (63.63%) had palpable inguinal nodes at the time of primary presentation. All 21 patients' FNAC tests were positive for metastases, in 16 patients (76.19%). 5 patients on FNAC (23.80%) exhibited not metastases. The remaining 12 patients did not have enlarged lymph nodes at the time of their initial presentation. Patients who did not have palpable lymph node were given the option of having a modified inguinal block dissection. 8 patients with metastatic disease have nodes that are positive in histology. In addition, out of 5 patients with negative nodes 4 (80%) showed evidence of metastasis.</p><p><strong>Conclusion: </strong>The conclusion of this retrospective observational study is that although palpable lymph nodes in groin are unquestionably a sign that inguinal nodes should be dissected, prophylactic lymph node dissection should be still done even if nodes are not palpable or provide a negative FNAC result. Given that delayed lymphadenectomy has a significant effect on survival, delaying inguinal lymphadenectomy in non-palpable nodes could cause you to lose the battle against cancer in your lower limb. The related surgical morbidity is the only downside to prophylactic lymph node dissection. This can, however, be effectively decreased with a modified inguinal lymphadenectomy operation.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":"23 4","pages":"656-662"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypothyroidism in Metabolic Syndrome. 代谢综合征中的甲状腺功能减退症
IF 0.6
Annals of African Medicine Pub Date : 2024-10-01 Epub Date: 2024-09-14 DOI: 10.4103/aam.aam_25_24
Durga Prasad Verma, Shyam Chand Chaudhary, Abhishek Singh, Kamal Kumar Sawlani, Kamlesh Kumar Gupta, Kauser Usman, Himanshu Dandu Reddy, Munna Lal Patel, Sudhir Kumar Verma, Virendra Atam
{"title":"Hypothyroidism in Metabolic Syndrome.","authors":"Durga Prasad Verma, Shyam Chand Chaudhary, Abhishek Singh, Kamal Kumar Sawlani, Kamlesh Kumar Gupta, Kauser Usman, Himanshu Dandu Reddy, Munna Lal Patel, Sudhir Kumar Verma, Virendra Atam","doi":"10.4103/aam.aam_25_24","DOIUrl":"10.4103/aam.aam_25_24","url":null,"abstract":"<p><strong>Introduction: </strong>Metabolic syndrome (MetS) and hypothyroidism are well-established forerunners of atherogenic cardiovascular disease (CVD). It is possible that patients suffering from both these disease entities may have a compounded risk. This study aimed at determining the prevalence of hypothyroidism in MetS.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted from September 2017 to August 2018 in the department of medicine at a tertiary care hospital in Northern India. Ethical approval was obtained from the institutional ethical committee. The study subjects consisted of 157 patients with MetS, the diagnosis of which was based on the International Diabetes Federation criteria. After a detailed history and physical examination, relevant investigations including complete thyroid profile were done. The data were analyzed using appropriate statistical tests (P < 0.05).</p><p><strong>Results: </strong>In our study, the age of subjects ranged between 14 and 92 years, with a mean ± standard deviation of 48.1 ± 17.01 years. There were more females than males with a male-to-female ratio of 1:1.3. The prevalence of hypothyroidism was 46.5%. Hypothyroidism was more common in females (58.9%) as compared to males (41.1%). Patients with hypothyroidism had significantly higher body weight and body mass index (BMI) in comparison to euthyroid patients. The rest of the anthropometric parameters were comparable. Waist circumference and BMI of overt hypothyroid patients were found to be higher as compared to subclinical hypothyroid patients. Total cholesterol and triglyceride were significantly higher (P = 0.001 and P < 0.001, respectively), while high-density lipoprotein levels were significantly lower in patients with hypothyroidism than the euthyroid group (P < 0.001).</p><p><strong>Conclusion: </strong>Hypothyroidism, especially subclinical hypothyroidism, is a common endocrine disorder in patients with MetS. As MetS and hypothyroidism are independent risk factors for CVD, hence there is a need for screening for hypothyroidism and the treatment of the same can be beneficial in reducing the cardiovascular morbidity and mortality in patients with MetS.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":"23 4","pages":"717-722"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Management of a Late Referred Giant Choledochal Cyst Type Ia in 8-Year-old Girl. 成功治愈一名晚期转诊的 8 岁女孩 Ia 型巨大胆总管囊肿
