Annals of Neurosciences最新文献

{"title":"Resting State Networks and Their Associations with Cognitive Functions in Traumatic Brain Injury: An Integrative Review.","authors":"Madhumathi P C, Visvanathan Krishnaswamy, Rajeswaran Rangasami, Rimjhim Agrawal, Vijayalakshmi Purushothaman, Varadharajan Sivaraman","doi":"10.1177/09727531261452860","DOIUrl":"10.1177/09727531261452860","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) is a significant global health concern resulting in persistent physical, cognitive, and social impairments that affect daily functioning and quality of life. Resting-state functional magnetic resonance imaging (rs-fMRI) has emerged as a valuable neuroimaging modality offering novel insights into brain function at rest.</p><p><strong>Summary: </strong>This integrative review synthesised evidence from studies indexed in PubMed, ScienceDirect, and Scopus on resting-state network (RSN) alterations and their association with cognitive dysfunction in TBI. Consistent alterations in functional connectivity were identified across multiple RSNs in TBI population, particularly within the default mode network (DMN), frontoparietal network (FPN), and salience network. DMN connectivity showed strong associations with attention, processing speed, and memory. FPN connectivity changes corresponded with executive function deficits, while sensorimotor network disruptions were linked to attentional impairments. Dynamic longitudinal changes in network connectivity further suggested underlying neuroplasticity mechanisms.</p><p><strong>Key message: </strong>Resting-state functional connectivity demonstrates as a potential sensitive biomarker for TBI diagnosis, prognosis, and rehabilitation monitoring. With implications for individualised rehabilitation, these findings highlight the need for a network oriented approach for understanding, diagnosing, and treating TBI. Future research should explore longitudinal changes in RSN connectivity and their implications for neuro-rehabilitation strategies.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261452860"},"PeriodicalIF":3.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148325383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual Dementia in the Digital Age: Neurocognitive Mechanisms, Behavioural Impact and Public Health Implications of Technology Overuse.","authors":"Arunkumar Subramanian, R Aishwarya Reddy, Ashwin Ravichandran, Mahendran Sekar, Ling Shing Wong, Yashas Chandra, Mariyammal R, Tamilanban T, Manasa K, Vinoth Kumarasamy, Vetriselvan Subramaniyan","doi":"10.1177/09727531261420601","DOIUrl":"10.1177/09727531261420601","url":null,"abstract":"<p><strong>Background: </strong>Digital technology has rapidly transformed how people communicate, learn, and perform professional activities. While technological advancements have improved access to information, productivity, and global connectivity, excessive reliance on digital devices has raised concerns regarding cognitive and behavioral health. Emerging evidence suggests that prolonged screen exposure, constant multitasking, and dependence on digital aids may contribute to cognitive symptoms resembling dementia, including impaired attention, memory difficulties, reduced problem-solving ability, and emotional disengagement. This phenomenon, often described as \"virtual dementia\" or \"digital dementia,\" has become an area of growing scientific and public health interest.</p><p><strong>Summary: </strong>Current evidence indicates that excessive digital technology use may alter neural circuits involved in cognition, particularly within the prefrontal cortex, hippocampus, and the Default Mode Network. These changes may manifest as digital amnesia, attentional fragmentation, mental fatigue, reduced social engagement, and emotional blunting. Adolescents and young adults appear especially vulnerable due to ongoing neurodevelopment, although many of these changes may be reversible with behavioral modification. Unlike neurodegenerative disorders such as Alzheimer's disease, virtual dementia is characterized by lifestyle-associated and potentially reversible cognitive dysfunction. At the same time, digital technologies also show therapeutic potential in cognitive monitoring, rehabilitation, and preventive interventions, highlighting their dual role in brain health.</p><p><strong>Key message: </strong>Virtual dementia represents a potentially reversible form of technology-associated cognitive impairment driven by maladaptive digital behaviours. Promoting digital hygiene, mindful technology use, cognitive training, and responsible technology policies may help protect cognitive health. Future longitudinal and mechanistic studies are needed to establish diagnostic criteria, clarify long-term neurological effects, and develop evidence-based prevention and intervention strategies.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261420601"},"PeriodicalIF":3.1,"publicationDate":"2026-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13269118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pornography Use, Motivational Patterns and Suicidal Ideation Among Young Adults: A Cross-sectional Behavioural Analysis.","authors":"Chandreyee Roy, Ahmed Sameer","doi":"10.1177/09727531261450406","DOIUrl":"10.1177/09727531261450406","url":null,"abstract":"<p><strong>Background: </strong>Pornography engagement is frequently examined through exposure-based frameworks that assume higher levels of consumption are associated with adverse psychological outcomes. Emerging evidence suggests that such engagement reflects underlying reward-processing and affect-regulation mechanisms. However, prior findings regarding its association with suicidal ideation remain inconsistent.