Dementia (Basel, Switzerland)最新文献_第7页

Electroencephalographic correlates of periventricular white matter lesions in probable Alzheimer's disease. 脑电图与可能的阿尔茨海默病脑室周围白质病变的相关性。

Dementia (Basel, Switzerland) Pub Date : 1995-11-01 DOI: 10.1159/000106968

O L Lopez, R P Brenner, J T Becker, C A Jungreis, D Rezek, S T DeKosky

引用次数: 3

Heat shock protein 70 mRNA levels in mononuclear blood cells from patients with dementia of the Alzheimer type. 阿尔茨海默型痴呆患者单核血细胞热休克蛋白70mrna水平的研究。

Dementia (Basel, Switzerland) Pub Date : 1995-11-01 DOI: 10.1159/000106962

Y Wakutani, K Urakami, T Shimomura, K Takahashi

引用次数: 15

Cumulative risk of Alzheimer-like dementia in relatives of autopsy-confirmed cases of Alzheimer's disease. 尸检证实的阿尔茨海默病病例亲属的阿尔茨海默样痴呆累积风险

Dementia (Basel, Switzerland) Pub Date : 1995-11-01 DOI: 10.1159/000106970

L B Hocking, J C Breitner

引用次数: 5

Alzheimer's disease: distribution of changes in intraneuronal lipopigment in the frontal cortex. 阿尔茨海默病:额叶皮质神经元内脂质色素变化的分布。

Dementia (Basel, Switzerland) Pub Date : 1995-11-01 DOI: 10.1159/000106967

J H Dowson, C Q Mountjoy, M R Cairns, H Wilton-Cox

引用次数: 9

Evidence of blood-cerebrospinal fluid-barrier impairment in a subgroup of patients with dementia of the Alzheimer type and major depression: a possible indicator for immunoactivation. 阿尔茨海默型痴呆和重度抑郁症患者亚组血-脑脊液屏障损伤的证据:免疫激活的可能指标

Dementia (Basel, Switzerland) Pub Date : 1995-11-01 DOI: 10.1159/000106969

H Hampel, F Müller-Spahn, C Berger, A Haberl, M Ackenheil, C Hock

{"title":"Evidence of blood-cerebrospinal fluid-barrier impairment in a subgroup of patients with dementia of the Alzheimer type and major depression: a possible indicator for immunoactivation.","authors":"H Hampel, F Müller-Spahn, C Berger, A Haberl, M Ackenheil, C Hock","doi":"10.1159/000106969","DOIUrl":"https://doi.org/10.1159/000106969","url":null,"abstract":"Serum and cerebrospinal fluid (CSF) from 44 patients with clinical probable Alzheimer's disease (AD) (subdivided in two groups with 18 early onset, EO, and 26 late onset, LO, cases), 10 patients with vascular dementia (VD) and 24 patients with major depression (MD) were assayed for concentrations of albumin and IgG. The severity of dementia was assessed with the Mini Mental State Examination. The CSF/serum ratio for albumin and IgG as well as the IgG index were used to evaluate blood-CSF barrier function. Various patients showed signs of blood-CSF-barrier (BCB) dysfunction and only few displayed evidence of local IgG synthesis in the central nervous system (CNS) in the AD, VD and in the MD group (IgG index > 0.7). The permeability of the blood-CSF barrier was not correlated to measures of dementia severity. Our data support the hypothesis of a BCB leakage in a subgroup of all investigated patients. Furthermore, we found a small number of patients with increased intrathecal IgG synthesis. Elevated CSF immunoglobulins combined with BCB impairment might be associated or caused by a general immune activation. Our data are in agreement with the assumption that an inflammatory process may play a role in a subgroup of patients with AD but also with MD and less likely in VD. In conclusion BCB impairment and elevated IgG immunoglobulin levels are unspecific either for AD, VD or MD.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"6 6","pages":"348-54"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19544364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Cognitive performance after small strokes correlates with ischemia, not atrophy of the brain. 小中风后的认知表现与脑缺血有关，而不是脑萎缩。

Dementia (Basel, Switzerland) Pub Date : 1995-11-01 DOI: 10.1159/000106964

J S Meyer, K Obara, K Muramatsu, K F Mortel, T Shirai

引用次数: 16

Temporal quantification of Alzheimer's disease severity: 'time index' model. 阿尔茨海默病严重程度的时间量化:“时间指数”模型。

Dementia (Basel, Switzerland) Pub Date : 1995-09-01 DOI: 10.1159/000106958

J W Ashford, M Shan, S Butler, A Rajasekar, F A Schmitt

{"title":"Temporal quantification of Alzheimer's disease severity: 'time index' model.","authors":"J W Ashford, M Shan, S Butler, A Rajasekar, F A Schmitt","doi":"10.1159/000106958","DOIUrl":"https://doi.org/10.1159/000106958","url":null,"abstract":"A fundamental issue in the clinical and neuropathological assessment of Alzheimer's disease patients is quantification of dementia severity progression. Several methods have been advanced for the purpose of staging dementia with various sensitivities at different phases of the disease, but no mathematical function has been developed to link these measures to a physical continuum. Using a dynamic method for quantifying illness severity, change in severity over time was referenced to a cumulative temporal index, a physical dimension. Data from 33 patients with probable Alzheimer's disease with at least 2 successive assessments on three 50-point scales measuring cognitive, behavioral, and daily living skills were used to determine rate of change. 'Fuzzylogic' smoothing of the data, integration over time, and least-squares regression were used to derive a cubic polynomial function to calculate a severity measure in which 'days of illness' was estimated from the severity score. This method can be used to improve the comparability of performance across various mental status tests, and to link measures of very early phases of preclinical dementia and late profound dementia phases. This method also provides a description of an 'average' time course for any population from which the index is derived.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"6 5","pages":"269-80"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19508621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Tetraethylammonium-induced calcium concentration changes in skin fibroblasts from patients with Alzheimer disease. 四乙基铵诱导的阿尔茨海默病患者皮肤成纤维细胞钙浓度变化

Dementia (Basel, Switzerland) Pub Date : 1995-09-01 DOI: 10.1159/000106953

S S Matsuyama, D T Yamaguchi, Y Vergara, L F Jarvik

引用次数: 10

Intravascular malignant lymphomatosis: a cause of subacute dementia. 血管内恶性淋巴瘤病:亚急性痴呆的一个原因。

Dementia (Basel, Switzerland) Pub Date : 1995-09-01 DOI: 10.1159/000106960

T A Treves, N Gadoth, S Blumen, A D Korczyn

引用次数: 42

A case of Alzheimer's disease with extensive focal white matter changes. 阿尔茨海默病伴广泛局灶性白质改变1例。

Dementia (Basel, Switzerland) Pub Date : 1995-09-01 DOI: 10.1159/000106961

B Zahner, C J Lang, A Engelhardt, P Thierauf, B Neundörfer

引用次数: 4