Annals of Neurosciences最新文献

{"title":"The Distribution of Lifestyle Risk Factors Among Patients with Stroke in the Indian Setting: Systematic Review and Meta-Analysis.","authors":"Biji P Varkey, Jaison Joseph, Abin Varghese, Suresh K Sharma, Elezebeth Mathews, Manju Dhandapani, Venkata Lakshmi Narasimha, Radha Kuttan, Saleena Shah, Surekha Dabla, Sivashanmugam Dhandapani","doi":"10.1177/09727531221115899","DOIUrl":"10.1177/09727531221115899","url":null,"abstract":"<p><strong>Background: </strong>The burden of stroke is increasing in India, but there is limited understanding of the distribution of reported risk factors in the Indian setting. It is vital to generate robust data on these modifiable risk factors to scale up appropriate strategies for the prevention of cerebrovascular diseases in this setting.</p><p><strong>Summary: </strong>The objective of this study is to estimate the overall proportion of life style risk factors of patients with stroke in the Indian setting. We searched PubMed and Google Scholar and relevant studies published till February 2022 were included. The risk of bias assessment was considered for the study selection criterion in the meta-analysis. The publication bias was evaluated by funnel plots and Egger's test. We identified 61 studies in the systematic review and after quality assessment, 36 studies were included for meta-analysis. Random effect model was used due to the significant inconsistency among the included studies (I2 > 97%). The mean age of the participants was 53.84±9.3 years and patients with stroke were predominantly males (64%). Hypertension (56.69%; 95% CI: - 48.45 - 64.58), obesity (36.61%; 95% CI: - 19.31 - 58.23), dyslipidemia (30.6%; 95% CI: - 22 - 40.81) and diabetes mellitus (23.8%; 95% CI: - 18.79 - 29.83) are the leading intermediate conditions associated with stroke. The Physical inactivity - 29.9% (95% CI: - 22.9 - 37.1), history of tobacco use (28.59 %; 95% CI: - 22.22 - 32.94) and alcohol use (28.15 %; 95% CI: - 20.49 - 37.33) were reported as the behavioral risk factors for stroke in this setting.</p><p><strong>Key messages: </strong>The current meta-analysis provides robust estimates of the life style related risk-factor of stroke in India based on the observational studies conducted from 1994 to 2019. Estimating the pooled analysis of stroke risk factors is crucial to predict the imposed burden of the illness and ascertain the treatment and prevention strategies for controlling the modifiable risk factors in this setting.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 1","pages":"40-53"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9988695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minority Stress in Emotion Suppression and Mental Distress Among Sexual and Gender Minorities: A Systematic Review.","authors":"Akanksha Singh,&nbsp;Anu Dandona,&nbsp;Vibha Sharma,&nbsp;S Z H Zaidi","doi":"10.1177/09727531221120356","DOIUrl":"https://doi.org/10.1177/09727531221120356","url":null,"abstract":"<p><strong>Background: </strong>The existing structural framework of defining gender and sexuality based on heteronormative ideology led to the succession of the notions of stigma, prejudice, and hate towards the sexual and gender minority population. The presence of strong scientific evidence for the negative consequences of discriminatory and violent events has directed the association with mental and emotional distress. This study aims to comprehend the role of minority stress in emotional regulation and suppression among the sexual minority population globally using systematic review of literature through elaborate Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines.</p><p><strong>Summary: </strong>The analyses of the sorted literature premised on the PRISMA guidelines revealed that minority stress mediates the emotion regulation processes among the individuals who witness continuous episodes of discrimination and violence leading to emotional dysregulation and emotion suppression. Studies also reported the dominance of various health-risk behaviors such as alcohol addiction, drug abuse, and other forms of intoxication among sexual minority individuals. Increased instances of anxiety, stress, depression, and suicidal ideations were prominent in the findings of the empirical research suggesting an intricate role of minority stress in advancing the faulty emotion suppression and mental health concerns among the sexual and gender minority population.</p><p><strong>Key message: </strong>Minority stressors among sexual and gender minority individuals mediate emotion suppression and mental distress.