</p><p><strong>Purpose: </strong>The present study aimed to examine the association between pornography exposure, consumption motives, depressive symptoms and suicidal ideation among young adults.</p><p><strong>Methods: </strong>A cross-sectional sample of 541 university students completed measures of pornography exposure intensity, pornography consumption motives, depressive symptoms and suicidal ideation. Bayesian regression analyses were conducted to examine associations between pornography use, motives, depressive symptoms and suicidal ideation.</p><p><strong>Results: </strong>Depressive symptoms emerged as the most robust predictor of suicidal ideation across all models. Pornography exposure intensity demonstrated a small negative association with suicidal ideation (<i>β</i> = -0.09, 94% highest density interval (HDI) [-0.15, -0.03]) after accounting for depressive vulnerability. Among motivational factors, emotional avoidance was positively associated with suicidal ideation (<i>β</i> = 0.15, 94% HDI [0.06, 0.23]), whereas sexual pleasure motives were negatively associated (<i>β</i> = -0.18, 94% HDI [-0.29, -0.08]) with suicidal ideation. A significant interaction was observed between depressive symptoms and sexual curiosity.</p><p><strong>Conclusion: </strong>The findings suggest that pornography use is not uniformly associated with suicidal ideation. Instead, associations vary depending on various psychological factors and motives for use. As the study is cross-sectional, the findings should be interpreted as associational rather than causal. These results highlight the importance of considering emotional regulation and individual vulnerability when examining the mental health implications of pornography use.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261450406"},"PeriodicalIF":3.1,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to Mainstream School Inclusion Among Children with Autism Spectrum Disorder.","authors":"Rajni Sharma, Niharika Dadoo, Bikash Medhi","doi":"10.1177/09727531261451929","DOIUrl":"10.1177/09727531261451929","url":null,"abstract":"","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"273-274"},"PeriodicalIF":3.1,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13259880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal Fluid Cytokine and Chemokine Profiles in Autoimmune Encephalitis: A Cross-sectional Study.","authors":"Arpna Srivastava, Rajesh Kumar Singh, Jyotirmoy Banerjee, Elavarasi A, Animesh Das, Bhargavi Ramanujam, Jasmine Parihar, Awadh Kishor Pandit, Vishnu V Y, Deepti Vibha, Sarat Chandra, M V Padma Srivastava, Manjari Tripathi","doi":"10.1177/09727531261445199","DOIUrl":"10.1177/09727531261445199","url":null,"abstract":"<p><strong>Background: </strong>Autoimmune encephalitis (AE) is a major cause of acute and subacute neuropsychiatric syndromes.</p><p><strong>Purpose: </strong>While neuronal autoantibody testing aids diagnosis, results are often delayed or negative in seronegative cases. Cerebrospinal fluid (CSF) cytokine profiling may provide a rapid diagnostic adjunct.</p><p><strong>Methods: </strong>In this cross-sectional study, we analysed CSF from 43 AE patients (29 seronegative, 9 <i>N</i>-methyl-d-aspartate receptor antibody-positive, 3 leucine-rich glioma-inactivated 1 (LGI1)-positive, and 2 with rare antibodies) and 34 controls (33 idiopathic intracranial hypertension and 1 viral encephalitis). Cytokine levels (IL-6, IL-7, IL-13, IL-21, CXCL10 and CXCL13) were quantified using a multiplex immunoassay.</p><p><strong>Results: </strong>All measured cytokines were significantly elevated in AE compared with controls (<i>p</i> < .001). CXCL10 and CXCL13 showed the largest differences between AE and controls, with CXCL13 particularly high in LGI1-positive cases. IL-6 correlated positively with IL-13 (<i>r</i> = 0.47, <i>p</i> = .0013) and CXCL13 (<i>r</i> = 0.41, <i>p</i> = .0064), while IL-7 correlated with IL-21 (<i>r</i> = 0.33, <i>p</i> = .029). Cytokine profiles in seronegative AE were comparable to antibody-positive AE, with no statistically significant differences.</p><p><strong>Conclusions: </strong>CSF cytokines-particularly CXCL10, CXCL13, IL-6 and IL-13-are consistently elevated in AE and reflect shared intrathecal immune activation across antibody-positive and seronegative cases. These findings are exploratory, and cytokines are proposed as adjunctive immunological markers rather than standalone diagnostic tools.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261445199"},"PeriodicalIF":3.1,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motivational Interviewing: Exploring Predictors of Motivation to Change in Individuals with Borderline Personality Disorder.","authors":"Shrawasti Lavanya, Soniya Vats, Vinod Kumar Shanwal","doi":"10.1177/09727531261447067","DOIUrl":"10.1177/09727531261447067","url":null,"abstract":"<p><strong>Background: </strong>Borderline personality disorder (BPD) is a complex condition in which individuals often face significant challenges with low motivation and high ambivalence in treatment. The present study aimed to qualitatively explore the predictors of motivation to change in females with BPD through motivational interviewing (MI) as an adjunctive, pre-therapy intervention.