Dementia (Basel, Switzerland)最新文献_第10页

Quantitative EEG mapping, regional cerebral blood flow, and neuropsychological function in Alzheimer's disease. 阿尔茨海默病的定量脑电图定位、局部脑血流和神经心理功能。

Dementia (Basel, Switzerland) Pub Date : 1995-05-01 DOI: 10.1159/000106938

S Passero, R Rocchi, G Vatti, L Burgalassi, N Battistini

引用次数: 71

Procedural memory and Parkinson's disease. 程序性记忆和帕金森病

Dementia (Basel, Switzerland) Pub Date : 1995-05-01 DOI: 10.1159/000106942

H Allain, A Lieury, V Quemener, V Thomas, J M Reymann, J M Gandon

{"title":"Procedural memory and Parkinson's disease.","authors":"H Allain, A Lieury, V Quemener, V Thomas, J M Reymann, J M Gandon","doi":"10.1159/000106942","DOIUrl":"https://doi.org/10.1159/000106942","url":null,"abstract":"A detailed analysis of the mnestic deficits associated with Parkinson's disease (PD) contributes to explaining the cognitive disorders and their well documented consequences. This study was designed to show that, in PD declarative as well as procedural memory is severely impaired. Three tests designed to explore this aspect of mnestic functioning were proposed to a group of 16 parkinsonian patients whose motoricity was controlled: inverted reading, braille reading, sound form association. The results obtained, compared with those of young and aged controls, show that PD is associated with marked deficits in both declarative and procedural memory. Declarative memory impairment was similar to that observed in the control population (healthy elderly subjects, age-matched with the PD patients) but more marked in PD subjects. The procedural memory deficit was linked with age and pathology. Procedural memory involves a variety of processing modules dedicated to the type of information (visual, auditive, tactile codes). The deficits observed were more like a loss of automatism than procedural impairment stricto sensu ('knowing how'). It would be worth pursuing research by studying akinesia and motor disorders from the angle of automatic memory impairment.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"6 3","pages":"174-8"},"PeriodicalIF":0.0,"publicationDate":"1995-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106942","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18625969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Neuropathological diagnoses in elderly patients in Oslo: Alzheimer's disease, Lewy body disease, vascular lesions. 奥斯陆老年患者的神经病理学诊断:阿尔茨海默病、路易体病、血管病变。

Dementia (Basel, Switzerland) Pub Date : 1995-05-01 DOI: 10.1159/000106940

P G Ince, F K McArthur, E Bjertness, A Torvik, J M Candy, J A Edwardson

{"title":"Neuropathological diagnoses in elderly patients in Oslo: Alzheimer's disease, Lewy body disease, vascular lesions.","authors":"P G Ince, F K McArthur, E Bjertness, A Torvik, J M Candy, J A Edwardson","doi":"10.1159/000106940","DOIUrl":"https://doi.org/10.1159/000106940","url":null,"abstract":"Neuropathological changes in elderly residents of Oslo, Norway were characterised with respect to the cerebral substrates of dementia. Ninety-two brains were examined, representing 41% of all deaths occurring in 10 nursing homes during a 9-month period. The autopsy cohort showed a similar mean age (85 years) and sex ratio (73% female) and proportion of demented patients (75%) compared to all the patients resident in these homes who died during the same period. Clinical data was compiled retrospectively. Diagnosis was made using the CERAD protocol, and criteria for the diagnosis of Lewy body dementia. Lewy body formation was present in 20% and cerebral infarction in 21% of patients. In the demented group (69 patients) 90% fulfilled CERAD criteria for definite or probable Alzheimer's disease. Eight demented cases had absent neocortical neurofibrillary tangles and 6 other cases showed Lewy body dementia (9% of demented patients). A further 8 of these demented cases had brain stem Lewy bodies with only minimal cortical involvement. Thirteen cases (19% of the sample) had cerebral infarcts but these were considered to be clinically significant in only 4 (6%). In the non-demented patients (23) 4 patients had brain stem Lewy bodies and 6 had cerebral infarcts. Despite inclusion criteria biased towards the collection of Alzheimer's disease and normal patients, both Lewy body dementia (7%) and cerebral infarcts contributing to dementia (6%) were frequent.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"6 3","pages":"162-8"},"PeriodicalIF":0.0,"publicationDate":"1995-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18625970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 89

Severity of dementia correlates with loss of broad-band visual cortical responses. 痴呆的严重程度与宽带视觉皮层反应的丧失相关。

Dementia (Basel, Switzerland) Pub Date : 1995-05-01 DOI: 10.1159/000106941

A L Politoff, N Monson, R P Stadter, P Hass

引用次数: 5

Visual memory in Alzheimer patients: effects of practice, retention interval and severity of cognitive decline. 阿尔茨海默病患者的视觉记忆:练习的影响、保留间隔和认知衰退的严重程度。