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 1","pages":"54-69"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/26/10.1177_09727531221120356.PMC10259152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9633088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future of Monoclonal Antibody Therapy in Parkinson's Disease.","authors":"Sanjeev Kharel,&nbsp;Rajeev Ojha","doi":"10.1177/09727531221136349","DOIUrl":"https://doi.org/10.1177/09727531221136349","url":null,"abstract":"Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons AttributionNonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-Commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https:// us.sagepub.com/en-us/nam/open-access-at-sage). Commentary","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 1","pages":"8-10"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/3c/10.1177_09727531221136349.PMC10259150.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9988694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive Psychological Changes at High Altitude Shown by the Low Landers after the Yoga Intervention-Sudarshan Kriya Yoga (SKY).","authors":"Sheetal J Gupta,&nbsp;Balaram Pradhan,&nbsp;Disha Bhanushali,&nbsp;Rishi Nityapragya Nitin Limaye","doi":"10.1177/09727531221117637","DOIUrl":"https://doi.org/10.1177/09727531221117637","url":null,"abstract":"<p><strong>Background: </strong>Immediate assent to high altitude affects the cognitive performance and mood of an individual, which is followed by depression and anxiety. It also affects the sleep quality, general health, and happiness quotient of an individual. Sudarshan Kriya Yoga (SKY) is a cyclical breathing technique, which has been proven successful in managing stress, depression, anxiety, and helps in the improvement of sleep quality.</p><p><strong>Purpose: </strong>The current study was to understand the role of SKY meditation on psychological parameters, happiness quotient of low landers at high altitude (Leh).</p><p><strong>Methods: </strong>It is a two-armed pre-post study with experimental and control group both are lowlanders, and their psychological parameters are being assessed when they immediately assent to high altitude (Leh). There are two groups experimental group (SKY) was from AOL SKY-AMP and has prior SKY meditation experience. The control group does not have any yoga or meditation experience. SKY-AMP is a 4 days protocol done at high altitude by the SKY group. Both groups reach Leh through air mode transportation.</p><p><strong>Results: </strong>Oxford Happiness Questionnaire (OHQ) showed a significant result in the SKY group with P ≤ .001, whereas it is nonsignificant in the control group. We also observed anthropometric and physiological changes in the participants showing significant effects on weight, BMI, waist circumference, hip circumference, and blood pressure; with no significant effect in the control group. It is one of the first studies done with both two groups, where yoga and meditation are done at high altitude and then seen the changes in the groups at physical and psychological level.</p><p><strong>Conclusion: </strong>Yogic practices can be helpful in having positive psychological change in the lowlanders at high altitude.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 1","pages":"20-25"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/4a/10.1177_09727531221117637.PMC10259153.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9633095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADHD and Neuropsychology: Developmental Perspective, Assessment, and Interventions.","authors":"Amrina Bhullar,&nbsp;Krishan Kumar,&nbsp;Akshay Anand","doi":"10.1177/09727531231171765","DOIUrl":"https://doi.org/10.1177/09727531231171765","url":null,"abstract":"Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons AttributionNonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-Commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https:// us.sagepub.com/en-us/nam/open-access-at-sage). Editorial","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 1","pages":"5-7"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/6a/10.1177_09727531231171765.PMC10259154.