Journal of cardiovascular risk最新文献_第3页

Serum lipopotein (a) levels in a large sample of subjects affected by familial combined hyperlipoproteinaemia and in general population. 家族性合并高脂蛋白血症患者和普通人群的血清脂蛋白(a)水平

Journal of cardiovascular risk Pub Date : 2003-04-01 DOI: 10.1097/01.hjr.0000060835.46105.75

Arrigo F G Cicero, Maria P Panourgia, Simona Linarello, Sergio D'Addato, Zina Sangiorgi, Antonio Gaddi

{"title":"Serum lipopotein (a) levels in a large sample of subjects affected by familial combined hyperlipoproteinaemia and in general population.","authors":"Arrigo F G Cicero, Maria P Panourgia, Simona Linarello, Sergio D'Addato, Zina Sangiorgi, Antonio Gaddi","doi":"10.1097/01.hjr.0000060835.46105.75","DOIUrl":"https://doi.org/10.1097/01.hjr.0000060835.46105.75","url":null,"abstract":"Background: Serum lipoprotein (a) [Lp(a)] is a lipidic parameter, strictly under genetic control. Lp(a) levels vary in different dyslipidaemias according to the underlying disease.Design: The aim of this study was to evaluate and compare serum Lp(a) mean levels distribution in a large familial combined hyperlipoproteinaemia (FCH) patients sample with a normolipidaemic group.Methods: FCH group included 138 subjects (74 males and 65 females) aged from 16 to 88 years; the control group included 438 normolipidaemic subjects (238 males and 200 females) aged from 16 to 91 years. In both groups we have measured Lp(a) concentrations and other lipidic parameters.Results: Serum lipid levels as well as Lp(a) log-transformed concentrations were on average higher in FCH patients than in control subjects. Lp(a) concentrations were not significantly different between sexes and among 20-year age classes in both groups.Conclusions: The relationship between FCH and Lp(a) remains controversial. However, since both are considered independent risk factors for premature CHD development, even if their pathogenic interaction is still unclear, we suggest that Lp(a) values should be carefully monitored in dyslipidaemic subjects and particularly in FCH ones. In FCH subjects with elevated Lp(a) levels, aggressive intervention could be required.","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 2","pages":"149-51"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22316943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The metabolic syndrome: targeting dyslipidaemia to reduce coronary risk. 代谢综合征:针对血脂异常降低冠状动脉风险。

Journal of cardiovascular risk Pub Date : 2003-04-01 DOI: 10.1097/01.hjr.0000060840.46106.ea

Henry N Ginsberg, Anton F H Stalenhoef

{"title":"The metabolic syndrome: targeting dyslipidaemia to reduce coronary risk.","authors":"Henry N Ginsberg, Anton F H Stalenhoef","doi":"10.1097/01.hjr.0000060840.46106.ea","DOIUrl":"https://doi.org/10.1097/01.hjr.0000060840.46106.ea","url":null,"abstract":"The metabolic syndrome is a complex constellation of disorders, each one a significant risk factor for the development of cardiovascular disease (CVD). The increasing prevalence of this condition is a major concern for healthcare providers both in Europe and North America. The concern surrounding the prevalence of the metabolic syndrome is reflected in the recently published National Cholesterol Education Program Adult Treatment Panel III guidelines. Although complex in nature, the individual components of the metabolic syndrome appear to be linked by the presence of insulin resistance. Concurrently treating the underlying insulin resistance along with the complex array of other disorders should form the core of any management strategy. Treatment of atherogenic dyslipidaemia should be a major aim, since it is associated with a significant risk of CVD. While lifestyle modifications form the cornerstone of any dyslipidaemia management strategy, many patients require the addition of lipid-modifying drugs. Several agents are available for the treatment of lipid abnormalities, including fibrates, bile acid sequestrants, niacin and hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins). Of these, statins should be used as the first treatment option in the majority of patients because they are efficacious for reducing low-density lipoprotein cholesterol, are effective across the lipid profile and are well tolerated in the majority of cases. Furthermore, the American Diabetes Association (ADA) recommends statins as first-line pharmacological treatment of dyslipidaemia in patients with diabetes mellitus. This review discusses the diagnosis and management of the metabolic syndrome and examines the potential of future treatment options.","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 2","pages":"121-8"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22318120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insufficient use of lipid-lowering drugs and measurement of serum cholesterol among patients with a history of myocardial infarction. 心肌梗死史患者降脂药物使用不足及血清胆固醇测定。

Journal of cardiovascular risk Pub Date : 2003-02-01 DOI: 10.1097/01.hjr.0000048740.87586.f8

John Larsen, Morten Andersen, Lars Bjerrum, Jakob Kragstrup, Lars F Gram

引用次数: 2

Alcohol and cardiovascular disease--more than one paradox to consider. Alcohol and hypertension--does it matter? (no!). 酒精和心血管疾病——不止一个悖论需要考虑。酒精和高血压有关系吗?(不!)。

Journal of cardiovascular risk Pub Date : 2003-02-01 DOI: 10.1097/01.hjr.0000051962.68260.eb

Gregory Y H Lip, D Gareth Beevers

引用次数: 14

Alcohol and cardiovascular disease--more than one paradox to consider. Alcohol and type 2 diabetes--another paradox? 酒精和心血管疾病——不止一个悖论需要考虑。酒精和2型糖尿病——又一个悖论?

