Dementia (Basel, Switzerland)最新文献_第2页

An enriched-population, double-blind, placebo-controlled, crossover study of tacrine and lecithin in Alzheimer's disease. The Tacrine 970-6 Study Group. 阿尔茨海默病中他克林和卵磷脂的富人群，双盲，安慰剂对照，交叉研究。Tacrine 970-6研究小组。

Dementia (Basel, Switzerland) Pub Date : 1996-09-01 DOI: 10.1159/000106890

N L Foster, R C Petersen, S I Gracon, K Lewis

引用次数: 34

Apolipoprotein E and Alzheimer's disease: strength of association is related to age at onset. 载脂蛋白E与阿尔茨海默病:关联强度与发病年龄有关

Dementia (Basel, Switzerland) Pub Date : 1996-09-01 DOI: 10.1159/000106888

D L Murman, N L Foster, S P Kilgore, C A McDonagh, J K Fink

{"title":"Apolipoprotein E and Alzheimer's disease: strength of association is related to age at onset.","authors":"D L Murman, N L Foster, S P Kilgore, C A McDonagh, J K Fink","doi":"10.1159/000106888","DOIUrl":"https://doi.org/10.1159/000106888","url":null,"abstract":"Apolipoprotein E (apoE) epsilon 4 allele frequency among Alzheimer's disease (AD) patients is increased compared to control subjects and is influenced by the presence of other genetic factors and age at symptom onset. We examined the relationship between age at AD symptom onset and apoE by comparing the apoE epsilon 4 allele frequency of normal, elderly control subjects (n = 107) to that in AD patients (n = 123), divided into four age-at-onset periods. Additionally, the distribution of symptom onset ages of AD patients with and without apoE epsilon 4 alleles was determined. We observed increased apoE epsilon 4 allele frequencies between the AD onset ages of 55 and 75 years, but not at the extremes of onset ages (i.e. onset between 45 and 54 years of age and after age 75). Our data suggests that having an apoE epsilon 4 allele increases the likelihood that AD patients will develop symptoms in the middle range of onset ages. At the extremes of AD onset ages, non-apoE factors, including other genetic factors and age, are more important determinants of risk of developing AD.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 5","pages":"251-5"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106888","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19837059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Serum amyloid P component level in Alzheimer's disease. 阿尔茨海默病血清淀粉样蛋白P成分水平。

Dementia (Basel, Switzerland) Pub Date : 1996-09-01 DOI: 10.1159/000106889

E Nishiyama, N Iwamoto, M Kimura, H Arai

引用次数: 19

Cerebral metabolic changes in Alzheimer's disease: neurobehavioral patterns. 阿尔茨海默病的大脑代谢变化:神经行为模式。

Dementia (Basel, Switzerland) Pub Date : 1996-09-01 DOI: 10.1159/000106886

R Blesa, E Mohr, R S Miletich, K Hildebrand, M Sampson, T N Chase

{"title":"Cerebral metabolic changes in Alzheimer's disease: neurobehavioral patterns.","authors":"R Blesa, E Mohr, R S Miletich, K Hildebrand, M Sampson, T N Chase","doi":"10.1159/000106886","DOIUrl":"https://doi.org/10.1159/000106886","url":null,"abstract":"Regional cerebral glucose metabolism was surveyed in 37 Alzheimer's disease (AD) patients and 21 normal controls using positron emission tomography. Where possible, brain regions were specified according to their neurobehavioral function rather than as anatomically demarcated structures. Absolute metabolic values revealed significant differences (p < 0.05) between AD patients and controls for whole brain and the more superior supratentorial brain slices. Normalized values (region/brain stem) showed the most striking declines (p < 0.001) in the association cortex (heteromodal region -21%; unimodal region -19%) and the primary sensory-motor cortex (-13%), with motor, auditory, and visual areas more affected than somatosensory areas. Limbic and paralimbic systems were equally affected (-14%; -11%; p < 0.001). Thalamus, striatum, cerebellum and brain stem were minimally or not affected. Neurobehaviorally defined hypometabolic regions largely parallel affected areas noted in anatomic and previous metabolic studies, with the possible exception of metabolic deficits in the primary sensory-motor complex. Conceivably, brain areas unaffected morphologically by the pathophysiological processes of AD may become dysfunctional due to a disruption of connectivity between regions.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 5","pages":"239-45"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106886","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19837741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Dementia (Basel, Switzerland) Pub Date : 1996-09-01 DOI: 10.1159/000106893