</p><p><strong>Purpose: </strong>In patients with BPD due to sudden shifts in mood there is lack of motivation and poor treatment adherence, resulting in poor prognosis. To enhance the treatment compliance and motivation in BPD patients the present study was designed to explore the predictors of motivation to change in patients with BPD with the help of Motivational Interview as an adjunctive therapy.</p><p><strong>Methods: </strong>A qualitative design was employed, utilising Braun and Clarke's (2006, <i>Qual Res Psychol</i>, 3, 2, 77-101) Thematic Analysis. A purposive sample of five BPD-diagnosed female participants, aged 20-35, was recruited from the Hospital for Mental Health, Ahmedabad, Gujarat. Participants underwent six to eight sessions of MI, followed by semi-structured interviews. Data were transcribed and analysed using an inductive thematic approach.</p><p><strong>Results and discussion: </strong>The analysis yielded a thematic framework of six interconnected themes, with participants moving 'From Emotional Turmoil to Meaning-Making', navigating the central conflict of 'Struggling Between Hope and Helplessness' (the nature of ambivalence) and contending with 'Working Through the Wall' (barriers to change). Forward momentum was driven by 'Seeds of Motivation' (internal and external factors) and facilitated by 'Catalysts of Change' (supports and small steps). 'The MI Experience' was identified as a primary predictor of change.</p><p><strong>Conclusion: </strong>MI as a 'therapeutic bridge' for individuals with BPD may help them transition from self-blame to self-reflection and from ambivalence to action. It appears to be a valuable adjunct to enhance the effectiveness of intensive therapies.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261447067"},"PeriodicalIF":3.1,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intimate Partner Violence and Mental Health in Rural Women.","authors":"Krishan Kumar, Aseem Mehra, Sandeep Kaur, Tanvi Kiran, Kapil Goel","doi":"10.1177/09727531261447039","DOIUrl":"10.1177/09727531261447039","url":null,"abstract":"<p><strong>Background: </strong>Intimate partner violence (IPV) is a significant problem; however, researchers and clinicians have not paid much attention.</p><p><strong>Purpose: </strong>To assess the prevalence of IPV among married rural women and its correlates.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in a rural area. All the eligible females were assessed on the Intimate Partner Violence Questionnaire (IPVQ), Generalised Anxiety Disorder Questionnaire-7 (GAD-7) and Patient Health Questionnaire (PHQ)-9.</p><p><strong>Results: </strong>169 females included with the mean age of 35.8 years. The prevalence of lifetime experience of IPV was 29.0%. Controlling behaviour was most common, followed by physical violence, threatening behaviour and sexual behaviour. About one-fourth (26%) had depres-sion, and a little less than one-third (30.8%) had an anxiety disorder. Severity of depression and anxiety had a significant posi-tive correlation with IPV and other domains of IPV. Those participants whose husbands were consuming alcohol or other illicit drugs and were from a lower socio-economic status reported a significantly higher experience of IPV.</p><p><strong>Conclusion: </strong>The stakeholders, such as community health organisations, Ministry of Family and Healthcare organisations and others, should work in collaboration with a non-govern-mental organisation in a coordinated and planned manner and can take a pivotal role in research, prevention of IPV and other psychiatric problems among rural females.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261447039"},"PeriodicalIF":3.1,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Approach of Development of Robust Animal Model for Autism Spectrum Disorder.","authors":"Shonam Tamrakar, Veeraraghavan Gayathri, Natesan Pazhanivel, Suvarna Jyothi Kantipudi","doi":"10.1177/09727531261447058","DOIUrl":"10.1177/09727531261447058","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder. Numerous environmental risk factors have been implicated in the development of ASD in human cases, suggesting that multiple aetiological agents may contribute to developing an ASD rodent model. In this study, we have investigated the pathobiological processes and outcomes in a novel rat model of ASD that incorporates clinically relevant prenatal and perinatal insults. Specifically, a gamma-aminobutyric acid modulator, valproic acid (VPA), used for perinatal insults, and postnatal hypoxia was combined to understand the critical stages of brain development in rat pups and to explore potential causal mechanisms underlying ASD.</p><p><strong>Purpose: </strong>To develop the robust animal model for ASD using VPA and hypoxia as causative agents in combination to test other efficacious medicines for ASD in future.