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9686232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Anti-epileptic Drugs for Post Traumatic Seizure: A Global Survey.","authors":"Harison Gopalan,&nbsp;Krishnakumar P,&nbsp;Arun S","doi":"10.1177/09727531221120765","DOIUrl":"https://doi.org/10.1177/09727531221120765","url":null,"abstract":"Background Post traumatic seizures (PTS) and post traumatic epilepsy (PTE) are potential consequences of traumatic brain injury (TBI). There is no consensus regarding its management among treating doctors. Purpose We have undertaken a global survey to assess the variability of management practices of PTS and PTE and highlight the pressing need to formulate uniform practice guidelines. Methods A questionnaire consisting of sixteen questions were developed with the help of Google survey and sent through e-mail, or social media platforms like WhatsApp, Facebook messenger or Telegram, to practicing Neurologists and Neurosurgeons round the world. Results There were a total of 220 responses. Majority of our responders (n = 202; 91.8%) would start an anti-epileptic (AED) prophylaxis to prevent PTS; 18 people (8.18%) told that they would not start AED prophylaxis for TBI. Phenytoin (n = 98; 48.5%) followed by Levetiracetam (n = 78; 38.6%) was the preferred drug, although the latter was significantly preferred by high and upper middle-income countries (p<.001). Majority (n = 99; 49%) would not use it beyond two weeks. Most clinicians would manage PTE with a single drug (n = 160; 72.7%) either Phenytoin (n = 69; 31.3%) or levetiracetam (n = 67; 30.4%). Most of them (n = 174; 86%) would treat for less than one year. Conclusions Practices in the management of PTS and PTE vary widely among clinicians. Our study point towards the need for the development of a more robust and comprehensive practice guidelines for the management of the same.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 1","pages":"26-32"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/c1/10.1177_09727531221120765.PMC10259155.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9988693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homocysteine, Vitamins B6, B12, and Folate and the Risk of Ischemic and Hemorrhagic Stroke: A Case-control Study from Northeast India.","authors":"Manash Ghose,&nbsp;Madhumita Das,&nbsp;Rupjyoti Das,&nbsp;Amit Ranjan Barua,&nbsp;Prasenjit Deka,&nbsp;Aparajita Barman,&nbsp;Vivekananda Lahan,&nbsp;Dhruba Jyoti Choudhury,&nbsp;Jai Prakash Sharma,&nbsp;Manik Mathur,&nbsp;Nomal Chandra Borah,&nbsp;Nupur Choudhury,&nbsp;Ananya Barman","doi":"10.1177/09727531221124425","DOIUrl":"https://doi.org/10.1177/09727531221124425","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a major leading global health complication. Identification and management of risk factors associated with stroke can help in prior detection, prevention, and improvement in patient care.</p><p><strong>Purpose: </strong>To investigate the prevalence of hyperhomocysteinemia (HHcy) and Vitamins B6, B12, and folate deficiency in stroke patients and also to assess other risk factors associated with ischemic and hemorrhagic stroke.</p><p><strong>Methods: </strong>Detail history of all the subjects in the study including history of hypertension, anemia, fasting glucose, carotid artery thickness, smoking, alcohol, and dietary intake was recorded. Standard assays for homocysteine (Hcy), Vitamins B6, B12, and folate estimation were done. Lipid and renal profile tests were also performed. The prevalence and odds of having HHcy, Vitamins B6, B12, and folate deficiency, and other risk factors in ischemic and hemorrhagic stroke patients were evaluated. Student's <i>t</i>-tests and chi-square tests were done for statistical validation of the data.</p><p><strong>Results: </strong>Prevalence of HHcy and Vitamins B6, B12, and folate deficiency was not observed in ischemic cases. HHcy and folate deficiency was found to be prevalent in hemorrhagic stroke patients. The odds that a person with HHcy and folate deficiency has hemorrhagic stroke was found to be significantly high.</p><p><strong>Conclusion: </strong>In our study, high Hcy and low folate levels emerged as risk factors for hemorrhagic stroke.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 1","pages":"33-39"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/d5/10.1177_09727531221124425.PMC10259151.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9633087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Low-Intensity Magnetic Field Stimulation in 6-Hydroxydopamine Rat Model of Parkinson's Disease: From Inflammation to Motor Function.","authors":"Samrat Bose,&nbsp;Tapas Chandra Nag,&nbsp;Soumil Dey,&nbsp;Monica Sundd,&nbsp;Suman Jain","doi":"10.1177/09727531221117634","DOIUrl":"https://doi.org/10.1177/09727531221117634","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a progressive neurodegenerative disorder that mainly affects the aged population. Transcranial magnetic field (MF) stimulation has shown to provide temporary motor recovery in neurological disorders.