Dementia (Basel, Switzerland)最新文献_第4页

Apolipoprotein E genotype in the prediction of cognitive decline and dementia in a prospectively studied elderly population. 载脂蛋白E基因型在预测前瞻性老年人群认知能力下降和痴呆中的作用。

Dementia (Basel, Switzerland) Pub Date : 1996-05-01 DOI: 10.1159/000106873

C Brayne, C R Harrington, C M Wischik, F A Huppert, L Y Chi, J H Xuereb, D W O'Connor, E S Paykel

{"title":"Apolipoprotein E genotype in the prediction of cognitive decline and dementia in a prospectively studied elderly population.","authors":"C Brayne, C R Harrington, C M Wischik, F A Huppert, L Y Chi, J H Xuereb, D W O'Connor, E S Paykel","doi":"10.1159/000106873","DOIUrl":"https://doi.org/10.1159/000106873","url":null,"abstract":"An increased apolipoprotein E (ApoE) type epsilon 4 allele frequency is associated with both sporadic and familial late-onset Alzheimer's disease (AD). The age of onset of disease in patients homozygous for the epsilon 4 allele appears to be decreased by approximately 15 years compared with E2/3 individuals. In order to assess the influence of this allele on both dementia and cognitive decline in the elderly we have determined the ApoE genotype of 150 individuals over the age of 75 years who have taken part in a longitudinal study. Homozygosity for the epsilon 4 allele was rare. Of the 2 homozygotes, 1 was severely demented but the other did not receive a clinical diagnosis of dementia. The latter individual did demonstrate marked cognitive decline over a 28-month period. There was a consistent association between the presence of an epsilon 4 allele and both the clinical diagnosis of dementia and cognitive decline. These findings confirm a genetic heterogeneity in late-onset sporadic AD and prompt caution in the use of ApoE genotype to predict an elderly individual's susceptibility to either dementia or cognitive decline.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 3","pages":"169-74"},"PeriodicalIF":0.0,"publicationDate":"1996-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106873","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19713041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Acetylcholinesterase activity of synaptic plasma membranes during ageing: effect of L-acetylcarnitine. 衰老过程中突触质膜乙酰胆碱酯酶活性:l -乙酰肉碱的影响。

Dementia (Basel, Switzerland) Pub Date : 1996-05-01 DOI: 10.1159/000106870

A Gorini, B Ghigini, R F Villa

引用次数: 32

Dementia of the frontal lobe type: report of the neuroimaging and neuropsychological results of a case study. 额叶型痴呆:一例病例研究的神经影像学和神经心理学结果报告。

Dementia (Basel, Switzerland) Pub Date : 1996-05-01 DOI: 10.1159/000106871

A Venneri, F Grassi, P Caffarra

引用次数: 5

Cerebral ischemia: pharmacological bases of drug therapy. 脑缺血:药物治疗的药理学基础。

Dementia (Basel, Switzerland) Pub Date : 1996-05-01 DOI: 10.1159/000106872

D Ferger, J Krieglstein

引用次数: 7

Clustering of pathological features in Alzheimer's disease: clinical and neuroanatomical aspects. 阿尔茨海默病病理特征的聚类:临床和神经解剖学方面。

Dementia (Basel, Switzerland) Pub Date : 1996-05-01 DOI: 10.1159/000106866

Z Nagy, M M Esiri, K A Jobst, J H Morris, E M King, B McDonald, S Litchfield, L Barnetson

