Dementia (Basel, Switzerland)最新文献_第6页

Deterioration of spontaneous speech in AD patients during a 1-year follow-up: homogeneity of profiles and factors associated with progression. 1年随访期间阿尔茨海默病患者自发语言恶化:特征的同质性和与进展相关的因素

Dementia (Basel, Switzerland) Pub Date : 1996-01-01 DOI: 10.1159/000106850

B Romero, A Kurz

引用次数: 24

Senile dementia of Alzheimer type and multi-infarct dementia investigated by transcranial Doppler sonography. 经颅多普勒超声对老年痴呆和多发梗死痴呆的研究。

Dementia (Basel, Switzerland) Pub Date : 1996-01-01 DOI: 10.1159/000106851

H Sattel, H Förstl, S Biedert

{"title":"Senile dementia of Alzheimer type and multi-infarct dementia investigated by transcranial Doppler sonography.","authors":"H Sattel, H Förstl, S Biedert","doi":"10.1159/000106851","DOIUrl":"https://doi.org/10.1159/000106851","url":null,"abstract":"Dementia of the Alzheimer type, senile onset (SDAT), and multi-infarct dementia (MID) exhibit differences in cerebrovascular blood flow velocity profiles, which were investigated by means of transcranial Doppler sonography. The pulsatility indices (PI), as angle-independent parameters of peripheral vascular resistance measured in the basal cerebral arteries, were significantly increased in MID patients with respect to SDAT cases. In an analysis of the correlations between several variables and the magnitude of PI, we found strong inverse correlations of the CAMCOG score, and strong direct correlations of the blood pressure and the duration of illness, with the PI of all basal cerebral arteries only in MID patients. In SDAT patients, we found a direct correlation between the Hachinski ischemia score and the PI of all basal cerebral arteries. All 3 ischemia scores (Hachinski, Rosen, Loeb and Gandolfo) were significantly correlated with the PI of the middle cerebral and basilar arteries. By analyzing the correlations of the single items of the 3 different ischemia scores with the PI values obtained, we only found a clearcut correlation with the item focal neurological signs. Thus, our findings stress the relative importance of a concomitant cerebrovascular factor in the development of dementia in old age, even in patients with probable SDAT. A raise of the PI in the basal cerebral arteries allows early suspicion of a cerebrovascular factor even in only slight dementia so that possible risk factors for further aggravation of this type of vascular dementia might be detected and treated early in the course of disease.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 1","pages":"41-6"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106851","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19759413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Frontal lobe degeneration and Alzheimer's disease: a controlled study on clinical findings, volumetric brain changes and quantitative electroencephalography data. 额叶退化和阿尔茨海默病:临床表现、脑容量变化和定量脑电图数据的对照研究。

Dementia (Basel, Switzerland) Pub Date : 1996-01-01 DOI: 10.1159/000106849

H Förstl, C Besthorn, F Hentschel, C Geiger-Kabisch, H Sattel, U Schreiter-Gasser

引用次数: 50

The effects of nicotine in dermal plaster on cognitive functions in patients with Alzheimer's disease. 皮肤膏中尼古丁对阿尔茨海默病患者认知功能的影响。

Dementia (Basel, Switzerland) Pub Date : 1996-01-01 DOI: 10.1159/000106852

J Snaedal, T Johannesson, J E Jonsson, G Gylfadottir

引用次数: 48

Usefulness of simple measures of temporal lobe atrophy in probable Alzheimer's disease. 颞叶萎缩的简单测量在可能的阿尔茨海默病中的作用。

Dementia (Basel, Switzerland) Pub Date : 1996-01-01 DOI: 10.1159/000106847

G B Frisoni, A Beltramello, C Weiss, C Geroldi, A Bianchetti, M Trabucchi

{"title":"Usefulness of simple measures of temporal lobe atrophy in probable Alzheimer's disease.","authors":"G B Frisoni, A Beltramello, C Weiss, C Geroldi, A Bianchetti, M Trabucchi","doi":"10.1159/000106847","DOIUrl":"https://doi.org/10.1159/000106847","url":null,"abstract":"Diagnosis of Alzheimer's disease is made on clinical grounds, and the availability of a simple and sensitive quantitative index of the disease might aid in the routine diagnosis. The aim of this study was to assess whether linear measures of brain atrophy as detected by magnetic resonance imaging can be helpful in the differentiation of mild to moderate Alzheimer's disease from nondemented elderly. Measures of global (bifrontal index and interuncal distance) and hippocampal (minimum thickness of the medial temporal lobe, hippocampal height, width of the choroid fissure, and width of the temporal horn) atrophy were taken from 26 cases and 21 controls. Measures of hippocampal atrophy were the most sensitive in the differentiation of cases from controls, and among them width of the temporal horn yielded the highest sensitivity, predicting the disease in 73% of cases with 95% specificity. A compound measure comprising width of the temporal horn, width of the choroid fissure, and hippocampal height increased sensitivity to 85%. These results suggest that selected simple indices of hippocampal atrophy might be useful in the diagnosis of Alzheimer's disease.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106847","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19758887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Aphasia, apraxia, and agnosia in the diagnosis of dementia. 失语症、失用症和失认症在痴呆诊断中的作用。