</p><p><strong>Purpose: </strong>The aim of this study was to understand the cellular and molecular mechanism of low-intensity MF stimulation (17.96 µT; 50Hz; 2 h/day, four weeks) in a rat model of severe PD.</p><p><strong>Methods: </strong>A clinically relevant, bilateral striatal 6-hydroxydopamine (6-OHDA) lesioned rat model of severe PD was employed to test the efficacy of low-intensity MF stimulation in the management of motor symptoms. The mechanism of action of MF was dissected by assessing the microglial activation, tissue ultrastructure, and cerebrospinal fluid (CSF) metabolomics using microdialysis.</p><p><strong>Results: </strong>We observed a significant improvement in the postural balance and gait after MF exposure with a significant reduction in the number of activated microglia. There was an improvement in striatal dopaminergic innervation and glutamate levels but it did not reach a level of statistical significance.</p><p><strong>Conclusion: </strong>MF stimulation helped ameliorate the motor deficits and reduced inflammation but was unable to provide a significant change in terms of dopaminergic innervation and metabolic profile in the severe 6-OHDA PD rat model.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 1","pages":"11-19"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ed/1b/10.1177_09727531221117634.PMC10259148.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9633090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Contribution Towards Management of COVID-19 Patients with Yoga and Naturopathy Intervention.","authors":"Poornima Ravi, Venugopal Vijayakumar, Maheshkumar Kuppusamy, Velan Arumugam","doi":"10.1177/09727531221130558","DOIUrl":"10.1177/09727531221130558","url":null,"abstract":"","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"29 4","pages":"199-200"},"PeriodicalIF":1.8,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/93/10.1177_09727531221130558.PMC10101162.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9686349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online Yoga and Ayurveda Intervention as Tertiary Prevention of Psychological Comorbidities in COVID-19 Survivors: A Randomized Controlled Trial.","authors":"Rudra Bhandari","doi":"10.1177/09727531221117623","DOIUrl":"https://doi.org/10.1177/09727531221117623","url":null,"abstract":"<p><strong>Background and purpose: </strong>About 56% of symptomatic COVID-19 survivors have been found with neuropsychological comorbidities, such as depression, anxiety, posttraumatic stress disorders (PTSD), and impaired quality of life (QoL). Alongside, antimicrobial, anti-inflammatory, neuroprotective, regenerative, immunomodulatory, cardio-pulmonary health promotive, and psychological benefits of yogic and Ayurvedic intervention are well documented. Therefore, this study aimed to assess the effect of online Yoga (OYI) and Yoga cum Ayurveda intervention (OYAI) on COVID-19-induced depression, anxiety, PTSD, and poor QoL.</p><p><strong>Method: </strong>Seventy-two participants (males/females: 33/26) with at least a 3-month back history of symptomatic COVID-19 infection and age (mean ± SD: 32.33 ± 9.9 and 33.04 ± 12.9 for males and females, respectively) were recruited from Patanjali Ayurveda Hospital, Haridwar, India, and All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India, before random allocation into an equal-sized control group (CG), Yoga group (YG) and Yoga cum concoction (YCG) group. Split-plot analysis of variance and Kruskal-Wallis tests with Bonferroni adjusted <i>post hoc</i> comparisons were computed for normal and nonnormal data using IBM SPSS (25th Version, SPSS South Asia Private Limited, Bangalore, India).</p><p><strong>Results: </strong>Both the treatments-the 30-day OYI and OYAI, significantly improved depression (<i>P</i> < .002, ES: -0.99 and <i>P</i> < .001, ES: -2.11), anxiety (<i>P</i> < .001, ES: -1.32 and -1.89), PTSD (<i>P</i> < .001, ES: -1.8 and -1.83) and QoL related constructs (<i>P</i> < .001, ES: 0.63 and 0.76; 0.71 and 0.93 for each OYI and OYAI versus general health and physical health; <i>P</i> < .001, ES: 0.65 for OYAI versus psychological health; and <i>P</i> < .003, ES: 0.54 for OYI versus environment) of the participants compared to the controls.</p><p><strong>Conclusion: </strong>OYAI may better ameliorate COVID-19-induced psychological comorbidities than OYI with no adverse effects.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"29 4","pages":"233-244"},"PeriodicalIF":1.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/a1/10.1177_09727531221117623.PMC10101154.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9686356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}