Journal of cardiovascular risk最新文献

{"title":"Clustering of cardiovascular risk factors and risk of development of hypertension in Japanese male office workers.","authors":"Noriyuki Nakanishi,&nbsp;Kenji Suzuki,&nbsp;Kozo Tatara","doi":"10.1097/01.hjr.0000065929.57001.04","DOIUrl":"https://doi.org/10.1097/01.hjr.0000065929.57001.04","url":null,"abstract":"<p><strong>Background: </strong>Obesity, hypercholesterolaemia, low high-density lipoprotein cholesterol levels, hypertriglyceridaemia, high fasting plasma glucose levels, hyperuricaemia and increased white blood cell count levels are all positively associated with the risk of hypertension, but the effect of the clustering of these risk factors on the risk for development of hypertension remains unclear.</p><p><strong>Design: </strong>Longitudinal study at a work site in Osaka, Japan.</p><p><strong>Methods: </strong>We examined 3784 Japanese male office workers aged 30 to 59 years who were hypertension-free [systolic blood pressure (SBP) < 140 mmHg, diastolic blood pressure (DBP) < 90 mmHg, no medication for hypertension, and no past history of hypertension]. Blood pressures were measured at annual health examinations from May 1996 to May 2001.</p><p><strong>Results: </strong>After controlling for potential predictors of hypertension, the relative risk of hypertension (SBP>/=140 mmHg, DBP>/=90 mmHg, or both or prescription of antihypertensive medication) compared with the presence of no risk factors was 1.41 (95% CI, 1.21 to 1.64), 1.64 (95% CI, 1.38 to 1.96), 1.93 (95% CI, 1.56 to 2.39), 2.01 (95% CI, 1.51 to 2.68) and 3.34 (95% CI, 2.07 to 5.38) (P value for trend < 0.001) for respective risk factors of 1, 2, 3, 4 and >/=5. Even after the subjects were stratified according to blood pressure, the clustering of risk factors was associated with an increased risk of hypertension for subjects in all three categories of normotension: low-normal, normal, and high-normal.</p><p><strong>Conclusions: </strong>Clustering of cardiovascular risk factors associated with hypertension precedes an increase in the risk of hypertension in Japanese men.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 3","pages":"213-20"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/01.hjr.0000065929.57001.04","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22410548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HMG-CoA reductase inhibition: anti-inflammatory effects beyond lipid lowering?","authors":"Winfried März,&nbsp;Wolfgang Köenig","doi":"10.1097/01.hjr.0000073686.78271.6d","DOIUrl":"https://doi.org/10.1097/01.hjr.0000073686.78271.6d","url":null,"abstract":"<p><p>Atherosclerosis has many features of a chronic inflammatory disease. Atherosclerotic lesions contain inflammatory cells. Systemic markers of inflammation, such as white blood cells, C-reactive protein, serum amyloid A, interleukin-6, and soluble adhesion molecules are predictive of future cardiovascular events. Atherogenic lipoprotein particles, in particular modified low-density lipoproteins (LDL), elicit pro-inflammatory responses of cellular elements of the vessel wall, including endothelial dysfunction and activation of monocyte-derived macrophages. High-density lipoproteins (HDL) oppose these effects by inhibiting the oxidation of LDL, and by down-regulating the expression of adhesion molecules and selectins. Treatment with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) has proven the most successful strategy to reduce the concentration of LDL in the circulation. These compounds lower LDL cholesterol by inhibiting the mevalonate pathway in the liver. Prospective clinical trials have convincingly demonstrated that HMG-CoA reductase inhibitors can effectively lower the incidence of cardiovascular events in primary and secondary prevention. Post hoc analyses of these trials suggest that the clinical benefit brought about by statins may not entirely be due to their effect on the levels of circulating lipoproteins. In vitro observations of anti-inflammatory actions of statins on vascular cells may contribute to explain effects beyond lipid lowering. It is, however, not clear whether these findings are relevant to the in vivo situation. Further investigation is now necessary in order to determine the relative significance of cholesterol lowering and of ancillary effects on the net clinical benefit of statin treatment.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 3","pages":"169-79"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/01.hjr.0000073686.78271.6d","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22410670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol?","authors":"Sarah Wilson,&nbsp;Atholl Johnston,&nbsp;John Robson,&nbsp;Neil R Poulter,&nbsp;David J Collier,&nbsp;Gene S Feder,&nbsp;Mark J Caulfield","doi":"10.1097/01.hjr.0000060844.48106.ff","DOIUrl":"https://doi.org/10.1097/01.hjr.0000060844.48106.ff","url":null,"abstract":"<p><strong>Background: </strong>The Joint British Societies Coronary Risk Prediction Charts recommend the use of a high-density lipoprotein cholesterol value of 1 mmol/l where actual values have not been measured. It is important to quantify the impact of this advice if risk assessments are to be sufficiently accurate to guide treatment decisions.