Dementia (Basel, Switzerland)最新文献_第3页

A pilot study of prednisone in Alzheimer's disease. 强的松治疗阿尔茨海默病的初步研究。

Dementia (Basel, Switzerland) Pub Date : 1996-07-01 DOI: 10.1159/000106879

P S Aisen, D Marin, L Altstiel, C Goodwin, B Baruch, R Jacobson, T Ryan, K L Davis

引用次数: 50

Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments. 成对螺旋细丝发育过程中tau位点特异性磷酸化的顺序变化。

Dementia (Basel, Switzerland) Pub Date : 1996-07-01 DOI: 10.1159/000106875

T Kimura, T Ono, J Takamatsu, H Yamamoto, K Ikegami, A Kondo, M Hasegawa, Y Ihara, E Miyamoto, T Miyakawa

{"title":"Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments.","authors":"T Kimura, T Ono, J Takamatsu, H Yamamoto, K Ikegami, A Kondo, M Hasegawa, Y Ihara, E Miyamoto, T Miyakawa","doi":"10.1159/000106875","DOIUrl":"https://doi.org/10.1159/000106875","url":null,"abstract":"It has been reported that many tau sites in neurofibrillary tangles (NFT) are abnormally phosphorylated. We investigated the phosphorylation of tau in the hippocampus of nondemented patients and Alzheimer's disease patients by immunostaining with five site-specific antibodies against phosphorylated tau. In the pretangle stage, tau in neuropil threads was phosphorylated at serines 199, 202 and 409, numbered according to the longest human tau isoform, whereas tau in some neuronal soma was phosphorylated at serines 199, 202, 409 and 422. Tau at the stage of NFT was phosphorylated at serine 396 and threonine 231 in addition to serines 199, 202, 409 and 422. In the advanced stage, tau in ghost tangles was phosphorylated mainly at serine 396. These results suggest that the phosphorylation of each site in tau differs among the maturing stages of neurofibrillary change and that abnormal phosphorylation of tau in the neuronal soma occurs at 199, 202, 409 and 422 earlier than at threonine 231 and serine 396.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 4","pages":"177-81"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106875","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19803849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 136

PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man. 猴和人m1激动剂[11C]异丙胺和[11C]丁基硫代tztp的PET研究。

Dementia (Basel, Switzerland) Pub Date : 1996-07-01 DOI: 10.1159/000106877

L Farde, T Suhara, C Halldin, H Nybäck, Y Nakashima, C G Swahn, P Karlsson, N Ginovart, F P Bymaster, H E Shannon, C Foged, P D Suzdak, P Sauerberg

引用次数: 30

Atrophy of hippocampus in patients with Alzheimer's disease and other diseases with memory impairment. 阿尔茨海默病及其他伴有记忆障碍的疾病患者的海马萎缩。

Dementia (Basel, Switzerland) Pub Date : 1996-07-01 DOI: 10.1159/000106876

R Horn, B Ostertun, M Fric, L Solymosi, A Steudel, H J Möller

{"title":"Atrophy of hippocampus in patients with Alzheimer's disease and other diseases with memory impairment.","authors":"R Horn, B Ostertun, M Fric, L Solymosi, A Steudel, H J Möller","doi":"10.1159/000106876","DOIUrl":"https://doi.org/10.1159/000106876","url":null,"abstract":"In clinical practice, Alzheimer's disease (AD), multi-infarct Dementia (MID) and depression are often difficult to differentiate and may coexist. This study reports the findings of CT and MRI focused on hippocampal atrophy (HA). Quantitative volumetric MRI measurements of the hippocampus showed a reduced volume in AD patients compared to normal controls with no overlap. CT studies reported a significant widening of the hippocampal fissure in AD patients. Because volumetric measurements are not available for routine examinations, so far we are required to use the finding of hippocampal lucency in CT and dilatation of the directly visible hippocampal fissure in coronal MRI scans as criteria for HA. These findings were visually classified on a 4-point scale by 2 neuroradiologists, who had no knowledge of the clinical diagnosis. The examinations of 80 patients (42 with AD, 22 with major depression, 3 with MID, 6 classified as age-associated memory impairment (AAMI) and 8 'normals' with only subjective memory impairment) showed that the HA strongly supports the diagnosis of AD, by correctly identifying 95% of the AD patients and 47.8% of the patients without AD. These results suggest that CT and MRI examinations of the hippocampus are capable of demonstrating HA in clinical practice, which is strongly correlated with the diagnosis of AD.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 4","pages":"182-6"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106876","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19803850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

The use of multivariate methods in the identification of subtypes of Alzheimer's disease: a comparison of principal components and cluster analysis. 多变量方法在阿尔茨海默病亚型鉴定中的应用:主成分和聚类分析的比较

Dementia (Basel, Switzerland) Pub Date : 1996-07-01 DOI: 10.1159/000106882

R A Armstrong, L Wood, D Myers, C U Smith

引用次数: 13

Cortical NMDA receptor properties and membrane fluidity are altered in Alzheimer's disease. 皮层NMDA受体特性和膜流动性在阿尔茨海默病中改变。