IF 0.6
Annals of African Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.4103/aam.aam_9_24
Boniphace Tresphory, Alessandro Calisti
{"title":"Successful Management of a Late Referred Giant Choledochal Cyst Type Ia in 8-Year-old Girl.","authors":"Boniphace Tresphory, Alessandro Calisti","doi":"10.4103/aam.aam_9_24","DOIUrl":"10.4103/aam.aam_9_24","url":null,"abstract":"<p><p>A choledochal cyst is a rare condition with a variable incidence and different modalities of presentation according to the context and the age of patients. Early diagnosis and complete resection are the only therapeutic options to prevent complications and malignancies. Type Ia, cystic dilatation of the entire extrahepatic duct, is the most observed, and a giant size (more than 10 cm in diameter) may rarely be reached. This patient group often has a long-lasting clinical history and a shared experience of uneasy access to specialist care. Huge dimensions are a complex challenge for complete resection, and the risk of permanent liver functional damage must be considered, as in the current case.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"740-742"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posttraumatic Anterior Hip Dislocation with Ipsilateral Comminuted Intertrochanteric Fracture: A Rare Case Report. 创伤后髋关节前脱位伴同侧粉碎性转子间骨折:罕见病例报告
IF 0.6
Annals of African Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-13 DOI: 10.4103/aam.aam_62_24
Vinay Prabhat, Verma Dipak Kumar Prakash Prasad, Rohit Topno, Sabyasachi Kundu
{"title":"Posttraumatic Anterior Hip Dislocation with Ipsilateral Comminuted Intertrochanteric Fracture: A Rare Case Report.","authors":"Vinay Prabhat, Verma Dipak Kumar Prakash Prasad, Rohit Topno, Sabyasachi Kundu","doi":"10.4103/aam.aam_62_24","DOIUrl":"10.4103/aam.aam_62_24","url":null,"abstract":"<p><p>Hip joint is a ball and socket type of joint and its anatomic features makes it very stable. However, Incidence of hip dislocation has increased recently due to high energy trauma like road traffic accident, fall from height etc. It is usually associated with fracture of femoral head, neck, shaft and acetabular wall. Association of ipsilateral intertrochantric fracture is exceedingly rare and only a few case reports are available in the literature. We are presenting a rare case report of neglected anterior hip dislocation with ipsilateral comminuted intertrochanteric fracture managed with hemiarthroplasty using long cemented distal press-fit revision stem. A 66-year-old male presented to our outpatient department with history of fall from a tree 22 days back with pain in right hip and inability to bear weight on right lower limb. Radiographs were suggestive of anterior hip dislocation with fracture of ipsilateral comminuted intertrochanteric fracture of right side. Anterior hip dislocation with ipsilateral intertrochanteric fracture is a very rare entity, and only a few case reports are available in the literature. Management includes early open reduction and fixation to achieve optimal outcomes, but doing primary arthroplasty is also a viable option especially in neglected cases as there is high chances of avascular necrosis and secondary osteoarthritis of the hip joint later on.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"748-751"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indirect Immunofluorescence-Aided Detection of Antimyelin Oligodendrocyte Glycoprotein Antibodies in Neuromyelitis Optica Spectrum Disorder/Myelin Oligodendrocyte Glycoprotein-Associated Antibody Disorder: A Case Series Involving Five Patients. 间接免疫荧光辅助检测神经脊髓炎谱系障碍/髓鞘少突胶质细胞糖蛋白相关抗体紊乱症中的抗髓鞘少突胶质细胞糖蛋白抗体:涉及五名患者的病例系列。
IF 0.6
Annals of African Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-13 DOI: 10.4103/aam.aam_37_24
Debamita Datta, Mala Mahto, Upasna Sinha, Sushil Kumar
