Dementia (Basel, Switzerland)最新文献_第5页

The role of autoimmunity in vascular dementia. 自身免疫在血管性痴呆中的作用。

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106860

S Tekin, C Aykut, S Ozgün, S Aktan

引用次数: 2

Comparative study of aprosody in Alzheimer's disease and in multi-infarct dementia. 阿甘肽治疗阿尔茨海默病与多梗死性痴呆的比较研究。

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106854

J M Pérez Trullen, P J Modrego Pardo

引用次数: 4

Steady-state pharmacokinetics of tacrine in long-term treatment of Alzheimer patients. 他克林长期治疗阿尔茨海默病患者的稳态药代动力学。

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106863

M Johansson, E Hellström-Lindahl, A Nordberg

{"title":"Steady-state pharmacokinetics of tacrine in long-term treatment of Alzheimer patients.","authors":"M Johansson, E Hellström-Lindahl, A Nordberg","doi":"10.1159/000106863","DOIUrl":"https://doi.org/10.1159/000106863","url":null,"abstract":"The pharmacokinetics of the cholinesterase inhibitor tacrine was studied in 5 Alzheimer patients during 12-31 months of treatment. A mean average steady-state concentration in plasma ranging from 1.1 to 30 ng/ml was obtained with doses ranging from 40 to 160 mg of tacrine daily. During treatment with 80 mg daily a maximal plasma concentration of tacrine (8.7 +/- 0.6 ng/ml) was obtained 1.3 +/- 0.2 h after intake of the morning dose. The mean elimination half-life was estimated at 5-7 h and remained unchanged when the tacrine dose was increased. The plasma concentration of tacrine was stable during long-term treatment with tacrine and no tolerance was observed regarding its cholinesterase inhibitory effect. A maximal 40% inhibition of plasma cholinesterase (ChE) activity and 60% inhibition of acetylcholinesterase activity in red blood cells was measured following treatment with the highest dose of 160 mg tacrine daily. A significant correlation was obtained between the plasma concentration of tacrine and the inhibition of ChE activity (p < 0.001). The tacrine concentration in CSF was measured in each patient on 1-3 occasions during the treatment and the ratio CSF/plasma concentration was estimated to be 0.47 +/- 0.09 (n = 11).","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 2","pages":"111-7"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106863","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19832172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Low apolipoprotein E4 allelic frequency in Alzheimer's disease and functional psychiatric disorders. 低载脂蛋白E4等位基因频率与阿尔茨海默病和功能性精神障碍有关。

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106864

P Thilmann, C Ernst, C Czech, S Kaumeier, K Beyreuther, H Förstl

引用次数: 12

Alterations in tau protein metabolism during normal aging. 正常衰老过程中tau蛋白代谢的改变。

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106861

E B Mukaetova-Ladinska, C R Harrington, M Roth, C M Wischik

{"title":"Alterations in tau protein metabolism during normal aging.","authors":"E B Mukaetova-Ladinska, C R Harrington, M Roth, C M Wischik","doi":"10.1159/000106861","DOIUrl":"https://doi.org/10.1159/000106861","url":null,"abstract":"It is unknown whether aging and Alzheimer's disease (AD) are on the same continuum, or whether they are qualitatively distinct. Tau protein has been identified as a major constituent of paired helical filaments (PHFs) and AD is characterised by a major redistribution of the normal tau protein pool into PHFs. Little is known about the changes in tau protein distribution that occur in the course of normal aging. We have examined PHF-bound and normal tau fractions in frontal, temporal, parietal and occipital neocortex, cerebellum, hippocampus and entorhinal cortex in 15 cognitively unimpaired individuals aged 19-88 years at death. Insoluble tau protein in the PHF fraction did not increase with aging in any brain region, despite the appearance of neurofibrillary pathology at low density in the more elderly cases. By contrast, normal tau protein decreased with aging (r = 0.32, p < 0.001), with an average loss of 14% of soluble tau per decade after the age of 20 years. This was unrelated either to neurofibrillary or beta-amyloid pathology. Frontal grey matter and hippocampus were most vulnerable to age-related tau loss, decreasing by as much as 90% in the older subgroup. These findings contrast with those we have previously reported in AD, where the redistribution of tau protein into the PHF-bound fraction was highly correlated with the extent of neurofibrillary pathology, and suggest that the mechanisms of tau loss in aging and AD are distinct. Age-related tau loss may underlie the neuropsychological impairments seen in the non-demented elderly.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 2","pages":"95-103"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106861","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19832805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Pattern visual evoked potential mapping in Alzheimer's disease: correlations with visuospatial impairment. 阿尔茨海默病的模式视觉诱发电位映射:与视觉空间损害的相关性