Dementia (Basel, Switzerland) Pub Date : 1996-07-01 DOI: 10.1159/000106881

K Scheuer, A Maras, W F Gattaz, N Cairns, H Förstl, W E Müller

引用次数: 51

Psychotherapeutic intervention in dementia. 痴呆的心理治疗干预。

Dementia (Basel, Switzerland) Pub Date : 1996-07-01 DOI: 10.1159/000106880

M Haupt

引用次数: 6

Tau proteins in cerebrospinal fluid from patients with Alzheimer's disease: a longitudinal study. 阿尔茨海默病患者脑脊液中的Tau蛋白:一项纵向研究

Dementia (Basel, Switzerland) Pub Date : 1996-05-01 DOI: 10.1159/000106874

K Isoe, K Urakami, T Shimomura, Y Wakutani, Y Ji, Y Adachi, K Takahashi

引用次数: 32

Cortical synaptic changes and gliosis in normal aging, Alzheimer's disease and frontal lobe degeneration. 正常衰老、阿尔茨海默病和额叶退行性变的皮质突触改变和神经胶质瘤。

Dementia (Basel, Switzerland) Pub Date : 1996-05-01 DOI: 10.1159/000106867

X Liu, C Erikson, A Brun

{"title":"Cortical synaptic changes and gliosis in normal aging, Alzheimer's disease and frontal lobe degeneration.","authors":"X Liu, C Erikson, A Brun","doi":"10.1159/000106867","DOIUrl":"https://doi.org/10.1159/000106867","url":null,"abstract":"The most important new development during recent years in the field of degenerative dementia concerns synaptic pathology. So far it has been investigated in some regions and some cortical laminae in Alzheimer's disease (AD). The present communication is a more comprehensive study of all laminae in four different regions, the prefrontal, parietal, inferior temporal and posterior cingulate cortex. Against the background of normal aging, AD was compared with another degenerative disorder, frontal lobe degeneration of non-Alzheimer type (FLD). The synapse density was measured using synaptophysin as a marker. Astrocytes were also counted in the molecular layer. In normals, the cortex showed successively lower synaptic density from layer I to layer VI and relatively lowest density in the prefrontal cortex and a general decline with increasing age. A 46-49% decrease in synaptic density was found in all laminae in all regions of AD brains, a finding different from that in FLD. The number of astrocytes increased significantly in the prefrontal cortex both in AD and FLD but parietally only in AD. These results contribute to the understanding of normal synaptic organization of cortex, demonstrate the laminar and regional distribution of synaptic loss in AD and underscore the difference between AD and FLD. The gliosis appears to be secondary to the neurodegenerative changes. Synaptic loss is likely to be a common pathogenetic feature of neurodegenerative disorders and a likely cause of clinical symptoms and regional metabolic decrements in dementia.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 3","pages":"128-34"},"PeriodicalIF":0.0,"publicationDate":"1996-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106867","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19714275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 151

Differential susceptibility to neurofibrillary pathology among patients with Down syndrome. 唐氏综合征患者对神经原纤维病理的不同易感性。

Dementia (Basel, Switzerland) Pub Date : 1996-05-01 DOI: 10.1159/000106868

J Wegiel, H M Wisniewski, J Dziewiatkowski, E R Popovitch, M Tarnawski

{"title":"Differential susceptibility to neurofibrillary pathology among patients with Down syndrome.","authors":"J Wegiel, H M Wisniewski, J Dziewiatkowski, E R Popovitch, M Tarnawski","doi":"10.1159/000106868","DOIUrl":"https://doi.org/10.1159/000106868","url":null,"abstract":"Individual differences in the development of neurofibrillary changes were examined in eight cortical regions in the brains of 43 subjects with Down syndrome (DS; age range, 15-69 years) using sections stained with monoclonal antibodies (mAb) tau-1 and 3-39. Neurofibrillary pathology was found in 4 cases below 36 years of age and in all 20 cases above that age. In the 24 positive cases, numerical density of pretangles stained with tau-1 and 3-39, respectively, was 6.1/mm2 and 0/mm2; early tangles, 5.0/mm2 and 5.3/mm2; mature tangles, 4.0/mm2 and 5.0/mm2 (p < 0.01); and end-stage tangles, 0.04/mm2 and 2.5/mm2 (p < 0.001). Numerical density of pretangles stained with mAb tau-1 and tangles and plaques stained with mAb 3-39 correlates weakly with age (r = 0.43; p< 0.02), and together with the wide range of numerical densities suggested heterogeneity of the population examined. Cluster analysis based on two variables - i.e., numerical density of pretangles stained with mAb tau-1 and neurofibrillary tangles (NFTs) and plaques stained with mAB 3-39, distinguished three groups of subjects with severe, moderate and weak changes. The severely affected group of 5 subject (21%) had an average 54.6/mm2 of neurons and 13.9/mm/ plaques with neurofibrillary changes, whereas the moderately affected group (6 subjects; 25%) showed a significantly lower numerical density of neurons and plaques with neurofibrillary changes (25.7/mm2 and 8.1/mm2, respectively) as compared with the most affected group. Most of the subjects (13; 54%) belong to the third group with only 2.2/mm2 of neurons and 1.4/mm2 plaques with neurofibrillary pathology. Comparison of these three groups of Down syndrome subjects representing high, moderate, and low susceptibility to neurofibrillary changes with the general population suggests that the risk of Alzheimer disease is similar but the onset of pathological changes is earlier in DS.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 3","pages":"135-41"},"PeriodicalIF":0.0,"publicationDate":"1996-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106868","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19713039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27