</p><p><strong>Design: </strong>The risks of 5005 individuals from the Health Survey for England 1998 were calculated using the Joint British Societies charts. Each individual's risk was recalculated assuming a high-density lipoprotein cholesterol value of 1 mmol/l. These risk estimates were compared with those derived from the Framingham equation.</p><p><strong>Methods: </strong>Using the Framingham equation as the gold standard, the positive and negative predictive values, sensitivity and specificity with 95% confidence intervals of the Joint British charts with actual and estimated high-density lipoprotein cholesterol values were calculated.</p><p><strong>Results: </strong>At the 30% 10-year coronary heart disease risk threshold using measured high-density lipoprotein cholesterol values, the charts had a sensitivity of 83% and specificity of 99%. Using an estimated high-density lipoprotein cholesterol value of 1 mmol/l reduced the sensitivity to 58% with a specificity of 98%.</p><p><strong>Conclusions: </strong>In the presence of measured high-density lipoprotein cholesterol values there was good agreement between the Framingham equation and the Joint British Societies charts. The use of a fixed high-density lipoprotein cholesterol value of 1 mmol/l introduced important and significant errors into the risk assessment. This study reinforces the need to measure both total and high-density lipoprotein cholesterol when assessing coronary risk.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 2","pages":"137-41"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22318123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes in Africa. Diabetes microvascular and macrovascular disease in Africa.","authors":"Jean-Claude Mbanya,&nbsp;Eugene Sobngwi","doi":"10.1097/01.hjr.0000060842.48106.78","DOIUrl":"https://doi.org/10.1097/01.hjr.0000060842.48106.78","url":null,"abstract":"<p><p>This review on the prevalence and characteristics of diabetes micro- and macrovascular disease in Africa is based on a bibliographical Medline search and diabetes conference proceedings of published data over the past decade. The prevalence of diabetic retinopathy varies from 16 to 77% depending on the duration of diabetes and glycaemic control, with severe retinopathy representing 15% of all cases. At diagnosis, 21-25% of type 2 patients and 9.5% of type 1 patients have retinopathy. The prevalence of nephropathy varies between 32-57% after a mean duration of diabetes of 5-10 years, and 5-28% within the first year following the diagnosis of diabetes. The prevalence of neuropathy varies widely depending on the methodology used. Macrovascular complications of diabetes are considered rare in Africa despite a high prevalence of hypertension. Coronary heart disease may affect 5-8% of type 2 diabetic patients and cardiomyopathy up to 50% of all patients. Lower extremity amputation varies from 1.5 to 7%, and about 12% of all hospitalized diabetic patients have foot ulceration. Neuropathy underlies diabetic foot more often than peripheral vascular disease. In conclusion, whereas microvascular complications of diabetes are highly prevalent and occur early during the course of disease, macrovascular disease is rare. Late diagnosis of diabetes, poor metabolic control and nonstandardized diagnostic procedures rather than genetic predisposition may account for this difference from other populations around the world.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 2","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22318117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes in Africa. Challenges to health care for diabetes in Africa.","authors":"David R Whiting,&nbsp;Louise Hayes,&nbsp;Nigel C Unwin","doi":"10.1097/01.hjr.0000060846.48106.6d","DOIUrl":"https://doi.org/10.1097/01.hjr.0000060846.48106.6d","url":null,"abstract":"<p><p>The aim of this review is to summarize the contextual, clinical and health system challenges to the delivery of health care for diabetes in Africa. Planners need to allocate sufficient resources in a context where resources for health in general are insufficient. Choices need to be made between different options for health care within this context and mechanisms are required to facilitate the implementation of the selected options and ensure that quality of care is maintained.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 2","pages":"103-10"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22318118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective cohort studies of coronary heart disease in the UK: a systematic review of past, present and planned studies.","authors":"Julia A Critchley,&nbsp;Simon Capewell","doi":"10.1097/01.hjr.0000060836.46105.ae","DOIUrl":"https://doi.org/10.1097/01.hjr.0000060836.46105.ae","url":null,"abstract":"<p><strong>Background: </strong>Prospective cohort studies have made enormous contributions to our understanding of coronary heart disease (CHD) epidemiology in the UK. However, identification of cohorts and dissemination of key characteristics and results can be haphazard, and it is difficult to identify studies which are at the planning stage.</p><p><strong>Methods: </strong>We carried out a systematic review of cohort studies by searching MEDLINE and relevant websites and consulting key individuals. We included all large prospective UK cohort studies that focused on the development of CHD in predominantly healthy subjects.