G G Bader, K Turesson, A Wallin

{"title":"Sleep-related breathing and movement disorders in healthy elderly and demented subjects.","authors":"G G Bader, K Turesson, A Wallin","doi":"10.1159/000106893","DOIUrl":"https://doi.org/10.1159/000106893","url":null,"abstract":"Reported findings regarding sleep and sleep disorders in the elderly often conflict. Differences in results across studies may arise from selection of subjects, definitions and recording conditions. Our purpose was to test a method to study elderly, both healthy and demented, under the most natural conditions, without disturbing a fragile sleep. Using clinical parameters and a non-disturbing recording method, we evaluated sleep quality in patients with carefully diagnosed dementia and compared the results to a group of healthy subjects between 50 and 70 years of age. Healthy subjects awoke less and had more quiet sleep than patients, while in patients a tendency for delayed sleep latency and more active sleep was observed. Consistent with previous investigations, sleep-related respiratory disorders (SRRD) were more common in patients than in the matched control group, and periodic breathing appeared only among patients. SRRD, of both obstructive and central types, were only mild, with periodic breathing dominating only among patients. Most of the desaturations were less than 10%. We did not observe respiration of the Cheyne-Stokes type. Patients had more sleep-related movement disorders (SRMD), particularly with increase of twitches and long movements. Periodic movements were not significantly increased among the patients. The method, and the data obtained may be useful for practitioners dealing with sleep disorders in geriatric populations. In the elderly, interactivity between sleep, SRRD and SRMD may be bidirectional and as elderly and demented subjects might have a distorted homeostatic sleep response, SRRD and SRMD, even in a mild form, may cause sleep disruption and worsen dementia.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 5","pages":"279-87"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19837066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Letter and category fluency in Alzheimer's disease: a prognostic indicator of progression? 阿尔茨海默病的字母和类别流畅性:进展的预后指标?

Dementia (Basel, Switzerland) Pub Date : 1996-09-01 DOI: 10.1159/000106887

R F Coen, C Maguire, G R Swanwick, M Kirby, T Burke, B A Lawlor, J B Walsh, D Coakley

{"title":"Letter and category fluency in Alzheimer's disease: a prognostic indicator of progression?","authors":"R F Coen, C Maguire, G R Swanwick, M Kirby, T Burke, B A Lawlor, J B Walsh, D Coakley","doi":"10.1159/000106887","DOIUrl":"https://doi.org/10.1159/000106887","url":null,"abstract":"This study investigated differential patterns of performance by 40 Alzheimer's disease (AD) patients on standardised letter and category fluency tests. The performance of 24 age and education matched controls was used to classify patients as relatively more letter fluency impaired (L < C, n = 15) or more category fluency impaired (C < L, n = 25), and clinical features distinguishing these patient subgroups were investigated. Category performance was equally impaired in both patient subgroups, whereas the L < C subgroups were particularly impaired on letter fluency. The subgroups differed significantly in duration of illness (24 months for L < C group, 47 months for C < L group; t = 2.69, p = 0.01) but did not differ in global dementia severity, age, education, general language ability, or functional status. Data on annual rate of change (ARC) on the Mini-Mental State Examination were available for 26 patients. While not statistically significant, subgroup ARC differences were suggestive of more rapid decline in the L < C patients, consistent with the finding of shorter duration of illness in this group. Word fluency tests may have potential as early predictors of rate of progression in AD.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"7 5","pages":"246-50"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19837742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Glial fibrillary acidic protein in the cerebrospinal fluid of patients with dementia. 痴呆患者脑脊液中胶质原纤维酸性蛋白的研究。

Dementia (Basel, Switzerland) Pub Date : 1996-09-01 DOI: 10.1159/000106891

A Wallin, K Blennow, L E Rosengren

引用次数: 66

Intact brain serotonin system in vascular dementia. 血管性痴呆的完整脑血清素系统。

Dementia (Basel, Switzerland) Pub Date : 1996-07-01 DOI: 10.1159/000106878

G Hansson, I Alafuzoff, B Winblad, J Marcusson

引用次数: 11

Quantitative assessment of synaptic density in the outer molecular layer of the hippocampal dentate gyrus in Alzheimer's disease. 阿尔茨海默病海马齿状回外分子层突触密度的定量评估。

Dementia (Basel, Switzerland) Pub Date : 1996-07-01 DOI: 10.1159/000106884

S W Scheff, D L Sparks, D A Price