{"title":"Indirect Immunofluorescence-Aided Detection of Antimyelin Oligodendrocyte Glycoprotein Antibodies in Neuromyelitis Optica Spectrum Disorder/Myelin Oligodendrocyte Glycoprotein-Associated Antibody Disorder: A Case Series Involving Five Patients.","authors":"Debamita Datta, Mala Mahto, Upasna Sinha, Sushil Kumar","doi":"10.4103/aam.aam_37_24","DOIUrl":"10.4103/aam.aam_37_24","url":null,"abstract":"<p><p>Autoantibodies are the cause of the chronic inflammatory diseases known as neuromyelitis optica spectrum disorders (NMOSD). Serum antibodies (Abs) that specifically target the aquaporin-4 (AQP-4) water channel are the cause of recurrent episodes of optic neuritis, myelitis, and/or brain stem disorders. In contrast to AQP-4 Abs, myelin oligodendrocyte glycoprotein (MOG) Abs are detected in some patients exhibiting nonmotor cognitive impairment. These days, the term \"MOG-encephalomyelitis\" (MOG-EM) is frequently used to describe these clinical syndromes. The diagnosis of these cases involves the use of magnetic resonance imaging, optical coherence tomography, antibody detection, and additional laboratory testing. By detecting the patient's Abs in their serum or cerebrospinal fluid (CSF), indirect immunofluorescence (IIF) aids in the proper diagnosis. We highlight five NMOSD cases where serum anti-MOG antibody positivity was found using IIF, but CSF was not. In none of the cases, anti-AQP Abs were found. Effective patient management strategies include the treatment of acute attacks and long-term immunosuppressive drugs such as rituximab, azathioprine, and immunoglobulins. IIF is a quick and easy tool to detect anti-MOG Abs in patients with NMOSD/myelin oligodendrocyte glycoprotein antibody-associated disorder. CSF testing for MOG or AQP-4 Abs is not usually advised. It does not offer additional benefits to help with MOG-EM or NMOSD diagnosis.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"731-736"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Patterns of Seizure-related Injuries: A Study of People Living with Epilepsy Found in a Community-based Door-to-door Survey in Southeast Nigeria. 癫痫发作相关伤害的发生率和模式:尼日利亚东南部社区挨家挨户调查发现的癫痫患者。
IF 0.6
Annals of African Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-13 DOI: 10.4103/aam.aam_39_24
Obiora Daniel Anaje, Paul Osemeke Nwani, Maduaburochukwu Cosmas Nwosu, Lasbrey Azuoma Asomugha, Chetanna Chioma Anaje, Ifeoma Adaigwe Amaechi, Olisaeloka Ginikachi Ebeogu, Sunday Onyemaechi Oriji, Chinwe Chioma Ndukwe, Linda Ifunanya Eze, Nnamdi Joseph Morah, Imelda Chinenye Omaga, Adesola Ogunniyi
{"title":"Prevalence and Patterns of Seizure-related Injuries: A Study of People Living with Epilepsy Found in a Community-based Door-to-door Survey in Southeast Nigeria.","authors":"Obiora Daniel Anaje, Paul Osemeke Nwani, Maduaburochukwu Cosmas Nwosu, Lasbrey Azuoma Asomugha, Chetanna Chioma Anaje, Ifeoma Adaigwe Amaechi, Olisaeloka Ginikachi Ebeogu, Sunday Onyemaechi Oriji, Chinwe Chioma Ndukwe, Linda Ifunanya Eze, Nnamdi Joseph Morah, Imelda Chinenye Omaga, Adesola Ogunniyi","doi":"10.4103/aam.aam_39_24","DOIUrl":"10.4103/aam.aam_39_24","url":null,"abstract":"<p><strong>Context: </strong>Epileptic seizures and the unpredictable falls resulting from epileptic seizures predispose the people living with epilepsy (PLWE) to various physical injuries as well as postictal cognitive and behavioral changes.</p><p><strong>Aims: </strong>The aim of the study was to determine the frequency and patterns of seizure-related physical injuries, postictal cognitive impairments, and behavioral changes.</p><p><strong>Settings and design: </strong>This was a cross-sectional descriptive study in a Southeast Nigeria local government area.</p><p><strong>Subjects and methods: </strong>PLWE identified during a two-phase door-to-door survey and their caregivers were interviewed using a semi-structured questionnaire.</p><p><strong>Statistical analysis used: </strong>The Statistical Package for the Social Sciences version 22.0 was used.