Dementia (Basel, Switzerland) Pub Date : 1996-01-01 DOI: 10.1159/000106848

J H Kramer, J M Duffy

{"title":"Aphasia, apraxia, and agnosia in the diagnosis of dementia.","authors":"J H Kramer, J M Duffy","doi":"10.1159/000106848","DOIUrl":"https://doi.org/10.1159/000106848","url":null,"abstract":"The association of aphasia, apraxia and agnosia with cortical but not subcortical dementias, is a widely held belief. The purpose of the present study was to determine the frequency of aphasia, apraxia, and agnosia in groups of cortical and subcortical dementia patients, and to assess the diagnostic utility of these symptoms. Subjects were 64 patients with subcortical dementias (Parkinson's disease and normal pressure hydrocephalus) and 192 patients with cortical dementia (probable Alzheimer's disease) matched for sex, age, and Mini-Mental State Examination score. Each patient was evaluated for the presence of aphasia, apraxia, and agnosia. Results indicated that only aphasia was reported significantly more often in cortical dementia patients than in subcortical dementia patients. The presence of either of these three symptoms has very low diagnostic sensitivity, specificity, and total predictive value. The severity of the patient's dementia was predicted whether the patient had aphasia or apraxia; type of dementia had no predictive value. These data led to the conclusion that cortical and subcortical dementias cannot be reliably dissociated on the basis of aphasia, apraxia, or agnosia.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 1","pages":"23-6"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106848","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19758888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 65

Aluminium and Alzheimer's disease: review of possible pathogenic mechanisms. 铝与阿尔茨海默病:可能的致病机制综述。

Dementia (Basel, Switzerland) Pub Date : 1996-01-01 DOI: 10.1159/000106845

R A Armstrong, S J Winsper, J A Blair

引用次数: 62

Chromogranin A in cerebrospinal fluid: a biochemical marker for synaptic degeneration in Alzheimer's disease? 脑脊液中嗜铬粒蛋白A:阿尔茨海默病突触变性的生化标志物?

Dementia (Basel, Switzerland) Pub Date : 1995-11-01 DOI: 10.1159/000106963

K Blennow, P Davidsson, A Wallin, R Ekman

{"title":"Chromogranin A in cerebrospinal fluid: a biochemical marker for synaptic degeneration in Alzheimer's disease?","authors":"K Blennow, P Davidsson, A Wallin, R Ekman","doi":"10.1159/000106963","DOIUrl":"https://doi.org/10.1159/000106963","url":null,"abstract":"Biochemical markers for AD would be of great value both to improve the clinical diagnostic accuracy in scientific studies and to increase the knowledge of the pathogenesis of the disorder. One of the main features of AD is a degeneration of synapses. Therefore, we examined if chromogranin A (CrA), the major protein of large dense-core synaptic vesicles, in cerebrospinal fluid (CSF) may be of value as a biochemical marker for the synaptic function in AD. The mean concentration of CrA in CSF was about 7.5 times higher than its concentration in serum, and there was no significant correlation between CSF-CrA and the blood-brain barrier function (measured as the CSF/serum albumin ratio), nor between CSF-CrA and serum-CrA. These findings suggest that the major portion of CSF-CrA is locally produced within the CNS. There were no significant differences in CSF-CrA between the AD (n = 29), vascular dementia (n = 13), and age-matched control (n = 9) groups (99.9 +/- 58.9 ng/ml, 108.0 +/- 69.4 ng/ml, and 115.1 +/- 44.4 ng/ml, respectively). However, when the AD group was subdivided into AD type I (n = 12) and AD type II (n = 17), a lower concentration of CSF-CrA was found in AD type I (72.8 +/- 28.9 ng/ml) compared with controls (115.1 +/- 44.4 ng/ml), p < 0.02, and compared with AD type II (119.1 +/- 67.5 ng/ml), p < 0.05, while CSF-CrA did not significantly differ between AD type II and controls. These findings suggest that CSF-CrA has a potential as a biochemical marker for the synaptic degeneration in AD type I, and gives further support for the relevance of identifying the AD type I (pure AD) subgroup in scientific studies.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"6 6","pages":"306-11"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106963","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19544464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

EEG findings in dementia are related to the parietal lobe syndrome. 痴呆的脑电图表现与顶叶综合征有关。

Dementia (Basel, Switzerland) Pub Date : 1995-11-01 DOI: 10.1159/000106965

A Edman, M Matousek, A Wallin

引用次数: 9

Number of platelet dense granules varies with age, schizophrenia and dementia. 血小板致密颗粒的数量随年龄、精神分裂症和痴呆而变化。

Dementia (Basel, Switzerland) Pub Date : 1995-11-01 DOI: 10.1159/000106966

A Kessler, M Shinitzky, B Kessler

引用次数: 7