Annals of Neurosciences最新文献

{"title":"Mind-Body Interventions as Modulators of Neural Connectivity and Cognition in Individuals at Risk for Alzheimer's Disease: A Systematic Review.","authors":"Dwivedi Krishna, Avinash Chandra Pandey, Saurav Nilesh, Sridam Ananda, Jyoti Amit Singh, Amit Singh","doi":"10.1177/09727531261441080","DOIUrl":"10.1177/09727531261441080","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is the leading cause of dementia worldwide, contributing to nearly 60%-70% of dementia cases. Current pharmacological treatments provide limited symptomatic relief and minimal efficacy in altering disease progression, highlighting the need for complementary interventions. Mind-body practices such as yoga and meditation are increasingly explored for preserving cognitive abilities and reducing neurodegenerative risk.</p><p><strong>Summary: </strong>This systematic review evaluated randomized controlled trials investigating yoga, meditation, and related mind-body interventions on cognitive and neural health in individuals with normal cognition, mild cognitive impairment, or subjective memory decline. Following PRISMA guidelines, studies published up to March 2025 were reviewed. Findings showed improvements in memory, attention, executive functions, mood, and quality of life. Neurobiological benefits included preservation of hippocampal volume, improved functional connectivity, increased brain-derived neurotrophic factor levels, and reduced neuroinflammation markers. However, methodological limitations such as small sample sizes and short intervention durations were common.</p><p><strong>Key message: </strong>Mind-body interventions show promising cognitive and neurobiological benefits in populations at risk of AD. Yoga and meditation may serve as feasible, cost-effective complementary approaches alongside conventional therapy. Larger long-term clinical trials are needed to establish standardized protocols and sustained therapeutic effectiveness.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261441080"},"PeriodicalIF":3.1,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13226303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148154984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Care Quality for Metabolic Dysfunction-associated Steatotic Liver Disease Through a Structured Yogic Intervention: Protocol for a Randomised Controlled Trial.","authors":"Gautam Panwar, Garima Singh, Kanchan Joshi, Sanjay Gupta, Kuldeep Singh, Vikas Upadhyay","doi":"10.1177/09727531261444545","DOIUrl":"10.1177/09727531261444545","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in the world. It is strongly linked to obesity, high blood pressure, type 2 diabetes and dyslipidaemia. Yoga, which includes asanas, pranayama, shat-karmas and meditation, may offer a holistic approach to improve the liver, metabolism and mental health.</p><p><strong>Purpose: </strong>To evaluate the effectiveness of a 60-min yoga module in improving liver health and metabolic parameters in MASLD patients.</p><p><strong>Methods: </strong>This open-label, two-arm, randomised controlled trial enrolled 72 adults aged 18-60 years diagnosed with MASLD, who received standard care at a hospital in Dehradun. Participants were randomised equally into a yoga group, which received a 60-min online yoga module 5 days per week for 3 months, or a control group receiving standard treatment alone. Key assessments include ultrasound measurement of liver fat, liver enzymes (serum glutamate pyruvate transaminase [SGPT], serum glutamic-oxaloacetic transaminase [SGOT]), HbA1c, lipid profile, body mass index, blood pressure, mental health and quality of life. Data collection occurred at baseline and 3 months post-intervention.</p><p><strong>Results: </strong>The study is designed to assess improvements in hepatic steatosis and metabolic and psychosocial parameters following intervention.</p><p><strong>Conclusion: </strong>This trial will provide evidence on the role of yoga as an adjunct therapy in MASLD management.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261444545"},"PeriodicalIF":3.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative and Complementary Therapies: A Review Exploring the Role of Yoga and Ayurveda-based Herbal Medicines in Alleviating Hypothyroidism and Its Neuropsychiatric Manifestations.","authors":"Garima Jaglan, Acharya Balkrishna, Anurag Varshney","doi":"10.1177/09727531261440119","DOIUrl":"10.1177/09727531261440119","url":null,"abstract":"<p><strong>Background: </strong>Hypothyroidism is the most prevalent endocrine disorder characterised by low thyroid hormone production, leading to a wide spectrum of cognitive and neuropsychiatric manifestations such as fatigue, depression, anxiety, cognitive impairment, peripheral neuropathy, Parkinsonism, tremor, ataxia, seizures and dementia. Although conventional treatment with levothyroxine replacement remains the standard of care, neuropsychiatric symptoms often persist, highlighting the need for safer and more effective alternative therapeutic strategies.</p><p><strong>Purpose: </strong>This narrative review aims to explore the effects of yoga-based interventions and Ayurveda-based herbal medicines in mitigating hypothyroidism and related neuropsychiatric symptoms.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across PubMed, Scopus, Cochrane and Google Scholar. Studies examining the effects of yoga practices (asanas, pranayama, meditation) and Ayurveda-based herbal medicines such as <i>Withania somnifera, Coriandrum sativum, Melissa officinalis, Commiphora wightii</i> and other adaptogenic herbs on levels of thyroid hormones and neuropsychiatric outcomes of hypothyroidism were selected and included.