</p><p><strong>Results: </strong>The MEDLINE search retrieved 1558 hits and we identified 39 cohorts that met inclusion criteria. 'Early' cohorts were important in defining the major risk factors for CHD, particularly smoking, cholesterol, blood pressure, physical activity and body mass index. Prospective cohort studies have subsequently appraised potentially important novel risk factors including nutritional status, genetic determinants, haemostatic factors, lipid sub-fractions, psychosocial factors and the 'life course' perspective. Psychosocial factors have been relatively neglected, as have women, ethnic minorities and the elderly. Key methodological issues include minimizing losses to follow up, standardized measurements, quality assurance systems, change in risk factors over time, residual confounding, regression dilution bias, detection of non-fatal events, measurement of quality of life, and generalizability.</p><p><strong>Conclusions: </strong>The current and proposed prospective UK cohorts have sufficient power potentially to determine the importance of many traditional and newer CHD risk factors on cardiovascular risk in men, women and even ethnic minorities. However, secure financial support and hence sustainability will remain essential to maximize long-term benefits.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 2","pages":"111-9"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22318119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A high risk score for coronary heart disease is associated with the metabolic syndrome in 40-year-old men and women.","authors":"Serena Tonstad,&nbsp;Ingvar Hjermann","doi":"10.1097/01.hjr.0000060837.46105.e7","DOIUrl":"https://doi.org/10.1097/01.hjr.0000060837.46105.e7","url":null,"abstract":"<p><strong>Objective: </strong>Guidelines recommend follow-up of people whose 10-year risk of coronary heart disease (CHD) is > 10%. We calculated CHD risk, number of risk factors and occurrence of the metabolic syndrome among screened 40-year-old men and women.</p><p><strong>Design: </strong>A total of 1547 women and 1374 men participated in a cardiovascular risk factor screening programme in 1997-1999 in Oslo. Of 387 (13%) recalled for further examination and advice, 337 (87%) attended. We used the National Cholesterol Education Program criteria to define the metabolic syndrome and the Framingham risk score to assess absolute 10-year risk of CHD and counted nine risk factors (male, southeast-Asian origin, low education, smoking, premature familial cardiovascular disease (CVD), hypertension, high waist circumference, impaired fasting glucose or diabetes and high apolipoprotein B).</p><p><strong>Results: </strong>More than one-third of subjects recalled for hypertension (n = 88) or low high-density lipoprotein (HDL) cholesterol (n = 95) had the metabolic syndrome. Of 55 subjects with a 10-year risk score > 10%, 33 (60%) had the metabolic syndrome. Subjects with the metabolic syndrome had a higher risk score compared with their counterparts (P < 0.001); among men with the metabolic syndrome, the mean +/- SD risk score was 10.0 +/- 4.4%. Subjects with dyslipidaemia [high triglyceride and normal low-density lipoprotein (LDL) cholesterol levels] or combined hyperlipidaemia had a higher risk score and more risk factors compared with subjects with isolated high LDL cholesterol (P < 0.05). Only 12% of subjects with hypertension were taking drugs and of 237 subjects with a lipid disorder, 30% had been given dietary advice and one was taking a lipid-lowering drug.</p><p><strong>Conclusion: </strong>CVD screening should focus on identifying people with features of the metabolic syndrome in this age group. The screening programme uncovered a substantial potential for CVD prevention.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 2","pages":"129-35"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22318121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes in Africa. Epidemiology of type 1 and type 2 diabetes in Africa.","authors":"Ayesha A Motala,&nbsp;Mahomed A K Omar,&nbsp;Fraser J Pirie","doi":"10.1097/01.hjr.0000060843.48106.31","DOIUrl":"https://doi.org/10.1097/01.hjr.0000060843.48106.31","url":null,"abstract":"<p><p>Until recently, there was a paucity of data on the epidemiology of diabetes mellitus in Africa. Over the past decade, information on the prevalence of type 2 diabetes has increased, albeit still limited, but there is still a lack of adequate data on type 1 diabetes in sub-Saharan Africa (SSA). For type 2 diabetes, although the prevalence is low in some rural populations, moderate and even high rates have been reported from other countries. In low diabetes prevalence populations, the moderate to high rates of impaired glucose tolerance is a possible indicator of the early stage of a diabetes epidemic. Diabetes prevalence is higher in urban, migrant and African-origin populations living abroad. There is evidence for a significant association with preventable and modifiable risk factors viz. adiposity, known diabetes, physical activity; but a dearth of data on the impact of dietary and genetic factors. For type 1 diabetes, the limited available data suggest that in SSA the frequency is low and that age of onset occurs later than in the western world. There is evidence for the role of genetic and immunological factors in its pathogenesis. The impact of HIV/AIDS on projected estimates for diabetes prevalence in Africa needs to be established.