Dementia (Basel, Switzerland) Pub Date : 1995-03-01 DOI: 10.1159/000106932

R Heun, J Bierbrauer, O Benkert

引用次数: 6

Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease. 路易体痴呆和阿尔茨海默病的淀粉样前体蛋白积累。

Dementia (Basel, Switzerland) Pub Date : 1995-03-01 DOI: 10.1159/000106923

D Van Gool, B De Strooper, F Van Leuven, R Dom

{"title":"Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease.","authors":"D Van Gool, B De Strooper, F Van Leuven, R Dom","doi":"10.1159/000106923","DOIUrl":"https://doi.org/10.1159/000106923","url":null,"abstract":"The presence of amyloid precursor protein (APP) and beta-amyloid protein (beta A4) was investigated in the cerebra of 4 patients with Alzheimer's disease (AD), 1 patient with Down's syndrome, 4 patients with dementia of the Lewy body type (DLB) and 4 age-matched, clinically nondemented controls, of which one displayed many amyloid plaques. The different types of amyloid plaques stained strongly with antibodies against beta A4. Antibodies against the C-terminal region of APP reacted only weakly with small swollen neurites and with globular deposits in neuritic-type plaques from patients with AD. The antibody against the N-terminal region of APP stained strongly cellular elements in the neuritic type plaques of patients with AD but not dense cored plaques. In contrast, patients with DLB displayed with this antibody a homogeneous staining of dense cored amyloid plaques. Some Lewy bodies stained with the antibody against the N-terminal region of APP as well. These results indicate that the processing of APP in AD and DLB could be different, to yield different fragments deposited in AD and DLB amyloid plaques.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"6 2","pages":"63-8"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106923","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18611965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Diagnosis of dementias using partial least squares discriminant analysis. 用偏最小二乘判别分析诊断痴呆。

Dementia (Basel, Switzerland) Pub Date : 1995-03-01 DOI: 10.1159/000106926

J Gottfries, K Blennow, A Wallin, C G Gottfries

引用次数: 45

Cerebrovascular reactivity to acetazolamide in (senile) dementia of Alzheimer's type: relationship to disease severity. 阿尔茨海默氏型(老年)痴呆患者对乙酰唑胺的脑血管反应性:与疾病严重程度的关系

Dementia (Basel, Switzerland) Pub Date : 1995-03-01 DOI: 10.1159/000106925

G Stoppe, R Schütze, A Kögler, J Staedt, D L Munz, D Emrich, E Rüther

引用次数: 34

Quality of life in Alzheimer's disease. 阿尔茨海默病的生活质量。

Dementia (Basel, Switzerland) Pub Date : 1995-03-01 DOI: 10.1159/000106931

K Howard, K Rockwood

引用次数: 95

Long-term estrogen replacement therapy in female patients with dementia of the Alzheimer type: 7 case reports. 长期雌激素替代治疗女性阿尔茨海默型痴呆7例报告

Dementia (Basel, Switzerland) Pub Date : 1995-03-01 DOI: 10.1159/000106929

T Ohkura, K Isse, K Akazawa, M Hamamoto, Y Yaoi, N Hagino

{"title":"Long-term estrogen replacement therapy in female patients with dementia of the Alzheimer type: 7 case reports.","authors":"T Ohkura, K Isse, K Akazawa, M Hamamoto, Y Yaoi, N Hagino","doi":"10.1159/000106929","DOIUrl":"https://doi.org/10.1159/000106929","url":null,"abstract":"Seven female patients with mild to moderate dementia of the Alzheimer type (DAT) were treated with long-term, low-dose estrogen replacement therapy (ERT) over a period of 5-45 months. Five of the 7 patients were cases who had responded well to short-term ERT with 1.25 mg/day of conjugated equine estrogens (CEE) for 6 weeks. The 7 patients from 56 to 77 years of age received 0.625 mg/day of CEE for 21 days, followed by a pause of 7 days. A 28-day cycle of low-dose ERT was performed repeatedly. In 4 cases, these patients received 5 mg/day of medroxyprogesterone acetate (MPA) during the last 10-12 days of estrogen treatment. Therapeutic efficacy of estrogen was evaluated by psychometric assessments such as the Mini-Mental State Examination (MMSE) and the Hasegawa Dementia Scale (HDS) and a behavior rating scale of the Gottfries-Bråne-Steen geriatric rating scale (GBS). The MMSE and HDS evaluations were performed principally once in 2-4 weeks. In 4 out of the 7 patients, the MMSE and HDS scores were elevated above the pretreatment levels during ERT. The termination of ERT resulted in a decrease in both scores. Furthermore, the GBS scores and daily activities of the same 4 patients were improved during ERT. In these 4 patients cognitive functions were markedly improved throughout the treatment period, while the other 2 patients responded moderately well and another patient did not respond at all. These observations suggest that long-term, low-dose ERT improves cognitive functions, dementia symptoms and daily activities in women with mild to moderate DAT.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"6 2","pages":"99-107"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106929","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18611968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 153