</p><p><strong>Results: </strong>Emerging evidence suggests that yogic interventions improve thyroid function and mental well-being by modulating the hypothalamic-pituitary-thyroid axis and neuroendocrine pathways. Ayurveda-based herbal medicines have been shown to exhibit antioxidant, anti-inflammatory and adaptogenic properties, contributing to enhanced thyroid function and neuroprotection. However, most studies are limited by small sample sizes, heterogeneity in intervention protocols, lack of standardisation and short follow-up periods, restricting the reproducibility and generalisability of study findings.</p><p><strong>Conclusion: </strong>Holistic interventions such as yoga and Ayurveda-based herbal medicines may offer potential benefits in managing hypothyroidism and addressing its neuropsychiatric manifestations. However, current evidence remains preliminary and heterogeneous. High-quality, randomised controlled trials with standardised protocols are necessary to substantiate these findings and assess their efficacy, safety, long-term outcomes and clinical relevance.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261440119"},"PeriodicalIF":3.1,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13190364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Disability and Loneliness Among Clinically Stable Individuals with Schizophrenia: A Cross-sectional Study.","authors":"Stephy S, Pradeep Kumar Pc, Sojan Antony, E Sinu","doi":"10.1177/09727531261441117","DOIUrl":"10.1177/09727531261441117","url":null,"abstract":"<p><strong>Background: </strong>Functional disability and loneliness frequently persist among clinically stable individuals with schizophrenia, thereby impeding recovery and restricting social participation.</p><p><strong>Purpose: </strong>This study assessed functional disability and loneliness in clinically stable individuals with schizophrenia and to examine their associations with socio-demographic variables and employment status.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted with 50 clinically stable individuals with schizophrenia, aged 18 to 60 years. Data were collected using socio-demographic schedule, the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), and the UCLA Loneliness Scale.</p><p><strong>Results: </strong>The mean loneliness and WHODAS scores were 43.16 ± 11.96 and 74.28 ± 14.65, respectively. No significant differences were observed by gender or domicile. Participants from joint families showed higher disability in self-care (p = .005), household activities (p = .041), and participation (p = .007). Duration of unemployment was positively correlated with disability (r = 0.311-0.517, p < .05), whereas employment duration was negatively correlated with disability in interpersonal, work, and participation domains.</p><p><strong>Conclusion: </strong>Unemployment and joint family dynamics are associated with increased disability, underscoring the importance of vocational rehabilitation and family-focused psychosocial interventions.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261441117"},"PeriodicalIF":3.1,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of the Self-Efficacy Scale for Bharatanatyam Dancers.","authors":"Swarnamalya M, D C Mathangi, Padmavathi, Mahesh Kumar","doi":"10.1177/09727531261441998","DOIUrl":"10.1177/09727531261441998","url":null,"abstract":"<p><strong>Background: </strong>Self-efficacy, the belief in one's ability to succeed, plays a crucial role in learning, consistent practice and performance in skill-intensive fields. Bharatanatyam, a classical Indian dance form, requires high levels of technical precision, artistic expression and physical endurance. While research in sports and Western dance has shown that self-efficacy enhances performance, there is limited evidence in Indian classical dance, and no validated self-efficacy tool specific to Bharatanatyam exists. Standard scales do not capture the cultural, physical and expressive dimensions of Bharatanatyam. This gap in measurement limits researchers' understanding of dancers' confidence levels in specific performance domains.</p><p><strong>Purpose: </strong>This study aimed to develop and validate a self-efficacy scale tailored to Bharatanatyam dancers.</p><p><strong>Methods: </strong>A 20-item scale was developed and validated, categorised into four domains: technical skills, expressive abilities, performance readiness and overall confidence. Items were rated on a five-point Likert scale. Content validation involved expert review (<i>n</i> = 6), focusing on item relevance and clarity. Experts evaluated each item, and feedback was used to refine the tool. As a part of initial validation, Cronbach's alpha was calculated to assess the internal consistency reliability of the 20-item scale.</p><p><strong>Results: </strong>Experts unanimously agreed on the relevance and clarity of all items. The scale demonstrated strong content validity, with a content validity ratio of 1.00 and Item Content Validity Index values ranging from 0.83 to 1.00, indicating accurate reflection of key performance areas in Bharatanatyam.</p><p><strong>Conclusion: </strong>The Self-Efficacy Scale for Bharatanatyam Dancers developed is a contextually relevant and valid tool for assessing dancers' confidence across performance domains. It has potential applications in the design of psychological support in classical dance education.