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 2","pages":"77-83"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22318221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes in Africa. Pathogenesis of type 1 and type 2 diabetes mellitus in sub-Saharan Africa: implications for transitional populations.","authors":"Kwame Osei,&nbsp;Dara P Schuster,&nbsp;Albert G B Amoah,&nbsp;Samuel K Owusu","doi":"10.1097/01.hjr.0000060841.48106.a3","DOIUrl":"https://doi.org/10.1097/01.hjr.0000060841.48106.a3","url":null,"abstract":"<p><p>The increasing prevalence and incidence of diabetes and its long-term complications in sub-Saharan Africa (SSA) could have devastating human and economic toll if the trends remain unabated in the future. Approximately 90% or majority of patients with diabetes belongs to the adult onset, type 2 diabetes category while 10% have type 1 diabetes in SSA. However, because of the paucity of metabolic and clinical data, a clear understanding of the natural history of both diseases and the classification of diabetes subtypes has been hampered. Nevertheless, we have attempted to provide a concise review of the pathophysiology of both type 1 and type 2 diabetes as well as phenotypic and clinical variations in patients residing in SSA. The limited metabolic data, (albeit increasing), from high-risk and diabetic individuals in the SSA, have contributed significantly to the understanding of the pathogenetic mechanisms of diabetes and the variations in the presentation of the disease. Sub-Saharan African patients with type 1 diabetes have essentially absolute insulin deficiency. In addition, patients with type 2 diabetes in SSA region also manifest severe insulin deficiency with varying degrees of insulin resistance. Although the exact genetic markers of both diseases are unknown, we believe studies in patients of SSA origin who reside in diverse geographic environments (African diaspora) could potentially contribute to our understanding of the genetic and environmental mediators of both diseases. However, many intrinsic, individual and societal obstacles such as poor education and illiteracy, low socio-economic status and lack of access to health care make uncertain the translation of diabetes research in SSA. In this regard, effective management and/or prevention of diabetes in SSA individuals should adopt multidisciplinary approaches. Finally, innovative health care delivery and educational models will be needed to manage diabetes and its long-term complications in SSA.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 2","pages":"85-96"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22318222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regression dilution bias in blood total and high-density lipoprotein cholesterol and blood pressure in the Glostrup and Framingham prospective studies.","authors":"Sarah Lewington,&nbsp;Troels Thomsen,&nbsp;Michael Davidsen,&nbsp;Paul Sherliker,&nbsp;Robert Clarke","doi":"10.1097/01.hjr.0000060834.46105.3c","DOIUrl":"https://doi.org/10.1097/01.hjr.0000060834.46105.3c","url":null,"abstract":"<p><strong>Background: </strong>In epidemiological studies, within-person variability in measured values of a risk factor may underestimate the association between prolonged or 'usual' levels of a risk factor with risk of disease - 'regression dilution'. The importance of regression dilution for high-density lipoprotein (HDL)-cholesterol and the extent to which this may differ from that for total cholesterol is not known. The aim of this study was to assess the magnitude of regression dilution bias for HDL-cholesterol, total cholesterol and blood pressure after varying intervals of follow-up in two prospective cohort studies.</p><p><strong>Methods: </strong>Regression dilution ratios were estimated for each risk factor using the correlations between baseline and re-survey values in the Glostrup Population Studies and the NHLBI Framingham Heart Study after various time intervals. The regression dilution ratios in each cohort after a fixed interval between measurements were compared.</p><p><strong>Results: </strong>The regression dilution ratios after 10 years were 0.51 and 0.56 for systolic blood pressure in Glostrup and Framingham, respectively; 0.52 and 0.54 for diastolic blood pressure; and 0.68 and 0.63 for total cholesterol. In both studies, the regression dilution ratios for these risk factors became more extreme with increasing intervals between measurements. The regression dilution ratio for HDL-cholesterol after 10 years in Glostrup was 0.72, which suggests that the importance of regression dilution for HDL-cholesterol was similar to that for total cholesterol.</p><p><strong>Conclusion: </strong>Failure to correct for increasing regression dilution with longer follow-up may account for some of the discrepant results obtained for the importance of these risk factors in epidemiological studies at varying intervals of follow-up.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 2","pages":"143-8"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22316942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}