Journal of cardiovascular risk Pub Date : 2003-02-01 DOI: 10.1097/01.hjr.0000051965.16636.3c

Renate R Zilkens, Ian B Puddey

引用次数: 64

Cardiovascular risk factors in the elderly: the Tehran Lipid and Glucose Study. 老年人心血管危险因素:德黑兰血脂和血糖研究

Journal of cardiovascular risk Pub Date : 2003-02-01 DOI: 10.1097/01.hjr.0000050202.47754.1b

Fereidoun Azizi, Habib Emami, Payam Salehi, Arash Ghanbarian, Parvin Mirmiran, Mohammadreza Mirbolooki, Tohid Azizi

{"title":"Cardiovascular risk factors in the elderly: the Tehran Lipid and Glucose Study.","authors":"Fereidoun Azizi, Habib Emami, Payam Salehi, Arash Ghanbarian, Parvin Mirmiran, Mohammadreza Mirbolooki, Tohid Azizi","doi":"10.1097/01.hjr.0000050202.47754.1b","DOIUrl":"https://doi.org/10.1097/01.hjr.0000050202.47754.1b","url":null,"abstract":"Background: Coronary artery disease is becoming more prevalent in developing countries, particularly in urban areas. Because the proportion of elderly individuals in the population is on the rise, this study was conducted to determine the prevalence of cardiovascular risk factors among the Tehran urban elderly population.Design and methods: Among 15,005 urban individuals of 3 years old and over who had been chosen in a cross-sectional phase of a longitudinal study in Tehran, there were 1,799 people aged 60 years and over. The prevalence and distribution of high blood pressure, cigarette smoking, dyslipoproteinemia, diabetes mellitus and obesity were determined in this population. Dietary intake was assessed in a subsidiary of 54 people by means of two 24 h dietary recalls.Results: The percentage of women with two or more cardiovascular disease risk factors was significantly greater than in men (74% compared with 53%, P < 0.001). One fourth of men and 55% of women had high serum cholesterol levels (>/=240 mg/dl). The prevalence of diabetes mellitus and impaired glucose tolerance was 24% and 21% in men and 29% and 20% in women, respectively. The prevalence of obesity (body mass index >/=30 kg/m(2)) was 15% for men and 36% for women. Fifty-five per cent of men and 94% of women had high waist-to-hip ratios (>0.95 in men and >0.8 in women). The mean percentage values of energy intake derived from carbohydrate, protein and fat were 60.5 +/- 8.0, 11.5 +/- 2.0 and 27.8 +/- 8.9, respectively.Conclusions: The prevalence of cardiovascular risk factors among the Tehran urban elderly population is high. Some efforts should be made to reverse the recent trend towards increasing age-related mortality and morbidity rates of coronary heart disease.","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 1","pages":"65-73"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22230537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol and cardiovascular disease--more than one paradox to consider. Type of alcoholic beverage and cardiovascular disease--does it matter? 酒精和心血管疾病——不止一个悖论需要考虑。酒精饮料的种类和心血管疾病有关系吗?

Journal of cardiovascular risk Pub Date : 2003-02-01 DOI: 10.1097/01.hjr.0000051963.68260.a2

Morten Grønbaek

引用次数: 13

Alcohol and cardiovascular disease--more than one paradox to consider. Average volume of alcohol consumption, patterns of drinking and risk of coronary heart disease--a review. 酒精和心血管疾病——不止一个悖论需要考虑。平均饮酒量、饮酒模式与冠心病风险的综述

Journal of cardiovascular risk Pub Date : 2003-02-01 DOI: 10.1097/01.hjr.0000051961.68260.30

J Rehm, C T Sempos, M Trevisan

引用次数: 23

Novel biomedical risk markers for cardiovascular disease. 心血管疾病新的生物医学风险标记。

Journal of cardiovascular risk Pub Date : 2003-02-01 DOI: 10.1097/01.hjr.0000043733.45539.e6

Dianna J Magliano, Danny Liew, Emma L Ashton, Vijaya Sundararajan, John J McNeil

引用次数: 0

Influence of hormone replacement therapy on C-reactive protein: population-based data. 激素替代疗法对c反应蛋白的影响:基于人群的数据。

Journal of cardiovascular risk Pub Date : 2003-02-01 DOI: 10.1097/01.hjr.0000050717.61003.d4

Paola Primatesta, Emanuela Falaschetti, Neil R Poulter

{"title":"Influence of hormone replacement therapy on C-reactive protein: population-based data.","authors":"Paola Primatesta, Emanuela Falaschetti, Neil R Poulter","doi":"10.1097/01.hjr.0000050717.61003.d4","DOIUrl":"https://doi.org/10.1097/01.hjr.0000050717.61003.d4","url":null,"abstract":"Background: Observational data, possibly resulting from confounding due to self-selection, show that use of hormone replacement therapy (HRT) is associated with reduced coronary risk, while randomized trial data do not. One possible explanation for the trial findings is that adverse effects of HRT-- such as an elevation of C-reactive protein (CRP)--might counterbalance other benefits of HRT.Design: Women aged 40-74 years were identified from a cross-sectional, annual nationally representative study of the English population, the Health Survey for England 1998. Valid data were available from 4,112 of the 4,319 women in this age group. Of these, 710 (17%) were current, 465 (11%) past and 2,937 (71%) never users of HRT.Methods: To study the association between current and past use of HRT and CRP levels. CRP was expressed as a continuous variable (logged) and in percentiles.Results: Current, past and never users of HRT did not differ in terms of age, body mass index or smoking status. However, compared with past and never users of HRT, current users tended to take more vigorous physical activity and were more likely to drink more alcohol than is currently recommended. Excluding potentially confounding conditions, median CRP levels were significantly higher in current (2.5 mg/l) and in past (1.9 mg/l) than never HRT users (1.4 mg/l). Controlling for age, smoking and body mass index logged CRP remained significantly raised only among current users.Conclusions: HRT use was significantly and independently associated with raised CRP levels in an English nationally representative sample. Increases in CRP may represent one plausible mechanism by which HRT may adversely affect risk of coronary heart disease.","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 1","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22230605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0