</p><p><strong>Results: </strong>There were 56 cases of active convulsive seizures comprising 33 (58.9%) males and 23 (41.1%) females, with a mean age of 32.9 ± 14.2. The lifetime prevalence of seizure-related physical injuries, postictal behavioral changes, and postictal cognitive impairments was 9.8 per 1000 (95% confidence interval [CI]: 9.1-10.0), 8.4 per 1000 (95% CI: 7.2-9.2), and 6.3 per 1000 (95% CI: 4.9-7.5), respectively. Skin/soft-tissue injuries and tongue laceration were the most frequent physical injuries found in 66.1% ( n = 37/56) and 60.7% ( n = 34/56) of cases, respectively. The frequency of soft-tissue injuries was significantly higher (χ 2 = 5.038; P = 0.0248) in the females 78.3% ( n = 18/23) than the males 48.5% ( n = 16/33). About a third of the females 39.1% had burn injuries compared to 18.1% of the males.</p><p><strong>Conclusions: </strong>Seizure-related injuries are common and have the tendency to increase the burden of epilepsy and epilepsy-related stigma from deformities and the chronic disfiguring scars resulting from such injuries.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"628-634"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relative Impact of Clinical and Investigational Factors to Predict the Outcome in Stroke Patients. 预测中风患者预后的临床和研究因素的相对影响。
IF 0.6
Annals of African Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.4103/aam.aam_22_23
Rizwana Shahid, Azra Zafar, Saima Nazish, Erum Shariff, Foziah Alshamrani, Danah Aljaafari, Nehad Mahmoud Soltan, Fahad A Alkhamis, Aishah Ibrahim Albakr, Majed Alabdali, Maher Saqqur
{"title":"The Relative Impact of Clinical and Investigational Factors to Predict the Outcome in Stroke Patients.","authors":"Rizwana Shahid, Azra Zafar, Saima Nazish, Erum Shariff, Foziah Alshamrani, Danah Aljaafari, Nehad Mahmoud Soltan, Fahad A Alkhamis, Aishah Ibrahim Albakr, Majed Alabdali, Maher Saqqur","doi":"10.4103/aam.aam_22_23","DOIUrl":"10.4103/aam.aam_22_23","url":null,"abstract":"<p><strong>Objective: </strong>As stroke is still considered a significant cause of mortality and morbidity, it is crucial to find the factors affecting the outcome in these patients. We aimed to interpret the various clinical and investigational parameters and establish their association with the outcome in stroke patients.</p><p><strong>Materials and methods: </strong>This is a retrospective, cross-sectional study, conducted in the Department of Neurology between June 2019 to November 2021. The study involved the review and analysis of medical records pertaining to 264 patients, admitted with the diagnosis of stroke. Various clinical, radiological, and electroencephalographic (EEG) patterns in stroke patients were analyzed and their association with outcome was established. The association between the studied variables was performed by the logistic regression (LR) and presented as odds ratio (OR) and 95% confidence interval (CI).</p><p><strong>Results: </strong>The study sample consisted of 264 patients. Males comprised 165 (62.5%) with the mean participant age of 57.17 ± 18.7 3 years (range: 18-94). Patients younger than 50 years had a better likelihood of a good outcome in comparison to patients older than 50. The admission location was the most significant factor in predicting the outcome ( P = 0.00) in favor of inpatient department and outpatient department (OPD), in contrast to patients admitted directly to intensive care unit (ICU). Normal EEG was associated with good outcome ( P = 0.04; OR, 3.3; CI, 1.01-10.88) even after adjustment of the confounders, whereas patients having marked EEG slowing had a poor outcome ( P = 0.05; OR, 2.4; CI, 0.65-8.79). Among the clinical parameters, hemiparesis ( P = 0.03), trauma ( P = 0.01), generalized tonic-clonic seizures (GTC) ( P = 0.00), and National Institutes of Health Stroke Scale of more than 4 were more likely associated with a poor outcome as well as the presence of intracranial hemorrhage (ICH) or infarction in the cortical and cortical/subcortical locations were associated with poor outcomes. After adjustment of confounders, the factors found to have prognostic significance in favor of good outcomes were inpatients or OPD referrals and normal EEG while direct admission to ICU, marked slowing on EEG, and presence of ICH were found to be associated with poor outcome.</p><p><strong>Conclusion: </strong>Certain patterns are predictive of good or worse outcomes in stroke patients. Early identification of these factors can lead to early intervention, which in turn might help in a better outcome. The results of the study, therefore, have some prognostic significance.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"548-555"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prevalence of Comorbidities Associated with Multiple Sclerosis in Saudi Arabia. 沙特阿拉伯多发性硬化症相关并发症的患病率。
