酒精和心血管疾病——不止一个悖论需要考虑。酒精和2型糖尿病——又一个悖论?

Renate R Zilkens, Ian B Puddey
{"title":"酒精和心血管疾病——不止一个悖论需要考虑。酒精和2型糖尿病——又一个悖论?","authors":"Renate R Zilkens,&nbsp;Ian B Puddey","doi":"10.1097/01.hjr.0000051965.16636.3c","DOIUrl":null,"url":null,"abstract":"<p><p>The French Paradox relates to the observation that mortality rates due to coronary heart disease are relatively low in France despite a diet rich in saturated fats. Another paradox linked to alcohol is the diverse associations of acute and chronic alcohol use with respect to insulin resistance, incidence of type 2 diabetes and incidence of cardiovascular disease in type 2 diabetes. Reports consistently suggest that the acute affects of alcohol induce a state of insulin resistance following either an oral and/or intravenous glucose load. Contrary to the acute alcohol studies is a large body of epidemiological evidence from cross-sectional studies which suggests that long-term exposure to alcohol is associated with an improvement in insulin sensitivity. Furthermore, a substantial number of prospective studies point to a protective role for light to moderate chronic alcohol intake against the development of diabetes as well as a protective effect of regular mild to moderate drinking against coronary artery disease in type 2 diabetic subjects.</p>","PeriodicalId":79345,"journal":{"name":"Journal of cardiovascular risk","volume":"10 1","pages":"25-30"},"PeriodicalIF":0.0000,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"64","resultStr":"{\"title\":\"Alcohol and cardiovascular disease--more than one paradox to consider. Alcohol and type 2 diabetes--another paradox?\",\"authors\":\"Renate R Zilkens,&nbsp;Ian B Puddey\",\"doi\":\"10.1097/01.hjr.0000051965.16636.3c\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The French Paradox relates to the observation that mortality rates due to coronary heart disease are relatively low in France despite a diet rich in saturated fats. Another paradox linked to alcohol is the diverse associations of acute and chronic alcohol use with respect to insulin resistance, incidence of type 2 diabetes and incidence of cardiovascular disease in type 2 diabetes. Reports consistently suggest that the acute affects of alcohol induce a state of insulin resistance following either an oral and/or intravenous glucose load. Contrary to the acute alcohol studies is a large body of epidemiological evidence from cross-sectional studies which suggests that long-term exposure to alcohol is associated with an improvement in insulin sensitivity. Furthermore, a substantial number of prospective studies point to a protective role for light to moderate chronic alcohol intake against the development of diabetes as well as a protective effect of regular mild to moderate drinking against coronary artery disease in type 2 diabetic subjects.</p>\",\"PeriodicalId\":79345,\"journal\":{\"name\":\"Journal of cardiovascular risk\",\"volume\":\"10 1\",\"pages\":\"25-30\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"64\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of cardiovascular risk\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/01.hjr.0000051965.16636.3c\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cardiovascular risk","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/01.hjr.0000051965.16636.3c","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 64

摘要

法国悖论与以下观察结果有关:尽管法国饮食中富含饱和脂肪,但因冠心病导致的死亡率相对较低。与酒精有关的另一个悖论是,急性和慢性酒精使用与胰岛素抵抗、2型糖尿病发病率和2型糖尿病心血管疾病发病率之间存在多种关联。报告一致表明,酒精的急性影响在口服和/或静脉葡萄糖负荷后诱发胰岛素抵抗状态。与急性酒精研究相反,大量来自横断面研究的流行病学证据表明,长期接触酒精与胰岛素敏感性的改善有关。此外,大量的前瞻性研究指出,轻度至中度慢性酒精摄入对糖尿病的发展具有保护作用,以及定期轻度至中度饮酒对2型糖尿病受试者的冠状动脉疾病具有保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alcohol and cardiovascular disease--more than one paradox to consider. Alcohol and type 2 diabetes--another paradox?

The French Paradox relates to the observation that mortality rates due to coronary heart disease are relatively low in France despite a diet rich in saturated fats. Another paradox linked to alcohol is the diverse associations of acute and chronic alcohol use with respect to insulin resistance, incidence of type 2 diabetes and incidence of cardiovascular disease in type 2 diabetes. Reports consistently suggest that the acute affects of alcohol induce a state of insulin resistance following either an oral and/or intravenous glucose load. Contrary to the acute alcohol studies is a large body of epidemiological evidence from cross-sectional studies which suggests that long-term exposure to alcohol is associated with an improvement in insulin sensitivity. Furthermore, a substantial number of prospective studies point to a protective role for light to moderate chronic alcohol intake against the development of diabetes as well as a protective effect of regular mild to moderate drinking against coronary artery disease in type 2 diabetic subjects.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信