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261441998"},"PeriodicalIF":3.1,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Fluid-based Biomarkers for Cognitive Impairment in Parkinson's Disease.","authors":"Ragini R, Shatabdi Choudhury, Krithika N C, M M Srinivas Bharath, B L Sujatha Rathod, Ravi Yadav, Phalguni Anand Alladi","doi":"10.1177/09727531261442666","DOIUrl":"10.1177/09727531261442666","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is the second most common neurodegenerative disorder with cognitive impairment as a prime non-motor symptom. Biomarkers can assist in detecting cognitive impairment, which normally follows movement dysfunction, and also assist in the differentiation of PD patients with and without cognitive dysfunction, facilitating the early diagnosis and disease management while also allowing for timely therapeutic intervention.</p><p><strong>Summary: </strong>Here, we have reviewed the biomarkers of Parkinson's disease from different sources i.e., body fluids (CSF, blood, salivary, urine and tear) and tissues (gut and skin), along with the techniques used for the detection of these biomarkers. We further discuss the importance of biomarker validation and the significance of cohort studies in biomarker discoveries.</p><p><strong>Key message: </strong>The chapter is aimed at updating the knowhow of the disease biomarkers that may assist differentiation of these overlapping entities.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261442666"},"PeriodicalIF":3.1,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burnout and Well-being at Work: Exploring Psychological Mechanisms Through Stress Appraisal Perspective.","authors":"Richa Gupta, Hariom Sharma, Priya Choudhary","doi":"10.1177/09727531261443125","DOIUrl":"10.1177/09727531261443125","url":null,"abstract":"<p><strong>Background: </strong>Escalating workplace stress has made employee well-being a global concern, necessitating the identification of factors and underlying mechanisms that impair psychological health. Against this backdrop, examining burnout as a potential workplace stressor and its implications for employee well-being is both timely and crucial.</p><p><strong>Purpose: </strong>Building upon the Stress Appraisal Theory, this study endeavoured to assess the impact of burnout on employee well-being at work in terms of their work engagement and job satisfaction. The relationship between these variables has been elucidated through the lens of a moderated mediation framework of psychological capital (PsyCap) and psychological distress. Specifically, the contribution of psychological distress in mediating the relationship between burnout and employee workplace well-being was ascertained. Further, the function of PsyCap in alleviating the influence of burnout on the workplace well-being of employees was examined.</p><p><strong>Methods: </strong>This study proposed a moderated mediation model exploring the underlying and intervening mechanisms of the association between burnout and employee workplace well-being, with reference to psychological distress and PsyCap. The model was tested among 439 human service professionals using a two-step approach to structural equation modelling.</p><p><strong>Results: </strong>The findings revealed that burnout results in poor workplace well-being of employees in terms of work disengagement and job dissatisfaction through an indirect relationship via psychological distress. Further, it was found that PsyCap has moderated this indirect relationship such that employees with high PsyCap suffer less from the repercussions of burnout and subsequent psychological distress.</p><p><strong>Conclusion: </strong>The study highlights the role of personal factors in a comprehensible model of burnout and well-being. Insights about such factors and their latent processes are indispensable for designing effective mental health interventions at work.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261443125"},"PeriodicalIF":3.1,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147961858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Adjustment of Institutionalised Children: A Thematic Analysis of Caregiver Perspectives in Delhi.","authors":"Nishtha Grover, Kritika Rastogi, Swarnali Chakraborty","doi":"10.1177/09727531261435741","DOIUrl":"10.1177/09727531261435741","url":null,"abstract":"<p><strong>Background: </strong>A substantial proportion of institutionalised children come from environments marked by exploitation, parental death or incapacity, and unstable housing. Prior research indicates that early life trauma and institutionalisation adversely affect emotional regulation and psychosocial adjustment.</p><p><strong>Purpose: </strong>This study examines how trauma, institutional environments in Indian child care settings, and the absence of stable familial support influence children's psychosocial development and their preparedness for life outside institutional care.</p><p><strong>Methods: </strong>A qualitative design was adopted. Five caregivers from a boys' child care institution in Jahangirpuri, Delhi-serving as Child Protection Officer, counsellor, housefather, and other roles-were interviewed. Data were analysed using thematic analysis as outlined by Clarke and Braun.</p><p><strong>Results: </strong>Caregivers reported persistent challenges among children, including verbal and physical aggression, low academic motivation, and difficulties in emotional regulation and forming social relationships. These findings reflect the compounded effects of trauma and institutional living conditions.</p><p><strong>Conclusion: </strong>The study underscores the significant impact of trauma and institutionalisation on psychosocial development. It highlights the need for trauma-informed care and strengthened support systems to improve developmental outcomes and facilitate successful reintegration into society.