</p><p><strong>Method: </strong>A total of 16 female and 4 male Wistar rats were selected for mating, and the delivered pups were used for the study. The pregnant female animals were divided into four groups: G1: normal control group, G2: VPA group-received a single injection of VPA intraperitoneal (i.p.) on gestational day (GD) 12.5, G3: hypoxia group, rat pups were subjected to postnatal hypoxia, G4: VPA + hypoxia group, pregnant females received VPA (i.p. on GD 12.5), followed by normal delivery, after which the pups were subjected to postnatal hypoxia. Neurodevelopmental reflex tests, neurobehavioural assessments (open field test and Morris water maze) and three-chamber social interaction tests were conducted on the rat pups. Histopathological evaluation of the pups' brains was performed.</p><p><strong>Results: </strong>The VPA, hypoxia and combined VPA + hypoxia groups exhibited significant neurobehavioural alterations, with marked delays in neurodevelopmental reflexes compared to the normal control group. Histopathological examination of the brain revealed a reduction in Purkinje cells within the Purkinje cell layer, along with extensive neuronal degeneration. The severity of both neurobehavioural deficits and histopathological abnormalities was greatest in the combined VPA + hypoxia group compared to the other experimental groups.</p><p><strong>Conclusions: </strong>These findings suggest that the combination of prenatal VPA exposure and postnatal hypoxia, representing pre- and perinatal insults, induces ASD-like conditions in rat pups that closely resemble the clinical behaviour features and redox imbalance of human ASD. Thus, this combined model could serve as a potential animal model for ASD and could be used for screening pharmacological agents aimed at treating and managing ASD.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261447058"},"PeriodicalIF":3.1,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Architecture in Parkinson's Disease with Rapid Eye Movement Sleep Behaviour Disorder: Insights from a Scoping Review.","authors":"Megha Shri Nanjundaswamy, Pooja Mailankody, Monojit Debnath, Pramod Kumar Pal, Ravi Yadav","doi":"10.1177/09727531261446810","DOIUrl":"10.1177/09727531261446810","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is the leading age-related neurodegenerative disorder with a deposition of α-synuclein-containing Lewy bodies. Idiopathic REM sleep behaviour disorder (iRBD) can occur a decade prior to motor symptoms onset in PD. The retina acts as a window to the brain and its structural changes, along with RBD, may serve as a prodromal marker for PD.</p><p><strong>Summary: </strong>We evaluated the existing scientific evidence on structural retinal alterations in subjects with iRBD and PD with and without RBD. The selected four studies were observational and investigated the structural retinal layer thickness in iRBD patients, PD patients who likely had RBD (probable RBD), PD lacking RBD, and healthy individuals. Findings reported thinning of the retinal ganglion cell layer, nerve fibre layer (RNFL), outer and inner plexiform layers, inner and outer nuclear layers, reduced ganglion cell complex thickness, and peripapillary RNFL. Additionally, one study reported functional changes, including diminished contrast sensitivity and visual acuity in both the iRBD and PD groups.</p><p><strong>Key message: </strong>This scoping review highlights significant thinning of retinal layers in RBD subjects in the context of PD. Retinal imaging serves as a biomarker in the early detection of neurodegeneration.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261446810"},"PeriodicalIF":3.1,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13233593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Load in the Age of Artificial Intelligence: A Bibliometric Analysis (2021-2025).","authors":"Suraj Gupta, Badri Narayan Mishra, Rashmi Gore, Sandeep Kumar Singh, Anita Awasthi, Anurag Mishra, Ram Kishore, Vimal Singh","doi":"10.1177/09727531261443089","DOIUrl":"10.1177/09727531261443089","url":null,"abstract":"<p><strong>Background: </strong>The integration of AI and digital learning technologies has transformed education but introduced cognitive overload challenges. Cognitive Load Theory (CLT) offers a framework for understanding information processing in technology-enhanced environments, yet its intellectual structure in the post-pandemic AI-driven landscape remains underexplored.</p><p><strong>Summary: </strong>This bibliometric analysis of 1,600 open-access CLT publications (2021-2025) from HYPERLINK \"https://dimensions.ai/\"Dimensions.ai examined publication trends, citation impact, collaboration patterns, and thematic clusters using VOSviewer. Results show 28% annual growth. Three clusters dominate (74% link strength): (a) Educational and Developmental Psychology (motivation, resilience, schema construction); (b) Clinical and Cognitive Sciences (cognitive interventions, well-being); and (c) Information and Computing in Human-centred Contexts (AI-driven adaptive learning). The USA, Australia, and UK lead in impact; Asia-Pacific (China, Singapore, Hong Kong) emerges as a technology-focused hub. Education and Information Technologies showed the highest mean citation rate.</p><p><strong>Key message: </strong>This first bibliometric review maps CLT's post-2020 evolution toward human-AI symbiosis, providing an empirical framework for cognitively sustainable digital learning environments and confirming CLT's growing interdisciplinary integration with educational technology and cognitive science.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261443089"},"PeriodicalIF":3.1,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}