Recent Advances and Perspectives of Atherosclerotic Occlusive Disease.

Abstract

Abstract: Atherosclerotic occlusive disease in developed nations, the primary causes of death and disability are atherosclerotic diseases, such as stroke and acute coronary syndromes. The most common acute vascular events are brought on by the rupture or erosion of hemodynamically insignificant atherosclerotic plaques. The most frequent cause of both carotid and coronary steno-occlusive disease is atherosclerosis. The atherosclerotic plaque starts progressing when the foam cells break down and release lipids into the extracellular space when the stimulus for atherogenesis is intensified. Thus, creating a lipid pool that is primarily acellular. At the same time, activated smooth muscle cells go into the intimal layer and multiply, dramatically improving their capacity to make collagen and maintain the fibrous cap. As the plaque thickens, its deeper layers may become hypoxic, causing angiogenesis and microvessel multiplication from the adventitial vasa vasorum. Since the middle of the 20th century, there have been significant drops in the incidence and mortality from ischemic heart disease and ischemic stroke in high-income countries. Blood tests are typically performed to measure cholesterol and blood sugar levels and are used as diagnostic tests for atherosclerosis. Cardiograms and exercise stress tests are also used for diagnosis. Risk factors of atherosclerosis include high blood pressure, smoking, diabetes mellitus, high blood pressure, obesity, diet, sedentary lifestyle, and high total cholesterol and low-density lipoprotein cholesterol. The cornerstones of managing atherosclerotic are still medical care and lifestyle changes. A growing number of atherosclerotic types can benefit greatly from endovascular therapy. When compared to normal surgical procedures, it is linked with much lower morbidity and mortality, as well as a quicker recovery time. This article aims to provide a brief introduction, risk factors, epidemiology, diagnostic tests, prevention, and good practice management advice for atherosclerosis.