IF 0.6
Annals of African Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-13 DOI: 10.4103/aam.aam_49_24
Hind Alnajashi, Abdullah Wali, Ali Aqeeli, Almothanna Magboul, Mohammed Alfulayt, Abdullah Baasher, Samer Alzahrani
{"title":"The Prevalence of Comorbidities Associated with Multiple Sclerosis in Saudi Arabia.","authors":"Hind Alnajashi, Abdullah Wali, Ali Aqeeli, Almothanna Magboul, Mohammed Alfulayt, Abdullah Baasher, Samer Alzahrani","doi":"10.4103/aam.aam_49_24","DOIUrl":"10.4103/aam.aam_49_24","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is a chronic, immune mediated demyelinating illness of the central nervous system. This study looks at various comorbidities associated with MS, focusing on their impact on disease progression. Understanding comorbidities in MS is important as it can impact treatment selection and overall disease management and prognosis.</p><p><strong>Aims and objectives: </strong>Our aim is to show the prevalence of comorbidities along with MS. This research focuses on the comorbidities associated with MS and their impact on disease progression in the Arab Gulf region, with a special emphasis on Jeddah, Saudi Arabia.</p><p><strong>Material and methods: </strong>A retrospective record review was conducted from July 2022 to July 2023. The study included 286 patients, selected based on a definitive MS diagnosis in accordance with McDonald's 2017 criteria. Data collected included demographic information, MS type, duration of diagnosis, type of disease modifying therapy (DMT) used, Expanded Disability Status Scale (EDSS) score, and type of comorbidities.</p><p><strong>Results: </strong>The majority of the patients were female (70%) with an average age of 36 years. Most patients had relapsing remitting MS, and the majority were on DMTs, with fingolimod being the most common. Nearly half of the patients had comorbidities, with mood disorders, diabetes mellitus (DM), migraine, and hypertension (HTN) being prevalent. A significant positive association was found between the EDSS scores and both DM and HTN, but there was no significant link with migraine.</p><p><strong>Conclusion: </strong>The findings indicate that individuals with MS have an increased risk of developing comorbidities such as migraine, DM, and HTN. Emphasizing a healthy lifestyle could potentially reduce the incidence of DM and HTN and their related vascular complications. The research also notes the prevalence of mood disorders among the MS population, although it remains inconclusive whether these are separate comorbid conditions or inherent symptoms of MS.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":"600-605"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Demographic Characteristics and Functional Outcome in Posterior Circulation Strokes. 后循环脑卒中患者的人口统计学特征和功能预后
IF 0.6
Annals of African Medicine Pub Date : 2024-07-01 Epub Date: 2024-07-20 DOI: 10.4103/aam.aam_196_23
Rizwana Shahid
{"title":"Demographic Characteristics and Functional Outcome in Posterior Circulation Strokes.","authors":"Rizwana Shahid","doi":"10.4103/aam.aam_196_23","DOIUrl":"10.4103/aam.aam_196_23","url":null,"abstract":"<p><strong>Introduction: </strong>The constantly increasing incidence of stroke in Saudi Arabia substantiates an urgent need to elucidate underlying risk factors and etiologies. In terms of improving outcomes, the predictors of functional outcomes need to be identified as well. As posterior circulation strokes (PCS) have not been studied in detail, the current study aimed to identify the risk factors, etiology, and predictors of outcome in PCS.