Dementia (Basel, Switzerland)最新文献_第8页

Long-term effects of tacrine on regional cerebral blood flow changes in Alzheimer's disease. 他克林对阿尔茨海默病局部脑血流变化的长期影响。

Dementia (Basel, Switzerland) Pub Date : 1995-09-01 DOI: 10.1159/000106954

L Minthon, K Nilsson, L Edvinsson, P E Wendt, L Gustafson

引用次数: 17

Effect of seizures on progression of dementia of the Alzheimer type. 癫痫发作对阿尔茨海默型痴呆进展的影响。

Dementia (Basel, Switzerland) Pub Date : 1995-09-01 DOI: 10.1159/000106956

L Volicer, S Smith, B J Volicer

引用次数: 108

Changes of the relative severity of naming, fluency and recall impairment in the course of dementia of the Alzheimer type. 阿尔茨海默型痴呆病程中命名、流畅性和回忆障碍相对严重程度的变化。

Dementia (Basel, Switzerland) Pub Date : 1995-09-01 DOI: 10.1159/000106955

S Pollman, M Haupt, A Kurz

引用次数: 14

Changes in a CSF antigen associated with dementia. 脑脊液抗原变化与痴呆相关。

Dementia (Basel, Switzerland) Pub Date : 1995-09-01 DOI: 10.1159/000106959

M T Carretero, C R Harrington, C M Wischik

引用次数: 9

Eye movement dysfunction in dementia of the Alzheimer type. 阿尔茨海默型痴呆的眼动功能障碍。

Dementia (Basel, Switzerland) Pub Date : 1995-09-01 DOI: 10.1159/000106957

A Moser, D Kömpf, J Olschinka

引用次数: 42

Synaptophysin immunoreactivity is stable 36 h postmortem. 突触体素免疫反应性在死后36小时稳定。

Dementia (Basel, Switzerland) Pub Date : 1995-07-01 DOI: 10.1159/000106949

X Liu, A Brun

引用次数: 30

Striatonigral degeneration combined with olivopontocerebellar atrophy with subcortical dementia and hallucinatory state. 纹状体变性合并橄榄桥脑小脑萎缩伴皮质下痴呆和幻觉状态。

Dementia (Basel, Switzerland) Pub Date : 1995-07-01 DOI: 10.1159/000106952

Y Fukutani, N Takeuchi, K Kobayashi, K Miyazu, N Yamaguchi, T Terada, I Nakamura, K Isaki

{"title":"Striatonigral degeneration combined with olivopontocerebellar atrophy with subcortical dementia and hallucinatory state.","authors":"Y Fukutani, N Takeuchi, K Kobayashi, K Miyazu, N Yamaguchi, T Terada, I Nakamura, K Isaki","doi":"10.1159/000106952","DOIUrl":"https://doi.org/10.1159/000106952","url":null,"abstract":"We present an autopsied case of striatonigral degeneration (SND) combined with olivopontocerebellar atrophy (OPCA) with subcortical dementia and hallucinatory state. A Japanese woman without a remarkable family history showed hand tremor at the age of 35 years, followed by bradykinesia, muscle rigidity, orthostatic hypotension, neurogenic bladder and pyramidal signs. No obvious cerebellar symptoms were found. Various antiparkinsonian drugs were administered, but were not markedly effective for the parkinsonism. She developed a mild dementia characterized by mild memory disturbance with preservation of orientation, slowing of thought processes, emotional lability toward sadness, impaired ability to manipulate acquired knowledge and poor calculating, and by the absence of aphasia, apraxia and agnosia. The features in this patient were consistent with those seen in subcortical dementia. She also had auditory hallucinations. MRI revealed hypointense T2 signals in the putamina and substantia nigra. T1-weighted MRI demonstrated atrophy of both the pons and cerebellum in addition to atrophy of the putamina and substantia nigra. EEG showed slowing of background activity. She died of cardiac failure at the age of 47. Autopsy disclosed brain stem tegmental atrophy, SND, OPCA and many glial cytoplasmic inclusions in the central nervous system, but well-preserved cerebrum. We discuss the relationship between the psychiatric symptoms and pathologic findings of brain stem tegmentum.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"6 4","pages":"235-40"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106952","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18557746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Dietary changes, compulsions and sexual behavior in frontotemporal degeneration. 额颞叶变性患者的饮食改变、强迫行为和性行为。

Dementia (Basel, Switzerland) Pub Date : 1995-07-01 DOI: 10.1159/000106946

B L Miller, A L Darby, J R Swartz, G G Yener, I Mena

{"title":"Dietary changes, compulsions and sexual behavior in frontotemporal degeneration.","authors":"B L Miller, A L Darby, J R Swartz, G G Yener, I Mena","doi":"10.1159/000106946","DOIUrl":"https://doi.org/10.1159/000106946","url":null,"abstract":"The occurrence of weight gain, sweet and carbohydrate craving, hyposexuality, and compulsions in frontal lobe dementia (FLD) compared to Alzheimer's disease (AD) was evaluated. FLD is a progressive dementia with a high rate of misdiagnosis and therefore better diagnostic criteria for FLD are needed. Fourteen patients meeting research criteria for AD were compared to 14 with suspected FLD. All had cerebral perfusion measured with xenon-133 and imaged with HMPAO using brain-dedicated SPECT. The FLD group showed frontotemporal and AD posterior temporoparietal hypoperfusion. The primary caregivers were queried regarding weight gain, sweet/carbohydrate preference, sexual drive, and compulsions. Differences were compared with Fisher's exact test. The following was found in FLD versus AD: Weight gain in FLD patients amounted to 64% (AD 7%), carbohydrate craving was 79% (vs. 0%) and compulsive behavior 64% (vs. 14%). The differences for these symptoms were statistically significant, whereas for the symptoms increased sexual drive (8 vs. 8%) and reduced sexual drive (54 vs. 23%) no significant difference could be found. In FLD the first symptoms were often dietary changes or hyposexuality. Compulsions were more bizarre and severely disabling in FLD than in AD. Dietary changes, hyposexuality, and disabling compulsions are prominent early symptoms in FLD but not AD. The cause of these symptoms may be due to both frontal and subcortical serotonin loss and dysfunction of the anterior temporal lobes.","PeriodicalId":79336,"journal":{"name":"Dementia (Basel, Switzerland)","volume":"6 4","pages":"195-9"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106946","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18556568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 157

Familial Alzheimer's disease and cortical Lewy bodies: is there a genetic susceptibility factor? 家族性阿尔茨海默病与皮质路易体:是否存在遗传易感性因素?

Dementia (Basel, Switzerland) Pub Date : 1995-07-01 DOI: 10.1159/000106945

C F Lippa, T W Smith, L Nee, Y Robitaille, B Crain, D Dickson, D Pulaski-Salo, D A Pollen

引用次数: 17

A decrease in neural sialyltransferase activity in Alzheimer's disease. 阿尔茨海默病中神经唾液转移酶活性的降低。

Dementia (Basel, Switzerland) Pub Date : 1995-07-01 DOI: 10.1159/000106944

T M Maguire, K C Breen

引用次数: 49