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261435741"},"PeriodicalIF":3.1,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Efficacy of Spiritually Integrated Psychological Sessions in Managing Internet Addiction and Other Comorbid Symptoms.","authors":"Madhu Pandey, Kritika Rastogi, Suvarna Sharma, Chhaya Gupta, Reetika Pal, Namita Srivastava, S Z H Zaidi","doi":"10.1177/09727531261441453","DOIUrl":"10.1177/09727531261441453","url":null,"abstract":"<p><strong>Background: </strong>In this fast-paced world, the use of the internet has become very fundamental to both professional and personal existence, ultimately influencing human cognition. This has grown as a global concern for every age group, particularly among young adults. There have been many psychological therapies to effectively deal with internet addiction, and one such intervention can be through enhancing the spirituality component within individuals. Therefore, spiritually integrated psychological sessions (SIPS) within counselling settings can serve as a significant framework in managing internet addiction, particularly related to spending excessive time on social media platforms.</p><p><strong>Purpose: </strong>(a) The purpose of this study is to assess the effectiveness of spirituality-based counselling sessions on reducing internet addiction (time spent ≥8 h/day on social media platforms), depression, anxiety and stress. (b) To enhance emotional and spiritual intelligence within the participants.</p><p><strong>Methods: </strong>The present study used a single-case experimental design (SCED) using a phased intervention model inspired by non-concurrent multiple baseline design (NCMBD) to assess the effectiveness of the well-structured SIPS on reducing internet addiction, while enhancing emotional and spiritual intelligence as well as managing other comorbid symptoms reported by the participants, which are depression, anxiety and stress. A total of three participants (age between 15 and 18 years) were selected through purposive sampling with criterion-based selection. The methodology strictly followed the SCRIBE guidelines across the implementation of the sessions.</p><p><strong>Results: </strong>The results obtained showed consistent patterns of stability in managing the usage of the internet, significant reduction in the reported symptoms of depression, anxiety and stress. There was also an enhancement in the emotional and spiritual intelligence among the participants.</p><p><strong>Conclusion: </strong>The present research indicates that SIPS is an effective framework in reducing internet addiction (time spent ≥8 h/day on social media platforms like Instagram, WhatsApp, Facebook and Snapchat) and other symptoms of depression, anxiety and stress. The activities as well as techniques involved in SIPS have also been found to be effective in regulating both emotional and spiritual intelligence among adolescents while managing and improving their behavioural patterns.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261441453"},"PeriodicalIF":3.1,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Trait Emotional Intelligence with Perceived Stress, Body Image and Quality of Life in Indian Women with Polycystic Ovary Syndrome: A Cross-sectional Study.","authors":"Pranav Venkatachaliah Kanamanapalli, Saranya Kuppusamy, Chitra Thyagaraju, Senthil Kumar Subramanian","doi":"10.1177/09727531261440667","DOIUrl":"10.1177/09727531261440667","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) imposes a substantial psychological burden, with affected women experiencing an increased risk of depression and suicidal behaviour. Although the clinical features of PCOS are well documented, the influence of modifiable psychological factors such as emotional intelligence (EI) remains underexplored, particularly among Indian women.</p><p><strong>Purpose: </strong>This study examined the associations between trait EI, perceived stress, body shape concern and quality of life in Indian women with PCOS.</p><p><strong>Methods: </strong>A cross-sectional analytical study was conducted at a tertiary care centre in Puducherry, India. One hundred women aged 18-35 with confirmed PCOS were recruited. Participants completed validated questionnaires: the Trait Emotional Intelligence Questionnaire-Short Form, Perceived Stress Scale-10, Body Shape Questionnaire-16A and Polycystic Ovary Syndrome Questionnaire. Multiple linear regression models were used to identify independent correlates of psychological outcomes.</p><p><strong>Results: </strong>A significant psychological burden was evident, with 91% of participants reporting moderate to high perceived stress. Higher trait EI was significantly associated with better psychological well-being, showing negative correlations with both perceived stress (<i>ρ</i> = -0.60) and body shape concern (<i>ρ</i> = -0.43). Multiple linear regression analysis, after controlling for covariates, confirmed that higher EI was the strongest independent correlate of lower perceived stress (<i>β</i> = -0.58, <i>p</i> < .001), reduced body shape concern (<i>β</i> = -0.34, <i>p</i> < .001) and higher overall quality of life (<i>β</i> = 0.51, <i>p</i> < .001). Additionally, moderate physical activity was independently associated with lower perceived stress (<i>p</i> < .001) and higher quality of life (<i>p</i> = .011).</p><p><strong>Conclusion: </strong>Trait EI emerged as a key independent correlate of lower perceived stress, reduced body shape concern and improved quality of life. Moderate physical activity also contributed independently to lower stress and better quality of life. These findings support incorporating emotion-focused interventions into comprehensive PCOS management.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261440667"},"PeriodicalIF":3.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}