</p><p><strong>Methods: </strong>This retrospective study included the data for 138 patients with PCS. Demographics, risk factors, clinical signs/symptoms, etiology, and outcome at discharge and 3-month follow-up were recorded. Factors associated with outcomes were identified, and the difference was ascertained using Chi-square, odds ratios, and 95% confidence intervals.</p><p><strong>Results: </strong>The mean participant age was 58 ± 14.8 years with 73% being males. The mean arrival time was 26.5 ± 31.6 h; with a mean National Institute of Health Stroke scale (NIHSS) score of 7.2 ± 5.6. Motor deficit and dysarthria were the most common presentations. Twenty percent of patients received intravenous recombinant tissue plasminogen activator, whereas endovascular thrombectomy was performed in 9 (6.5%). Follow-up outcome at 3 months was available in 113 (81.8%). Male sex, baseline modified Rankin scale of <2, low baseline NIHSS, and stable or improvement in baseline NIHSS during 24 h of admission were documented as predictors of a good outcome, whereas history of atrial fibrillation and prior stroke, high NIHSS at admission and worsening of symptoms during 24 h of admission, as well as bilateral body involvement were associated with poor outcome.</p><p><strong>Conclusion: </strong>The functional outcomes and the predictors of functional outcomes did not differ from the previously published literature; however, significant differences were observed in the risk factors and etiological profile in our population. These differences are of potential interest to the researchers and clinicians, as they carry important therapeutic and prognostic implications and need to be verified through large prospective studies.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":"23 3","pages":"328-334"},"PeriodicalIF":0.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Surface Roughness and Microhardness of Bulk-fill and Nanohybrid Composite after Exposure to Different Beverages at Various Time Intervals - An In vitro Study. 不同时间间隔暴露于不同饮料后团状填充和纳米杂化复合材料表面粗糙度和显微硬度的评估--一项体外研究。
IF 0.6
Annals of African Medicine Pub Date : 2024-07-01 Epub Date: 2024-07-20 DOI: 10.4103/aam.aam_157_23
Sachin Bengal, Gautam P Badole, Pratima R Shenoi, Rajesh Kubde, Shriya Shahu
{"title":"Evaluation of Surface Roughness and Microhardness of Bulk-fill and Nanohybrid Composite after Exposure to Different Beverages at Various Time Intervals - An In vitro Study.","authors":"Sachin Bengal, Gautam P Badole, Pratima R Shenoi, Rajesh Kubde, Shriya Shahu","doi":"10.4103/aam.aam_157_23","DOIUrl":"10.4103/aam.aam_157_23","url":null,"abstract":"<p><strong>Aim: </strong>The aim of the study was to compare the surface roughness and microhardness of bulk-fill composite and nanohybrid composite resin after exposure to three different beverages at different time intervals.</p><p><strong>Methodology: </strong>In this study, 60 composite discs each for bulk fill and nanohybrid, of dimensions 10 mm × 2 mm were made. Both composites were randomly divided into four subgroups, i.e., 15 samples each for artificial saliva, tea, coffee, and soft drinks which were further subdivided into five samples for three time intervals. Composite resin discs were immersed in beverages for 4 min in 24 h for 7, 15, and 30 days. All samples were evaluated for surface roughness and microhardness before and after immersion.</p><p><strong>Results: </strong>Both the composites showed a significant increase in surface roughness in all the beverages with maximum change in surface roughness observed in nanohybrid composite resin immersed in soft drinks. Furthermore, the microhardness of both the composites was decreased significantly in all beverages with maximum change in microhardness observed in nanohybrid composite resin immersed in soft drinks.</p><p><strong>Conclusions: </strong>Bulk-fill composite resin has better resistance to surface roughness and higher microhardness as compared to nanohybrid. Furthermore, acidic beverages highly affect the physical properties of both composite resins for longer periods.</p>","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":"23 3","pages":"466-473"},"PeriodicalIF":0.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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