{"title":"Clustering of pathological features in Alzheimer's disease: clinical and neuroanatomical aspects.","authors":"Z Nagy, M M Esiri, K A Jobst, J H Morris, E M King, B McDonald, S Litchfield, L Barnetson","doi":"10.1159/000106866","DOIUrl":"https://doi.org/10.1159/000106866","url":null,"abstract":"We have analyzed the tendency of amyloid load, neuritic plaques and neurofibrillary tangles (NFT) in the hippocampus and neocortex to occur in clusters in 49 consecutive cases of Alzheimer's disease (AD). This clustering tendency of the pathology was analysed in relation to severity of clinical disease assessed within 6 months before death, duration and age at onset of disease and at death. Amyloid plaques showed only a slight tendency to cluster together while neuritic plaques and, even more, NFT were clearly clustered. A greater clustering tendency was associated with more severe clinical impairment with particularly strong correlations being found between the clustering tendency of NFT in the hippocampus and clinical memory deficit, and between the clustering tendency of NFT in the parietal neocortex and overall cognitive deficit. Neuritic plaques showed similar but less pronounced and robust correlations between clustering and cognitive status. In the hippocampus NFT clustering was also negatively correlated with age at death, but not duration of disease nor age of disease onset. We conclude that clustering characterises neuritic pathology but not diffuse amyloid deposits and significantly affects cognition. The discrepancies between the group diagnosed as AD-only and the patient group that contained all patients, including the ones with mixed pathology, lead us to believe that any additional pathology might have a significant effect on the cognitive status of AD patients.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 3","pages":"121-7"},"PeriodicalIF":0.0,"publicationDate":"1996-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106866","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19714274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

An atypical neuroleptic drug in the treatment of behavioural disturbances and psychotic symptoms in elderly people. 一种治疗老年人行为障碍和精神病症状的非典型抗精神病药物。

Dementia (Basel, Switzerland) Pub Date : 1996-05-01 DOI: 10.1159/000106869

B Robertsson, I Karlsson, L Eriksson, J O Olsson, H Olofsson, N O Jacobsson, G Arnell

引用次数: 8

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106856

A L Politoff, R P Stadter, N Monson, P Hass

引用次数: 27

The spatial pattern of discrete beta-amyloid deposits in Alzheimer's disease reflects synaptic disconnection. 阿尔茨海默病中离散的β -淀粉样蛋白沉积的空间模式反映了突触的断开。

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106859

R A Armstrong

引用次数: 17

Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria. 海马体病理反映阿尔茨海默病的记忆缺陷和脑成像测量:使用三组病理诊断标准的临床病理相关性

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106857

Z Nagy, K A Jobst, M M Esiri, J H Morris, E M King, B MacDonald, S Litchfield, L Barnetson, A D Smith

{"title":"Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria.","authors":"Z Nagy, K A Jobst, M M Esiri, J H Morris, E M King, B MacDonald, S Litchfield, L Barnetson, A D Smith","doi":"10.1159/000106857","DOIUrl":"https://doi.org/10.1159/000106857","url":null,"abstract":"Neurofibrillary tangles (NFT), neuritic plaques and amyloid load were quantified in sections of the hippocampus at the level of the lateral geniculate body in 41 consecutive cases fulfilling pathological criteria for diagnosis of Alzheimer's disease (AD) and coming to autopsy after longitudinal study during life. A strong correlation was found between NFT density in the hippocampus and cognitive impairment scores obtained shortly before death, particularly with scores of memory impairment. Weaker and less consistent correlations were found for hippocampal neuritic plaques and amyloid load with cognitive/memory deficits. No significant correlations were found between hippocampal pathology and either age of onset or disease duration. All three measures of hippocampal pathology were inversely correlated with the minimum medial temporal lobe (MTL) width, a measure of the MTL atrophy made from temporal-lobe-oriented X-ray computed tomography scans performed during life; the strongest correlation being between atrophy of the MTL and NFT density in the hippocampus.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 2","pages":"76-81"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106857","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19832800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 98

Analysis of amyloid precursor protein mRNAs in skin fibroblasts in Down's syndrome. 唐氏综合征皮肤成纤维细胞中淀粉样前体蛋白mrna的分析。

Dementia (Basel, Switzerland) Pub Date : 1996-03-01 DOI: 10.1159/000106858

K Urakami, J Kataoka, A Okada, K Isoe, Y Wakutani, Y Ji, Y Adachi, K Ohno, K Takahashi

引用次数: 9