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106855

V Martinelli, T Locatelli, G Comi, C Lia, M Alberoni, S Bressi, M Rovaris, M Franceschi, N Canal

{"title":"Pattern visual evoked potential mapping in Alzheimer's disease: correlations with visuospatial impairment.","authors":"V Martinelli, T Locatelli, G Comi, C Lia, M Alberoni, S Bressi, M Rovaris, M Franceschi, N Canal","doi":"10.1159/000106855","DOIUrl":"https://doi.org/10.1159/000106855","url":null,"abstract":"We evaluated pattern visual evoked potentials (PVEPs) in patients with Alzheimer's disease (AD) and correlated the neurophysiological results with visuospatial performances in order to understand better the underlying causes of visual disturbances. Latencies and topographical distribution of PVEP components were evaluated in 20 AD patients who underwent an extensive battery of neuropsychological tests. Mean latencies of N70 and P100 were normal in AD patients, while mean latencies of N140 and P200 were significantly increased in comparison with age-matched healthy controls. The topographical distribution of PVEP components did not show any significant difference between the two groups. Visuospatial impairment was detected in 8 patients (40%). Statistically significant positive correlations were observed between P200 amplitude (posterior right hemisphere mean z score) and performance in visuospatial tests. Our data are consistent with a sparing of foveal retinocortical pathways and with the selective dysfunction of either corticocortical connections between the striate cortex and the visual associative structures or of right temporo-parieto-occipital visual analyzers.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 2","pages":"63-8"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106855","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19833489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Apolipoprotein E genotype does not promote the clinical progression of manifest Alzheimer's disease. 载脂蛋白E基因型不促进显性阿尔茨海默病的临床进展。

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106865

M Sarochan, H Förstl, H Sattel, R Zerfass, C Czech, K Beyreuther

引用次数: 7

Isolated amnesia with slow onset and stable course, without ensuing dementia: MRI and PET data and a six-year neuropsychological follow-up. 孤立性失忆，起病缓慢，病程稳定，无痴呆:MRI和PET数据及6年神经心理学随访。

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106862

G Miceli, C Colosimo, A Daniele, C Marra, D Perani, F Fazio

引用次数: 14

Visual and somatosensory evoked potentials in Parkinson's and Binswanger's disease. 帕金森病和宾斯旺格病的视觉和体感诱发电位。

Dementia (Basel, Switzerland) Pub Date : 1996-01-01 DOI: 10.1159/000106853

B Okuda, H Tachibana, M Takeda, K Kawabata, M Sugita

引用次数: 9

Specificity of temporal amygdala atrophy in Alzheimer's disease: quantitative assessment with magnetic resonance imaging. 阿尔茨海默病颞杏仁核萎缩的特异性:磁共振成像定量评估。

Dementia (Basel, Switzerland) Pub Date : 1996-01-01 DOI: 10.1159/000106846

C Maunoury, J L Michot, H Caillet, V Parlato, A Leroy-Willig, P Jehenson, A Syrota, F Boller

{"title":"Specificity of temporal amygdala atrophy in Alzheimer's disease: quantitative assessment with magnetic resonance imaging.","authors":"C Maunoury, J L Michot, H Caillet, V Parlato, A Leroy-Willig, P Jehenson, A Syrota, F Boller","doi":"10.1159/000106846","DOIUrl":"https://doi.org/10.1159/000106846","url":null,"abstract":"The aim of the study was to assess the specificity of temporal amygdala (TA) atrophy with magnetic resonance imaging (MRI) by comparing a group of early impaired patients with Alzheimer's disease (AD) with 'other types of dementia' and controls. In this prospective case-control study, 41 patients were selected: 12 with probable AD according to NINCDS-ADRDA and CERAD inclusion and exclusion criteria, 14 with other types of dementia and 15 age-matched control subjects. Two radiologists blindly measured the TA volumes on coronal oblique contiguous slices with a 1.5-tesla MRI scanner. TA volume measurements obtained by the 2 observers and right-left TA values were not significantly different. A significant TA atrophy was found in the AD group as compared to the other groups, with 39.7% (p < 0.001) difference in TA volumes between AD and other types of dementia groups and 41.4% (p < 0.0005) difference between AD and control groups. There was no significant difference between other types of dementia and control groups. There was an overlap between the three groups for 4 patients. TA atrophy assessed with MRI could be of diagnostic value in AD, especially in the early stage of the disease.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 1","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19758886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24